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The map label for this gene is cysM [H]

Identifier: 186475519

GI number: 186475519

Start: 850444

End: 851346

Strand: Direct

Name: cysM [H]

Synonym: Bphy_0754

Alternate gene names: 186475519

Gene position: 850444-851346 (Clockwise)

Preceding gene: 186475518

Following gene: 186475521

Centisome position: 24.44

GC content: 62.9

Gene sequence:

>903_bases
ATGGCTTACAAAACGATTGAAGACACGATTGGCAATACGCCCCTCATTCAACTCGTCCGCGTCGTGGACGAAGACATCCG
CGCCCGCAACAACGTCGTGCTTGGCAAGCTGGAAGGCAATAATCCCGCGGGTTCGGTCAAGGACCGCCCGGCGCTGTCGA
TGATCAAGCAGGCGGAACTGCGCGGGCGCATCAAACCGGGCGACACGCTGATCGAAGCGACGAGCGGCAACACGGGCATC
GCGCTGGCGATGGCCGCGGCCATCCGCGGCTACAAGATGATTCTCATCATGCCGGAAGACCTGTCGCTGGAGCGGCGTCA
AAGCATGGCCGCATACGGCGCGCAGATCGTGCTGACGCCCGTCACGGGCGGCATGGAATACGCACGCGATCTCGCCGAGC
AGATGCAGCGCGAAGGCAAAGGAATCATCCTCGACCAGTTCGGCAACCCGGACAATCCGCTTGCGCACTACGAAGCGACG
GGCCCTGAAATCTGGCGCGATACGGAAGGACGCATCACACACTTCGTGTCGGCGATGGGCACGACGGGCACGATCATGGG
CGTGTCGCAGTATCTGAAAGAACTGAAGCCGTCGATCGAAATCGTGGGCGCGCAGCCTGAAGAGGGCTCGCGCATCCCGG
GCATCCGCAAATGGCCGGAGGCGTATCTGCCGAAAATTTTCGACCGCAGCCGCGTCGATCGCGTCGAAAACGTGAGCCAG
GCAGCGTCGGAAGCGATGGCGCGCCGGTTGGCGTCTGTCGAGGGCGTGTTCTGCGGCATTTCTTCGGCGGGTGCGTGCGA
AGTGGCGCTGCGTGTCGCGCGCCAGGTGGAGAACGCGACCATCGTGTTCATCGTCTGCGATCGCGGCGACCGTTATCTGT
CGACGGGCGTGTTCCCCGCCTGA

Upstream 100 bases:

>100_bases
AAGCATCCATGCGCGCGACAGGGGCTGTCGGCAGCGCCACGCACGGTAGTTTAGAATCGACGGATTCAGGACTCCCGGCA
CCGTCACGCACGTAACGCAC

Downstream 100 bases:

>100_bases
GTCGCGGTGCCGCGTGGGAGCGGCCTTCGCATCCAGATAAAGACAAACGCCGGCATCTGCCGGCGTTTTTCATGGTTGTG
CGCGAGTGTGCTTACTGCGA

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MAYKTIEDTIGNTPLIQLVRVVDEDIRARNNVVLGKLEGNNPAGSVKDRPALSMIKQAELRGRIKPGDTLIEATSGNTGI
ALAMAAAIRGYKMILIMPEDLSLERRQSMAAYGAQIVLTPVTGGMEYARDLAEQMQREGKGIILDQFGNPDNPLAHYEAT
GPEIWRDTEGRITHFVSAMGTTGTIMGVSQYLKELKPSIEIVGAQPEEGSRIPGIRKWPEAYLPKIFDRSRVDRVENVSQ
AASEAMARRLASVEGVFCGISSAGACEVALRVARQVENATIVFIVCDRGDRYLSTGVFPA

Sequences:

>Translated_300_residues
MAYKTIEDTIGNTPLIQLVRVVDEDIRARNNVVLGKLEGNNPAGSVKDRPALSMIKQAELRGRIKPGDTLIEATSGNTGI
ALAMAAAIRGYKMILIMPEDLSLERRQSMAAYGAQIVLTPVTGGMEYARDLAEQMQREGKGIILDQFGNPDNPLAHYEAT
GPEIWRDTEGRITHFVSAMGTTGTIMGVSQYLKELKPSIEIVGAQPEEGSRIPGIRKWPEAYLPKIFDRSRVDRVENVSQ
AASEAMARRLASVEGVFCGISSAGACEVALRVARQVENATIVFIVCDRGDRYLSTGVFPA
>Mature_299_residues
AYKTIEDTIGNTPLIQLVRVVDEDIRARNNVVLGKLEGNNPAGSVKDRPALSMIKQAELRGRIKPGDTLIEATSGNTGIA
LAMAAAIRGYKMILIMPEDLSLERRQSMAAYGAQIVLTPVTGGMEYARDLAEQMQREGKGIILDQFGNPDNPLAHYEATG
PEIWRDTEGRITHFVSAMGTTGTIMGVSQYLKELKPSIEIVGAQPEEGSRIPGIRKWPEAYLPKIFDRSRVDRVENVSQA
ASEAMARRLASVEGVFCGISSAGACEVALRVARQVENATIVFIVCDRGDRYLSTGVFPA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=302, Percent_Identity=36.7549668874172, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI295821200, Length=302, Percent_Identity=36.7549668874172, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI4557415, Length=302, Percent_Identity=36.7549668874172, Blast_Score=179, Evalue=3e-45,
Organism=Escherichia coli, GI2367138, Length=294, Percent_Identity=61.9047619047619, Blast_Score=366, Evalue=1e-103,
Organism=Escherichia coli, GI1788754, Length=317, Percent_Identity=41.6403785488959, Blast_Score=195, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=41.9672131147541, Blast_Score=210, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI17562970, Length=302, Percent_Identity=41.7218543046358, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI32566674, Length=297, Percent_Identity=42.4242424242424, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI115535073, Length=300, Percent_Identity=40.3333333333333, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=40.3973509933775, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI25147552, Length=315, Percent_Identity=35.5555555555556, Blast_Score=147, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17534315, Length=317, Percent_Identity=36.5930599369085, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=35.8490566037736, Blast_Score=131, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6321594, Length=317, Percent_Identity=37.8548895899054, Blast_Score=169, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=32.4324324324324, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24643623, Length=313, Percent_Identity=37.6996805111821, Blast_Score=167, Evalue=6e-42,
Organism=Drosophila melanogaster, GI20129101, Length=313, Percent_Identity=37.6996805111821, Blast_Score=167, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32622; Mature: 32491

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYKTIEDTIGNTPLIQLVRVVDEDIRARNNVVLGKLEGNNPAGSVKDRPALSMIKQAEL
CCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
RGRIKPGDTLIEATSGNTGIALAMAAAIRGYKMILIMPEDLSLERRQSMAAYGAQIVLTP
CCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEE
VTGGMEYARDLAEQMQREGKGIILDQFGNPDNPLAHYEATGPEIWRDTEGRITHFVSAMG
CCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEECCCCHHHCCCCCHHHHHHHHHC
TTGTIMGVSQYLKELKPSIEIVGAQPEEGSRIPGIRKWPEAYLPKIFDRSRVDRVENVSQ
CCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AASEAMARRLASVEGVFCGISSAGACEVALRVARQVENATIVFIVCDRGDRYLSTGVFPA
HHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCCCC
>Mature Secondary Structure 
AYKTIEDTIGNTPLIQLVRVVDEDIRARNNVVLGKLEGNNPAGSVKDRPALSMIKQAEL
CCCCHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
RGRIKPGDTLIEATSGNTGIALAMAAAIRGYKMILIMPEDLSLERRQSMAAYGAQIVLTP
CCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEE
VTGGMEYARDLAEQMQREGKGIILDQFGNPDNPLAHYEATGPEIWRDTEGRITHFVSAMG
CCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEECCCCHHHCCCCCHHHHHHHHHC
TTGTIMGVSQYLKELKPSIEIVGAQPEEGSRIPGIRKWPEAYLPKIFDRSRVDRVENVSQ
CCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AASEAMARRLASVEGVFCGISSAGACEVALRVARQVENATIVFIVCDRGDRYLSTGVFPA
HHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]