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The map label for this gene is map [H]

Identifier: 186475419

GI number: 186475419

Start: 739727

End: 740512

Strand: Direct

Name: map [H]

Synonym: Bphy_0653

Alternate gene names: 186475419

Gene position: 739727-740512 (Clockwise)

Preceding gene: 186475418

Following gene: 186475420

Centisome position: 21.26

GC content: 63.74

Gene sequence:

>786_bases
ATGGCCATCACCTATAAAACCTCAGAAGACATCGCGCGCCTGCGCATCTCGGGCCGGCTCGCCGCCGACGTGCTCGCCAT
GATTGGCGAGCACGTGAAGCCCGGCGTTTCGACGGGCGAGCTCGACGCGATATGCCACGACTACATCGTCAACACGCAGA
AGGCGATTGCCGCGAACGTCGGCTATATGGGCTTTCCGAAGACGGTCTGCACGTCCGTGAACGCCGTCGTGTGCCACGGC
ATTCCCGATCGCAGCGAAGTCCTCAAGGACGGCGACATCATCAACATCGACGTGGCCGTCATCAAGGATGGCTACTTCGG
CGACACGAGCCGCATGTACACGGTCGGCCAGTCGAGCACCGTCGCGCAACAGCTGATCGATACGACGTATGAGGCGATGC
TCGCCGGCATCCGCCAGGTGAAGCCTGGCGCGACGCTCGGCGACGTCGGCCATGCCATCCAGCAGATCGCGCAGCGCGAG
GGCTTTTCGATCGTGCGCGATTACTGCGGGCATGGCATCGGCAAGGTCTATCACGAAGACCCTCAGGTGTTGCACTACGG
CCAGCCGGGGCAGGGAGTACGCCTGAAGCCGGGCATGGTGTTCACGATCGAACCGATGATCAATGCGGGCCGCGCCGGTA
CGACGGTGATGCGCGACGGCTGGACTGTCGTCACCAAAGACCGTTCGCTGTCCGCGCAGTGGGAGCACATGGTCGCCGTC
ACCGACGACAGCTATGAGCTGCTCACGCCGTGGCCCGACGGTACGGGGCGCTATGAGGCGCCGTGA

Upstream 100 bases:

>100_bases
GTGCAGATCCAGGCACCGCCGCGATCACCGCGGCGCCGGCGCTCAGGCGAAAGCCGCTGATCCGCTCGCCGCGTCATGCG
TCCCGTCAACCGTTCCCGAC

Downstream 100 bases:

>100_bases
TGGGCGGCTGCGCGCGGGAATGGCGGCTTGCAACCGTTTGCGGCAGTCTGCATACGATGCGGCGCCCCTTTCCGGCACGT
GCGTGTGCCGTTTTTGCGCG

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MAITYKTSEDIARLRISGRLAADVLAMIGEHVKPGVSTGELDAICHDYIVNTQKAIAANVGYMGFPKTVCTSVNAVVCHG
IPDRSEVLKDGDIINIDVAVIKDGYFGDTSRMYTVGQSSTVAQQLIDTTYEAMLAGIRQVKPGATLGDVGHAIQQIAQRE
GFSIVRDYCGHGIGKVYHEDPQVLHYGQPGQGVRLKPGMVFTIEPMINAGRAGTTVMRDGWTVVTKDRSLSAQWEHMVAV
TDDSYELLTPWPDGTGRYEAP

Sequences:

>Translated_261_residues
MAITYKTSEDIARLRISGRLAADVLAMIGEHVKPGVSTGELDAICHDYIVNTQKAIAANVGYMGFPKTVCTSVNAVVCHG
IPDRSEVLKDGDIINIDVAVIKDGYFGDTSRMYTVGQSSTVAQQLIDTTYEAMLAGIRQVKPGATLGDVGHAIQQIAQRE
GFSIVRDYCGHGIGKVYHEDPQVLHYGQPGQGVRLKPGMVFTIEPMINAGRAGTTVMRDGWTVVTKDRSLSAQWEHMVAV
TDDSYELLTPWPDGTGRYEAP
>Mature_260_residues
AITYKTSEDIARLRISGRLAADVLAMIGEHVKPGVSTGELDAICHDYIVNTQKAIAANVGYMGFPKTVCTSVNAVVCHGI
PDRSEVLKDGDIINIDVAVIKDGYFGDTSRMYTVGQSSTVAQQLIDTTYEAMLAGIRQVKPGATLGDVGHAIQQIAQREG
FSIVRDYCGHGIGKVYHEDPQVLHYGQPGQGVRLKPGMVFTIEPMINAGRAGTTVMRDGWTVVTKDRSLSAQWEHMVAVT
DDSYELLTPWPDGTGRYEAP

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=247, Percent_Identity=44.5344129554656, Blast_Score=215, Evalue=3e-56,
Organism=Homo sapiens, GI40385867, Length=251, Percent_Identity=39.4422310756972, Blast_Score=188, Evalue=5e-48,
Organism=Escherichia coli, GI1786364, Length=255, Percent_Identity=59.6078431372549, Blast_Score=330, Evalue=6e-92,
Organism=Escherichia coli, GI1788728, Length=211, Percent_Identity=26.0663507109005, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789275, Length=224, Percent_Identity=28.125, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=252, Percent_Identity=38.8888888888889, Blast_Score=187, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6323273, Length=242, Percent_Identity=41.7355371900826, Blast_Score=205, Evalue=5e-54,
Organism=Drosophila melanogaster, GI21355531, Length=249, Percent_Identity=39.7590361445783, Blast_Score=193, Evalue=8e-50,
Organism=Drosophila melanogaster, GI24583427, Length=244, Percent_Identity=38.9344262295082, Blast_Score=187, Evalue=7e-48,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28287; Mature: 28155

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITYKTSEDIARLRISGRLAADVLAMIGEHVKPGVSTGELDAICHDYIVNTQKAIAANV
CEEEECCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHCC
GYMGFPKTVCTSVNAVVCHGIPDRSEVLKDGDIINIDVAVIKDGYFGDTSRMYTVGQSST
CCCCCCHHHHHCCCEEEEECCCCHHHHHCCCCEEEEEEEEEECCCCCCCCEEEEECCCHH
VAQQLIDTTYEAMLAGIRQVKPGATLGDVGHAIQQIAQREGFSIVRDYCGHGIGKVYHED
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCC
PQVLHYGQPGQGVRLKPGMVFTIEPMINAGRAGTTVMRDGWTVVTKDRSLSAQWEHMVAV
CCEEEECCCCCCEEECCCEEEEEECCCCCCCCCCEEEECCCEEEEECCCCCCCEEEEEEE
TDDSYELLTPWPDGTGRYEAP
ECCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure 
AITYKTSEDIARLRISGRLAADVLAMIGEHVKPGVSTGELDAICHDYIVNTQKAIAANV
EEEECCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHCC
GYMGFPKTVCTSVNAVVCHGIPDRSEVLKDGDIINIDVAVIKDGYFGDTSRMYTVGQSST
CCCCCCHHHHHCCCEEEEECCCCHHHHHCCCCEEEEEEEEEECCCCCCCCEEEEECCCHH
VAQQLIDTTYEAMLAGIRQVKPGATLGDVGHAIQQIAQREGFSIVRDYCGHGIGKVYHED
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCC
PQVLHYGQPGQGVRLKPGMVFTIEPMINAGRAGTTVMRDGWTVVTKDRSLSAQWEHMVAV
CCEEEECCCCCCEEECCCEEEEEECCCCCCCCCCEEEECCCEEEEECCCCCCCEEEEEEE
TDDSYELLTPWPDGTGRYEAP
ECCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]