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The map label for this gene is clpP [H]

Identifier: 186475776

GI number: 186475776

Start: 1133680

End: 1134339

Strand: Direct

Name: clpP [H]

Synonym: Bphy_1011

Alternate gene names: 186475776

Gene position: 1133680-1134339 (Clockwise)

Preceding gene: 186475775

Following gene: 186475777

Centisome position: 32.58

GC content: 61.52

Gene sequence:

>660_bases
ATGACCTTTCGCGCTCAAATGCTGGACACGTTGACCTCGCAGTCGTCGCGAGATCGGGATCTCGAAGCGCAAGCGCTCGG
CCTCGTGCCGATCGTGGTCGAAACGAGCGGCCGCGGTGAACGTTCGTATGACATCTACTCGCGCCTGCTAAAGGAGCGCG
TGGTGTTTCTGGTCGGCGAGGTGAATGATCAGACCGCCAACCTGGTGATTGCGCAGTTGCTGTTCCTCGAAAGCGAAAAT
CCGGACAAGGACATCAGCTTCTACATCAACAGCCCGGGCGGCTCGGTGTCAGCGGGGATGGCGATCTACGACACGATGCA
ATTCATCAAGCCAGACGTATCGACGCTCTGCATGGGTCTTGCGGCCAGCATGGGCGCATTCCTGCTGGCAGCAGGCGCGA
AGGGCAAGCGTTTCGCGCTGCCGAACGCACGCGTGATGATTCACCAGCCGCTGGGCGGCGCGCGCGGCCAGGCGTCGGAC
ATCGAAATTCAGGCGCGCGAAATCCTGTACTTGAAGGAGCGCCTGAACCAGTTGCTGTCGCACCACACGGGTCAACCCGT
CGAGCGCATCCAGCGCGACACCGACCGCGACAACTTCATGTCGGGCGACGACGCGCAGGCGTACGGTCTCGTCGATCAGG
TTCTGCACAAGCGGCCGTAA

Upstream 100 bases:

>100_bases
AACAGCGCGTGTCGACCGTGGCAGCTCTTGAAGAAGCGAGCGGCTGCACCCACTTGTCCAGAACCGATTATCAGAACATT
TCCTGACAAGGATCCATTGC

Downstream 100 bases:

>100_bases
TCAATCGCTGAAACATGGCTGATCCGGAGCGCTTTTTCCTCCAATTGGGGGGAGAGCGCCGGCGCAAAACCTTGTGAAAT
AATAAGACCCGTCTGAACGC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2 [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MTFRAQMLDTLTSQSSRDRDLEAQALGLVPIVVETSGRGERSYDIYSRLLKERVVFLVGEVNDQTANLVIAQLLFLESEN
PDKDISFYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAASMGAFLLAAGAKGKRFALPNARVMIHQPLGGARGQASD
IEIQAREILYLKERLNQLLSHHTGQPVERIQRDTDRDNFMSGDDAQAYGLVDQVLHKRP

Sequences:

>Translated_219_residues
MTFRAQMLDTLTSQSSRDRDLEAQALGLVPIVVETSGRGERSYDIYSRLLKERVVFLVGEVNDQTANLVIAQLLFLESEN
PDKDISFYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAASMGAFLLAAGAKGKRFALPNARVMIHQPLGGARGQASD
IEIQAREILYLKERLNQLLSHHTGQPVERIQRDTDRDNFMSGDDAQAYGLVDQVLHKRP
>Mature_218_residues
TFRAQMLDTLTSQSSRDRDLEAQALGLVPIVVETSGRGERSYDIYSRLLKERVVFLVGEVNDQTANLVIAQLLFLESENP
DKDISFYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAASMGAFLLAAGAKGKRFALPNARVMIHQPLGGARGQASDI
EIQAREILYLKERLNQLLSHHTGQPVERIQRDTDRDNFMSGDDAQAYGLVDQVLHKRP

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=213, Percent_Identity=55.868544600939, Blast_Score=240, Evalue=7e-64,
Organism=Escherichia coli, GI1786641, Length=203, Percent_Identity=68.4729064039409, Blast_Score=301, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=56.989247311828, Blast_Score=224, Evalue=3e-59,
Organism=Drosophila melanogaster, GI20129427, Length=194, Percent_Identity=54.1237113402062, Blast_Score=236, Evalue=9e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 24173; Mature: 24042

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFRAQMLDTLTSQSSRDRDLEAQALGLVPIVVETSGRGERSYDIYSRLLKERVVFLVGE
CCHHHHHHHHHHCCCCCCCCCHHHHHCEEEEEEECCCCCCCCHHHHHHHHHHHHEEEEEC
VNDQTANLVIAQLLFLESENPDKDISFYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGL
CCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHH
AASMGAFLLAAGAKGKRFALPNARVMIHQPLGGARGQASDIEIQAREILYLKERLNQLLS
HHHHHHHHHHCCCCCCEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
HHTGQPVERIQRDTDRDNFMSGDDAQAYGLVDQVLHKRP
HCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TFRAQMLDTLTSQSSRDRDLEAQALGLVPIVVETSGRGERSYDIYSRLLKERVVFLVGE
CHHHHHHHHHHCCCCCCCCCHHHHHCEEEEEEECCCCCCCCHHHHHHHHHHHHEEEEEC
VNDQTANLVIAQLLFLESENPDKDISFYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGL
CCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHH
AASMGAFLLAAGAKGKRFALPNARVMIHQPLGGARGQASDIEIQAREILYLKERLNQLLS
HHHHHHHHHHCCCCCCEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
HHTGQPVERIQRDTDRDNFMSGDDAQAYGLVDQVLHKRP
HCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA