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The map label for this gene is hom [H]

Identifier: 186475696

GI number: 186475696

Start: 1034336

End: 1035667

Strand: Direct

Name: hom [H]

Synonym: Bphy_0931

Alternate gene names: 186475696

Gene position: 1034336-1035667 (Clockwise)

Preceding gene: 186475695

Following gene: 186475697

Centisome position: 29.73

GC content: 64.49

Gene sequence:

>1332_bases
ATGGAACCGATCAAAGTTGGACTGCTGGGCTTCGGCACGGTAGGCAGCGGCACCTTCACGGTACTGCGCCGCAACCAGGA
AGAAATCAACCGACGCGCGGGCCGCGGCATTGAGATTGCGCGCATTGCCGTGCGCAATTCCGCCAAGGCGACGGCGGCGC
TGGGCGCCGAAGCGGGCACGGTGGTGATCACCGATGACTTCGGTTCGGTGGTGGACGATCCGTCCATCGACATCGTCGCC
GAGATGATCGGCGGCACGGGCATTGCGCGCGAACTCGTGTTGCGCGCGATCGGCAACGGCAAGCACGTCGTGACCGCCAA
CAAGGCGCTGCTCGCCGTGCACGGCACGGAAATTTTCGAGGCGGCGCGCGCGAAGGGCGTCATGGTCGCGTTCGAGGCGG
CCGTCGCGGGCGGCATTCCCATCATCAAGGCGCTGCGCGAAGGCTTGACGGCGAACCGCATCCAGTACATCGCGGGCATC
ATCAACGGCACGACGAACTACATCCTGTCGGAGATGCGCGACCGCGGCCTTGATTTCGCAACGGCGCTGAAGGCCGCCCA
GGAGCTCGGCTACGCGGAAGCGGACCCGACCTTCGATATCGAAGGCGTCGACGCCGCGCACAAGGCGACCATCATGAGCG
CGATCGCGTTTGGCGTGCCCGTGCAGTTCGACAAGGCGTACGTCGAAGGCATCAGCAAGCTCGCCGCGATCGACATCAAG
TACGCGGAAGAGCTCGGCTATCGCATCAAGCTGCTCGGCATTACCCGCCGCACGGACAAGGGCATCGAGCTGCGCGTGCA
TCCCACGCTGATTCCCGCCAAGCGTCTGCTCGCCAACGTGGAAGGCGCAATGAATGCGGTGGTGGTCCATGGCGACGCCG
TCGGCACGACGCTGTACTACGGCAAGGGCGCGGGCGCGGAGCCGACGGCTTCGGCCGTGGTGGCCGATCTGGTCGATGTG
ACGCGCCTGCATACGGCCGACCCGGAGCATCGCGTGCCGCATCTGGCTTTCCAGCCAGACCGTCTGTCGAACACGCCCAT
CCTGCCAATCGACGAAGTGACGAGCGGCTATTACCTGCGTCTGCGCGTGGCCGACGTGACGGGCGTGCTGGCCGACATCA
CGCGTATCCTGGCCGACACGGGTATCTCGATCGACGCGCTGCTGCAGAAGGAATCGGAGCATGTCGACGCATCGAAGAAG
GGCGAGACGGACATCATCCTGATCACGCACGAGACGGTCGAAAAGAACGTGAACGCTGCGATCGCGAACATCGAGGCGCT
GAAGACGGTCGTGTCGAAAGTGACGAAGCTGCGCATGGAAGCGCTGGACTGA

Upstream 100 bases:

>100_bases
GGGCGTTTCCTCGACGGCTATCGCAAACGCCACGCGGCCTGAGCGCATTGCATCCGCGCCCGAACCAATTTACCAATCTC
TCACTCGAAATACACGCTGC

Downstream 100 bases:

>100_bases
CGCACCGCACACACGTAAAGAGGCAAGCTCATGAATTACATTTCCACGCGCGGCGCCGGCATCGGCGAGCGCCACACGTT
CTCCGACATCCTGCTCGGTG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MEPIKVGLLGFGTVGSGTFTVLRRNQEEINRRAGRGIEIARIAVRNSAKATAALGAEAGTVVITDDFGSVVDDPSIDIVA
EMIGGTGIARELVLRAIGNGKHVVTANKALLAVHGTEIFEAARAKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMRDRGLDFATALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDKAYVEGISKLAAIDIK
YAEELGYRIKLLGITRRTDKGIELRVHPTLIPAKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDRLSNTPILPIDEVTSGYYLRLRVADVTGVLADITRILADTGISIDALLQKESEHVDASKK
GETDIILITHETVEKNVNAAIANIEALKTVVSKVTKLRMEALD

Sequences:

>Translated_443_residues
MEPIKVGLLGFGTVGSGTFTVLRRNQEEINRRAGRGIEIARIAVRNSAKATAALGAEAGTVVITDDFGSVVDDPSIDIVA
EMIGGTGIARELVLRAIGNGKHVVTANKALLAVHGTEIFEAARAKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMRDRGLDFATALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDKAYVEGISKLAAIDIK
YAEELGYRIKLLGITRRTDKGIELRVHPTLIPAKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDRLSNTPILPIDEVTSGYYLRLRVADVTGVLADITRILADTGISIDALLQKESEHVDASKK
GETDIILITHETVEKNVNAAIANIEALKTVVSKVTKLRMEALD
>Mature_443_residues
MEPIKVGLLGFGTVGSGTFTVLRRNQEEINRRAGRGIEIARIAVRNSAKATAALGAEAGTVVITDDFGSVVDDPSIDIVA
EMIGGTGIARELVLRAIGNGKHVVTANKALLAVHGTEIFEAARAKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMRDRGLDFATALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDKAYVEGISKLAAIDIK
YAEELGYRIKLLGITRRTDKGIELRVHPTLIPAKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDRLSNTPILPIDEVTSGYYLRLRVADVTGVLADITRILADTGISIDALLQKESEHVDASKK
GETDIILITHETVEKNVNAAIANIEALKTVVSKVTKLRMEALD

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=253, Percent_Identity=26.8774703557312, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=135, Percent_Identity=34.8148148148148, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47036; Mature: 47036

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPIKVGLLGFGTVGSGTFTVLRRNQEEINRRAGRGIEIARIAVRNSAKATAALGAEAGT
CCCEEEEEEEECCCCCCEEEEEECCHHHHHHHCCCCCEEEEEEECCCCCHHHHCCCCCCE
VVITDDFGSVVDDPSIDIVAEMIGGTGIARELVLRAIGNGKHVVTANKALLAVHGTEIFE
EEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHH
AARAKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGIINGTTNYILSEMRDRGLDFA
HHHHCCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHH
TALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDKAYVEGISKLAAIDIK
HHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHH
YAEELGYRIKLLGITRRTDKGIELRVHPTLIPAKRLLANVEGAMNAVVVHGDAVGTTLYY
HHHHCCCEEEEEEEEECCCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCEEEE
GKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDRLSNTPILPIDEVTSGYYLR
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCHHHCCCCEEEE
LRVADVTGVLADITRILADTGISIDALLQKESEHVDASKKGETDIILITHETVEKNVNAA
EEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHCCCHHH
IANIEALKTVVSKVTKLRMEALD
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEPIKVGLLGFGTVGSGTFTVLRRNQEEINRRAGRGIEIARIAVRNSAKATAALGAEAGT
CCCEEEEEEEECCCCCCEEEEEECCHHHHHHHCCCCCEEEEEEECCCCCHHHHCCCCCCE
VVITDDFGSVVDDPSIDIVAEMIGGTGIARELVLRAIGNGKHVVTANKALLAVHGTEIFE
EEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHH
AARAKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGIINGTTNYILSEMRDRGLDFA
HHHHCCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHH
TALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDKAYVEGISKLAAIDIK
HHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHH
YAEELGYRIKLLGITRRTDKGIELRVHPTLIPAKRLLANVEGAMNAVVVHGDAVGTTLYY
HHHHCCCEEEEEEEEECCCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCEEEE
GKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDRLSNTPILPIDEVTSGYYLR
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCHHHCCCCEEEE
LRVADVTGVLADITRILADTGISIDALLQKESEHVDASKKGETDIILITHETVEKNVNAA
EEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHCCCHHH
IANIEALKTVVSKVTKLRMEALD
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]