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The map label for this gene is leuE [H]

Identifier: 186475997

GI number: 186475997

Start: 1391053

End: 1391691

Strand: Direct

Name: leuE [H]

Synonym: Bphy_1238

Alternate gene names: 186475997

Gene position: 1391053-1391691 (Clockwise)

Preceding gene: 186475989

Following gene: 186476001

Centisome position: 39.98

GC content: 66.67

Gene sequence:

>639_bases
ATGTTCGGCATCAACCAGTTTCCGCTTTTTCTCCTGGCCGTCACCGTGCTCAACCTGACGCCCGGACCGGATATCGCATA
CGTCGCGGGCCAGAGCATCGCACAGGGCCGGCGCGCGGGCCTGCTGTCCGCGCTGGGTGTCGCGTTCGGCGGCTGCATGC
ATACGGTTGCGTGTGCGCTTGGCATCACGGCGCTGCTAGCGGCGTCGCCGGGTGCCTTCAATGCGATCAAGTGGATCGGC
GCTGCCTATCTGATGTATCTCGGGCTGCGCATGGTGTGGCCCGCGGCGGCTGCCGTCGCCAACGGCGATGCCGTGCCCGG
CACACCGCGTCTGTCGCGCGGCACGCTGCTCTTTCGCGGCTTCGTCACGAACGCGTCGAACCCGAAGGTGCTGCTGTTCT
ATATCGCGTTCTTCCCGCAGTTCGTCAGCGCGGACAGCCCGCACAAGACGCTCGCGTTTCTCGTGCTGGGCGCTGTGTTC
GTGACACTTGGCCTCGTCAACGATTGCGTGATCGCGTGGGTCGCCGCGACGGCCGCACGCGCCGTACGCTCGCAGCCTGC
CGTGCGGCGCTGGATCGATCGCGTAGTGGGTGCAGGCTTCATCGGTCTTGGTGTGCGGCTCGCGCTGACCCGGCGTTGA

Upstream 100 bases:

>100_bases
CGATCTGCGCAACAGGTGCGGCGTGGGTATCATGAACTCGAATGGGTTCGGTCAGCGTGTCGGCACCGAAACAGGCCGCA
CCTTCATGCGTGGAGTCGTC

Downstream 100 bases:

>100_bases
CGCGTCTGCGCTCGCACGGAGGAGACGTCCACGCGGTGCGAGCACGCGCTACAGCCAGTTCGCCTTCTTGAACCCCCGGT
ACAGCGCGATGTCGATCAGC

Product: lysine exporter protein LysE/YggA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MFGINQFPLFLLAVTVLNLTPGPDIAYVAGQSIAQGRRAGLLSALGVAFGGCMHTVACALGITALLAASPGAFNAIKWIG
AAYLMYLGLRMVWPAAAAVANGDAVPGTPRLSRGTLLFRGFVTNASNPKVLLFYIAFFPQFVSADSPHKTLAFLVLGAVF
VTLGLVNDCVIAWVAATAARAVRSQPAVRRWIDRVVGAGFIGLGVRLALTRR

Sequences:

>Translated_212_residues
MFGINQFPLFLLAVTVLNLTPGPDIAYVAGQSIAQGRRAGLLSALGVAFGGCMHTVACALGITALLAASPGAFNAIKWIG
AAYLMYLGLRMVWPAAAAVANGDAVPGTPRLSRGTLLFRGFVTNASNPKVLLFYIAFFPQFVSADSPHKTLAFLVLGAVF
VTLGLVNDCVIAWVAATAARAVRSQPAVRRWIDRVVGAGFIGLGVRLALTRR
>Mature_212_residues
MFGINQFPLFLLAVTVLNLTPGPDIAYVAGQSIAQGRRAGLLSALGVAFGGCMHTVACALGITALLAASPGAFNAIKWIG
AAYLMYLGLRMVWPAAAAVANGDAVPGTPRLSRGTLLFRGFVTNASNPKVLLFYIAFFPQFVSADSPHKTLAFLVLGAVF
VTLGLVNDCVIAWVAATAARAVRSQPAVRRWIDRVVGAGFIGLGVRLALTRR

Specific function: Exporter of leucine [H]

COG id: COG1280

COG function: function code E; Putative threonine efflux protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI1788099, Length=210, Percent_Identity=29.0476190476191, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI48994979, Length=203, Percent_Identity=30.0492610837438, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786522, Length=141, Percent_Identity=29.7872340425532, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI48994978, Length=198, Percent_Identity=23.7373737373737, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 22230; Mature: 22230

Theoretical pI: Translated: 11.59; Mature: 11.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGINQFPLFLLAVTVLNLTPGPDIAYVAGQSIAQGRRAGLLSALGVAFGGCMHTVACAL
CCCCCHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GITALLAASPGAFNAIKWIGAAYLMYLGLRMVWPAAAAVANGDAVPGTPRLSRGTLLFRG
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEE
FVTNASNPKVLLFYIAFFPQFVSADSPHKTLAFLVLGAVFVTLGLVNDCVIAWVAATAAR
EECCCCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVRSQPAVRRWIDRVVGAGFIGLGVRLALTRR
HHHCCHHHHHHHHHHHCCCHHHHHHEEEEECC
>Mature Secondary Structure
MFGINQFPLFLLAVTVLNLTPGPDIAYVAGQSIAQGRRAGLLSALGVAFGGCMHTVACAL
CCCCCHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GITALLAASPGAFNAIKWIGAAYLMYLGLRMVWPAAAAVANGDAVPGTPRLSRGTLLFRG
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEE
FVTNASNPKVLLFYIAFFPQFVSADSPHKTLAFLVLGAVFVTLGLVNDCVIAWVAATAAR
EECCCCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVRSQPAVRRWIDRVVGAGFIGLGVRLALTRR
HHHCCHHHHHHHHHHHCCCHHHHHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]