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The map label for this gene is dxr

Identifier: 186476090

GI number: 186476090

Start: 1492089

End: 1493294

Strand: Reverse

Name: dxr

Synonym: Bphy_1332

Alternate gene names: 186476090

Gene position: 1493294-1492089 (Counterclockwise)

Preceding gene: 186476091

Following gene: 186476089

Centisome position: 42.92

GC content: 65.51

Gene sequence:

>1206_bases
ATGCAAAAACGACTTACTTTGCTAGGTTCCACGGGCTCGATCGGAGACAGCACGCTCGACGTCGTCGCGCGTCATCCTGA
CCGCTTCTTCGTGTACGCGCTGACGGCACACCGAAATGGCGACAAGCTCGTCGAGCAATGCTTGCGCTTCCAGCCCGAAG
TGGCCGTGGTCGGGGATGCCGACACGGCTGCGAAGGTGGCCGCGAAATTGCGCGCAGCGGGCTGCAAGACGGCAGTTGCG
TACGGTCCGCAGGCATTGGTCGACGTGTCGAAGAGCGACGGCTGCGATACCGTGGTGGCGGCGATCGTCGGTGCGGCTGG
TCTGGAGCCGAGTCTTGCGGCGGCGCGCGCCGGCAAGCGCATCCTGCTCGCGAACAAGGAAGCGCTCGTGATGTCCGGCT
CGATCTTCATGGACGCGGTGCACGATAACGGCGCGATCCTGTTGCCCGTCGACAGCGAGCACAACGCCATCTTCCAATGT
CTGCCGCGCGAATCGGCGTTGCATGGCGGCGTGTCGAAGATCATTCTCACGGCCTCGGGCGGCCCGTTCCGCACGCGCGA
GCCTGCCTCGCTCGTCGACGTGACGCCGGACGAGGCGTGCAAGCACCCCAACTGGGTGATGGGCCGCAAGATTTCGGTCG
ATTCGGCAACGATGATGAACAAGGGTCTCGAAGTCATCGAAGCGCACTGGCTCTTCAACTTGCCGGGCGACCGTATCGAC
GTGCTGATCCATCCGCAGAGCGTGATCCATTCGCTCGTGTCGTACGCGGACGGTTCGGTGCTCGCGCAACTCGGCAATCC
GGACATGCGCACGCCCATCGCGCACGCGCTCGCGTTTCCGGATCGGGTGGACTCTGGTGTCGGGCAACTCGATCTCGCGC
AGATCGCGCAGCTGTCGTTCGAGAAGCCCGACTACACGCGCTTCCCGTGCCTCGCGCTGGCCATGAAGGCGCTGGCGGAA
GGCGGCGTCGCTAGCGCGGCGTTGAATGCCGCTAACGAGATCGCGGTCGAAGCGTTCCTGACGCGCCGCATCGGCTTCAT
GGCGATCGCGCAAGTGGTCGACGCCGTGCTGAATAGCTTGCCCAACCGCGAGGCGACGAGCCTCGCCGACGTGGTCGATG
CCGACGCCGCCGCGCGCCGCGCTGCCCACGCGTACATCGACGGATTGCCGGCGGGCGCTCGCCTTACGGAACGCGCCGTC
CAGTGA

Upstream 100 bases:

>100_bases
CCGGGTCACGGCGGCGTGCTCGACCGCATCGACGCTTTATTGCCGGTGTTGCCGCTCGCGATGCTCGTATTGTCGTAGCC
CATTGGCTAGAGAAAGAGAT

Downstream 100 bases:

>100_bases
GGCGATTATGAACCTGCTGATCGAACTGGTCGCCTTCGCCGTCGCGATTGGCGTACTGGTGGTCGTCCATGAGTATGGCC
ACTACAGCGTCGCGCGCCTG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MQKRLTLLGSTGSIGDSTLDVVARHPDRFFVYALTAHRNGDKLVEQCLRFQPEVAVVGDADTAAKVAAKLRAAGCKTAVA
YGPQALVDVSKSDGCDTVVAAIVGAAGLEPSLAAARAGKRILLANKEALVMSGSIFMDAVHDNGAILLPVDSEHNAIFQC
LPRESALHGGVSKIILTASGGPFRTREPASLVDVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWLFNLPGDRID
VLIHPQSVIHSLVSYADGSVLAQLGNPDMRTPIAHALAFPDRVDSGVGQLDLAQIAQLSFEKPDYTRFPCLALAMKALAE
GGVASAALNAANEIAVEAFLTRRIGFMAIAQVVDAVLNSLPNREATSLADVVDADAAARRAAHAYIDGLPAGARLTERAV
Q

Sequences:

>Translated_401_residues
MQKRLTLLGSTGSIGDSTLDVVARHPDRFFVYALTAHRNGDKLVEQCLRFQPEVAVVGDADTAAKVAAKLRAAGCKTAVA
YGPQALVDVSKSDGCDTVVAAIVGAAGLEPSLAAARAGKRILLANKEALVMSGSIFMDAVHDNGAILLPVDSEHNAIFQC
LPRESALHGGVSKIILTASGGPFRTREPASLVDVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWLFNLPGDRID
VLIHPQSVIHSLVSYADGSVLAQLGNPDMRTPIAHALAFPDRVDSGVGQLDLAQIAQLSFEKPDYTRFPCLALAMKALAE
GGVASAALNAANEIAVEAFLTRRIGFMAIAQVVDAVLNSLPNREATSLADVVDADAAARRAAHAYIDGLPAGARLTERAV
Q
>Mature_401_residues
MQKRLTLLGSTGSIGDSTLDVVARHPDRFFVYALTAHRNGDKLVEQCLRFQPEVAVVGDADTAAKVAAKLRAAGCKTAVA
YGPQALVDVSKSDGCDTVVAAIVGAAGLEPSLAAARAGKRILLANKEALVMSGSIFMDAVHDNGAILLPVDSEHNAIFQC
LPRESALHGGVSKIILTASGGPFRTREPASLVDVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWLFNLPGDRID
VLIHPQSVIHSLVSYADGSVLAQLGNPDMRTPIAHALAFPDRVDSGVGQLDLAQIAQLSFEKPDYTRFPCLALAMKALAE
GGVASAALNAANEIAVEAFLTRRIGFMAIAQVVDAVLNSLPNREATSLADVVDADAAARRAAHAYIDGLPAGARLTERAV
Q

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=392, Percent_Identity=56.3775510204082, Blast_Score=414, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_BURP8 (B2JIC0)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001857560.1
- ProteinModelPortal:   B2JIC0
- SMR:   B2JIC0
- GeneID:   6242823
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_1332
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42219; Mature: 42219

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: BINDING 126-126 BINDING 153-153 BINDING 179-179 BINDING 202-202 BINDING 224-224

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKRLTLLGSTGSIGDSTLDVVARHPDRFFVYALTAHRNGDKLVEQCLRFQPEVAVVGDA
CCCEEEEEECCCCCCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHCCCCEEEEECC
DTAAKVAAKLRAAGCKTAVAYGPQALVDVSKSDGCDTVVAAIVGAAGLEPSLAAARAGKR
HHHHHHHHHHHHCCCCHHHHCCCHHEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCE
ILLANKEALVMSGSIFMDAVHDNGAILLPVDSEHNAIFQCLPRESALHGGVSKIILTASG
EEEECCCEEEEECCEEEEEEECCCEEEEEECCCCCCEEEECCCHHHHHCCCEEEEEEECC
GPFRTREPASLVDVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWLFNLPGDRID
CCCCCCCCCCEEECCCHHHHCCCCCCCCCEECCCHHHHHHCCHHHEEEEEEEECCCCEEE
VLIHPQSVIHSLVSYADGSVLAQLGNPDMRTPIAHALAFPDRVDSGVGQLDLAQIAQLSF
EEECCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHCCHHHCCCCCCHHHHHHHHHCC
EKPDYTRFPCLALAMKALAEGGVASAALNAANEIAVEAFLTRRIGFMAIAQVVDAVLNSL
CCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PNREATSLADVVDADAAARRAAHAYIDGLPAGARLTERAVQ
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCC
>Mature Secondary Structure
MQKRLTLLGSTGSIGDSTLDVVARHPDRFFVYALTAHRNGDKLVEQCLRFQPEVAVVGDA
CCCEEEEEECCCCCCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHCCCCEEEEECC
DTAAKVAAKLRAAGCKTAVAYGPQALVDVSKSDGCDTVVAAIVGAAGLEPSLAAARAGKR
HHHHHHHHHHHHCCCCHHHHCCCHHEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCE
ILLANKEALVMSGSIFMDAVHDNGAILLPVDSEHNAIFQCLPRESALHGGVSKIILTASG
EEEECCCEEEEECCEEEEEEECCCEEEEEECCCCCCEEEECCCHHHHHCCCEEEEEEECC
GPFRTREPASLVDVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWLFNLPGDRID
CCCCCCCCCCEEECCCHHHHCCCCCCCCCEECCCHHHHHHCCHHHEEEEEEEECCCCEEE
VLIHPQSVIHSLVSYADGSVLAQLGNPDMRTPIAHALAFPDRVDSGVGQLDLAQIAQLSF
EEECCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHCCHHHCCCCCCHHHHHHHHHCC
EKPDYTRFPCLALAMKALAEGGVASAALNAANEIAVEAFLTRRIGFMAIAQVVDAVLNSL
CCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PNREATSLADVVDADAAARRAAHAYIDGLPAGARLTERAVQ
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA