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The map label for this gene is serC

Identifier: 186475505

GI number: 186475505

Start: 835573

End: 836655

Strand: Direct

Name: serC

Synonym: Bphy_0740

Alternate gene names: 186475505

Gene position: 835573-836655 (Clockwise)

Preceding gene: 186475504

Following gene: 186475506

Centisome position: 24.02

GC content: 61.22

Gene sequence:

>1083_bases
ATGCGCGTCTTCAATTTCTCCGCCGGTCCGGCGGCCATGCCCGAAGAAGTGCTGCGCCAGGCAGCCGACGAAATGCTCGA
TTGGGGCGGCAGCGGCATGAGCGTGATGGAAATGAGCCACCGCGGCAAAGAATTCATGACGATTCATGAAGAGGCGCTGA
CGGATCTGCGGGAACTGCTGCAGGTGCCGTCCAGTCACCACATTCTTTTCCTGCAAGGCGGGGGGCTCGGCGAAAACGCG
ATCGTGCCGATGAACCTCATGGGGCGCAAGGCGCGCGCAGACTTCGTCGTGACGGGCTCCTGGTCGCAGAAATCGTTCAA
GGAAGCGCAGAAATACGGCACCGTGCACCTGGCCGCGAGCGGCGAAACGGCCAACGGATTTACGCACGTTCCGGCGCGCG
CCGAGTGGAGCCTGTCCGACGATCCCGCCTACGTGCACCTGTGCACGAACGAAACCATCCACGGCGTCGAGACGTTCGAG
ATTCCCGATCTCGGCGACATTCCCCTCGTCGCCGATGCGTCGTCACACATCCTGTCGCGCCCGATGGACATTGCCAAATA
TGGCGTGCTGTTCGGCGGTGCGCAGAAGAACATCGGCATGGCGGGCGTCACGGTCGTGATCGTGCGTGAAGATCTGCTGG
AACGCTCGATGAGCATTTGCCCGTCGGCGTTCGAATGGAAGACGGTTGCGCTCAACAATTCGATGTACAACACGCCGCCT
ACGTATGCGATCTATATCGCCGGACTGGTGTTCAAGTGGTTGAAGAAGCAGGGCGGGTTGACAGCGATCGAGGCACGCAA
CGTCGAGAAGGCGAAGCTGCTCTACGACACGATCGACTCGAGCAGTTTTTATCTGAACAAGGTCGAGCGCAACGCGCGGT
CGCGGATGAACGTCCCGTTCTTCCTCGCCGACGAGTCGCGCAATGAAGATTTCCTGGCCGGCGCGAAAGCGCGCGGGCTG
GTGCAGCTGAAGGGCCACAAGTCCGTCGGCGGCATGCGGGCGTCGATTTACAACGCGGTGCCGCTCGAAGGCGTCAAGGC
GCTTGTCGAGTACATGAGGGAATTCGAACAGCGCGGCGCGTGA

Upstream 100 bases:

>100_bases
GATAATGGCCGTTTGCGCTTGCGCGCAGACGGCCATTTTCTTTCAGGCGCTATTTCCGGCTCTTTGATACGCCGTGCGCC
TGCTTCCCAGGGTTCTCACG

Downstream 100 bases:

>100_bases
TCTTACTGGTTGCGGTGCGCGCATCCTCTCCGAACCGGGCCCTGGCTGGACCCGAATTGGCCCTTTAGAAGCATGGACGA
CGAACTCAATTCTCAACTCA

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MRVFNFSAGPAAMPEEVLRQAADEMLDWGGSGMSVMEMSHRGKEFMTIHEEALTDLRELLQVPSSHHILFLQGGGLGENA
IVPMNLMGRKARADFVVTGSWSQKSFKEAQKYGTVHLAASGETANGFTHVPARAEWSLSDDPAYVHLCTNETIHGVETFE
IPDLGDIPLVADASSHILSRPMDIAKYGVLFGGAQKNIGMAGVTVVIVREDLLERSMSICPSAFEWKTVALNNSMYNTPP
TYAIYIAGLVFKWLKKQGGLTAIEARNVEKAKLLYDTIDSSSFYLNKVERNARSRMNVPFFLADESRNEDFLAGAKARGL
VQLKGHKSVGGMRASIYNAVPLEGVKALVEYMREFEQRGA

Sequences:

>Translated_360_residues
MRVFNFSAGPAAMPEEVLRQAADEMLDWGGSGMSVMEMSHRGKEFMTIHEEALTDLRELLQVPSSHHILFLQGGGLGENA
IVPMNLMGRKARADFVVTGSWSQKSFKEAQKYGTVHLAASGETANGFTHVPARAEWSLSDDPAYVHLCTNETIHGVETFE
IPDLGDIPLVADASSHILSRPMDIAKYGVLFGGAQKNIGMAGVTVVIVREDLLERSMSICPSAFEWKTVALNNSMYNTPP
TYAIYIAGLVFKWLKKQGGLTAIEARNVEKAKLLYDTIDSSSFYLNKVERNARSRMNVPFFLADESRNEDFLAGAKARGL
VQLKGHKSVGGMRASIYNAVPLEGVKALVEYMREFEQRGA
>Mature_360_residues
MRVFNFSAGPAAMPEEVLRQAADEMLDWGGSGMSVMEMSHRGKEFMTIHEEALTDLRELLQVPSSHHILFLQGGGLGENA
IVPMNLMGRKARADFVVTGSWSQKSFKEAQKYGTVHLAASGETANGFTHVPARAEWSLSDDPAYVHLCTNETIHGVETFE
IPDLGDIPLVADASSHILSRPMDIAKYGVLFGGAQKNIGMAGVTVVIVREDLLERSMSICPSAFEWKTVALNNSMYNTPP
TYAIYIAGLVFKWLKKQGGLTAIEARNVEKAKLLYDTIDSSSFYLNKVERNARSRMNVPFFLADESRNEDFLAGAKARGL
VQLKGHKSVGGMRASIYNAVPLEGVKALVEYMREFEQRGA

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=361, Percent_Identity=46.814404432133, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI10863955, Length=357, Percent_Identity=42.8571428571429, Blast_Score=300, Evalue=2e-81,
Organism=Escherichia coli, GI1787136, Length=358, Percent_Identity=54.4692737430168, Blast_Score=405, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17506897, Length=362, Percent_Identity=46.1325966850829, Blast_Score=341, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6324758, Length=392, Percent_Identity=41.5816326530612, Blast_Score=291, Evalue=1e-79,
Organism=Drosophila melanogaster, GI21356589, Length=359, Percent_Identity=49.3036211699164, Blast_Score=368, Evalue=1e-102,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_BURP8 (B2JF00)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001856975.1
- ProteinModelPortal:   B2JF00
- SMR:   B2JF00
- GeneID:   6242238
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_0740
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 39612; Mature: 39612

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 41-41 BINDING 101-101 BINDING 152-152 BINDING 172-172 BINDING 195-195

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVFNFSAGPAAMPEEVLRQAADEMLDWGGSGMSVMEMSHRGKEFMTIHEEALTDLRELL
CEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHEEHHHHHHHHHHHHH
QVPSSHHILFLQGGGLGENAIVPMNLMGRKARADFVVTGSWSQKSFKEAQKYGTVHLAAS
HCCCCCEEEEEECCCCCCCCEEEHHHCCCCCCCCEEEECCCCHHHHHHHHHCCCEEEEEC
GETANGFTHVPARAEWSLSDDPAYVHLCTNETIHGVETFEIPDLGDIPLVADASSHILSR
CCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCCCEEEECCCCCCCCCEEECCHHHHHHC
PMDIAKYGVLFGGAQKNIGMAGVTVVIVREDLLERSMSICPSAFEWKTVALNNSMYNTPP
CHHHHHHHHEECCCCCCCCCCCEEEEEEEHHHHHHHHHHCCCCCCEEEEEECCCCCCCCC
TYAIYIAGLVFKWLKKQGGLTAIEARNVEKAKLLYDTIDSSSFYLNKVERNARSRMNVPF
CHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCE
FLADESRNEDFLAGAKARGLVQLKGHKSVGGMRASIYNAVPLEGVKALVEYMREFEQRGA
EEECCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRVFNFSAGPAAMPEEVLRQAADEMLDWGGSGMSVMEMSHRGKEFMTIHEEALTDLRELL
CEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHEEHHHHHHHHHHHHH
QVPSSHHILFLQGGGLGENAIVPMNLMGRKARADFVVTGSWSQKSFKEAQKYGTVHLAAS
HCCCCCEEEEEECCCCCCCCEEEHHHCCCCCCCCEEEECCCCHHHHHHHHHCCCEEEEEC
GETANGFTHVPARAEWSLSDDPAYVHLCTNETIHGVETFEIPDLGDIPLVADASSHILSR
CCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCCCEEEECCCCCCCCCEEECCHHHHHHC
PMDIAKYGVLFGGAQKNIGMAGVTVVIVREDLLERSMSICPSAFEWKTVALNNSMYNTPP
CHHHHHHHHEECCCCCCCCCCCEEEEEEEHHHHHHHHHHCCCCCCEEEEEECCCCCCCCC
TYAIYIAGLVFKWLKKQGGLTAIEARNVEKAKLLYDTIDSSSFYLNKVERNARSRMNVPF
CHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCE
FLADESRNEDFLAGAKARGLVQLKGHKSVGGMRASIYNAVPLEGVKALVEYMREFEQRGA
EEECCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA