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The map label for this gene is trxA [H]

Identifier: 186475715

GI number: 186475715

Start: 1061421

End: 1061747

Strand: Reverse

Name: trxA [H]

Synonym: Bphy_0950

Alternate gene names: 186475715

Gene position: 1061747-1061421 (Counterclockwise)

Preceding gene: 186475723

Following gene: 186475714

Centisome position: 30.52

GC content: 57.8

Gene sequence:

>327_bases
ATGAGCGAACACATCAAGCATATTAGCGACGCGTCGTTTGAACAGGACGTCGTCAAATCCGACAAACCCGTGCTGCTCGA
CTTCTGGGCAGAATGGTGCGGCCCGTGCAAGATGATCGCGCCGATCCTCGACGAAGTTGCGAAGGACTACGCCGATCGCC
TGCAGATCGCCAAGATCAACGTTGATGAACATCAGTCCACGCCCGTCAAGTTCGGCGTGCGCGGCATCCCCACGCTGATC
CTCTTCAAGAATGGCGCGGTCGCGGCGCAGAAGGTCGGCGCATTGTCGAAGTCGCAACTCACCGCATTCCTCGACGGCAA
CCTTTAA

Upstream 100 bases:

>100_bases
GGTTTGTCCTGTGGCAAAGCGAACGGAAAGTTTTCTGAGTTTGTTGTATCGTGGCGGGCATTCAAATGCAGGCCTCGAAT
CGAAAGAGGTATTCACACAA

Downstream 100 bases:

>100_bases
TCCGCCTACGCGGCCGGTGCGCACGCTTTGCGCGCCGCCCGGCTCGCCGCAATGCCTCGACATGTCGTGAAGTCGTGCAT
CGAGCGAGCCGCATGATTCT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSEHIKHISDASFEQDVVKSDKPVLLDFWAEWCGPCKMIAPILDEVAKDYADRLQIAKINVDEHQSTPVKFGVRGIPTLI
LFKNGAVAAQKVGALSKSQLTAFLDGNL

Sequences:

>Translated_108_residues
MSEHIKHISDASFEQDVVKSDKPVLLDFWAEWCGPCKMIAPILDEVAKDYADRLQIAKINVDEHQSTPVKFGVRGIPTLI
LFKNGAVAAQKVGALSKSQLTAFLDGNL
>Mature_107_residues
SEHIKHISDASFEQDVVKSDKPVLLDFWAEWCGPCKMIAPILDEVAKDYADRLQIAKINVDEHQSTPVKFGVRGIPTLIL
FKNGAVAAQKVGALSKSQLTAFLDGNL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=38.0434782608696, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=63.8888888888889, Blast_Score=155, Evalue=7e-40,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=39.1304347826087, Blast_Score=91, Evalue=2e-20,
Organism=Escherichia coli, GI87081747, Length=84, Percent_Identity=36.9047619047619, Blast_Score=67, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=37.6344086021505, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17509965, Length=76, Percent_Identity=42.1052631578947, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=87, Percent_Identity=39.0804597701149, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=87, Percent_Identity=36.7816091954023, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=82, Percent_Identity=31.7073170731707, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=85, Percent_Identity=41.1764705882353, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=76, Percent_Identity=40.7894736842105, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=90, Percent_Identity=41.1111111111111, Blast_Score=74, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=40.6976744186046, Blast_Score=73, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=90, Percent_Identity=31.1111111111111, Blast_Score=62, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639826, Length=83, Percent_Identity=45.7831325301205, Blast_Score=89, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=38.0434782608696, Blast_Score=85, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24664269, Length=75, Percent_Identity=42.6666666666667, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=41.025641025641, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=41.025641025641, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=31.1827956989247, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21358065, Length=102, Percent_Identity=30.3921568627451, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11880; Mature: 11749

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHIKHISDASFEQDVVKSDKPVLLDFWAEWCGPCKMIAPILDEVAKDYADRLQIAKIN
CCCHHHHHCCCCHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEEC
VDEHQSTPVKFGVRGIPTLILFKNGAVAAQKVGALSKSQLTAFLDGNL
CCCCCCCCEEECCCCCCEEEEEECCCHHHHHHCCCCHHHEEEEECCCC
>Mature Secondary Structure 
SEHIKHISDASFEQDVVKSDKPVLLDFWAEWCGPCKMIAPILDEVAKDYADRLQIAKIN
CCHHHHHCCCCHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEEC
VDEHQSTPVKFGVRGIPTLILFKNGAVAAQKVGALSKSQLTAFLDGNL
CCCCCCCCEEECCCCCCEEEEEECCCHHHHHHCCCCHHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]