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The map label for this gene is rotA [H]

Identifier: 186476150

GI number: 186476150

Start: 1565066

End: 1565647

Strand: Direct

Name: rotA [H]

Synonym: Bphy_1392

Alternate gene names: 186476150

Gene position: 1565066-1565647 (Clockwise)

Preceding gene: 186476149

Following gene: 186476151

Centisome position: 44.98

GC content: 58.59

Gene sequence:

>582_bases
ATGAAATGGTTGATGTTGGCGCTCGGCAGCGCCGCCCTGATCGCAAACGCCCCAGCCTTTGCGCAAAACGGGTCACAGGC
TGCGCATCCGTCCGTTCTCTTGAAAACATCGGAAGGCGATATCCGTGTCGAGCTGTATCCCGAGAAAGCGCCGAAGACGG
TCGCCAACTTCCTCGATTACGTGAAATCCGGTCAATATAACGGCACGATCTTCCATCGCGTGATCCCCGGCTTCATGATC
CAGGGCGGCGGCTATACGACGAGCTTCGCGGAGAAGCCGACGCGCGCGCCGATTTCTCTCGAAAGCCGCAATGGCCTGAA
GAACATGACGGGCACGATCGCGATGGCGCGCACGAGCGATCCGAATTCAGCCACGGCACAATTTTTCATCAACACGGTCG
ACAACGCCGGCCTCGACTATCCGAATCCTGACGGCAACGGTTATGCCGTGTTCGGCAAGGTCACGGCAGGCATGGACGTC
GTGAAGAAGATCGAAGGAACACCCACTGCGTCGCGCGGGCCGATGAGCGATGTGCCGCAAAAGCAGGTCGTGATCCAGTC
GGCGACAATAGTCGGCAAGTAA

Upstream 100 bases:

>100_bases
GTTGCACCATCGCAGTGAGCGCTTGCGCGCATGCTTTCGGGCTGCGCGCCGGCCGACGCTTTTCATCTGAGTTCACCCTG
CTTTCACCCCGAGGATTTAC

Downstream 100 bases:

>100_bases
GGCCGGCCCAACGGGCAACGCGACGGGCGAATCAGCCACGAAGCCAACATGCTGCACCGAAACTAACCATGCCACGGGCG
CGGGCCACTCACCGCACAAA

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MKWLMLALGSAALIANAPAFAQNGSQAAHPSVLLKTSEGDIRVELYPEKAPKTVANFLDYVKSGQYNGTIFHRVIPGFMI
QGGGYTTSFAEKPTRAPISLESRNGLKNMTGTIAMARTSDPNSATAQFFINTVDNAGLDYPNPDGNGYAVFGKVTAGMDV
VKKIEGTPTASRGPMSDVPQKQVVIQSATIVGK

Sequences:

>Translated_193_residues
MKWLMLALGSAALIANAPAFAQNGSQAAHPSVLLKTSEGDIRVELYPEKAPKTVANFLDYVKSGQYNGTIFHRVIPGFMI
QGGGYTTSFAEKPTRAPISLESRNGLKNMTGTIAMARTSDPNSATAQFFINTVDNAGLDYPNPDGNGYAVFGKVTAGMDV
VKKIEGTPTASRGPMSDVPQKQVVIQSATIVGK
>Mature_193_residues
MKWLMLALGSAALIANAPAFAQNGSQAAHPSVLLKTSEGDIRVELYPEKAPKTVANFLDYVKSGQYNGTIFHRVIPGFMI
QGGGYTTSFAEKPTRAPISLESRNGLKNMTGTIAMARTSDPNSATAQFFINTVDNAGLDYPNPDGNGYAVFGKVTAGMDV
VKKIEGTPTASRGPMSDVPQKQVVIQSATIVGK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=170, Percent_Identity=35.8823529411765, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI19557636, Length=167, Percent_Identity=35.9281437125749, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI22547212, Length=162, Percent_Identity=35.1851851851852, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI7657473, Length=162, Percent_Identity=35.1851851851852, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI22547215, Length=162, Percent_Identity=35.1851851851852, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI64276486, Length=127, Percent_Identity=38.5826771653543, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI7706339, Length=158, Percent_Identity=34.1772151898734, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI310110104, Length=139, Percent_Identity=35.2517985611511, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI10863927, Length=141, Percent_Identity=35.4609929078014, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI5031987, Length=159, Percent_Identity=36.4779874213836, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4758950, Length=210, Percent_Identity=31.9047619047619, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI5454154, Length=180, Percent_Identity=32.2222222222222, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI310129267, Length=141, Percent_Identity=34.0425531914894, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI310120620, Length=141, Percent_Identity=34.0425531914894, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI20911035, Length=154, Percent_Identity=33.7662337662338, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=59.2592592592593, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1786736, Length=161, Percent_Identity=54.0372670807453, Blast_Score=177, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71980594, Length=163, Percent_Identity=38.6503067484663, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71980590, Length=138, Percent_Identity=41.304347826087, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17539496, Length=166, Percent_Identity=34.3373493975904, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17565860, Length=203, Percent_Identity=33.9901477832512, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17552780, Length=161, Percent_Identity=34.1614906832298, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17566266, Length=153, Percent_Identity=35.2941176470588, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17559074, Length=155, Percent_Identity=34.1935483870968, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=162, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17506307, Length=162, Percent_Identity=34.5679012345679, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17539498, Length=139, Percent_Identity=34.5323741007194, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17552782, Length=163, Percent_Identity=33.1288343558282, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71997782, Length=127, Percent_Identity=33.8582677165354, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=160, Percent_Identity=38.75, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320510, Length=154, Percent_Identity=37.012987012987, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321848, Length=176, Percent_Identity=31.25, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320359, Length=141, Percent_Identity=34.7517730496454, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19922912, Length=165, Percent_Identity=36.3636363636364, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17986117, Length=144, Percent_Identity=35.4166666666667, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45549139, Length=158, Percent_Identity=36.0759493670886, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19922376, Length=170, Percent_Identity=30, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17647301, Length=156, Percent_Identity=35.2564102564103, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20130249, Length=161, Percent_Identity=32.9192546583851, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24652460, Length=154, Percent_Identity=30.5194805194805, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24664125, Length=161, Percent_Identity=33.5403726708075, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357783, Length=161, Percent_Identity=33.5403726708075, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20441; Mature: 20441

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWLMLALGSAALIANAPAFAQNGSQAAHPSVLLKTSEGDIRVELYPEKAPKTVANFLDY
CCEEEEECCCCEEEECCCHHHCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHH
VKSGQYNGTIFHRVIPGFMIQGGGYTTSFAEKPTRAPISLESRNGLKNMTGTIAMARTSD
HHCCCCCCEEHEEECCCEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEEECCC
PNSATAQFFINTVDNAGLDYPNPDGNGYAVFGKVTAGMDVVKKIEGTPTASRGPMSDVPQ
CCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHCCCCCCCCCCCCCCCC
KQVVIQSATIVGK
HHEEEEEEEEECC
>Mature Secondary Structure
MKWLMLALGSAALIANAPAFAQNGSQAAHPSVLLKTSEGDIRVELYPEKAPKTVANFLDY
CCEEEEECCCCEEEECCCHHHCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHH
VKSGQYNGTIFHRVIPGFMIQGGGYTTSFAEKPTRAPISLESRNGLKNMTGTIAMARTSD
HHCCCCCCEEHEEECCCEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEEECCC
PNSATAQFFINTVDNAGLDYPNPDGNGYAVFGKVTAGMDVVKKIEGTPTASRGPMSDVPQ
CCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHCCCCCCCCCCCCCCCC
KQVVIQSATIVGK
HHEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9418240 [H]