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The map label for this gene is norM [H]

Identifier: 186475710

GI number: 186475710

Start: 1055014

End: 1056375

Strand: Reverse

Name: norM [H]

Synonym: Bphy_0945

Alternate gene names: 186475710

Gene position: 1056375-1055014 (Counterclockwise)

Preceding gene: 186475711

Following gene: 186475707

Centisome position: 30.36

GC content: 65.86

Gene sequence:

>1362_bases
ATGTTTGACGATGTGCGGAAAATCGCCGGGCTCGCGTGGCCCGTGCTGATCGGCCAGCTGGCGATCATCGCGTTCGGCGT
GATCGATACAGCGATGGTCGGCCGCTTCTCGGCGACCGACCTTGCAGCCCTCGGCCTCGGTTCGTCGATCTATATCTCGG
TGTACATCGGCCTGACGGGCATTCTGACCGCGCTGCAACCGATTGCCGGCCAACTCTACGGCGCTGCGCGCTACGAGGAG
ATCGGCGAGGAGGTGCGTCAGGCGCTGTGGCTCGCGCTGGCGCTCGCCGCGCTCGGCTTTCTGGTTCTCTACTTCCCCCA
CCCGCTGCTGCAGCTGGCGCGGGCGCCCGAGGCGCTGCGCGAGCGCACTGTGTCCTATCTGCAGATTCTCGCGTTCGGGC
TGCCAGCGAGTCTCGCATTTCGCGTCTATAGCTCGCTGACGAATGCCGTCGGCCAGCCGCGGCTCGTGATGATCCTGCAG
ATCGGCGCGCTGATGCTCAAGGTGCCGCTCAATCTGCTGCTGATTTTCGGCAAGCTCGGCATGCCGGCGCTCGGTGGGCC
GGGGGCGGCGCTCGCCAGCATTCTGATCAACTGGACGCTGGCCGTCGTCGGCATGGTCGTGCTGACGAAGCTGGACGTGT
TCCAGCCGTTCGCGATCTTCCGGCATTTCTGCTGGCCCGTCTGGCGGCGTCAGGCGGCCCAGCTGAAGCTCGGCGTACCG
ATGGGGCTGTCGTATCTGATCGAAGTGACGTCGTATACCTTCATGGCGCTCTTCATCGCTCGCTTCGGCACGACCACGCT
GGCCGGTCATCAGATCGCGGGCAACATCGGCGCGGTGCTCTACATGACGCCGCTGTCGATCGGCATCGCTACTTCTACGC
TCGTCGCTCAGGCGCTCGGTGCACATCGCTACGAAGCGGCGCGCACGCTGGCGCGGCACGGCATCGCGATGGCCGTGGCG
ATTGCGTGCGGGTATGGCGTGATCGTGCTCGCGCTGCGGCCCGTCATCATCGCGGGCTACACGCCGAATGCGCAGGTCCT
GCAGGCGGCGATGCCGCTCGTGTTGATCGTCGCGTTCTACCATCTGTGCGACGCGTTGCAGATCACGTCGGCGTTCGTGC
TGCGGGCGTATCGGGTGGCCGTCGTGCCGACCCTGATCTATGCCATTGCACTGTGGGGCGTGGGACTCGGCGGCGGCTAT
GCGCTCGGGTTCGATCTCGGCGGCTGGGTGCCGGAGTCGCTCACCGGCGCGCGCGGATTCTGGCTCGCGAATACTGCGAG
CTTGCTGATTGCGGGTGTTGGGCTTGCCTTGTATTTGCGCTCGATCAGCACGCGGATAGGCGCTGGGCGGCACAGCGGGT
AG

Upstream 100 bases:

>100_bases
TGGCCGACCGCGACGAACGTTTCCGCCTGTACGTGCGCATCGACCGTCCGCAACCGCCCGTCAAGCGCCGTCCGTGGCGT
CCGAAGAAAAGCGGCTGAGC

Downstream 100 bases:

>100_bases
CTGCTGGCGCGGTCTGTCCTGTTCGCTGGCGTCCGCGACTTGCTTTTGATTTGCTGGTGTTACCCCTGTGCGGGGCAACG
CATGAATCACGAGGACAAAC

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MFDDVRKIAGLAWPVLIGQLAIIAFGVIDTAMVGRFSATDLAALGLGSSIYISVYIGLTGILTALQPIAGQLYGAARYEE
IGEEVRQALWLALALAALGFLVLYFPHPLLQLARAPEALRERTVSYLQILAFGLPASLAFRVYSSLTNAVGQPRLVMILQ
IGALMLKVPLNLLLIFGKLGMPALGGPGAALASILINWTLAVVGMVVLTKLDVFQPFAIFRHFCWPVWRRQAAQLKLGVP
MGLSYLIEVTSYTFMALFIARFGTTTLAGHQIAGNIGAVLYMTPLSIGIATSTLVAQALGAHRYEAARTLARHGIAMAVA
IACGYGVIVLALRPVIIAGYTPNAQVLQAAMPLVLIVAFYHLCDALQITSAFVLRAYRVAVVPTLIYAIALWGVGLGGGY
ALGFDLGGWVPESLTGARGFWLANTASLLIAGVGLALYLRSISTRIGAGRHSG

Sequences:

>Translated_453_residues
MFDDVRKIAGLAWPVLIGQLAIIAFGVIDTAMVGRFSATDLAALGLGSSIYISVYIGLTGILTALQPIAGQLYGAARYEE
IGEEVRQALWLALALAALGFLVLYFPHPLLQLARAPEALRERTVSYLQILAFGLPASLAFRVYSSLTNAVGQPRLVMILQ
IGALMLKVPLNLLLIFGKLGMPALGGPGAALASILINWTLAVVGMVVLTKLDVFQPFAIFRHFCWPVWRRQAAQLKLGVP
MGLSYLIEVTSYTFMALFIARFGTTTLAGHQIAGNIGAVLYMTPLSIGIATSTLVAQALGAHRYEAARTLARHGIAMAVA
IACGYGVIVLALRPVIIAGYTPNAQVLQAAMPLVLIVAFYHLCDALQITSAFVLRAYRVAVVPTLIYAIALWGVGLGGGY
ALGFDLGGWVPESLTGARGFWLANTASLLIAGVGLALYLRSISTRIGAGRHSG
>Mature_453_residues
MFDDVRKIAGLAWPVLIGQLAIIAFGVIDTAMVGRFSATDLAALGLGSSIYISVYIGLTGILTALQPIAGQLYGAARYEE
IGEEVRQALWLALALAALGFLVLYFPHPLLQLARAPEALRERTVSYLQILAFGLPASLAFRVYSSLTNAVGQPRLVMILQ
IGALMLKVPLNLLLIFGKLGMPALGGPGAALASILINWTLAVVGMVVLTKLDVFQPFAIFRHFCWPVWRRQAAQLKLGVP
MGLSYLIEVTSYTFMALFIARFGTTTLAGHQIAGNIGAVLYMTPLSIGIATSTLVAQALGAHRYEAARTLARHGIAMAVA
IACGYGVIVLALRPVIIAGYTPNAQVLQAAMPLVLIVAFYHLCDALQITSAFVLRAYRVAVVPTLIYAIALWGVGLGGGY
ALGFDLGGWVPESLTGARGFWLANTASLLIAGVGLALYLRSISTRIGAGRHSG

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=414, Percent_Identity=25.8454106280193, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI48994890, Length=439, Percent_Identity=30.751708428246, Blast_Score=193, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6320545, Length=454, Percent_Identity=24.6696035242291, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321821, Length=353, Percent_Identity=23.2294617563739, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48077; Mature: 48077

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDDVRKIAGLAWPVLIGQLAIIAFGVIDTAMVGRFSATDLAALGLGSSIYISVYIGLTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEHHHHHHH
ILTALQPIAGQLYGAARYEEIGEEVRQALWLALALAALGFLVLYFPHPLLQLARAPEALR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCHHHHH
ERTVSYLQILAFGLPASLAFRVYSSLTNAVGQPRLVMILQIGALMLKVPLNLLLIFGKLG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
MPALGGPGAALASILINWTLAVVGMVVLTKLDVFQPFAIFRHFCWPVWRRQAAQLKLGVP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
MGLSYLIEVTSYTFMALFIARFGTTTLAGHQIAGNIGAVLYMTPLSIGIATSTLVAQALG
HHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHCCCCCEEEECHHHHHHHHHHHHHHHHH
AHRYEAARTLARHGIAMAVAIACGYGVIVLALRPVIIAGYTPNAQVLQAAMPLVLIVAFY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHH
HLCDALQITSAFVLRAYRVAVVPTLIYAIALWGVGLGGGYALGFDLGGWVPESLTGARGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCE
WLANTASLLIAGVGLALYLRSISTRIGAGRHSG
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFDDVRKIAGLAWPVLIGQLAIIAFGVIDTAMVGRFSATDLAALGLGSSIYISVYIGLTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEHHHHHHH
ILTALQPIAGQLYGAARYEEIGEEVRQALWLALALAALGFLVLYFPHPLLQLARAPEALR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCHHHHH
ERTVSYLQILAFGLPASLAFRVYSSLTNAVGQPRLVMILQIGALMLKVPLNLLLIFGKLG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
MPALGGPGAALASILINWTLAVVGMVVLTKLDVFQPFAIFRHFCWPVWRRQAAQLKLGVP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
MGLSYLIEVTSYTFMALFIARFGTTTLAGHQIAGNIGAVLYMTPLSIGIATSTLVAQALG
HHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHCCCCCEEEECHHHHHHHHHHHHHHHHH
AHRYEAARTLARHGIAMAVAIACGYGVIVLALRPVIIAGYTPNAQVLQAAMPLVLIVAFY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHH
HLCDALQITSAFVLRAYRVAVVPTLIYAIALWGVGLGGGYALGFDLGGWVPESLTGARGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCE
WLANTASLLIAGVGLALYLRSISTRIGAGRHSG
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA