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The map label for this gene is ctaD [H]

Identifier: 183222041

GI number: 183222041

Start: 2779681

End: 2781294

Strand: Reverse

Name: ctaD [H]

Synonym: LEPBI_I2683

Alternate gene names: 183222041

Gene position: 2781294-2779681 (Counterclockwise)

Preceding gene: 183222042

Following gene: 183222040

Centisome position: 77.27

GC content: 45.29

Gene sequence:

>1614_bases
ATGAGTTCAGCACATACAAAAACCGAACATGGTCACACAGACCATAATTACCTGAACCACGGATCTGGAATCTGGTCTTG
GATGACCACTCTGGACCACAAACGCATTGGACTTATGTACTTTGCAACAGTTTCTACCCTTTTTCTAATTGGTGGTTTCT
TTGCATTGGGAATCCGTCTGCACTTAGCAAAATTTGGTGCAGAACCACTCCTAGATCCAGACACGTATAACAAGTTCATG
ACCTTCCATGGTGCCATCATGGTATTTATGGTGATCATTCCCGGAATTCCTGCTTTCCTTGGAAACTTTGTCCTCCCGAT
CCAACTCGGTGCCAAAGACGTTGCCTTCCCAAGGCTCAACCTTGCCTCTTACTACATTTTCATTGCGGGTGCTGCGATTG
CTGCATCTTCTATGGTTTTTAACCAAGTGGACACAGGTTGGACATTCTACACTCCGTACTCTACAGCAAAAACATCTAAT
GGGGTGATTTTACTGGTTTTGGGTGCGTTTACCATGGGATTTTCTTCCATCTTAACGGGACTAAACTTCATCGTCACCAC
TCACAAACTCCGAGCACCGGGAATGACAATGGATCGAATCCCACTTATGATTTGGGCACTCTACTCTACATCCATCATCC
AAATTCTTGCTACACCGATCCTTGCGATCACTCTCCTCCTCATCGGAGCTGAGAAAACTCTTGGAGTTGGAATTTTTGAT
CCAGACCTCGGTGGGGACCCTGTCCTTTTCCAACACTTCTTCTGGTTCTACTCTCACCCTGCGGTGTACATCATGATCCT
CCCTGCGATGGGTGTGATTTCTGAACTCATCACAGCATTCTCCAAAAAAACAATTTTTGGTTACCGTGCGATTGCTTACT
CATCGGTTGCGATTGCTGCAGTCTCCTTCCTAGTTTGGGGACACCATATGTTTGTGTCTGGCCAATCCACACTTGCTGGG
ATTGTTTTCTCCATCATCACTATGTTTGTTGGGGTTCCCACTGCCATCAAACTCTTCAACTGGATTTCCACAATGTATCG
CGGAACAGTCACATTCGAAGCGCCCATGCTCTTCGCTCTTGGTTTTATGTTCCTCTTTACCATCGGTGGTTTGACAGGGG
TATTCCTTGCTTCCACTGGTATGGACGTTCACTTCCATGACACTTACTTTGTTGTTGCTCACTTCCACTACGTAATGGTA
GGGGGAACACTCATGGCACTGATGGGTGGAATCTTCTATTGGTTCCCTAAGATGTTTGGAAGGATGACTTCTGACCTTGG
TGGACGTATTTCTTGGGTTCTCATCTTTACAGGATTCAACGTAACTTTCTTTCCACAATTCGTACTCGGTGCGATGGGAA
TGCCAAGACGTTACTTCGATTACCTTCCTGAATACACAAACTTAAACCAAATTTCAACCGTAGGGTCTTGGCTCATTGGT
CTTGGTTTCTTAGTAGGACTCATCACGATCATTCATGGAATTTTTAAAGGCGAAAAGGCTTCTGATAACCCTTGGGGTGC
AAAAACACTCGAATGGCAAACGTCTTCTCCACCTCCACACGAAAACTTTATCAATACTCCAACAGTAACTGCAGGGCCAT
ATGACTTCCGTTAG

Upstream 100 bases:

>100_bases
AACTTACCCAGCAGCCATGCCGTTATTCCAAGGCCAATTGTCTGATGAAGACGTTGCCAACTTAATTGAATATATCAAAT
CCATTAAATAAGGAAGAGAG

Downstream 100 bases:

>100_bases
TTCTTCAAGTGAATTTCAACACCAACACCATTTTAAGAGTGCAGAACACCAATATGCCTCTTCCAAACAAGGAATTTGGT
TATTCCTTTGCACTGAAATC

Product: cytochrome c oxidase polypeptide I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I; Oxidase aa(3) subunit 1 [H]

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MSSAHTKTEHGHTDHNYLNHGSGIWSWMTTLDHKRIGLMYFATVSTLFLIGGFFALGIRLHLAKFGAEPLLDPDTYNKFM
TFHGAIMVFMVIIPGIPAFLGNFVLPIQLGAKDVAFPRLNLASYYIFIAGAAIAASSMVFNQVDTGWTFYTPYSTAKTSN
GVILLVLGAFTMGFSSILTGLNFIVTTHKLRAPGMTMDRIPLMIWALYSTSIIQILATPILAITLLLIGAEKTLGVGIFD
PDLGGDPVLFQHFFWFYSHPAVYIMILPAMGVISELITAFSKKTIFGYRAIAYSSVAIAAVSFLVWGHHMFVSGQSTLAG
IVFSIITMFVGVPTAIKLFNWISTMYRGTVTFEAPMLFALGFMFLFTIGGLTGVFLASTGMDVHFHDTYFVVAHFHYVMV
GGTLMALMGGIFYWFPKMFGRMTSDLGGRISWVLIFTGFNVTFFPQFVLGAMGMPRRYFDYLPEYTNLNQISTVGSWLIG
LGFLVGLITIIHGIFKGEKASDNPWGAKTLEWQTSSPPPHENFINTPTVTAGPYDFR

Sequences:

>Translated_537_residues
MSSAHTKTEHGHTDHNYLNHGSGIWSWMTTLDHKRIGLMYFATVSTLFLIGGFFALGIRLHLAKFGAEPLLDPDTYNKFM
TFHGAIMVFMVIIPGIPAFLGNFVLPIQLGAKDVAFPRLNLASYYIFIAGAAIAASSMVFNQVDTGWTFYTPYSTAKTSN
GVILLVLGAFTMGFSSILTGLNFIVTTHKLRAPGMTMDRIPLMIWALYSTSIIQILATPILAITLLLIGAEKTLGVGIFD
PDLGGDPVLFQHFFWFYSHPAVYIMILPAMGVISELITAFSKKTIFGYRAIAYSSVAIAAVSFLVWGHHMFVSGQSTLAG
IVFSIITMFVGVPTAIKLFNWISTMYRGTVTFEAPMLFALGFMFLFTIGGLTGVFLASTGMDVHFHDTYFVVAHFHYVMV
GGTLMALMGGIFYWFPKMFGRMTSDLGGRISWVLIFTGFNVTFFPQFVLGAMGMPRRYFDYLPEYTNLNQISTVGSWLIG
LGFLVGLITIIHGIFKGEKASDNPWGAKTLEWQTSSPPPHENFINTPTVTAGPYDFR
>Mature_536_residues
SSAHTKTEHGHTDHNYLNHGSGIWSWMTTLDHKRIGLMYFATVSTLFLIGGFFALGIRLHLAKFGAEPLLDPDTYNKFMT
FHGAIMVFMVIIPGIPAFLGNFVLPIQLGAKDVAFPRLNLASYYIFIAGAAIAASSMVFNQVDTGWTFYTPYSTAKTSNG
VILLVLGAFTMGFSSILTGLNFIVTTHKLRAPGMTMDRIPLMIWALYSTSIIQILATPILAITLLLIGAEKTLGVGIFDP
DLGGDPVLFQHFFWFYSHPAVYIMILPAMGVISELITAFSKKTIFGYRAIAYSSVAIAAVSFLVWGHHMFVSGQSTLAGI
VFSIITMFVGVPTAIKLFNWISTMYRGTVTFEAPMLFALGFMFLFTIGGLTGVFLASTGMDVHFHDTYFVVAHFHYVMVG
GTLMALMGGIFYWFPKMFGRMTSDLGGRISWVLIFTGFNVTFFPQFVLGAMGMPRRYFDYLPEYTNLNQISTVGSWLIGL
GFLVGLITIIHGIFKGEKASDNPWGAKTLEWQTSSPPPHENFINTPTVTAGPYDFR

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=505, Percent_Identity=38.019801980198, Blast_Score=329, Evalue=3e-90,
Organism=Escherichia coli, GI1786634, Length=514, Percent_Identity=39.1050583657588, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6226519, Length=534, Percent_Identity=34.8314606741573, Blast_Score=337, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6226524, Length=323, Percent_Identity=33.7461300309598, Blast_Score=207, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6226523, Length=250, Percent_Identity=32.4, Blast_Score=123, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 59321; Mature: 59190

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAHTKTEHGHTDHNYLNHGSGIWSWMTTLDHKRIGLMYFATVSTLFLIGGFFALGIRL
CCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HLAKFGAEPLLDPDTYNKFMTFHGAIMVFMVIIPGIPAFLGNFVLPIQLGAKDVAFPRLN
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCEEEEEEECCCCCCCCCHH
LASYYIFIAGAAIAASSMVFNQVDTGWTFYTPYSTAKTSNGVILLVLGAFTMGFSSILTG
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHH
LNFIVTTHKLRAPGMTMDRIPLMIWALYSTSIIQILATPILAITLLLIGAEKTLGVGIFD
HHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCEEEC
PDLGGDPVLFQHFFWFYSHPAVYIMILPAMGVISELITAFSKKTIFGYRAIAYSSVAIAA
CCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSFLVWGHHMFVSGQSTLAGIVFSIITMFVGVPTAIKLFNWISTMYRGTVTFEAPMLFAL
HHHHHHHHHEEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEECHHHHHHH
GFMFLFTIGGLTGVFLASTGMDVHFHDTYFVVAHFHYVMVGGTLMALMGGIFYWFPKMFG
HHHHHHHHHHHHHHHHHCCCCEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMTSDLGGRISWVLIFTGFNVTFFPQFVLGAMGMPRRYFDYLPEYTNLNQISTVGSWLIG
HHHHHCCCCEEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHH
LGFLVGLITIIHGIFKGEKASDNPWGAKTLEWQTSSPPPHENFINTPTVTAGPYDFR
HHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSAHTKTEHGHTDHNYLNHGSGIWSWMTTLDHKRIGLMYFATVSTLFLIGGFFALGIRL
CCCCCCCCCCCCCCCHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HLAKFGAEPLLDPDTYNKFMTFHGAIMVFMVIIPGIPAFLGNFVLPIQLGAKDVAFPRLN
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCEEEEEEECCCCCCCCCHH
LASYYIFIAGAAIAASSMVFNQVDTGWTFYTPYSTAKTSNGVILLVLGAFTMGFSSILTG
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHH
LNFIVTTHKLRAPGMTMDRIPLMIWALYSTSIIQILATPILAITLLLIGAEKTLGVGIFD
HHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCEEEC
PDLGGDPVLFQHFFWFYSHPAVYIMILPAMGVISELITAFSKKTIFGYRAIAYSSVAIAA
CCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSFLVWGHHMFVSGQSTLAGIVFSIITMFVGVPTAIKLFNWISTMYRGTVTFEAPMLFAL
HHHHHHHHHEEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEECHHHHHHH
GFMFLFTIGGLTGVFLASTGMDVHFHDTYFVVAHFHYVMVGGTLMALMGGIFYWFPKMFG
HHHHHHHHHHHHHHHHHCCCCEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMTSDLGGRISWVLIFTGFNVTFFPQFVLGAMGMPRRYFDYLPEYTNLNQISTVGSWLIG
HHHHHCCCCEEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHH
LGFLVGLITIIHGIFKGEKASDNPWGAKTLEWQTSSPPPHENFINTPTVTAGPYDFR
HHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8399373 [H]