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The map label for this gene is lrp [H]

Identifier: 186475531

GI number: 186475531

Start: 863636

End: 864124

Strand: Direct

Name: lrp [H]

Synonym: Bphy_0766

Alternate gene names: 186475531

Gene position: 863636-864124 (Clockwise)

Preceding gene: 186475529

Following gene: 186475532

Centisome position: 24.82

GC content: 58.69

Gene sequence:

>489_bases
ATGCGTACACAGCGCCATCCGGTGCGAGCCCTCGACAAGCTCGATCACAAGATCCTGAAAATCCTCCAGATCGACGGCCG
GATCGCGATGAAGGAGTTGTCCGAACAGGTTGGTCTCTCCGTGACGCCGTGCATCGAGCGCGTCAAACGCATGGAGCGCG
ACGGTGTGATCACCGGCTACTATGCGCGCGTGAATCCCGCGGAGTTGGGCGCGGCGCTGCTCGTTTTCGTCGAGATCACG
CTCGATCACAAGAGCGGCAACATGTTCGACCAGTTCCGCCGCGAAGTGCAGAAGATCCCGGAAGTGCTGGAATGCCATCT
GGTGTCGGGTGACTTCGACTATCTGATCAAGGCGCGCATCGGTGAGATGGCCGATTATCGCAAGCTCCTCGGCGACATCC
TCCTGCAATTGCCCGGCGCAGTGCAGTCGAAAAGCTACGTCGTGATGGAAGAAATCAAGGAAACACTGACGATCGCGGTC
GGGGAATGA

Upstream 100 bases:

>100_bases
GATTGACGAGGTGAAATGCCGGATACCCAGTGTTAACCGCTATACTATTTCCGTTGCACTAGGTTTTGTTATTGTATTTT
GTAGATTTTCAGTAAATACT

Downstream 100 bases:

>100_bases
CGGGCTCCCCACGCTGAATCGACGGGTCGCTGCCGCAGCCGAACCGGCCCCCAAAATCGAACTCGACAAAGACGGTAAAC
ACTGTATATTTGTACAGTAT

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MRTQRHPVRALDKLDHKILKILQIDGRIAMKELSEQVGLSVTPCIERVKRMERDGVITGYYARVNPAELGAALLVFVEIT
LDHKSGNMFDQFRREVQKIPEVLECHLVSGDFDYLIKARIGEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLTIAV
GE

Sequences:

>Translated_162_residues
MRTQRHPVRALDKLDHKILKILQIDGRIAMKELSEQVGLSVTPCIERVKRMERDGVITGYYARVNPAELGAALLVFVEIT
LDHKSGNMFDQFRREVQKIPEVLECHLVSGDFDYLIKARIGEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLTIAV
GE
>Mature_162_residues
MRTQRHPVRALDKLDHKILKILQIDGRIAMKELSEQVGLSVTPCIERVKRMERDGVITGYYARVNPAELGAALLVFVEIT
LDHKSGNMFDQFRREVQKIPEVLECHLVSGDFDYLIKARIGEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLTIAV
GE

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=153, Percent_Identity=56.2091503267974, Blast_Score=184, Evalue=3e-48,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=34.6666666666667, Blast_Score=108, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18394; Mature: 18394

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTQRHPVRALDKLDHKILKILQIDGRIAMKELSEQVGLSVTPCIERVKRMERDGVITGY
CCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEE
YARVNPAELGAALLVFVEITLDHKSGNMFDQFRREVQKIPEVLECHLVSGDFDYLIKARI
EEECCHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLTIAVGE
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRTQRHPVRALDKLDHKILKILQIDGRIAMKELSEQVGLSVTPCIERVKRMERDGVITGY
CCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEE
YARVNPAELGAALLVFVEITLDHKSGNMFDQFRREVQKIPEVLECHLVSGDFDYLIKARI
EEECCHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLTIAVGE
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]