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The map label for this gene is ctaB [H]

Identifier: 186475055

GI number: 186475055

Start: 326318

End: 327223

Strand: Direct

Name: ctaB [H]

Synonym: Bphy_0286

Alternate gene names: 186475055

Gene position: 326318-327223 (Clockwise)

Preceding gene: 186475054

Following gene: 186475056

Centisome position: 9.38

GC content: 61.04

Gene sequence:

>906_bases
ATGGACAGCACAACTCTCCCCCATTCGCCCGGTAGCCGGATTTCTCAATACATTGCGTTGACGAAGCCGCGCGTGACGCA
GCTCGCCGTCTTCTGCGCGGTGATCGGCATGTTCCTGGCCACGCCCGGCATGGTGCCGTGGACGGTGCTGATCGGCGGCG
CGGTCGGCATCTGGTTGCTCGCGGGTGCGGCATTCGCCATCAACTGTCTGGTCGAGCAGAAAGTCGATGCGAAGATGCGC
CGCACGGCATGGCGTCCGTCGGCACGCGGTGAAATCACCACTTCGCAGATCCTGCTGTTTTCGGCCGTGCTCGGCGCCGT
CGGCATGTGGACGCTCTACACGTTCACCAACGCGCTGACGATGTGGCTCACTATCGCCACGTTCGTCGGCTACGCGATCA
TCTACACGCTGTTGCTCAAGCCCTATACGCCGCAGAACATCGTGATCGGCGGCGCATCGGGCGCGATGCCGCCGGCGCTC
GGCTGGGCAGCCGTGACGGGCGCCGTGCCCGGCGACGCGTGGATTCTCGTGCTGATCATCTTCGTCTGGACGCCGCCGCA
TTTCTGGGCACTCGCGCTCTATCGCCGCAAAGACTACGAAAACGCCGGCCTGCCGATGCTGCCTATCACGCACGGCGAGC
AGTACACGCGTCTGCATATCTTCCTGTACACGGTCATTCTGTTTGCCGTCACGATGATGCCGTTTATCTCGGGCATGAGC
GGAATCGTGTATCTGGCGTCGGCAGTTCTGTTGGGTGCCGTTTTCCTCGCGTATGCGTGGAAGATTTATCGGGAATATTC
TGACGACCTCGCGCGTAAAACCTTCCGTTATTCGATCGTTTATCTGTCGCTGCTGTTTGCGGCGCTGTTGATCGACCACT
ATGCGCGTGCCTTGATCGGCGCGTAA

Upstream 100 bases:

>100_bases
TCCTGCTGCTTTTGCTCGTTATGTTAAACTTTCGAATCGCTTATAGCCGTCCCGGCCGCGCCGTCATTCATGCGCGCGAT
GCCGCGCCAGCGTGACCCTC

Downstream 100 bases:

>100_bases
CACCATGCTCACTGAACGGTTCGCGCGCGCGGCGCGCGTTGCTTTCGTCGCGTGCGCGCTCGGCGGCGCGGCGCTGGTCT
CTGGATGCGGGAAAGAACAG

Product: protoheme IX farnesyltransferase

Products: heme O; pyrophosphate [C]

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MDSTTLPHSPGSRISQYIALTKPRVTQLAVFCAVIGMFLATPGMVPWTVLIGGAVGIWLLAGAAFAINCLVEQKVDAKMR
RTAWRPSARGEITTSQILLFSAVLGAVGMWTLYTFTNALTMWLTIATFVGYAIIYTLLLKPYTPQNIVIGGASGAMPPAL
GWAAVTGAVPGDAWILVLIIFVWTPPHFWALALYRRKDYENAGLPMLPITHGEQYTRLHIFLYTVILFAVTMMPFISGMS
GIVYLASAVLLGAVFLAYAWKIYREYSDDLARKTFRYSIVYLSLLFAALLIDHYARALIGA

Sequences:

>Translated_301_residues
MDSTTLPHSPGSRISQYIALTKPRVTQLAVFCAVIGMFLATPGMVPWTVLIGGAVGIWLLAGAAFAINCLVEQKVDAKMR
RTAWRPSARGEITTSQILLFSAVLGAVGMWTLYTFTNALTMWLTIATFVGYAIIYTLLLKPYTPQNIVIGGASGAMPPAL
GWAAVTGAVPGDAWILVLIIFVWTPPHFWALALYRRKDYENAGLPMLPITHGEQYTRLHIFLYTVILFAVTMMPFISGMS
GIVYLASAVLLGAVFLAYAWKIYREYSDDLARKTFRYSIVYLSLLFAALLIDHYARALIGA
>Mature_301_residues
MDSTTLPHSPGSRISQYIALTKPRVTQLAVFCAVIGMFLATPGMVPWTVLIGGAVGIWLLAGAAFAINCLVEQKVDAKMR
RTAWRPSARGEITTSQILLFSAVLGAVGMWTLYTFTNALTMWLTIATFVGYAIIYTLLLKPYTPQNIVIGGASGAMPPAL
GWAAVTGAVPGDAWILVLIIFVWTPPHFWALALYRRKDYENAGLPMLPITHGEQYTRLHIFLYTVILFAVTMMPFISGMS
GIVYLASAVLLGAVFLAYAWKIYREYSDDLARKTFRYSIVYLSLLFAALLIDHYARALIGA

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=192, Percent_Identity=34.8958333333333, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786631, Length=279, Percent_Identity=32.258064516129, Blast_Score=151, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71998235, Length=283, Percent_Identity=29.3286219081272, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6325085, Length=280, Percent_Identity=28.9285714285714, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19921064, Length=284, Percent_Identity=30.6338028169014, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.- [C]

Molecular weight: Translated: 33085; Mature: 33085

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSTTLPHSPGSRISQYIALTKPRVTQLAVFCAVIGMFLATPGMVPWTVLIGGAVGIWLL
CCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AGAAFAINCLVEQKVDAKMRRTAWRPSARGEITTSQILLFSAVLGAVGMWTLYTFTNALT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MWLTIATFVGYAIIYTLLLKPYTPQNIVIGGASGAMPPALGWAAVTGAVPGDAWILVLII
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHH
FVWTPPHFWALALYRRKDYENAGLPMLPITHGEQYTRLHIFLYTVILFAVTMMPFISGMS
HHHCCHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
GIVYLASAVLLGAVFLAYAWKIYREYSDDLARKTFRYSIVYLSLLFAALLIDHYARALIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
A
C
>Mature Secondary Structure
MDSTTLPHSPGSRISQYIALTKPRVTQLAVFCAVIGMFLATPGMVPWTVLIGGAVGIWLL
CCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AGAAFAINCLVEQKVDAKMRRTAWRPSARGEITTSQILLFSAVLGAVGMWTLYTFTNALT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MWLTIATFVGYAIIYTLLLKPYTPQNIVIGGASGAMPPALGWAAVTGAVPGDAWILVLII
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHH
FVWTPPHFWALALYRRKDYENAGLPMLPITHGEQYTRLHIFLYTVILFAVTMMPFISGMS
HHHCCHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
GIVYLASAVLLGAVFLAYAWKIYREYSDDLARKTFRYSIVYLSLLFAALLIDHYARALIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protoheme; farnesyl-PP [C]

Specific reaction: protoheme + farnesyl-PP = heme O + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA