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The map label for this gene is hisG

Identifier: 183221952

GI number: 183221952

Start: 2679763

End: 2680377

Strand: Reverse

Name: hisG

Synonym: LEPBI_I2593

Alternate gene names: 183221952

Gene position: 2680377-2679763 (Counterclockwise)

Preceding gene: 183221953

Following gene: 183221951

Centisome position: 74.46

GC content: 43.9

Gene sequence:

>615_bases
ATGTTAACTTTGGCTCTTCCGAAAGGTAGGCTTGCCGAAGAAACAGCACTTCTTTTGTTATCCAAAGGGTGGCTTAAAAA
TTTGCCATCCGAGGGTTCCAAAGAACTCACCTATGTCTCTGAAGACAAACGTATCCGCCTTTTATTTGTTAGATCCCAAG
ATGTTTGTACTTATGTAGAAGAAGCTGCCGCCGATGTTGGAATTGTGGGTTGGGACATCATCAGAGAAGGGGGATTTGAC
CTCATTGCACCTGTGGATTTAAAACTCGGAGCATGTAGGCTCTCCCTTGCATCCTTCCCTGACTTTGACCTGTTTGCCAA
ACGTTCCAAAGTACGCGTGGCGACCAAATACCCGAACCTGACTCGGGAGTATTTTTTTTCCAAGGGCATTTCTTGTGAAA
TCATCAAACTTTATGGTTCCATTGAACTGGCTCCCATCGTTGGACTTTCCGATTGTATTGTGGACTTAGTTTCGACTGGT
GGTACCCTAAAAGCCAATGGTTTGAAAGAATTTGAGTCCATTTTGTTTAGTACAGCCCGTTTGGTCAGCAATCGCTCCTC
TTTTTATCACAAACACGCCGAATTACGGTCTCTTATCGAGAGCCTAGAAAATTAA

Upstream 100 bases:

>100_bases
ATACCTTGAAAAAGCAGTCAAACTTGATGGGGCAGAATCTGGGGAAGATGTAAAACTCCTTAGCAGTTATTTACTCCTCA
AACTCGGTAAAAACTAACCT

Downstream 100 bases:

>100_bases
AATATTGTTTTCACATTGGATTTCCAAAACATAGTAAAAACCAGTTATAATTCCATAGAGGATAGCCATGGCAGTCCCAA
AGAGACGTAAATCAAAATCG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MLTLALPKGRLAEETALLLLSKGWLKNLPSEGSKELTYVSEDKRIRLLFVRSQDVCTYVEEAAADVGIVGWDIIREGGFD
LIAPVDLKLGACRLSLASFPDFDLFAKRSKVRVATKYPNLTREYFFSKGISCEIIKLYGSIELAPIVGLSDCIVDLVSTG
GTLKANGLKEFESILFSTARLVSNRSSFYHKHAELRSLIESLEN

Sequences:

>Translated_204_residues
MLTLALPKGRLAEETALLLLSKGWLKNLPSEGSKELTYVSEDKRIRLLFVRSQDVCTYVEEAAADVGIVGWDIIREGGFD
LIAPVDLKLGACRLSLASFPDFDLFAKRSKVRVATKYPNLTREYFFSKGISCEIIKLYGSIELAPIVGLSDCIVDLVSTG
GTLKANGLKEFESILFSTARLVSNRSSFYHKHAELRSLIESLEN
>Mature_204_residues
MLTLALPKGRLAEETALLLLSKGWLKNLPSEGSKELTYVSEDKRIRLLFVRSQDVCTYVEEAAADVGIVGWDIIREGGFD
LIAPVDLKLGACRLSLASFPDFDLFAKRSKVRVATKYPNLTREYFFSKGISCEIIKLYGSIELAPIVGLSDCIVDLVSTG
GTLKANGLKEFESILFSTARLVSNRSSFYHKHAELRSLIESLEN

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=206, Percent_Identity=36.4077669902913, Blast_Score=105, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320896, Length=169, Percent_Identity=29.585798816568, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_LEPBA (B0SDL3)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001963575.1
- ProteinModelPortal:   B0SDL3
- SMR:   B0SDL3
- GeneID:   6389369
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_2513
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- BioCyc:   LBIF355278:LBF_2513-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 22610; Mature: 22610

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLALPKGRLAEETALLLLSKGWLKNLPSEGSKELTYVSEDKRIRLLFVRSQDVCTYVE
CEEEECCCCCCHHHHHHHHHHCHHHHCCCCCCCCCEEEECCCCEEEEEEEECCHHHHHHH
EAAADVGIVGWDIIREGGFDLIAPVDLKLGACRLSLASFPDFDLFAKRSKVRVATKYPNL
HHHHCCCEEHHHHHHCCCCCEEECCCCEECCEEEECCCCCCHHHHHCCCCEEEEECCCCH
TREYFFSKGISCEIIKLYGSIELAPIVGLSDCIVDLVSTGGTLKANGLKEFESILFSTAR
HHHHHHHCCCCEEEEEEECCEEEEECCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHH
LVSNRSSFYHKHAELRSLIESLEN
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLTLALPKGRLAEETALLLLSKGWLKNLPSEGSKELTYVSEDKRIRLLFVRSQDVCTYVE
CEEEECCCCCCHHHHHHHHHHCHHHHCCCCCCCCCEEEECCCCEEEEEEEECCHHHHHHH
EAAADVGIVGWDIIREGGFDLIAPVDLKLGACRLSLASFPDFDLFAKRSKVRVATKYPNL
HHHHCCCEEHHHHHHCCCCCEEECCCCEECCEEEECCCCCCHHHHHCCCCEEEEECCCCH
TREYFFSKGISCEIIKLYGSIELAPIVGLSDCIVDLVSTGGTLKANGLKEFESILFSTAR
HHHHHHHCCCCEEEEEEECCEEEEECCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHH
LVSNRSSFYHKHAELRSLIESLEN
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA