| Definition | Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_010602 |
| Length | 3,599,677 |
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The map label for this gene is dxr
Identifier: 183221970
GI number: 183221970
Start: 2702377
End: 2703537
Strand: Reverse
Name: dxr
Synonym: LEPBI_I2611
Alternate gene names: 183221970
Gene position: 2703537-2702377 (Counterclockwise)
Preceding gene: 183221971
Following gene: 183221969
Centisome position: 75.1
GC content: 43.76
Gene sequence:
>1161_bases ATGGTAGGTGTTTCGGTATTAGGAATCTCTGGTTCTGTTGGTACTTCCACAGTGAAGGTACTCCGACAATTCCCTGACCA ATTTGATTTACGTAGTTTTTCCGTTCATTCCAATTGGAATGTAGCAAAGGCCTTGGTAGAAGAATTTTCTCCAGAAGTCA TTTGTATCACAGATCCCAAGTTAGTGGGGAAGTTTGGCGATTCGTATCTCTCAACAAAAATTTTGTATGGAGATAAAGCA CTCATTGATTTGGTACAATTGCCATCTGTTGGTGTGGTGGTGACGGCAGTGATGGGAGCACGCGGAGTGTTACCAACGAT TGCTGCCATTGAAGCCGGGAAAAAAATTGCCATCGCCAATAAGGAAACGCTTGTTACCTTTGGACCTCTTATCAATCGAT TGGTGGCAAAACACAATACCGTCATGGTCCCTGTGGATTCTGAACACAATGCACTCTTCCAACTCATCGAAAGAGAAACA AGGTCCAATATCCGAGCTATCACTCTCACGGCTTCGGGAGGAAGTTTTCGAACCCTTCCCTTGGAAGCATTGGAACATGT ATCCGTAAAACAGGCGCTCAATCATCCTACTTGGTCCATGGGTCCCAAAATCACAGTGGATTCAGCAGGTCTTATCAACA AAGGATTAGAAGTGATCGAAGCGCATTTTCTTTTTGGATTTTCGTATGACGAGATCGAGGTGGTGATTCATCCTCAGTCA ATCACCCACGGGATCATCGAAACGACAGACGGTGCTTGTTTGTTATATGCAAGCCATCCCGATATGGTCTATCCCATTGC TCACTCTTTATTTTATCCCAATCCAACACCTCAAATGCTCATCGAACGAAAACCTTCGACTTGGAACACGTTTGAATTTT TCCCACCAGATACGAAGCGATATCCGGGATTGTTACTGGCCTACCAAGCAGGGAAAGCAGGTGGTGCGGCTCCAGGTATC TTTAATGCCGCAAACGAAGAGGCAGTCGCTTTATTTTTAGAAGAAAAAATTTCTTTCACCACAATTCCAAGGCTCATCGA GTCGGCTCTGAACCAAATTGAGAACGTATTTCCAGAAACGTTAGATGGGTATTTGGAAAAAGACCAAGAAACACGAAATT ATATCCAAAGAGAATTTAATCAAGGGGGAGTGACTACATGA
Upstream 100 bases:
>100_bases ACTCCTTTTCACTGTGCCTGCGATTTATTATTATTTAGTTTTCAAAGGTTTCCTTGGATTCCCCGTCTGATTCATTTGAA TCAGACTGTCTAAGTTCTAT
Downstream 100 bases:
>100_bases TCATAATGATACTTGGCGCTGTATTCATGTTGGCTGTATCGATTTTTATCCATGAATTGGGGCACCTCTTATGTGGAAAA TTGGTGGGCGTTGAAGCCCG
Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Products: NA
Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase
Number of amino acids: Translated: 386; Mature: 386
Protein sequence:
>386_residues MVGVSVLGISGSVGTSTVKVLRQFPDQFDLRSFSVHSNWNVAKALVEEFSPEVICITDPKLVGKFGDSYLSTKILYGDKA LIDLVQLPSVGVVVTAVMGARGVLPTIAAIEAGKKIAIANKETLVTFGPLINRLVAKHNTVMVPVDSEHNALFQLIERET RSNIRAITLTASGGSFRTLPLEALEHVSVKQALNHPTWSMGPKITVDSAGLINKGLEVIEAHFLFGFSYDEIEVVIHPQS ITHGIIETTDGACLLYASHPDMVYPIAHSLFYPNPTPQMLIERKPSTWNTFEFFPPDTKRYPGLLLAYQAGKAGGAAPGI FNAANEEAVALFLEEKISFTTIPRLIESALNQIENVFPETLDGYLEKDQETRNYIQREFNQGGVTT
Sequences:
>Translated_386_residues MVGVSVLGISGSVGTSTVKVLRQFPDQFDLRSFSVHSNWNVAKALVEEFSPEVICITDPKLVGKFGDSYLSTKILYGDKA LIDLVQLPSVGVVVTAVMGARGVLPTIAAIEAGKKIAIANKETLVTFGPLINRLVAKHNTVMVPVDSEHNALFQLIERET RSNIRAITLTASGGSFRTLPLEALEHVSVKQALNHPTWSMGPKITVDSAGLINKGLEVIEAHFLFGFSYDEIEVVIHPQS ITHGIIETTDGACLLYASHPDMVYPIAHSLFYPNPTPQMLIERKPSTWNTFEFFPPDTKRYPGLLLAYQAGKAGGAAPGI FNAANEEAVALFLEEKISFTTIPRLIESALNQIENVFPETLDGYLEKDQETRNYIQREFNQGGVTT >Mature_386_residues MVGVSVLGISGSVGTSTVKVLRQFPDQFDLRSFSVHSNWNVAKALVEEFSPEVICITDPKLVGKFGDSYLSTKILYGDKA LIDLVQLPSVGVVVTAVMGARGVLPTIAAIEAGKKIAIANKETLVTFGPLINRLVAKHNTVMVPVDSEHNALFQLIERET RSNIRAITLTASGGSFRTLPLEALEHVSVKQALNHPTWSMGPKITVDSAGLINKGLEVIEAHFLFGFSYDEIEVVIHPQS ITHGIIETTDGACLLYASHPDMVYPIAHSLFYPNPTPQMLIERKPSTWNTFEFFPPDTKRYPGLLLAYQAGKAGGAAPGI FNAANEEAVALFLEEKISFTTIPRLIESALNQIENVFPETLDGYLEKDQETRNYIQREFNQGGVTT
Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
COG id: COG0743
COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the DXR family
Homologues:
Organism=Escherichia coli, GI1786369, Length=395, Percent_Identity=39.4936708860759, Blast_Score=254, Evalue=8e-69,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): DXR_LEPBA (B0SDN1)
Other databases:
- EMBL: CP000777 - RefSeq: YP_001963593.1 - ProteinModelPortal: B0SDN1 - SMR: B0SDN1 - GeneID: 6388254 - GenomeReviews: CP000777_GR - KEGG: lbf:LBF_2531 - HOGENOM: HBG430762 - OMA: IHSMVEY - ProtClustDB: PRK05447 - BioCyc: LBIF355278:LBF_2531-MONOMER - HAMAP: MF_00183 - InterPro: IPR003821 - InterPro: IPR013644 - InterPro: IPR013512 - InterPro: IPR016040 - Gene3D: G3DSA:3.40.50.720 - PIRSF: PIRSF006205 - TIGRFAMs: TIGR00243
Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom
EC number: =1.1.1.267
Molecular weight: Translated: 42212; Mature: 42212
Theoretical pI: Translated: 5.60; Mature: 5.60
Prosite motif: NA
Important sites: BINDING 121-121 BINDING 148-148 BINDING 172-172 BINDING 195-195 BINDING 217-217
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.1 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 2.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MVGVSVLGISGSVGTSTVKVLRQFPDQFDLRSFSVHSNWNVAKALVEEFSPEVICITDPK CCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHCCCCEEEEECCH LVGKFGDSYLSTKILYGDKALIDLVQLPSVGVVVTAVMGARGVLPTIAAIEAGKKIAIAN HHHHHCCHHHEEEEEECCHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHCCCEEEEEC KETLVTFGPLINRLVAKHNTVMVPVDSEHNALFQLIERETRSNIRAITLTASGGSFRTLP CCEEEEHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEEECCCCEEEEH LEALEHVSVKQALNHPTWSMGPKITVDSAGLINKGLEVIEAHFLFGFSYDEIEVVIHPQS HHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHEECCCCEEEEEECCCH ITHGIIETTDGACLLYASHPDMVYPIAHSLFYPNPTPQMLIERKPSTWNTFEFFPPDTKR HCCCCEECCCCEEEEEECCCCEEHHHHHHHCCCCCCHHHHEECCCCCCCCEEECCCCCCC YPGLLLAYQAGKAGGAAPGIFNAANEEAVALFLEEKISFTTIPRLIESALNQIENVFPET CCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEHHCCCHHHHHHHHHHHHHHHHHHCHHH LDGYLEKDQETRNYIQREFNQGGVTT HHHHHCCCHHHHHHHHHHHCCCCCCC >Mature Secondary Structure MVGVSVLGISGSVGTSTVKVLRQFPDQFDLRSFSVHSNWNVAKALVEEFSPEVICITDPK CCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHCCCCEEEEECCH LVGKFGDSYLSTKILYGDKALIDLVQLPSVGVVVTAVMGARGVLPTIAAIEAGKKIAIAN HHHHHCCHHHEEEEEECCHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHCCCEEEEEC KETLVTFGPLINRLVAKHNTVMVPVDSEHNALFQLIERETRSNIRAITLTASGGSFRTLP CCEEEEHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEEECCCCEEEEH LEALEHVSVKQALNHPTWSMGPKITVDSAGLINKGLEVIEAHFLFGFSYDEIEVVIHPQS HHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHEECCCCEEEEEECCCH ITHGIIETTDGACLLYASHPDMVYPIAHSLFYPNPTPQMLIERKPSTWNTFEFFPPDTKR HCCCCEECCCCEEEEEECCCCEEHHHHHHHCCCCCCHHHHEECCCCCCCCEEECCCCCCC YPGLLLAYQAGKAGGAAPGIFNAANEEAVALFLEEKISFTTIPRLIESALNQIENVFPET CCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEHHCCCHHHHHHHHHHHHHHHHHHCHHH LDGYLEKDQETRNYIQREFNQGGVTT HHHHHCCCHHHHHHHHHHHCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA