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The map label for this gene is bioC [H]

Identifier: 186475043

GI number: 186475043

Start: 315848

End: 316807

Strand: Direct

Name: bioC [H]

Synonym: Bphy_0274

Alternate gene names: 186475043

Gene position: 315848-316807 (Clockwise)

Preceding gene: 186475040

Following gene: 186475044

Centisome position: 9.08

GC content: 63.85

Gene sequence:

>960_bases
GTGTCTCCCACCGAAACTGGCCGTCCGGCCTATGATTCGCGCCGTCTTCGGAAGATTTTCGACCGCCGCGCCGCCACGTT
CGACGACGTCGCATTCCTGCCACGCGAGATCGCACAGCGCATGCGCGAGCGGCTCGACTACATCAAGGTCAATCCGGTGC
AGGTGCTGGATGCGGGATGCGGCGCGGGCGACGACCTTCCTTCATTGCGTGAGCGCTTTCCGGAAGCGCCCGTGTTCGGC
ACCGATCTGTCGGGCGCGATGCTGGCGCGCGCCGTCACGCACGATGCCGCCGATACCGGTTGGCGCCGGTTTCTGCCCGC
ATCGCTCGGCAAGGCGCTGGGCTCACGCGGTCCGAGGTTTGCTCAGGCTGACTTCTCGGCACTGCCGTTCGCATCGGGTG
CATTCGAACTCATCTGGTCGAATCTCGCGTTGCACTGGCACTCGCGGCCGGATCTTGTGTTCCCCGAATGGCAGCGGGTA
CTGAAGGTCAACGGCCTGCTGATGTTCAGCACGCTTGGGCCCGACACGCTGAAGGAACTGCGCGGCACGTATGCAGAGAT
CGAAGCGGCCCACGGCGTCAATACGCACAAACATGTAATCGACTTCGTAGACATGCACGATCTGGGCGATATGCTTGTCG
AAAGTGGCTTTGAGATTCCCGTGATGGACCAGGAGACGTTGACCATTACGTACAAGTCACCGGAGTCGCTGCTCGCCGAC
GTGCGCCGTTGGGGTGCCTATCCGTTCCGGCGTGAGGCGCTGCCGGGTGTGGCATCGAGACGCATGCACAAGGCGCTGCT
GGCCGCGCTCGAGGCACGCCGGCGCGGGGACGGCACGATTCCGCTCACCTTCGAGGTGATCTATGGGCACGCGTGGAAAG
CGGTGCCGCGCGTAACGCCGGAGGGACATGGAATCGTGCGGATAGAGGACATAGGGCGAGGGCGGCAGGGCAATCGCTGA

Upstream 100 bases:

>100_bases
CGATTTGGCATACCGACACGCCTCCGAAGGCCGCTGACGCTGAAGGGACGGAATCGAGCGAGTATACTTCGCACTCTTCG
TCCGTACGACTCGAATAACC

Downstream 100 bases:

>100_bases
GGCGGTAAAGAGGGCAGCCGTTATGCCCGAAATTAGCGGCTCAAAAAGTGCGTCAAAACGGCGCAGAGGCTTATGTGGCT
TGGGTTGGCGGCCGATAGAG

Product: type 11 methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MSPTETGRPAYDSRRLRKIFDRRAATFDDVAFLPREIAQRMRERLDYIKVNPVQVLDAGCGAGDDLPSLRERFPEAPVFG
TDLSGAMLARAVTHDAADTGWRRFLPASLGKALGSRGPRFAQADFSALPFASGAFELIWSNLALHWHSRPDLVFPEWQRV
LKVNGLLMFSTLGPDTLKELRGTYAEIEAAHGVNTHKHVIDFVDMHDLGDMLVESGFEIPVMDQETLTITYKSPESLLAD
VRRWGAYPFRREALPGVASRRMHKALLAALEARRRGDGTIPLTFEVIYGHAWKAVPRVTPEGHGIVRIEDIGRGRQGNR

Sequences:

>Translated_319_residues
MSPTETGRPAYDSRRLRKIFDRRAATFDDVAFLPREIAQRMRERLDYIKVNPVQVLDAGCGAGDDLPSLRERFPEAPVFG
TDLSGAMLARAVTHDAADTGWRRFLPASLGKALGSRGPRFAQADFSALPFASGAFELIWSNLALHWHSRPDLVFPEWQRV
LKVNGLLMFSTLGPDTLKELRGTYAEIEAAHGVNTHKHVIDFVDMHDLGDMLVESGFEIPVMDQETLTITYKSPESLLAD
VRRWGAYPFRREALPGVASRRMHKALLAALEARRRGDGTIPLTFEVIYGHAWKAVPRVTPEGHGIVRIEDIGRGRQGNR
>Mature_318_residues
SPTETGRPAYDSRRLRKIFDRRAATFDDVAFLPREIAQRMRERLDYIKVNPVQVLDAGCGAGDDLPSLRERFPEAPVFGT
DLSGAMLARAVTHDAADTGWRRFLPASLGKALGSRGPRFAQADFSALPFASGAFELIWSNLALHWHSRPDLVFPEWQRVL
KVNGLLMFSTLGPDTLKELRGTYAEIEAAHGVNTHKHVIDFVDMHDLGDMLVESGFEIPVMDQETLTITYKSPESLLADV
RRWGAYPFRREALPGVASRRMHKALLAALEARRRGDGTIPLTFEVIYGHAWKAVPRVTPEGHGIVRIEDIGRGRQGNR

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=307, Percent_Identity=24.1042345276873, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786994, Length=237, Percent_Identity=26.5822784810127, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17535003, Length=303, Percent_Identity=26.0726072607261, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19922210, Length=324, Percent_Identity=28.3950617283951, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 35680; Mature: 35549

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPTETGRPAYDSRRLRKIFDRRAATFDDVAFLPREIAQRMRERLDYIKVNPVQVLDAGC
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCHHHEEECCC
GAGDDLPSLRERFPEAPVFGTDLSGAMLARAVTHDAADTGWRRFLPASLGKALGSRGPRF
CCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AQADFSALPFASGAFELIWSNLALHWHSRPDLVFPEWQRVLKVNGLLMFSTLGPDTLKEL
CCCCCCCCCCCCCHHHHHHHHHHEEECCCCCCCCHHHHHHHHHCCEEEEECCCHHHHHHH
RGTYAEIEAAHGVNTHKHVIDFVDMHDLGDMLVESGFEIPVMDQETLTITYKSPESLLAD
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCEEEEEECCHHHHHHH
VRRWGAYPFRREALPGVASRRMHKALLAALEARRRGDGTIPLTFEVIYGHAWKAVPRVTP
HHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHCCCCCC
EGHGIVRIEDIGRGRQGNR
CCCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
SPTETGRPAYDSRRLRKIFDRRAATFDDVAFLPREIAQRMRERLDYIKVNPVQVLDAGC
CCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCHHHEEECCC
GAGDDLPSLRERFPEAPVFGTDLSGAMLARAVTHDAADTGWRRFLPASLGKALGSRGPRF
CCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AQADFSALPFASGAFELIWSNLALHWHSRPDLVFPEWQRVLKVNGLLMFSTLGPDTLKEL
CCCCCCCCCCCCCHHHHHHHHHHEEECCCCCCCCHHHHHHHHHCCEEEEECCCHHHHHHH
RGTYAEIEAAHGVNTHKHVIDFVDMHDLGDMLVESGFEIPVMDQETLTITYKSPESLLAD
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCEEEEEECCHHHHHHH
VRRWGAYPFRREALPGVASRRMHKALLAALEARRRGDGTIPLTFEVIYGHAWKAVPRVTP
HHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHCCCCCC
EGHGIVRIEDIGRGRQGNR
CCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3058702; 9278503 [H]