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The map label for this gene is mucB [H]

Identifier: 186475601

GI number: 186475601

Start: 934206

End: 935246

Strand: Direct

Name: mucB [H]

Synonym: Bphy_0836

Alternate gene names: 186475601

Gene position: 934206-935246 (Clockwise)

Preceding gene: 186475600

Following gene: 186475602

Centisome position: 26.85

GC content: 61.67

Gene sequence:

>1041_bases
ATGCAGAGTCTGCGGTTGAAAAAAACGACCATCTGGGGGCGGCTGCCGGCAATCCTGTTCTGCGCAGCCGTGCTCTTGTC
CGCTACGTCGCGCACCTTTGCGCAAACCGACGATTCTGCCGCCCGGCACAGCGCGGCGGAACTGCTTAACCGGATCCATC
AGGCCGCGCAGCAGCAAAACTACGAAGGCGCGTTCGTCTATCAGCGCGGCAACTTCGTGCAGTCCTCGCGCATTTCCCAC
TACGCGACACATAACGACGGCGAGTTCGAATCGCTGGAAAGCCTGGACGGCAAGCCGCGCAAGTTGCTGCGTCATAACGA
CGAACTCTATACATTCGTGCCTGAGCGGCATCTGTGTGTTGTCGAGAAGCGGCAGAACAAGGACTCGTTCCCGGCGCTGC
TGTCGGCGAGTGGCGAGCAGGTTTTGACCGTCTACGAACCGAAGATGCTCGGCACGGATCGCGTCGCAGGCGTCGACAGC
GAAGTGATCGAGCTGGATCCGAAGGACGCGAACCGCTTTGCGTACAAATTGTGGGCCGACACGAAAACGGGCCTGCTGCT
GCGCGCGCAGACGCTCGACCCGAGCGGCCAGGTGCTCGAACAGATGTCGTTCTCGCAGATTCGCATCGGCGTCCCCGTTG
ACAAGACGCCCATCGCGTCCGGCATCAAGAACACATCCGGCTGGACCGTCGTGCGTCCGCCCGTCGAGCCCGTCGACATG
GAAGCGCAGGGCTGGCAGCTCACCTCGCCCGTTGCGGGTTTCCGCAAGATTCGCGAGCTGCGTCGGCCGATGGCGGCGCA
TGATCCGTCCAATCCGCCTATCCCGGTCGACCAGATGGTGTTCTCCGACGGCCTTGCAGCGATCTCGATCTTCATCGAGC
CGGTCGAAAAAAGCACCCGTAAGGAAGGGGCGGGGAACAGCGGCGCAACCCACGTGCTGGTGAAGCGGCGCGGGGATTTC
TGGATCACCTTGCTCGGGGAAGTGCCTCAGACCACGTTGCAGCAATTTGCGGCTGCCATAGAATACAAGCCTTCCAGGTA
A

Upstream 100 bases:

>100_bases
TATCTGGAAGCGCATCAACAGTTCGGCCTGCAGCCTGTCGTATCGGGTTCGATGCCGTTGCTCCGCGCGGCTTCTCTGAC
CACGCAGGGCCACTAGTCTG

Downstream 100 bases:

>100_bases
TCCTTCGGTTCCCCACGACATGACGATTCTCTCGGTGCGCAAATTCTTCGCGGCCGCAGTACTGGTGGCTTGCCTGCCGC
TCGCGCCGCACACGGCGTCG

Product: sigma E regulatory protein, MucB/RseB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MQSLRLKKTTIWGRLPAILFCAAVLLSATSRTFAQTDDSAARHSAAELLNRIHQAAQQQNYEGAFVYQRGNFVQSSRISH
YATHNDGEFESLESLDGKPRKLLRHNDELYTFVPERHLCVVEKRQNKDSFPALLSASGEQVLTVYEPKMLGTDRVAGVDS
EVIELDPKDANRFAYKLWADTKTGLLLRAQTLDPSGQVLEQMSFSQIRIGVPVDKTPIASGIKNTSGWTVVRPPVEPVDM
EAQGWQLTSPVAGFRKIRELRRPMAAHDPSNPPIPVDQMVFSDGLAAISIFIEPVEKSTRKEGAGNSGATHVLVKRRGDF
WITLLGEVPQTTLQQFAAAIEYKPSR

Sequences:

>Translated_346_residues
MQSLRLKKTTIWGRLPAILFCAAVLLSATSRTFAQTDDSAARHSAAELLNRIHQAAQQQNYEGAFVYQRGNFVQSSRISH
YATHNDGEFESLESLDGKPRKLLRHNDELYTFVPERHLCVVEKRQNKDSFPALLSASGEQVLTVYEPKMLGTDRVAGVDS
EVIELDPKDANRFAYKLWADTKTGLLLRAQTLDPSGQVLEQMSFSQIRIGVPVDKTPIASGIKNTSGWTVVRPPVEPVDM
EAQGWQLTSPVAGFRKIRELRRPMAAHDPSNPPIPVDQMVFSDGLAAISIFIEPVEKSTRKEGAGNSGATHVLVKRRGDF
WITLLGEVPQTTLQQFAAAIEYKPSR
>Mature_346_residues
MQSLRLKKTTIWGRLPAILFCAAVLLSATSRTFAQTDDSAARHSAAELLNRIHQAAQQQNYEGAFVYQRGNFVQSSRISH
YATHNDGEFESLESLDGKPRKLLRHNDELYTFVPERHLCVVEKRQNKDSFPALLSASGEQVLTVYEPKMLGTDRVAGVDS
EVIELDPKDANRFAYKLWADTKTGLLLRAQTLDPSGQVLEQMSFSQIRIGVPVDKTPIASGIKNTSGWTVVRPPVEPVDM
EAQGWQLTSPVAGFRKIRELRRPMAAHDPSNPPIPVDQMVFSDGLAAISIFIEPVEKSTRKEGAGNSGATHVLVKRRGDF
WITLLGEVPQTTLQQFAAAIEYKPSR

Specific function: Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate- producing form. Inactivation of mucB causes conversion to mucoidy [H]

COG id: COG3026

COG function: function code T; Negative regulator of sigma E activity

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rseB family [H]

Homologues:

Organism=Escherichia coli, GI1788924, Length=308, Percent_Identity=26.9480519480519, Blast_Score=102, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005588 [H]

Pfam domain/function: PF03888 MucB_RseB [H]

EC number: NA

Molecular weight: Translated: 38466; Mature: 38466

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSLRLKKTTIWGRLPAILFCAAVLLSATSRTFAQTDDSAARHSAAELLNRIHQAAQQQN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
YEGAFVYQRGNFVQSSRISHYATHNDGEFESLESLDGKPRKLLRHNDELYTFVPERHLCV
CCCEEEEECCCCCHHCCCHHHCCCCCCCHHHHHHCCCCHHHHHHCCCCEEEECCCCCEEE
VEKRQNKDSFPALLSASGEQVLTVYEPKMLGTDRVAGVDSEVIELDPKDANRFAYKLWAD
EECCCCCCCCCHHHCCCCCEEEEEECCCCCCCCHHCCCCCCEEEECCCCCCCEEEEEECC
TKTGLLLRAQTLDPSGQVLEQMSFSQIRIGVPVDKTPIASGIKNTSGWTVVRPPVEPVDM
CCCCEEEEEECCCCHHHHHHHCCHHHEEECCCCCCCHHHHCCCCCCCCEEECCCCCCCCC
EAQGWQLTSPVAGFRKIRELRRPMAAHDPSNPPIPVDQMVFSDGLAAISIFIEPVEKSTR
CCCCCEECCHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHCCCEEEHEEEHHHHHHHH
KEGAGNSGATHVLVKRRGDFWITLLGEVPQTTLQQFAAAIEYKPSR
HCCCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQSLRLKKTTIWGRLPAILFCAAVLLSATSRTFAQTDDSAARHSAAELLNRIHQAAQQQN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
YEGAFVYQRGNFVQSSRISHYATHNDGEFESLESLDGKPRKLLRHNDELYTFVPERHLCV
CCCEEEEECCCCCHHCCCHHHCCCCCCCHHHHHHCCCCHHHHHHCCCCEEEECCCCCEEE
VEKRQNKDSFPALLSASGEQVLTVYEPKMLGTDRVAGVDSEVIELDPKDANRFAYKLWAD
EECCCCCCCCCHHHCCCCCEEEEEECCCCCCCCHHCCCCCCEEEECCCCCCCEEEEEECC
TKTGLLLRAQTLDPSGQVLEQMSFSQIRIGVPVDKTPIASGIKNTSGWTVVRPPVEPVDM
CCCCEEEEEECCCCHHHHHHHCCHHHEEECCCCCCCHHHHCCCCCCCCEEECCCCCCCCC
EAQGWQLTSPVAGFRKIRELRRPMAAHDPSNPPIPVDQMVFSDGLAAISIFIEPVEKSTR
CCCCCEECCHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHCCCEEEHEEEHHHHHHHH
KEGAGNSGATHVLVKRRGDFWITLLGEVPQTTLQQFAAAIEYKPSR
HCCCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8412698; 8378309; 8444793; 10984043 [H]