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The map label for this gene is arsB [H]

Identifier: 183222223

GI number: 183222223

Start: 2966328

End: 2967362

Strand: Direct

Name: arsB [H]

Synonym: LEPBI_I2874

Alternate gene names: 183222223

Gene position: 2966328-2967362 (Clockwise)

Preceding gene: 183222222

Following gene: 183222230

Centisome position: 82.41

GC content: 39.52

Gene sequence:

>1035_bases
ATGAAACAATTATCTTTTTTAGATCGTTATTTGACCGTTTGGATCTTTGGAGCCATGGCCATTGGAGTTTTGATTGGAAA
ATTTCTGCCATCGTTTGTAGGATCGTTTTCAAGCCTGAATGTGGGAACAACCAATATCCCATTAGCGATTGGTCTCATCC
TCATGATGGTTCCGCCTCTAGCCAAAGTAAAATACAAAGAAATGGGAAAGGTGTTTCGCGATGGAAAACTATTAAGTTTA
TCCCTACTCCTCAATTGGATTGTGGGACCCATCCTTATGTTTTTCCTTGCGATACTATTTTTGCATGATGAACCAGAATA
CAGAACAGGCTTAATTCTCATTGGGCTTGCCCGTTGCATTGCAATGGTGATTGTTTGGAACGATTTGGCAAACGGGGACA
GGGAATATGGTGCGGCTCTCGTTGCACTGAATAGCATTTTCCAAGTATTCTTTTATAGTTTTTATGCTTATCTTTTCATC
ACCGTACTTCCACCGTACTTTGGTTTGGCGGCAACGACTGTTCCGATTGAAATATCCGAAATTGCAAAGACAGTGGGAAT
TTACTTAGGGATCCCGTTTCTCATTGGATTTTTATTACGTTACGGCTTTGAAAGATTTGGTGGCAAAACTTATTATGAAT
CAAAATTTTTGCCGATCATATCACCAATCACACTCATTGCCTTACTTTTTACCATCATTGTGATGTTTAGTTTCAAAGGA
GAAATGATCATCGATTTGACAGATGATGTTTTCCGAGTTGCCATCCCTTTGCTTCTGTATTTTATAATTATGTTTTTTTT
GAGTTTGTGGATGGGTTACAAACTCGGAGTGGACTATTCAAAAAATGCAGCGGTGAGTTTTACGGCGACAGGAAATAATT
TTGAATTAGCAATCGCAGTATCCATTGGAGTTTTTGGAATCGGAAGTGGTGCCGCCTTTGTTGGTGTCATTGGACCACTG
ATTGAGGTACCAGCACTCATCCTACTTGTCAAAGTTGCCTTGGCTTTCCGGGATCGTTTTTATCAAAAAAAATGA

Upstream 100 bases:

>100_bases
CGGAATGACAAAAGAAAATCCAAAAATAGAGATCACTTCTTCTTCCTGTTGCAATCCAAGTGGATCCAAAAAAACAAAAG
AATCAGCAGGTTGTTGTTAG

Downstream 100 bases:

>100_bases
AGGTGAGACTTGGTTCGAATTGGTAAATGAGACTTTAGAAAATAGGTAAGCCAATTGGCATTGGCTCTACCTTTTTATTT
TCCAATCCATTTCAATTTTC

Product: arsenite efflux pump ACR3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MKQLSFLDRYLTVWIFGAMAIGVLIGKFLPSFVGSFSSLNVGTTNIPLAIGLILMMVPPLAKVKYKEMGKVFRDGKLLSL
SLLLNWIVGPILMFFLAILFLHDEPEYRTGLILIGLARCIAMVIVWNDLANGDREYGAALVALNSIFQVFFYSFYAYLFI
TVLPPYFGLAATTVPIEISEIAKTVGIYLGIPFLIGFLLRYGFERFGGKTYYESKFLPIISPITLIALLFTIIVMFSFKG
EMIIDLTDDVFRVAIPLLLYFIIMFFLSLWMGYKLGVDYSKNAAVSFTATGNNFELAIAVSIGVFGIGSGAAFVGVIGPL
IEVPALILLVKVALAFRDRFYQKK

Sequences:

>Translated_344_residues
MKQLSFLDRYLTVWIFGAMAIGVLIGKFLPSFVGSFSSLNVGTTNIPLAIGLILMMVPPLAKVKYKEMGKVFRDGKLLSL
SLLLNWIVGPILMFFLAILFLHDEPEYRTGLILIGLARCIAMVIVWNDLANGDREYGAALVALNSIFQVFFYSFYAYLFI
TVLPPYFGLAATTVPIEISEIAKTVGIYLGIPFLIGFLLRYGFERFGGKTYYESKFLPIISPITLIALLFTIIVMFSFKG
EMIIDLTDDVFRVAIPLLLYFIIMFFLSLWMGYKLGVDYSKNAAVSFTATGNNFELAIAVSIGVFGIGSGAAFVGVIGPL
IEVPALILLVKVALAFRDRFYQKK
>Mature_344_residues
MKQLSFLDRYLTVWIFGAMAIGVLIGKFLPSFVGSFSSLNVGTTNIPLAIGLILMMVPPLAKVKYKEMGKVFRDGKLLSL
SLLLNWIVGPILMFFLAILFLHDEPEYRTGLILIGLARCIAMVIVWNDLANGDREYGAALVALNSIFQVFFYSFYAYLFI
TVLPPYFGLAATTVPIEISEIAKTVGIYLGIPFLIGFLLRYGFERFGGKTYYESKFLPIISPITLIALLFTIIVMFSFKG
EMIIDLTDDVFRVAIPLLLYFIIMFFLSLWMGYKLGVDYSKNAAVSFTATGNNFELAIAVSIGVFGIGSGAAFVGVIGPL
IEVPALILLVKVALAFRDRFYQKK

Specific function: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump [H]

COG id: COG0798

COG function: function code P; Arsenite efflux pump ACR3 and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ACR3 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6325459, Length=371, Percent_Identity=35.3099730458221, Blast_Score=186, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004706
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 38215; Mature: 38215

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLSFLDRYLTVWIFGAMAIGVLIGKFLPSFVGSFSSLNVGTTNIPLAIGLILMMVPPL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCH
AKVKYKEMGKVFRDGKLLSLSLLLNWIVGPILMFFLAILFLHDEPEYRTGLILIGLARCI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AMVIVWNDLANGDREYGAALVALNSIFQVFFYSFYAYLFITVLPPYFGLAATTVPIEISE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHH
IAKTVGIYLGIPFLIGFLLRYGFERFGGKTYYESKFLPIISPITLIALLFTIIVMFSFKG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCC
EMIIDLTDDVFRVAIPLLLYFIIMFFLSLWMGYKLGVDYSKNAAVSFTATGNNFELAIAV
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCEEEEEEECCCEEEEEEE
SIGVFGIGSGAAFVGVIGPLIEVPALILLVKVALAFRDRFYQKK
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKQLSFLDRYLTVWIFGAMAIGVLIGKFLPSFVGSFSSLNVGTTNIPLAIGLILMMVPPL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCH
AKVKYKEMGKVFRDGKLLSLSLLLNWIVGPILMFFLAILFLHDEPEYRTGLILIGLARCI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AMVIVWNDLANGDREYGAALVALNSIFQVFFYSFYAYLFITVLPPYFGLAATTVPIEISE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHH
IAKTVGIYLGIPFLIGFLLRYGFERFGGKTYYESKFLPIISPITLIALLFTIIVMFSFKG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCC
EMIIDLTDDVFRVAIPLLLYFIIMFFLSLWMGYKLGVDYSKNAAVSFTATGNNFELAIAV
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCEEEEEEECCCEEEEEEE
SIGVFGIGSGAAFVGVIGPLIEVPALILLVKVALAFRDRFYQKK
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]