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The map label for this gene is cobA2 [H]

Identifier: 183222125

GI number: 183222125

Start: 2866694

End: 2867485

Strand: Direct

Name: cobA2 [H]

Synonym: LEPBI_I2768

Alternate gene names: 183222125

Gene position: 2866694-2867485 (Clockwise)

Preceding gene: 183222124

Following gene: 183222126

Centisome position: 79.64

GC content: 39.9

Gene sequence:

>792_bases
GTGAACTCTACTGCATCGGGAAAAAATCGAGGGAAGGTTTATTTGGTGGGTGCCGGACCTGGAGATCCAGAATTACTCAC
GATGAAAGCACTGAAAATCCTGAGAAAAGCAGACATCGTATTTTATGATGACTTAGTTTCCCCCCGAATTTTAGGAGTCT
GCCGTAAAAGAATTCAAATGGTGTACGTTGGAAAACGATCAGGTATCCATAGCTGCCTGCAAGATGAAATCAATCATAAA
CTCATACAAGCAACACACGAATTTAATACGATCGTAAGGCTTAAAGGTGGAGACCCATCCATATTTGGAAGAGTCGGTGA
AGAATATGCATCCCTACTCCAAGATGGGATCCAATGTGAAATTGTAGCCGGGATCACAACGGCCTTGGGAGTTGCGTCTT
CTCTTGGTTTTCCACTCACCCACAGAGACTATGCCAGAGAAATTTTATTTTTATCAGGCCATAAAAAAGACGGTCTGAAT
TCTGATTCCTTTCAAAACCTAAACTGCATTGGAAAAACGATTATCATCTATATGGGACTCAATTCTCTTGGAATGATTGT
TTCTGAACTCTTAAATTCAGGAAATCATAAAGAAACGAGAATCGCTGTGATCCAAAATGCAACTTTAGATTCAGAACGTG
TTTTTACTGGAAATCTGGAGACAATGGAATCCATCGTGGCAGAAAACAATGTTAAGTCACCTGCCATCATCGTGGTTGGG
GAAATTGTGCGTTTTTATGAAGAGATGAAATTTTTGAAAAATAGCTGTGCTTCCATTCTATCTCCTATATAA

Upstream 100 bases:

>100_bases
ATGAAAACCTGAAAGTGAGTTTGTATCAGGTACTTGTGGAGAATGGTTCTGTTTATTTAGAAATAGAGTCATCTCTTCTG
CAACAACTGGGTTACACATC

Downstream 100 bases:

>100_bases
GGGATAGGAATGAACGATATCACGGGAAAAAGAACCACGCTCCGTTACGCGGAAGCGGAAGGCTTTGTATACTGCCAAAA
AGAAACCATTCAAAGGATCA

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MNSTASGKNRGKVYLVGAGPGDPELLTMKALKILRKADIVFYDDLVSPRILGVCRKRIQMVYVGKRSGIHSCLQDEINHK
LIQATHEFNTIVRLKGGDPSIFGRVGEEYASLLQDGIQCEIVAGITTALGVASSLGFPLTHRDYAREILFLSGHKKDGLN
SDSFQNLNCIGKTIIIYMGLNSLGMIVSELLNSGNHKETRIAVIQNATLDSERVFTGNLETMESIVAENNVKSPAIIVVG
EIVRFYEEMKFLKNSCASILSPI

Sequences:

>Translated_263_residues
MNSTASGKNRGKVYLVGAGPGDPELLTMKALKILRKADIVFYDDLVSPRILGVCRKRIQMVYVGKRSGIHSCLQDEINHK
LIQATHEFNTIVRLKGGDPSIFGRVGEEYASLLQDGIQCEIVAGITTALGVASSLGFPLTHRDYAREILFLSGHKKDGLN
SDSFQNLNCIGKTIIIYMGLNSLGMIVSELLNSGNHKETRIAVIQNATLDSERVFTGNLETMESIVAENNVKSPAIIVVG
EIVRFYEEMKFLKNSCASILSPI
>Mature_263_residues
MNSTASGKNRGKVYLVGAGPGDPELLTMKALKILRKADIVFYDDLVSPRILGVCRKRIQMVYVGKRSGIHSCLQDEINHK
LIQATHEFNTIVRLKGGDPSIFGRVGEEYASLLQDGIQCEIVAGITTALGVASSLGFPLTHRDYAREILFLSGHKKDGLN
SDSFQNLNCIGKTIIIYMGLNSLGMIVSELLNSGNHKETRIAVIQNATLDSERVFTGNLETMESIVAENNVKSPAIIVVG
EIVRFYEEMKFLKNSCASILSPI

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=246, Percent_Identity=41.4634146341463, Blast_Score=199, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6322922, Length=254, Percent_Identity=28.3464566929134, Blast_Score=106, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 28802; Mature: 28802

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSTASGKNRGKVYLVGAGPGDPELLTMKALKILRKADIVFYDDLVSPRILGVCRKRIQM
CCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCEEEEHHHCCHHHHHHHHHHHHE
VYVGKRSGIHSCLQDEINHKLIQATHEFNTIVRLKGGDPSIFGRVGEEYASLLQDGIQCE
EEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEE
IVAGITTALGVASSLGFPLTHRDYAREILFLSGHKKDGLNSDSFQNLNCIGKTIIIYMGL
EEHHHHHHHHHHHHCCCCCCCHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHEEEEEECC
NSLGMIVSELLNSGNHKETRIAVIQNATLDSERVFTGNLETMESIVAENNVKSPAIIVVG
CHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEECCHHHHHHHHHHCCCCCCEEEHHH
EIVRFYEEMKFLKNSCASILSPI
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNSTASGKNRGKVYLVGAGPGDPELLTMKALKILRKADIVFYDDLVSPRILGVCRKRIQM
CCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCEEEEHHHCCHHHHHHHHHHHHE
VYVGKRSGIHSCLQDEINHKLIQATHEFNTIVRLKGGDPSIFGRVGEEYASLLQDGIQCE
EEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEE
IVAGITTALGVASSLGFPLTHRDYAREILFLSGHKKDGLNSDSFQNLNCIGKTIIIYMGL
EEHHHHHHHHHHHHCCCCCCCHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHEEEEEECC
NSLGMIVSELLNSGNHKETRIAVIQNATLDSERVFTGNLETMESIVAENNVKSPAIIVVG
CHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEECCHHHHHHHHHHCCCCCCEEEHHH
EIVRFYEEMKFLKNSCASILSPI
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA