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The map label for this gene is fadA [H]

Identifier: 186475156

GI number: 186475156

Start: 440467

End: 441666

Strand: Direct

Name: fadA [H]

Synonym: Bphy_0387

Alternate gene names: 186475156

Gene position: 440467-441666 (Clockwise)

Preceding gene: 186475155

Following gene: 186475157

Centisome position: 12.66

GC content: 63.75

Gene sequence:

>1200_bases
ATGACAAAGCAATTGCAGGACGCATATATCGTTGCCGCGAGCCGCACGCCGATCGGCAAGGCGCCGCGCGGGATGTTCCG
GAACACGCGTCCGGACGAACTGCTGGTGCACGCGATCAGGTCGGCTGTGGCGCAGGTGCCCGACCTGGACACGTCGCTGA
TCGAAGACGCGATTATCGGTTGTGCGATTCCCGAAGCCGAGCAGGGCTTGAACGTCGCGCGGATGGGCGCGCTGCTCGCC
GGTCTGCCGAGCACGGTCGGCGGTGTAACGGTGAACCGATTCTGTGCGTCAGGCGTCACGGCGCTCGCGATGGCAGCGGA
TCGCATCCGCGTCGGCGAGTCGGATGTGATGATCGCGGGCGGCTGCGAATCGATGAGCATGGTGCCGATGATGGGCAACA
AGCCGTCTCTGTCGCCGCATATTTTCGATCGCAATGAGGACGTCGGCATTGCATACGGAATGGGCCTGACGGCCGAGAAG
GTCGCTGAACGCTGGAAGGTGAGCCGGGAGCAGCAGGATCACTTTTCCGTCGAATCGCACCGCAAGGCGGTTGCCGCGCA
GCAGGCGGGCGAGTTCGCCGATGAGATCGCGCCGTACGCGATCACTGAGCGTTTCCCCGATCTGGCGACGGGCGAAGTTC
GTGTGACGATGCGCGAGGTGGCGCTCGATGAAGGTCCGCGCGCGGATACGTCGATGGAAGGTCTGGCGAAGCTGCGCACC
GTGTTTGCGAACAGGGGCACGGTGACGGCGGGTAACAGCTCGCAGACGTCGGACGGCGCGGGCGCGCTGATCGTCGTGTC
GGAGAAGATTCTCAAGCAGTTCAATCTGACGCCGCTCGCGCGGTTTGTGAGCTTCGCAGTGCGCGGAGTGCCGCCGGAGA
TCATGGGGATCGGTCCGAAGGAGGCGATTCCGGCCGCGCTGAAGGCGGCAGGTCTCAAGCAGGACGATATCGACTGGATC
GAACTCAATGAGGCTTTTGCGGCGCAGTCGCTGGCTGTGATCAACGATCTTGGGCTCGATGTTTCCAAGGTCAATCCGCT
TGGCGGCGCGATCGCGCTGGGTCACCCGCTCGGCGCGACAGGTGCGATTCGCGCGGCAACCGTTGTTCATGGCCTGCGGC
GCCGGAAGTTGAAGTACGGGATGGTGACCATGTGTGTGGGCACGGGCATGGGTGCTGCTGGGATTATCGAGCGGGTTTGA

Upstream 100 bases:

>100_bases
GTCGCGCGTTCGTCGAGTTGCTCGGCACGCAGAAGACGCAGGAACGGATCATGGGCATGCTGCAAACGGGTAAGCCGGTG
CGCAACTGAGGGAGCCTCAA

Downstream 100 bases:

>100_bases
TGTCTTGCTCGCGGCGCGGCCCTGCCCTGCCAGTTTTTGAGCTGGCATCCGATTTGCGATGGATGCCGGCGCAAGGGCCA
ACCGCGTGCGCCAGCGCAGG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTKQLQDAYIVAASRTPIGKAPRGMFRNTRPDELLVHAIRSAVAQVPDLDTSLIEDAIIGCAIPEAEQGLNVARMGALLA
GLPSTVGGVTVNRFCASGVTALAMAADRIRVGESDVMIAGGCESMSMVPMMGNKPSLSPHIFDRNEDVGIAYGMGLTAEK
VAERWKVSREQQDHFSVESHRKAVAAQQAGEFADEIAPYAITERFPDLATGEVRVTMREVALDEGPRADTSMEGLAKLRT
VFANRGTVTAGNSSQTSDGAGALIVVSEKILKQFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDIDWI
ELNEAFAAQSLAVINDLGLDVSKVNPLGGAIALGHPLGATGAIRAATVVHGLRRRKLKYGMVTMCVGTGMGAAGIIERV

Sequences:

>Translated_399_residues
MTKQLQDAYIVAASRTPIGKAPRGMFRNTRPDELLVHAIRSAVAQVPDLDTSLIEDAIIGCAIPEAEQGLNVARMGALLA
GLPSTVGGVTVNRFCASGVTALAMAADRIRVGESDVMIAGGCESMSMVPMMGNKPSLSPHIFDRNEDVGIAYGMGLTAEK
VAERWKVSREQQDHFSVESHRKAVAAQQAGEFADEIAPYAITERFPDLATGEVRVTMREVALDEGPRADTSMEGLAKLRT
VFANRGTVTAGNSSQTSDGAGALIVVSEKILKQFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDIDWI
ELNEAFAAQSLAVINDLGLDVSKVNPLGGAIALGHPLGATGAIRAATVVHGLRRRKLKYGMVTMCVGTGMGAAGIIERV
>Mature_398_residues
TKQLQDAYIVAASRTPIGKAPRGMFRNTRPDELLVHAIRSAVAQVPDLDTSLIEDAIIGCAIPEAEQGLNVARMGALLAG
LPSTVGGVTVNRFCASGVTALAMAADRIRVGESDVMIAGGCESMSMVPMMGNKPSLSPHIFDRNEDVGIAYGMGLTAEKV
AERWKVSREQQDHFSVESHRKAVAAQQAGEFADEIAPYAITERFPDLATGEVRVTMREVALDEGPRADTSMEGLAKLRTV
FANRGTVTAGNSSQTSDGAGALIVVSEKILKQFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDIDWIE
LNEAFAAQSLAVINDLGLDVSKVNPLGGAIALGHPLGATGAIRAATVVHGLRRRKLKYGMVTMCVGTGMGAAGIIERV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=44.1326530612245, Blast_Score=291, Evalue=8e-79,
Organism=Homo sapiens, GI167614485, Length=403, Percent_Identity=39.7022332506204, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=37.1794871794872, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI4557237, Length=407, Percent_Identity=36.3636363636364, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=32.3979591836735, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI4504327, Length=444, Percent_Identity=29.954954954955, Blast_Score=149, Evalue=4e-36,
Organism=Escherichia coli, GI1787663, Length=411, Percent_Identity=43.30900243309, Blast_Score=298, Evalue=5e-82,
Organism=Escherichia coli, GI48994986, Length=403, Percent_Identity=43.424317617866, Blast_Score=277, Evalue=9e-76,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=40.1477832512315, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI87082165, Length=406, Percent_Identity=39.4088669950739, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1788683, Length=384, Percent_Identity=32.03125, Blast_Score=155, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=40.8977556109726, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI25147385, Length=402, Percent_Identity=34.3283582089552, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=35.8024691358025, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=446, Percent_Identity=29.372197309417, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17535917, Length=395, Percent_Identity=29.1139240506329, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322031, Length=407, Percent_Identity=40.2948402948403, Blast_Score=287, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6325229, Length=408, Percent_Identity=38.7254901960784, Blast_Score=239, Evalue=5e-64,
Organism=Drosophila melanogaster, GI17648125, Length=412, Percent_Identity=39.5631067961165, Blast_Score=258, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=38.1188118811881, Blast_Score=255, Evalue=5e-68,
Organism=Drosophila melanogaster, GI24640423, Length=409, Percent_Identity=34.2298288508557, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17137578, Length=447, Percent_Identity=32.662192393736, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42040; Mature: 41909

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQLQDAYIVAASRTPIGKAPRGMFRNTRPDELLVHAIRSAVAQVPDLDTSLIEDAIIG
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAEQGLNVARMGALLAGLPSTVGGVTVNRFCASGVTALAMAADRIRVGESDVMIAG
CCCCCHHHCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEC
GCESMSMVPMMGNKPSLSPHIFDRNEDVGIAYGMGLTAEKVAERWKVSREQQDHFSVESH
CCCCCEECCCCCCCCCCCCEEECCCCCCEEEECCCCCHHHHHHHHHHCHHHHHHCCHHHH
RKAVAAQQAGEFADEIAPYAITERFPDLATGEVRVTMREVALDEGPRADTSMEGLAKLRT
HHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCEEEEHHHHHHCCCCCCCCHHHHHHHHHH
VFANRGTVTAGNSSQTSDGAGALIVVSEKILKQFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCEEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCH
EAIPAALKAAGLKQDDIDWIELNEAFAAQSLAVINDLGLDVSKVNPLGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRKLKYGMVTMCVGTGMGAAGIIERV
HHHHHHHHHHHHHHHHHHHCCEEEEHHCCCCHHHHHHCC
>Mature Secondary Structure 
TKQLQDAYIVAASRTPIGKAPRGMFRNTRPDELLVHAIRSAVAQVPDLDTSLIEDAIIG
CCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAEQGLNVARMGALLAGLPSTVGGVTVNRFCASGVTALAMAADRIRVGESDVMIAG
CCCCCHHHCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEC
GCESMSMVPMMGNKPSLSPHIFDRNEDVGIAYGMGLTAEKVAERWKVSREQQDHFSVESH
CCCCCEECCCCCCCCCCCCEEECCCCCCEEEECCCCCHHHHHHHHHHCHHHHHHCCHHHH
RKAVAAQQAGEFADEIAPYAITERFPDLATGEVRVTMREVALDEGPRADTSMEGLAKLRT
HHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCEEEEHHHHHHCCCCCCCCHHHHHHHHHH
VFANRGTVTAGNSSQTSDGAGALIVVSEKILKQFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCEEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCH
EAIPAALKAAGLKQDDIDWIELNEAFAAQSLAVINDLGLDVSKVNPLGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRKLKYGMVTMCVGTGMGAAGIIERV
HHHHHHHHHHHHHHHHHHHCCEEEEHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]