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The map label for this gene is uvrC [H]

Identifier: 186475616

GI number: 186475616

Start: 949920

End: 952142

Strand: Direct

Name: uvrC [H]

Synonym: Bphy_0851

Alternate gene names: 186475616

Gene position: 949920-952142 (Clockwise)

Preceding gene: 186475611

Following gene: 186475617

Centisome position: 27.3

GC content: 62.84

Gene sequence:

>2223_bases
ATGACCCGATCCGATTCCCCCCGCACCGCCGATCCCGCCGCGAATCAGGCCGCGAGTCAGGCCGCGAAGCAGGCCGCGAA
GACTGACGTGAGCGCAGCCGTCGCTGAAGAGTTCGACCCGAAAAAGGTGTTGCGGCAGCTGCCGCACATGCCCGGCGTCT
ATCGTTACTACGACGAGCAGGGCGCCGTGCTATACGTGGGCAAGGCGCGCGACTTGAAGAAGCGCGTGTCGAGCTACTTC
ACGAAGACGCTGCTGTCGCCGCGCATCGCGATGATGGTCTCGCGCATCGCGAAGATCGAAACGACGGTCACGCGTTCGGA
AGCGGAAGCGCTGTTGCTCGAGAACAATCTGATTAAGGCGTTGGCGCCGCGCTACAACATCCTATTTCGCGACGACAAGT
CATATCCGTACCTCAAACTGACAGGCCACCAGTTTCCGCGTATGGCGTATTACCGCGGTTCGGTCGACAAGAAGAATCAG
TATTTCGGACCGTTTCCGAGCGCGTGGGCTGTGCGTGAGAGCATTCAGATCCTGCAGCGCGTGTTTCAGTTGCGCACTTG
CGAAGACTCTGTATTCAACAACCGCACGCGCCCGTGTCTGTTGCATCAGATTGGACGATGCACGGCGCCGTGCGTCGGTG
CCGTCACAGAAGAGGACTACGCGCGCGATGTTTCCAATGCTTCGCGCTTCCTCCTCGGACGTCAGTCGGAAGTGATGAAA
GAACTTGAGCAGAAGATGCACGCATTCGCCAGCGAACTGAAGTTCGAGCAAGCGGCCGCGGTGCGCAATCAGATGAGTTC
GCTATCGACGGTGCTGCATCAGCAGGCGATCGAAGTCGGCGGCGATAGCGATGTCGACATCCTTGCCGTCGTCGCGCTAG
GCGGGCGCGTGTGCGTGAATCTCGCGATGGTGCGTGGCGGCCGGCATCTCGGCGACAAGGCTTACTTCCCAACGCATGTC
GAGAGCGCATTGACGGCGGATGAGGGCGGTATCGAAGACGGCGATGTTCTGCTATCGGCCGAAACCGCATCGGTGATCGA
CGTCGAGGCGGAACTGGGCGACGAGTCCGAGGACGCACTGAGCATCGACGAAGCCGCGTCGGAAGAAAGCGCGCCGGAAG
AAAGCGATTCCGAAGATGTTGCCGAGGATGCAGACAAGAAGCCGCGCCGCGCACACGGGATCGAATCCGAAGTACTCGAA
GCATTCATCGCGCAGCATTACCTCGGCAATCGGGTGCCGCCCGTGCTCGTGGTCAGCCATGCGCCCGCAAGCCGGGAACT
CGTCGATTTGCTGATCGAGCAGGCCGGGCATAAGGTCACGCTGCTGCGGCAGCCGCAGGGCCAGAAGCGGGCGTGGCTCG
CGATGGCCGAGCAGAATGCGAAAATCGCGCTCGCGCGGTTGCTGTCCGAACAAGGTTCGCAGCAGTCACGCACGCGTTCG
CTCGCTAACACGCTGTCGATGGAATGCGAAGACCTCGCCCATCTGCGCATCGAGTGCTTCGACATCAGCCATACGATGGG
CGAAGCGACGCAGGCATCGTGCGTGGTGTTTCACCATCACAAGATGCAGTCGTCCGAATACCGGCGCTACAACATCACGG
GCATCACGCCCGGCGACGACTACGCGGCGATGCGTCAGGTGCTCACGCGCCGCTACGAGAAGATGGTCGCGCAGGCCGCG
GCGAACGCGAACGACGAGGCGGCCGAATTGCAGCCCGAAGCGGCCGCCGATCCCGCCGCCGCGCCCGAAGGCGCGGAACC
TGTCGCTGCGGGCGGGCAGTTGCCGAACATCGTGTTGATCGACGGCGGCAAAGGGCAGGTCGAGATTGCGCGCCAGGTGT
TCAATGAGCTTGGGCTGGACCTCGGCATGCTGGTCGGTGTCGCAAAGGGCGAGGGCCGCAAGGTCGGGCTGGAAACGCTC
GTGTTCGCGGACGGCCGGCCGTCGCTCGAACTCGGCAAGGAAAGTGCGGCGCTGATGCTCGTCGCGCAGATCCGCGATGA
AGCACACCGCTTCGCGATCACCGGCATGCGCGCGAAGCGCGGCAAAACGCGGCAGACGTCGCGGCTCGAGGAACTGGAAG
GCGTTGGCGCCAAGCGACGTCAGCGCTTGCTCGCGCGCTTCGGCGGCTTGCGCGGCGTCGTGGCGGCGAGTATCGACGAT
CTTGCGAGTGTCGAAGGCATCTCGCGTGCGCTCGCCGAACAGATTTACCGTCAGTTGCATTGA

Upstream 100 bases:

>100_bases
GCCTGGCTTCGGGCCCGGGCGGAATGTTCTAAACTGGCGATTCTAAAGCACATCACCCACATGACGCGCCGTCATTACAC
GGCGTGCAAGCCGATTCTGC

Downstream 100 bases:

>100_bases
CGTGCCGTTCGCGCGCAACAGCAGGCCCTGACGCCTGGGCGCCCCACAGCCGCGATGCGCGCGCGCCGGGGCGTTGCTTG
TGGCGCGCCGGGTGAACCGG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 740; Mature: 739

Protein sequence:

>740_residues
MTRSDSPRTADPAANQAASQAAKQAAKTDVSAAVAEEFDPKKVLRQLPHMPGVYRYYDEQGAVLYVGKARDLKKRVSSYF
TKTLLSPRIAMMVSRIAKIETTVTRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTGHQFPRMAYYRGSVDKKNQ
YFGPFPSAWAVRESIQILQRVFQLRTCEDSVFNNRTRPCLLHQIGRCTAPCVGAVTEEDYARDVSNASRFLLGRQSEVMK
ELEQKMHAFASELKFEQAAAVRNQMSSLSTVLHQQAIEVGGDSDVDILAVVALGGRVCVNLAMVRGGRHLGDKAYFPTHV
ESALTADEGGIEDGDVLLSAETASVIDVEAELGDESEDALSIDEAASEESAPEESDSEDVAEDADKKPRRAHGIESEVLE
AFIAQHYLGNRVPPVLVVSHAPASRELVDLLIEQAGHKVTLLRQPQGQKRAWLAMAEQNAKIALARLLSEQGSQQSRTRS
LANTLSMECEDLAHLRIECFDISHTMGEATQASCVVFHHHKMQSSEYRRYNITGITPGDDYAAMRQVLTRRYEKMVAQAA
ANANDEAAELQPEAAADPAAAPEGAEPVAAGGQLPNIVLIDGGKGQVEIARQVFNELGLDLGMLVGVAKGEGRKVGLETL
VFADGRPSLELGKESAALMLVAQIRDEAHRFAITGMRAKRGKTRQTSRLEELEGVGAKRRQRLLARFGGLRGVVAASIDD
LASVEGISRALAEQIYRQLH

Sequences:

>Translated_740_residues
MTRSDSPRTADPAANQAASQAAKQAAKTDVSAAVAEEFDPKKVLRQLPHMPGVYRYYDEQGAVLYVGKARDLKKRVSSYF
TKTLLSPRIAMMVSRIAKIETTVTRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTGHQFPRMAYYRGSVDKKNQ
YFGPFPSAWAVRESIQILQRVFQLRTCEDSVFNNRTRPCLLHQIGRCTAPCVGAVTEEDYARDVSNASRFLLGRQSEVMK
ELEQKMHAFASELKFEQAAAVRNQMSSLSTVLHQQAIEVGGDSDVDILAVVALGGRVCVNLAMVRGGRHLGDKAYFPTHV
ESALTADEGGIEDGDVLLSAETASVIDVEAELGDESEDALSIDEAASEESAPEESDSEDVAEDADKKPRRAHGIESEVLE
AFIAQHYLGNRVPPVLVVSHAPASRELVDLLIEQAGHKVTLLRQPQGQKRAWLAMAEQNAKIALARLLSEQGSQQSRTRS
LANTLSMECEDLAHLRIECFDISHTMGEATQASCVVFHHHKMQSSEYRRYNITGITPGDDYAAMRQVLTRRYEKMVAQAA
ANANDEAAELQPEAAADPAAAPEGAEPVAAGGQLPNIVLIDGGKGQVEIARQVFNELGLDLGMLVGVAKGEGRKVGLETL
VFADGRPSLELGKESAALMLVAQIRDEAHRFAITGMRAKRGKTRQTSRLEELEGVGAKRRQRLLARFGGLRGVVAASIDD
LASVEGISRALAEQIYRQLH
>Mature_739_residues
TRSDSPRTADPAANQAASQAAKQAAKTDVSAAVAEEFDPKKVLRQLPHMPGVYRYYDEQGAVLYVGKARDLKKRVSSYFT
KTLLSPRIAMMVSRIAKIETTVTRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTGHQFPRMAYYRGSVDKKNQY
FGPFPSAWAVRESIQILQRVFQLRTCEDSVFNNRTRPCLLHQIGRCTAPCVGAVTEEDYARDVSNASRFLLGRQSEVMKE
LEQKMHAFASELKFEQAAAVRNQMSSLSTVLHQQAIEVGGDSDVDILAVVALGGRVCVNLAMVRGGRHLGDKAYFPTHVE
SALTADEGGIEDGDVLLSAETASVIDVEAELGDESEDALSIDEAASEESAPEESDSEDVAEDADKKPRRAHGIESEVLEA
FIAQHYLGNRVPPVLVVSHAPASRELVDLLIEQAGHKVTLLRQPQGQKRAWLAMAEQNAKIALARLLSEQGSQQSRTRSL
ANTLSMECEDLAHLRIECFDISHTMGEATQASCVVFHHHKMQSSEYRRYNITGITPGDDYAAMRQVLTRRYEKMVAQAAA
NANDEAAELQPEAAADPAAAPEGAEPVAAGGQLPNIVLIDGGKGQVEIARQVFNELGLDLGMLVGVAKGEGRKVGLETLV
FADGRPSLELGKESAALMLVAQIRDEAHRFAITGMRAKRGKTRQTSRLEELEGVGAKRRQRLLARFGGLRGVVAASIDDL
ASVEGISRALAEQIYRQLH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=285, Percent_Identity=47.0175438596491, Blast_Score=294, Evalue=1e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 81015; Mature: 80884

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSDSPRTADPAANQAASQAAKQAAKTDVSAAVAEEFDPKKVLRQLPHMPGVYRYYDEQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHEEECCC
GAVLYVGKARDLKKRVSSYFTKTLLSPRIAMMVSRIAKIETTVTRSEAEALLLENNLIKA
CCEEEEECHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAPRYNILFRDDKSYPYLKLTGHQFPRMAYYRGSVDKKNQYFGPFPSAWAVRESIQILQR
HCCCCEEEEECCCCCCEEEECCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
VFQLRTCEDSVFNNRTRPCLLHQIGRCTAPCVGAVTEEDYARDVSNASRFLLGRQSEVMK
HHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHCCHHHHHH
ELEQKMHAFASELKFEQAAAVRNQMSSLSTVLHQQAIEVGGDSDVDILAVVALGGRVCVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHH
LAMVRGGRHLGDKAYFPTHVESALTADEGGIEDGDVLLSAETASVIDVEAELGDESEDAL
HHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCEEEEEHHHCCCCCCCCC
SIDEAASEESAPEESDSEDVAEDADKKPRRAHGIESEVLEAFIAQHYLGNRVPPVLVVSH
CHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEC
APASRELVDLLIEQAGHKVTLLRQPQGQKRAWLAMAEQNAKIALARLLSEQGSQQSRTRS
CCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHH
LANTLSMECEDLAHLRIECFDISHTMGEATQASCVVFHHHKMQSSEYRRYNITGITPGDD
HHHHHHHHHHHHHHHEEEEEECHHHHCCCCCCEEEEEEHHHCCCCCCCEEEEEECCCCCH
YAAMRQVLTRRYEKMVAQAAANANDEAAELQPEAAADPAAAPEGAEPVAAGGQLPNIVLI
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
DGGKGQVEIARQVFNELGLDLGMLVGVAKGEGRKVGLETLVFADGRPSLELGKESAALML
ECCCCHHHHHHHHHHHHCCCHHHHHEEECCCCCEECCEEEEEECCCCCHHHCCCHHHHHH
VAQIRDEAHRFAITGMRAKRGKTRQTSRLEELEGVGAKRRQRLLARFGGLRGVVAASIDD
HHHHHHHHHHHHEECCHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHH
LASVEGISRALAEQIYRQLH
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TRSDSPRTADPAANQAASQAAKQAAKTDVSAAVAEEFDPKKVLRQLPHMPGVYRYYDEQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHEEECCC
GAVLYVGKARDLKKRVSSYFTKTLLSPRIAMMVSRIAKIETTVTRSEAEALLLENNLIKA
CCEEEEECHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAPRYNILFRDDKSYPYLKLTGHQFPRMAYYRGSVDKKNQYFGPFPSAWAVRESIQILQR
HCCCCEEEEECCCCCCEEEECCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
VFQLRTCEDSVFNNRTRPCLLHQIGRCTAPCVGAVTEEDYARDVSNASRFLLGRQSEVMK
HHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHCCHHHHHH
ELEQKMHAFASELKFEQAAAVRNQMSSLSTVLHQQAIEVGGDSDVDILAVVALGGRVCVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHH
LAMVRGGRHLGDKAYFPTHVESALTADEGGIEDGDVLLSAETASVIDVEAELGDESEDAL
HHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCEEEEEHHHCCCCCCCCC
SIDEAASEESAPEESDSEDVAEDADKKPRRAHGIESEVLEAFIAQHYLGNRVPPVLVVSH
CHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEC
APASRELVDLLIEQAGHKVTLLRQPQGQKRAWLAMAEQNAKIALARLLSEQGSQQSRTRS
CCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHH
LANTLSMECEDLAHLRIECFDISHTMGEATQASCVVFHHHKMQSSEYRRYNITGITPGDD
HHHHHHHHHHHHHHHEEEEEECHHHHCCCCCCEEEEEEHHHCCCCCCCEEEEEECCCCCH
YAAMRQVLTRRYEKMVAQAAANANDEAAELQPEAAADPAAAPEGAEPVAAGGQLPNIVLI
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
DGGKGQVEIARQVFNELGLDLGMLVGVAKGEGRKVGLETLVFADGRPSLELGKESAALML
ECCCCHHHHHHHHHHHHCCCHHHHHEEECCCCCEECCEEEEEECCCCCHHHCCCHHHHHH
VAQIRDEAHRFAITGMRAKRGKTRQTSRLEELEGVGAKRRQRLLARFGGLRGVVAASIDD
HHHHHHHHHHHHEECCHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHH
LASVEGISRALAEQIYRQLH
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA