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The map label for this gene is degU [H]

Identifier: 183221890

GI number: 183221890

Start: 2612685

End: 2613323

Strand: Direct

Name: degU [H]

Synonym: LEPBI_I2526

Alternate gene names: 183221890

Gene position: 2612685-2613323 (Clockwise)

Preceding gene: 183221889

Following gene: 183221891

Centisome position: 72.58

GC content: 34.12

Gene sequence:

>639_bases
ATGGATAGAAAAAAATCCATCACTGTTGGTATTTTAGAAAATGATGAATTTTTTTTAAATGAAGTCAAAGAACGACTCAA
ATCTATACCGGAAATTGATTCTGTATTAACCTGGGAATCTGCAGAAAATTTTTTTAAAGATCCGGCTATCGAATCTTTAG
ATATCTTATTTTTAGACATTATGCTTTCTGGAATGACTGGAATCGATGTGGTTGGAAAAATGAATGAGTCTGGATCCAAG
ATCAAAGTAATTATGCTTACCAATATGAGTTCTGATGAAATGATTTTTAATTCTATTAAAAATGGGGCACTTGGATATAT
TTTGAAATCTGATATCGGAAGGATTCGGGAAATTATCGAAGTTGTAAAAGGTGGTGGGGCAACCATTACACCAACGATTG
CCCTTCGGGTGTTTTCAAGTTTTCGCAAGGTAAAAACAAACGAGGAAGAATCCTTGACTGATCGCGAAACTCAAATTTTG
CAATTACTAGTAAAAGGAAAAAAGATATCTTCTATAGCCGAATTACTTTTGTTAAGCGAACATACTGTCCACGGGTATGT
AAAATCAATCTATAAAAAACTTATGGTACACAACCGAGTAGAGCTCACACTCAAAGCACAAAAGCTTTCCCTTCTATGA

Upstream 100 bases:

>100_bases
TATTTTCTTTTAAAGATCAAAAAAGAATTTTCCCTAGACGAAGATGGATTGGTTCCAAACCAAGACTTGCTCAACCACTC
AAAAGACCTAGTTGGAATCA

Downstream 100 bases:

>100_bases
AAGGGAATGTATGGGCCTTTCTACTCGGAGTTTGTTTATTTCTCAGTTTTTGTAAAGAAAGCACTACATTAAAGTCGGAT
CAAATTCCAATTCAAAATCA

Product: putative two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MDRKKSITVGILENDEFFLNEVKERLKSIPEIDSVLTWESAENFFKDPAIESLDILFLDIMLSGMTGIDVVGKMNESGSK
IKVIMLTNMSSDEMIFNSIKNGALGYILKSDIGRIREIIEVVKGGGATITPTIALRVFSSFRKVKTNEEESLTDRETQIL
QLLVKGKKISSIAELLLLSEHTVHGYVKSIYKKLMVHNRVELTLKAQKLSLL

Sequences:

>Translated_212_residues
MDRKKSITVGILENDEFFLNEVKERLKSIPEIDSVLTWESAENFFKDPAIESLDILFLDIMLSGMTGIDVVGKMNESGSK
IKVIMLTNMSSDEMIFNSIKNGALGYILKSDIGRIREIIEVVKGGGATITPTIALRVFSSFRKVKTNEEESLTDRETQIL
QLLVKGKKISSIAELLLLSEHTVHGYVKSIYKKLMVHNRVELTLKAQKLSLL
>Mature_212_residues
MDRKKSITVGILENDEFFLNEVKERLKSIPEIDSVLTWESAENFFKDPAIESLDILFLDIMLSGMTGIDVVGKMNESGSK
IKVIMLTNMSSDEMIFNSIKNGALGYILKSDIGRIREIIEVVKGGGATITPTIALRVFSSFRKVKTNEEESLTDRETQIL
QLLVKGKKISSIAELLLLSEHTVHGYVKSIYKKLMVHNRVELTLKAQKLSLL

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=200, Percent_Identity=29, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788521, Length=157, Percent_Identity=29.9363057324841, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790102, Length=198, Percent_Identity=24.2424242424242, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1786747, Length=153, Percent_Identity=32.6797385620915, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23806; Mature: 23806

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRKKSITVGILENDEFFLNEVKERLKSIPEIDSVLTWESAENFFKDPAIESLDILFLDI
CCCCCEEEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MLSGMTGIDVVGKMNESGSKIKVIMLTNMSSDEMIFNSIKNGALGYILKSDIGRIREIIE
HHCCCCCHHHHCCCCCCCCEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VVKGGGATITPTIALRVFSSFRKVKTNEEESLTDRETQILQLLVKGKKISSIAELLLLSE
HHCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
HTVHGYVKSIYKKLMVHNRVELTLKAQKLSLL
HHHHHHHHHHHHHHHHCCHHEEEEEHHHHCCC
>Mature Secondary Structure
MDRKKSITVGILENDEFFLNEVKERLKSIPEIDSVLTWESAENFFKDPAIESLDILFLDI
CCCCCEEEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MLSGMTGIDVVGKMNESGSKIKVIMLTNMSSDEMIFNSIKNGALGYILKSDIGRIREIIE
HHCCCCCHHHHCCCCCCCCEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VVKGGGATITPTIALRVFSSFRKVKTNEEESLTDRETQILQLLVKGKKISSIAELLLLSE
HHCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
HTVHGYVKSIYKKLMVHNRVELTLKAQKLSLL
HHHHHHHHHHHHHHHHCCHHEEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]