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The map label for this gene is norM [H]

Identifier: 186475562

GI number: 186475562

Start: 896124

End: 897515

Strand: Reverse

Name: norM [H]

Synonym: Bphy_0797

Alternate gene names: 186475562

Gene position: 897515-896124 (Counterclockwise)

Preceding gene: 186475563

Following gene: 186475561

Centisome position: 25.8

GC content: 67.1

Gene sequence:

>1392_bases
ATGAATCCAACCGGAATGTCCCGTGCAATCAGCGGGCCGCCCACGCTTTCGCGCCATGCCGCCGACACGGCGCGTCTCGC
CGCGCCGCTCGCCATCGCGCAGCTCTCGCAAATGGCGATGAGCGTCACGGACACCGTGCTGCTCGGCTCGCTCGGCCCCG
ACGCGCTGGCGGCGGGGGGCTTGGGCGCGAACCTGTTCTTTGTCGTCGTGACGTTGCTGCAGGGCGTACTCACGTCCGTG
AGCGTCAGCGTGTCGCATGCGCGCGGCGCGCAGGCGGAAGATCGAGTGCCGCACATCTACTGGACGGGCTTTCTGCTGTC
GCTGCTGCTCGCGGTGCCCGCCTTCGTGCTGTTGTCGTTCGCGGCGCCCATCATGACGGCGTTCGGCGAGCCGGCGCTGC
TGGCGCACAACGTCGGCGAGTATTGCGCCGCGCTGCGCTGGGGCGCGCCGGGCAGCCTGATCGGCATCGGCCTGATGCGC
TCGTTCCTGCCCGCGATCGGCGCGGCGCGACGCCTGCTGTGGGTGTCGATCGGCGGCGTGTTCGTCAATGCGTTCCTCAA
CTACGGGCTGATTCACGGCGCATACGGCCTGCCGCGGCTCGGCTTCCTCGGCTCGGCGGGCGCGACGACCTTTACCGTCT
GGCTCACGGCGCTCACGCTGATGGGGCTGCTGCATCTGCGGCCGCGCTTCCGGCATTTCGTGACGGCCGCTCGCCCGAAT
GTGCCGCTCATGGGCGAACTGTTCGGTATCGGCTGGCCCGTGGCGATCACGTATGGCGTCGAGTCGACGCTGTTTCTCGC
GACGGGCCTGATGGTCGGCCTGCTCGGCGAGTCGCAGCTGGCTGCGCACCAGATCGCGCTGAACGTCGCGTCGGTGGCGT
TCATGGTGCCGCTCGCGATCGGTCAGGCTGCGAACGTGCGCGTCGGCTTCTGGTCGGGGGCCGGACAGCCGCTCGCCGCG
CGCCACGCGGGCTTCGTCGCGCTCGGGCTAGGCGTCGCGTTCATGAGCCTGTCGGGCCTGCTGCTGATCACAGCGCCGCG
TTACATCGTCGGGCTGTATCTGCATCTCGACGATCCGGCCAATGCGCCGACTGTCGCACTTGCCAGTTCGCTGCTGGCTG
TCGCGGCCATTTTTCAGATCGTCGATGGGATGCAGACAGTGGGATCCGGGTGCTTGCGTGGTCTCAAGGACACGCGGGTT
CCGATGATCGCTGCCGCATTCGGGTATTGGGGTATTGGGTTCCCGACCGGTTATACCCTTGCATTTCACTTCGGGTTCGG
CGCCCGGGGTTTGTGGTGGGGGCTTGCTGCTGGACTCGCCAGCGTTGCCGTTTTGATGACCTTGCGGTTTCACAAGATGA
GCTTCCGGCGCGTGCGGGGTCTTGAAGATTAA

Upstream 100 bases:

>100_bases
CAGCGCCGCATTCCCGCAATAAGCTGTCCGTCTGGACAGAAAAACAAACAGCGCGGGCTGCTGACCGCGCGTACCGCCTA
TCGCGCATCGCGCTTCGAAT

Downstream 100 bases:

>100_bases
ACCGCGCTGACTTTTTGCGCCGGCATCCGCGATTTCATGTCGGTATTCAGGCGCTGCCCTGTGCAGGGGCACCTGGAAAG
CCGCTCACACCGCCCGCTCG

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MNPTGMSRAISGPPTLSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAGGLGANLFFVVVTLLQGVLTSV
SVSVSHARGAQAEDRVPHIYWTGFLLSLLLAVPAFVLLSFAAPIMTAFGEPALLAHNVGEYCAALRWGAPGSLIGIGLMR
SFLPAIGAARRLLWVSIGGVFVNAFLNYGLIHGAYGLPRLGFLGSAGATTFTVWLTALTLMGLLHLRPRFRHFVTAARPN
VPLMGELFGIGWPVAITYGVESTLFLATGLMVGLLGESQLAAHQIALNVASVAFMVPLAIGQAANVRVGFWSGAGQPLAA
RHAGFVALGLGVAFMSLSGLLLITAPRYIVGLYLHLDDPANAPTVALASSLLAVAAIFQIVDGMQTVGSGCLRGLKDTRV
PMIAAAFGYWGIGFPTGYTLAFHFGFGARGLWWGLAAGLASVAVLMTLRFHKMSFRRVRGLED

Sequences:

>Translated_463_residues
MNPTGMSRAISGPPTLSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAGGLGANLFFVVVTLLQGVLTSV
SVSVSHARGAQAEDRVPHIYWTGFLLSLLLAVPAFVLLSFAAPIMTAFGEPALLAHNVGEYCAALRWGAPGSLIGIGLMR
SFLPAIGAARRLLWVSIGGVFVNAFLNYGLIHGAYGLPRLGFLGSAGATTFTVWLTALTLMGLLHLRPRFRHFVTAARPN
VPLMGELFGIGWPVAITYGVESTLFLATGLMVGLLGESQLAAHQIALNVASVAFMVPLAIGQAANVRVGFWSGAGQPLAA
RHAGFVALGLGVAFMSLSGLLLITAPRYIVGLYLHLDDPANAPTVALASSLLAVAAIFQIVDGMQTVGSGCLRGLKDTRV
PMIAAAFGYWGIGFPTGYTLAFHFGFGARGLWWGLAAGLASVAVLMTLRFHKMSFRRVRGLED
>Mature_463_residues
MNPTGMSRAISGPPTLSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAGGLGANLFFVVVTLLQGVLTSV
SVSVSHARGAQAEDRVPHIYWTGFLLSLLLAVPAFVLLSFAAPIMTAFGEPALLAHNVGEYCAALRWGAPGSLIGIGLMR
SFLPAIGAARRLLWVSIGGVFVNAFLNYGLIHGAYGLPRLGFLGSAGATTFTVWLTALTLMGLLHLRPRFRHFVTAARPN
VPLMGELFGIGWPVAITYGVESTLFLATGLMVGLLGESQLAAHQIALNVASVAFMVPLAIGQAANVRVGFWSGAGQPLAA
RHAGFVALGLGVAFMSLSGLLLITAPRYIVGLYLHLDDPANAPTVALASSLLAVAAIFQIVDGMQTVGSGCLRGLKDTRV
PMIAAAFGYWGIGFPTGYTLAFHFGFGARGLWWGLAAGLASVAVLMTLRFHKMSFRRVRGLED

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=414, Percent_Identity=24.3961352657005, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI153792564, Length=420, Percent_Identity=25, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI38261960, Length=262, Percent_Identity=27.8625954198473, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI48994890, Length=436, Percent_Identity=32.7981651376147, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI226510954, Length=446, Percent_Identity=26.9058295964126, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320545, Length=427, Percent_Identity=22.7166276346604, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48373; Mature: 48373

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPTGMSRAISGPPTLSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAGG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
LGANLFFVVVTLLQGVLTSVSVSVSHARGAQAEDRVPHIYWTGFLLSLLLAVPAFVLLSF
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
AAPIMTAFGEPALLAHNVGEYCAALRWGAPGSLIGIGLMRSFLPAIGAARRLLWVSIGGV
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVNAFLNYGLIHGAYGLPRLGFLGSAGATTFTVWLTALTLMGLLHLRPRFRHFVTAARPN
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCC
VPLMGELFGIGWPVAITYGVESTLFLATGLMVGLLGESQLAAHQIALNVASVAFMVPLAI
CCCHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
GQAANVRVGFWSGAGQPLAARHAGFVALGLGVAFMSLSGLLLITAPRYIVGLYLHLDDPA
CCCCCEEEEEECCCCCCHHHHHCCHHHHHHHHHHHHHCCEEEEECCHHHEEEEEEECCCC
NAPTVALASSLLAVAAIFQIVDGMQTVGSGCLRGLKDTRVPMIAAAFGYWGIGFPTGYTL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEE
AFHFGFGARGLWWGLAAGLASVAVLMTLRFHKMSFRRVRGLED
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNPTGMSRAISGPPTLSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAGG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
LGANLFFVVVTLLQGVLTSVSVSVSHARGAQAEDRVPHIYWTGFLLSLLLAVPAFVLLSF
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
AAPIMTAFGEPALLAHNVGEYCAALRWGAPGSLIGIGLMRSFLPAIGAARRLLWVSIGGV
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVNAFLNYGLIHGAYGLPRLGFLGSAGATTFTVWLTALTLMGLLHLRPRFRHFVTAARPN
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCC
VPLMGELFGIGWPVAITYGVESTLFLATGLMVGLLGESQLAAHQIALNVASVAFMVPLAI
CCCHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
GQAANVRVGFWSGAGQPLAARHAGFVALGLGVAFMSLSGLLLITAPRYIVGLYLHLDDPA
CCCCCEEEEEECCCCCCHHHHHCCHHHHHHHHHHHHHCCEEEEECCHHHEEEEEEECCCC
NAPTVALASSLLAVAAIFQIVDGMQTVGSGCLRGLKDTRVPMIAAAFGYWGIGFPTGYTL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEE
AFHFGFGARGLWWGLAAGLASVAVLMTLRFHKMSFRRVRGLED
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA