Click here to switch to the map view.

The map label for this gene is tmk

Identifier: 186475808

GI number: 186475808

Start: 1172562

End: 1173182

Strand: Direct

Name: tmk

Synonym: Bphy_1043

Alternate gene names: 186475808

Gene position: 1172562-1173182 (Clockwise)

Preceding gene: 186475807

Following gene: 186475809

Centisome position: 33.7

GC content: 66.83

Gene sequence:

>621_bases
ATGGCGCGGGGAAAATTCATCACGTTCGAGGGCATCGACGGTGCGGGCAAGACCACGCATCTCGGCTGGTTTCGCGACCG
TCTGGAGCAGAAGGTCGCGCCGGCGGGCCGCTCCGTGGTCATGACGCGCGAGCCCGGCGGCACGAAGCTCGGCGAATCGC
TGCGCGACATCCTGCTGCACGAGGCAATGGATCTCGAAACCGAGGCGCTGCTGATGTTCGCCGCACGCCGCGAGCATCTG
GCGCAGGTGATCGAGCCGGCGCTCGCGCGTGGCGACTGGGTGCTGTCCGACCGTTTCACCGACGCGACGTTCGCCTACCA
GGGCGGCGGGCGCGGGCTGCCGCGCGACAAACTGGAGGCGCTCGAGCGCTGGGTGCAGGGCGGCTTCCAGCCGGATCTGA
CCGTGCTGTTCGACGTGCCGCCTGACACCGCAAGCGAACGTCGCAGCGCCGCCCGCGCCCCGGACCGCTTCGAGAGCGAG
TCGGACGCATTCTTCGCGCGCACGCGCGCCGAATATCTGCGTCGAGCCGAAGAAGCGCCGTATCGATTCGCTATCATCGA
CTCGACGCGCAGCATCGCAGACATTCAGAAGCAACTTGAAGATCTGATCGCATCCCTTTGA

Upstream 100 bases:

>100_bases
GCGCGCTGTATTTCGTGTCGCGCGGCGACGGCAGCAGCATCTTTTCTGACACGCTCGGCGATCACAACAAGGCCGTCGAC
AAGTACATTCGAGGGCAATG

Downstream 100 bases:

>100_bases
TTTTCCTGTATTACAAGCCGGCCTATCACAGAGTGCATGCTCGCCGGCCGATACACAGGAAATCGTCTTCGAACCATTGA
ATTGAAGAACCAACGATGAT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MARGKFITFEGIDGAGKTTHLGWFRDRLEQKVAPAGRSVVMTREPGGTKLGESLRDILLHEAMDLETEALLMFAARREHL
AQVIEPALARGDWVLSDRFTDATFAYQGGGRGLPRDKLEALERWVQGGFQPDLTVLFDVPPDTASERRSAARAPDRFESE
SDAFFARTRAEYLRRAEEAPYRFAIIDSTRSIADIQKQLEDLIASL

Sequences:

>Translated_206_residues
MARGKFITFEGIDGAGKTTHLGWFRDRLEQKVAPAGRSVVMTREPGGTKLGESLRDILLHEAMDLETEALLMFAARREHL
AQVIEPALARGDWVLSDRFTDATFAYQGGGRGLPRDKLEALERWVQGGFQPDLTVLFDVPPDTASERRSAARAPDRFESE
SDAFFARTRAEYLRRAEEAPYRFAIIDSTRSIADIQKQLEDLIASL
>Mature_205_residues
ARGKFITFEGIDGAGKTTHLGWFRDRLEQKVAPAGRSVVMTREPGGTKLGESLRDILLHEAMDLETEALLMFAARREHLA
QVIEPALARGDWVLSDRFTDATFAYQGGGRGLPRDKLEALERWVQGGFQPDLTVLFDVPPDTASERRSAARAPDRFESES
DAFFARTRAEYLRRAEEAPYRFAIIDSTRSIADIQKQLEDLIASL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=196, Percent_Identity=43.3673469387755, Blast_Score=139, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_BURP8 (B2JGP7)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001857278.1
- GeneID:   6242541
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_1043
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK00698
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23099; Mature: 22968

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARGKFITFEGIDGAGKTTHLGWFRDRLEQKVAPAGRSVVMTREPGGTKLGESLRDILLH
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHH
EAMDLETEALLMFAARREHLAQVIEPALARGDWVLSDRFTDATFAYQGGGRGLPRDKLEA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEECCCCCCCCHHHHHH
LERWVQGGFQPDLTVLFDVPPDTASERRSAARAPDRFESESDAFFARTRAEYLRRAEEAP
HHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
YRFAIIDSTRSIADIQKQLEDLIASL
EEEEEECCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARGKFITFEGIDGAGKTTHLGWFRDRLEQKVAPAGRSVVMTREPGGTKLGESLRDILLH
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHH
EAMDLETEALLMFAARREHLAQVIEPALARGDWVLSDRFTDATFAYQGGGRGLPRDKLEA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEECCCCCCCCHHHHHH
LERWVQGGFQPDLTVLFDVPPDTASERRSAARAPDRFESESDAFFARTRAEYLRRAEEAP
HHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
YRFAIIDSTRSIADIQKQLEDLIASL
EEEEEECCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA