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The map label for this gene is yegE [H]

Identifier: 183222726

GI number: 183222726

Start: 3501804

End: 3502721

Strand: Reverse

Name: yegE [H]

Synonym: LEPBI_I3382

Alternate gene names: 183222726

Gene position: 3502721-3501804 (Counterclockwise)

Preceding gene: 183222727

Following gene: 183222725

Centisome position: 97.31

GC content: 41.18

Gene sequence:

>918_bases
ATGAATGAGTTTCATACAGAGGCATTGTCAAAGGAAATAGTTTCCCAATCGATTGATTCGATTGTCGTTTTGGATACCAA
CCAAAAGATTTTATTTAGTAATGTAGCCTTACAAACATTAACTGGTTATACAGAAGAAGAGTTATACGGAAAAACATTTT
CCTTTTTGTTCCCACCGAATGAAAAAGGAGAACAATCTTCGATTGAATCCTTTGTTAGCTCGAATGAAGCACATTACATA
GCAGGTTTTTTAAAAGAATTAGAACTCATCACAAAACCAAAAGGTACGATTCCTGTGGAAATTCGTGCCTTTACCATCCA
AAATGAGAACAAAGAATACTATGCTGCCATCATTCGAGATGTTCGGGAACGTAGGCGACTAGAAGAACAAAAAAATGTTC
TCATCAATAGTTTGAAACGTTTGGCCTATATGGACGAACTCACGATGTTACCAAACCGTCGATCCTTTGCCGACACCTTA
CAAAAAACGATTGCTACCGTCAAACGACGTAACCGTGAATCTGTCCTTGCGGTGATGGACATTGACCATTTCAAAGTGAT
CAATGATACTTACGGGCATGACATCGGGGATTTGGTCTTAAAAAAAATGGCCAATATCTTTGTGGATTGCCTCCGCGAAG
AAGACACCGTCGGAAGGCTTGGTGGCGAGGAATTTGGATGTATCCTACCTGATACCACAACAGAAGGGGCCACCATTGTC
CTCGACCGGCTCCGCGAATCTGTGGAAACCCACCGGTTTTTTATTTTTGATAATTATTATTTGAACATCACCTTAAGCAT
TGGTTACACCAAGGTTCACCCGATCCAAAAGCCCGAAGAAGTTCTCAAATTTGCTGACATTGCCCTCTACCAGGCAAAAA
ATCACGGAAGGAACCGGATCCAAGTCTACCCTGTCTGA

Upstream 100 bases:

>100_bases
AAAGAGTTCAGGGTGAACCAACCTGAGATTAATTTTCGTCATATCCATAAGTGGCGGGATTCATTCCGAAGTGAAAAAGC
AAATGGGGAAATTTGGGGAA

Downstream 100 bases:

>100_bases
AAAAAATTAGCAGTTTGCCAGAAAGTCTGCTAAATTTCGCCCCTTGGATCAGCATCTTGCTTGACGAAAAAAATGGGAAT
TCGTAAACTTTAAGCATAGA

Product: hypothetical protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MNEFHTEALSKEIVSQSIDSIVVLDTNQKILFSNVALQTLTGYTEEELYGKTFSFLFPPNEKGEQSSIESFVSSNEAHYI
AGFLKELELITKPKGTIPVEIRAFTIQNENKEYYAAIIRDVRERRRLEEQKNVLINSLKRLAYMDELTMLPNRRSFADTL
QKTIATVKRRNRESVLAVMDIDHFKVINDTYGHDIGDLVLKKMANIFVDCLREEDTVGRLGGEEFGCILPDTTTEGATIV
LDRLRESVETHRFFIFDNYYLNITLSIGYTKVHPIQKPEEVLKFADIALYQAKNHGRNRIQVYPV

Sequences:

>Translated_305_residues
MNEFHTEALSKEIVSQSIDSIVVLDTNQKILFSNVALQTLTGYTEEELYGKTFSFLFPPNEKGEQSSIESFVSSNEAHYI
AGFLKELELITKPKGTIPVEIRAFTIQNENKEYYAAIIRDVRERRRLEEQKNVLINSLKRLAYMDELTMLPNRRSFADTL
QKTIATVKRRNRESVLAVMDIDHFKVINDTYGHDIGDLVLKKMANIFVDCLREEDTVGRLGGEEFGCILPDTTTEGATIV
LDRLRESVETHRFFIFDNYYLNITLSIGYTKVHPIQKPEEVLKFADIALYQAKNHGRNRIQVYPV
>Mature_305_residues
MNEFHTEALSKEIVSQSIDSIVVLDTNQKILFSNVALQTLTGYTEEELYGKTFSFLFPPNEKGEQSSIESFVSSNEAHYI
AGFLKELELITKPKGTIPVEIRAFTIQNENKEYYAAIIRDVRERRRLEEQKNVLINSLKRLAYMDELTMLPNRRSFADTL
QKTIATVKRRNRESVLAVMDIDHFKVINDTYGHDIGDLVLKKMANIFVDCLREEDTVGRLGGEEFGCILPDTTTEGATIV
LDRLRESVETHRFFIFDNYYLNITLSIGYTKVHPIQKPEEVLKFADIALYQAKNHGRNRIQVYPV

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: COG2199

COG function: function code T; FOG: GGDEF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=306, Percent_Identity=30.3921568627451, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786584, Length=166, Percent_Identity=36.7469879518072, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787262, Length=169, Percent_Identity=39.6449704142012, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI145693134, Length=160, Percent_Identity=35, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081881, Length=228, Percent_Identity=33.3333333333333, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI87082007, Length=178, Percent_Identity=33.7078651685393, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787541, Length=312, Percent_Identity=25.9615384615385, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787816, Length=159, Percent_Identity=37.1069182389937, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI87081977, Length=186, Percent_Identity=29.5698924731183, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787802, Length=172, Percent_Identity=29.6511627906977, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788085, Length=171, Percent_Identity=30.4093567251462, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788956, Length=157, Percent_Identity=32.484076433121, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787056, Length=166, Percent_Identity=31.9277108433735, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87081974, Length=105, Percent_Identity=31.4285714285714, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 35097; Mature: 35097

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS50112 PAS ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEFHTEALSKEIVSQSIDSIVVLDTNQKILFSNVALQTLTGYTEEELYGKTFSFLFPPN
CCHHHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHHHHHCCCCHHHHCCCEEEEEECCC
EKGEQSSIESFVSSNEAHYIAGFLKELELITKPKGTIPVEIRAFTIQNENKEYYAAIIRD
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHHH
VRERRRLEEQKNVLINSLKRLAYMDELTMLPNRRSFADTLQKTIATVKRRNRESVLAVMD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEE
IDHFKVINDTYGHDIGDLVLKKMANIFVDCLREEDTVGRLGGEEFGCILPDTTTEGATIV
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCEECCCCCCCCHHHH
LDRLRESVETHRFFIFDNYYLNITLSIGYTKVHPIQKPEEVLKFADIALYQAKNHGRNRI
HHHHHHHHHHCEEEEEEEEEEEEEEEECCEEECCCCCHHHHHHHHHHHHHHHHCCCCCEE
QVYPV
EEEEC
>Mature Secondary Structure
MNEFHTEALSKEIVSQSIDSIVVLDTNQKILFSNVALQTLTGYTEEELYGKTFSFLFPPN
CCHHHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHHHHHCCCCHHHHCCCEEEEEECCC
EKGEQSSIESFVSSNEAHYIAGFLKELELITKPKGTIPVEIRAFTIQNENKEYYAAIIRD
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHHH
VRERRRLEEQKNVLINSLKRLAYMDELTMLPNRRSFADTLQKTIATVKRRNRESVLAVMD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEE
IDHFKVINDTYGHDIGDLVLKKMANIFVDCLREEDTVGRLGGEEFGCILPDTTTEGATIV
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCEECCCCCCCCHHHH
LDRLRESVETHRFFIFDNYYLNITLSIGYTKVHPIQKPEEVLKFADIALYQAKNHGRNRI
HHHHHHHHHHCEEEEEEEEEEEEEEEECCEEECCCCCHHHHHHHHHHHHHHHHCCCCCEE
QVYPV
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]