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The map label for this gene is ppx [H]

Identifier: 186475654

GI number: 186475654

Start: 993642

End: 995249

Strand: Reverse

Name: ppx [H]

Synonym: Bphy_0889

Alternate gene names: 186475654

Gene position: 995249-993642 (Counterclockwise)

Preceding gene: 186475656

Following gene: 186475642

Centisome position: 28.61

GC content: 62.62

Gene sequence:

>1608_bases
ATGTCCAGTACGCTTAAAATGGCGACTTTGAACACCGCGCGAATCGGCGCGCCCAACATGGGCGACCTGTTTGTGCGCAT
GAGGTCCTCACTCCCGATGGTCAACACTCCGCCACTACTTGCCGCCGTCGATCTCGGCTCGAACAGCTTCCGTCTGATCG
TGGGCCGCGTCGAGGAGACGGAAGCGGGCAGCCAGATCTATCAGGTCGACGCGCTGCGCGAACCGGTGCGGCTCGGCGCG
GGCCTGTCGCGCGAAAAGATGCTCGACCGTGCTTCGCAGGTGCGCGGCTGGGACGCCCTCAAGCGCTTCGGCGAACGCCT
TCGCGACTTCCATCCCGACCATGTGCGCGCCGTCGCCACCAACACGTTGCGCGTCGCGAAGAACGCGGAGGAATTTCTCG
GCGAAGCGGAAGCGGCGCTGGGTTTCCCCGTCGAAGTGATCGCGGGTCGCGAAGAAGCGCGCCTGATTTATGCGGGCGCT
GCACATTCGGTGCCGGCGAGCGCGGGCAAGCGGCTCGTCGTGGACATCGGCGGCGGCTCGACCGAGTTCATTATCGGTTC
GCACTACACGCCGATCAGGATGGAAAGCCTGTACATTGGCTGCGTAAGCCACAGCCGTCAGTTCTTCCCGGCGGGTAACG
TCGACGAGTACACGATGCGTCAGGCCGAACTGGCGGCCTCGCGTGAGATCCAGATCATTTCGGCCGACTACAAGGGCGAG
GGATGGGACCAGGGTATCGGATCGTCCGGTACGGCGCGAGCGCTAGCGGAGCTGCTCGAAGCAAACGGCTTCAACGATCC
GGGCATCACGCACGGCATTTCACGCGGCGGCCTCGAGCGTCTGAAGCGTGCGTTGATCAAGGCGGAGAACGTCAATCGTC
TGAAGCTGATCGCGCTGAAGCCCGATCGCGTGCCGGTGCTGGCGGGCGGCCTATCCATCATGATCGCGGTGTTCGATGAA
CTGGGCGTCGATTATGTCGACACGACGGACGGCGCGCTGCGCCTTGGCGTGCTGTATGACCTGCTGGGACGCTCACAGCA
TCAGGACATGCGGACCATCACGGTCGAGGGTTTCATGCGCCGCTATGGCGTCGATCGTGCGCAGGCGAGCCGCATTGGCG
AGCTTGCGGTGCATTTCTACGATCAGCTCGACGAACCCGATACGGAAGTGCGTGAAGAGAATCGCATGTTCCTCGGCTGG
GCGGCGGCGCTGCACGAAATCGGGCTGTCGATTTCACACAGCGCATATCACAAGCATTCGGCGTATATCGCGAGCAATGC
GGACATGCCGGGTTTTTCACGCACCGATCAGGCGCGACTTGCGGCGCTCGTCGTAGGGCACGCAGGCAAGCTGGCGAAGC
TGGCGCAGACGCGCGATCTCGAATGGAAGCTGCTGTTCTGCCTGCGGCTCGCGGCGCTGTTCTGCCGGCGCCGTGCGGAT
GCCGGCTTGCCAGAAATCACCGTTGCGGAAGCGAATGGCGGGTATGAGGTTCGGCTGCCCAATTCGTGGGTCGCGAATAA
TCCGCTCACGGACTATAGCCTCATTCAGGAGGCGGCTGAGTGGGAGAAGATTCGGACGTCGTATCGAGTTGTTTATACGG
ACGATTGA

Upstream 100 bases:

>100_bases
TGACTTGTCACGTGATTTTACGCTTTTGCCGCCCTATGTCGTAAATATGACGCAGGCATGTGCGACCATATCGCACGACA
ATGGCGGAGGTGACAGCGTG

Downstream 100 bases:

>100_bases
TCTTTGTCCTCGACGCTGGTGTCGTTTTTTTCGCTGGCATCCGCTTTGTGCATCTGGTTTGCTGGTGTTGCCCCTGTGCC
AGATGCACAAAGCGGATGCC

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MSSTLKMATLNTARIGAPNMGDLFVRMRSSLPMVNTPPLLAAVDLGSNSFRLIVGRVEETEAGSQIYQVDALREPVRLGA
GLSREKMLDRASQVRGWDALKRFGERLRDFHPDHVRAVATNTLRVAKNAEEFLGEAEAALGFPVEVIAGREEARLIYAGA
AHSVPASAGKRLVVDIGGGSTEFIIGSHYTPIRMESLYIGCVSHSRQFFPAGNVDEYTMRQAELAASREIQIISADYKGE
GWDQGIGSSGTARALAELLEANGFNDPGITHGISRGGLERLKRALIKAENVNRLKLIALKPDRVPVLAGGLSIMIAVFDE
LGVDYVDTTDGALRLGVLYDLLGRSQHQDMRTITVEGFMRRYGVDRAQASRIGELAVHFYDQLDEPDTEVREENRMFLGW
AAALHEIGLSISHSAYHKHSAYIASNADMPGFSRTDQARLAALVVGHAGKLAKLAQTRDLEWKLLFCLRLAALFCRRRAD
AGLPEITVAEANGGYEVRLPNSWVANNPLTDYSLIQEAAEWEKIRTSYRVVYTDD

Sequences:

>Translated_535_residues
MSSTLKMATLNTARIGAPNMGDLFVRMRSSLPMVNTPPLLAAVDLGSNSFRLIVGRVEETEAGSQIYQVDALREPVRLGA
GLSREKMLDRASQVRGWDALKRFGERLRDFHPDHVRAVATNTLRVAKNAEEFLGEAEAALGFPVEVIAGREEARLIYAGA
AHSVPASAGKRLVVDIGGGSTEFIIGSHYTPIRMESLYIGCVSHSRQFFPAGNVDEYTMRQAELAASREIQIISADYKGE
GWDQGIGSSGTARALAELLEANGFNDPGITHGISRGGLERLKRALIKAENVNRLKLIALKPDRVPVLAGGLSIMIAVFDE
LGVDYVDTTDGALRLGVLYDLLGRSQHQDMRTITVEGFMRRYGVDRAQASRIGELAVHFYDQLDEPDTEVREENRMFLGW
AAALHEIGLSISHSAYHKHSAYIASNADMPGFSRTDQARLAALVVGHAGKLAKLAQTRDLEWKLLFCLRLAALFCRRRAD
AGLPEITVAEANGGYEVRLPNSWVANNPLTDYSLIQEAAEWEKIRTSYRVVYTDD
>Mature_534_residues
SSTLKMATLNTARIGAPNMGDLFVRMRSSLPMVNTPPLLAAVDLGSNSFRLIVGRVEETEAGSQIYQVDALREPVRLGAG
LSREKMLDRASQVRGWDALKRFGERLRDFHPDHVRAVATNTLRVAKNAEEFLGEAEAALGFPVEVIAGREEARLIYAGAA
HSVPASAGKRLVVDIGGGSTEFIIGSHYTPIRMESLYIGCVSHSRQFFPAGNVDEYTMRQAELAASREIQIISADYKGEG
WDQGIGSSGTARALAELLEANGFNDPGITHGISRGGLERLKRALIKAENVNRLKLIALKPDRVPVLAGGLSIMIAVFDEL
GVDYVDTTDGALRLGVLYDLLGRSQHQDMRTITVEGFMRRYGVDRAQASRIGELAVHFYDQLDEPDTEVREENRMFLGWA
AALHEIGLSISHSAYHKHSAYIASNADMPGFSRTDQARLAALVVGHAGKLAKLAQTRDLEWKLLFCLRLAALFCRRRADA
GLPEITVAEANGGYEVRLPNSWVANNPLTDYSLIQEAAEWEKIRTSYRVVYTDD

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=496, Percent_Identity=38.1048387096774, Blast_Score=324, Evalue=8e-90,
Organism=Escherichia coli, GI48994966, Length=496, Percent_Identity=36.491935483871, Blast_Score=304, Evalue=7e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 58768; Mature: 58636

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTLKMATLNTARIGAPNMGDLFVRMRSSLPMVNTPPLLAAVDLGSNSFRLIVGRVEET
CCCCEEEEEECEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEEECCCC
EAGSQIYQVDALREPVRLGAGLSREKMLDRASQVRGWDALKRFGERLRDFHPDHVRAVAT
CCCCCEEEHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHH
NTLRVAKNAEEFLGEAEAALGFPVEVIAGREEARLIYAGAAHSVPASAGKRLVVDIGGGS
HHHHHHCCHHHHHHHHHHHCCCCCCEECCCCCCEEEEECCCCCCCCCCCCEEEEEECCCC
TEFIIGSHYTPIRMESLYIGCVSHSRQFFPAGNVDEYTMRQAELAASREIQIISADYKGE
EEEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCC
GWDQGIGSSGTARALAELLEANGFNDPGITHGISRGGLERLKRALIKAENVNRLKLIALK
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEC
PDRVPVLAGGLSIMIAVFDELGVDYVDTTDGALRLGVLYDLLGRSQHQDMRTITVEGFMR
CCCCEEEECHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCCHHEEEHHHHHH
RYGVDRAQASRIGELAVHFYDQLDEPDTEVREENRMFLGWAAALHEIGLSISHSAYHKHS
HHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCEEEHHHHHHHHHCCCCCCHHHHHCC
AYIASNADMPGFSRTDQARLAALVVGHAGKLAKLAQTRDLEWKLLFCLRLAALFCRRRAD
EEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
AGLPEITVAEANGGYEVRLPNSWVANNPLTDYSLIQEAAEWEKIRTSYRVVYTDD
CCCCEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECC
>Mature Secondary Structure 
SSTLKMATLNTARIGAPNMGDLFVRMRSSLPMVNTPPLLAAVDLGSNSFRLIVGRVEET
CCCEEEEEECEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEEECCCC
EAGSQIYQVDALREPVRLGAGLSREKMLDRASQVRGWDALKRFGERLRDFHPDHVRAVAT
CCCCCEEEHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHH
NTLRVAKNAEEFLGEAEAALGFPVEVIAGREEARLIYAGAAHSVPASAGKRLVVDIGGGS
HHHHHHCCHHHHHHHHHHHCCCCCCEECCCCCCEEEEECCCCCCCCCCCCEEEEEECCCC
TEFIIGSHYTPIRMESLYIGCVSHSRQFFPAGNVDEYTMRQAELAASREIQIISADYKGE
EEEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCC
GWDQGIGSSGTARALAELLEANGFNDPGITHGISRGGLERLKRALIKAENVNRLKLIALK
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEC
PDRVPVLAGGLSIMIAVFDELGVDYVDTTDGALRLGVLYDLLGRSQHQDMRTITVEGFMR
CCCCEEEECHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCCHHEEEHHHHHH
RYGVDRAQASRIGELAVHFYDQLDEPDTEVREENRMFLGWAAALHEIGLSISHSAYHKHS
HHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCEEEHHHHHHHHHCCCCCCHHHHHCC
AYIASNADMPGFSRTDQARLAALVVGHAGKLAKLAQTRDLEWKLLFCLRLAALFCRRRAD
EEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
AGLPEITVAEANGGYEVRLPNSWVANNPLTDYSLIQEAAEWEKIRTSYRVVYTDD
CCCCEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]