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The map label for this gene is hemN [H]

Identifier: 183221686

GI number: 183221686

Start: 2380672

End: 2381895

Strand: Direct

Name: hemN [H]

Synonym: LEPBI_I2311

Alternate gene names: 183221686

Gene position: 2380672-2381895 (Clockwise)

Preceding gene: 183221682

Following gene: 183221687

Centisome position: 66.14

GC content: 39.87

Gene sequence:

>1224_bases
ATGTGTGAGTCCCATCCAAACCAAAATAAAACAAAACAATCGTTTCATCACATGAAAGAGTTTTCGAAAGATTCCATCTG
GCAAGTCAGAAATTCCACTTTAGGAGTGTATGTACACTTTCCTTATTGTTTGAAAAAATGTGATTATTGTGATTTTTATT
CCGAAGGGATCGGTAGCGGACCAGCTAACGACGAATCGACGCTCTTTTCTGCATACCAAAGTGAAGTGTCAGAACGTATC
TCCCATTTTCCCAAATTAAGGGAGAGGACAGTGGACACTGTTTTTTTTGGTGGAGGAACTCCTTCCAAAGCATCCACGAA
ACTTTGGAAACAGTTCCTAGAATTCCTCAGGTCGGAATTTTCATTTGCAGATGACACAGAAATCTCGATAGAAGTGAACC
CAGAAGACCTAAGCCCCGATTTACTTGATGAATATGCAAAAATTGGCATCAACCGTGTGAATGTAGGTGTACAAACTCTC
CATCCGGAAGGACTTTCATTTCTCGGTCGCCATTATGATAAAGGTAAATACACTTCCTTAGTCACGACCCTCACCCATTC
TCCGATCCAACGTGTGGGAATCGATTTGATGTATGGAATCCCAGGACTCAAGTCTTCTGATTTTTACCGAGACCTAGATC
AATTCCTAAGTGCAGGATTACCCCATTTGAGTTTGTATTCCCTTACTTTAGAAAAAGGAACCAAGTATTCACGTGATGTG
AGTGATAGTATCAAAAGGGAACCAGAAGAAATCACACAAGCGGAAATACTTGTCACCTTACCGGAATTAATGGAGAAATT
TGGATATAGGTGGTATGAAGTATCCAATTATGCAAAACCTGGATATGAATCCAAACACAACCTAAAGTATTGGACCTATG
AACCTTATCTTGGCATTGGCCCTGGTGCTCATGGAATGATTGAAGGACATCGATACGGAAACCCTAGGAACGCCAATCTT
TACCAAAAAAAACAAACTGAAGCGAAGTATGAGCCTGCAACGCCTAGTTCAGAACTAAGCCTCACTTTGTTTCGACTTTT
TTCCCCGTTTCGGTATTTGGAATTTATTGAAACTCACTTGGAAAAAAACTCTCAATCGAAATACATCCAAACAATTCAGT
CTTGGGAAAAAAGAGGACTTTGTGATCTATCCGATGGAGTTTTCCAATGGAGAAAAGAAGCATTACTTTTGTTAGATGAT
CTAATCCTTGAAATTTCCGATTGA

Upstream 100 bases:

>100_bases
TGGATTCCATTTTGAAAACAACAGGTTCAGGGAATGAAAAAGAAAATGATTCCCATACAAAGTTTTGGTTTGGTTCTATG
AGTGTCTGTGAAAGGATCGT

Downstream 100 bases:

>100_bases
ATTTTCCTCTTTCCTTTGCAAAATAATCCTAAAAAAAGATTGCCCAGAGACCCCACTCGAAAAATACTGTTCGTATCCCG
GGCCTGTAGCTCAGTTGGTT

Product: oxygen-independent coproporphyrinogen III oxidase-like protein

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MCESHPNQNKTKQSFHHMKEFSKDSIWQVRNSTLGVYVHFPYCLKKCDYCDFYSEGIGSGPANDESTLFSAYQSEVSERI
SHFPKLRERTVDTVFFGGGTPSKASTKLWKQFLEFLRSEFSFADDTEISIEVNPEDLSPDLLDEYAKIGINRVNVGVQTL
HPEGLSFLGRHYDKGKYTSLVTTLTHSPIQRVGIDLMYGIPGLKSSDFYRDLDQFLSAGLPHLSLYSLTLEKGTKYSRDV
SDSIKREPEEITQAEILVTLPELMEKFGYRWYEVSNYAKPGYESKHNLKYWTYEPYLGIGPGAHGMIEGHRYGNPRNANL
YQKKQTEAKYEPATPSSELSLTLFRLFSPFRYLEFIETHLEKNSQSKYIQTIQSWEKRGLCDLSDGVFQWRKEALLLLDD
LILEISD

Sequences:

>Translated_407_residues
MCESHPNQNKTKQSFHHMKEFSKDSIWQVRNSTLGVYVHFPYCLKKCDYCDFYSEGIGSGPANDESTLFSAYQSEVSERI
SHFPKLRERTVDTVFFGGGTPSKASTKLWKQFLEFLRSEFSFADDTEISIEVNPEDLSPDLLDEYAKIGINRVNVGVQTL
HPEGLSFLGRHYDKGKYTSLVTTLTHSPIQRVGIDLMYGIPGLKSSDFYRDLDQFLSAGLPHLSLYSLTLEKGTKYSRDV
SDSIKREPEEITQAEILVTLPELMEKFGYRWYEVSNYAKPGYESKHNLKYWTYEPYLGIGPGAHGMIEGHRYGNPRNANL
YQKKQTEAKYEPATPSSELSLTLFRLFSPFRYLEFIETHLEKNSQSKYIQTIQSWEKRGLCDLSDGVFQWRKEALLLLDD
LILEISD
>Mature_407_residues
MCESHPNQNKTKQSFHHMKEFSKDSIWQVRNSTLGVYVHFPYCLKKCDYCDFYSEGIGSGPANDESTLFSAYQSEVSERI
SHFPKLRERTVDTVFFGGGTPSKASTKLWKQFLEFLRSEFSFADDTEISIEVNPEDLSPDLLDEYAKIGINRVNVGVQTL
HPEGLSFLGRHYDKGKYTSLVTTLTHSPIQRVGIDLMYGIPGLKSSDFYRDLDQFLSAGLPHLSLYSLTLEKGTKYSRDV
SDSIKREPEEITQAEILVTLPELMEKFGYRWYEVSNYAKPGYESKHNLKYWTYEPYLGIGPGAHGMIEGHRYGNPRNANL
YQKKQTEAKYEPATPSSELSLTLFRLFSPFRYLEFIETHLEKNSQSKYIQTIQSWEKRGLCDLSDGVFQWRKEALLLLDD
LILEISD

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=273, Percent_Identity=33.6996336996337, Blast_Score=153, Evalue=3e-37,
Organism=Escherichia coli, GI1789325, Length=337, Percent_Identity=30.8605341246291, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI87082341, Length=287, Percent_Identity=25.7839721254355, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 46868; Mature: 46868

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCESHPNQNKTKQSFHHMKEFSKDSIWQVRNSTLGVYVHFPYCLKKCDYCDFYSEGIGSG
CCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCEEEEEEECHHHHHHCCCCHHHHHCCCCC
PANDESTLFSAYQSEVSERISHFPKLRERTVDTVFFGGGTPSKASTKLWKQFLEFLRSEF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHC
SFADDTEISIEVNPEDLSPDLLDEYAKIGINRVNVGVQTLHPEGLSFLGRHYDKGKYTSL
CCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHEECCEEEECCCHHHHHHHHCCCCHHHHH
VTTLTHSPIQRVGIDLMYGIPGLKSSDFYRDLDQFLSAGLPHLSLYSLTLEKGTKYSRDV
HHHHHHCHHHHHCCHHEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHCCCCCCCCH
SDSIKREPEEITQAEILVTLPELMEKFGYRWYEVSNYAKPGYESKHNLKYWTYEPYLGIG
HHHHHCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCC
PGAHGMIEGHRYGNPRNANLYQKKQTEAKYEPATPSSELSLTLFRLFSPFRYLEFIETHL
CCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EKNSQSKYIQTIQSWEKRGLCDLSDGVFQWRKEALLLLDDLILEISD
HCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MCESHPNQNKTKQSFHHMKEFSKDSIWQVRNSTLGVYVHFPYCLKKCDYCDFYSEGIGSG
CCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCEEEEEEECHHHHHHCCCCHHHHHCCCCC
PANDESTLFSAYQSEVSERISHFPKLRERTVDTVFFGGGTPSKASTKLWKQFLEFLRSEF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHC
SFADDTEISIEVNPEDLSPDLLDEYAKIGINRVNVGVQTLHPEGLSFLGRHYDKGKYTSL
CCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHEECCEEEECCCHHHHHHHHCCCCHHHHH
VTTLTHSPIQRVGIDLMYGIPGLKSSDFYRDLDQFLSAGLPHLSLYSLTLEKGTKYSRDV
HHHHHHCHHHHHCCHHEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHCCCCCCCCH
SDSIKREPEEITQAEILVTLPELMEKFGYRWYEVSNYAKPGYESKHNLKYWTYEPYLGIG
HHHHHCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCC
PGAHGMIEGHRYGNPRNANLYQKKQTEAKYEPATPSSELSLTLFRLFSPFRYLEFIETHL
CCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EKNSQSKYIQTIQSWEKRGLCDLSDGVFQWRKEALLLLDDLILEISD
HCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]