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The map label for this gene is capA [H]

Identifier: 183221484

GI number: 183221484

Start: 2195415

End: 2196557

Strand: Reverse

Name: capA [H]

Synonym: LEPBI_I2102

Alternate gene names: 183221484

Gene position: 2196557-2195415 (Counterclockwise)

Preceding gene: 183221485

Following gene: 183221482

Centisome position: 61.02

GC content: 38.85

Gene sequence:

>1143_bases
ATGAAATCATCTTATTTTGTTTCGTTAGTATTAATCCCCCTTTTTCTTTTTTCGGCAGACATACCGGAAGATCCTGAAAA
CAGATTAGAACTACCGGCAAACTCTCTGTATCAATTCCAAACAGAATCAGGAGAGACTCTTCAATATCCAAATTCCATAA
AACTCTGGTTTGGTGGGGATGTTATGTTTAATTGGGGAGTTCGGGATGCAATGCGATCGGATGATATCATGTTTTCGTTT
CGAAGTTTTTTCCGTTACCTGGATCAGTTTGACTATCGTTTCATCAATTTAGAAACACCAATTTTACACAAAACCCCAGC
TGCCGACCAAAGGAAATCGTATGTATTTTATGGGGAAAGAAGGGACCTAACTGTATTACGGTCTCTTGGAATCGATGGTG
TGTTTTTAGGGAATAACCATACCATGGACTTTGGGGAAAATGGATTATTTGAAACCTTAGATTTGTTAGATGAATTTAAG
ATTTTACATACAGGTGCAGGGAAAAACACAGACCAAGCCTTGTTGCCCATCCAAGTCAAAAAAGGGAATACAGAATTTCG
TTTGTTTTCCTTTTCCGATACAGGTGAGACACGACTTTTTTCGGGCACAAATTCTCCTGGAGCTGCTTACTTTCGTGTGG
CGACAGCAGAAAAGATCATCAAAAAAACAAAACCAGGTCAAGTGAATGTTTTGTCTGTTCATTGGGGAGTGGAATACAAC
CCGACACCAATGGAAACAGAACGTAATGCGGCAAAATATTTAATTAACGCAGGTTATAAGGTAATCATTGGCCACCATCC
TCACGTTCCACAAGGGATTGAAGTGTTCCCCAAAGGGATTGTTGTTTATTCTCTTGGTAATTTTTTCTTTGGTTCCAAAA
ACCAATACTTAAAACACAATATTTCTGTTGTGACCCATTTTGATGGAGACAAACTTCTGTTTGTGGAAGTGATTCCTGTG
TTTGGGAAACACCAATCGATGCCAGGGGATCATTACTTTTTTCCACTGGGTCCAAAAGAAGCCGAAAATTTTTTAAAAGA
GTATGCGATCCTCTGCAAACAATTGGGAACCGATTTGGTAATCTCTGGCGGAAGGGGTTATGTTTTTTTTGAAAAGGAAC
TAAAAGCCAAACTAAAACCATAA

Upstream 100 bases:

>100_bases
GATCAGTTTGGATACAGAAAAGGAAAATGTTCTCATTCAAATCAAATTGAAAAAATCTCAAATTACGGAAGTAGCTTCCC
AAGTATTTCGATTTTAATAA

Downstream 100 bases:

>100_bases
TGGAACCAGGTACAAACGAGTCCCAAAGCAAAAAAGGGAAAACTGAGTTCCAGTAAGTTTGTTCGGATGATGGAAAAGAT
CTGTAAAAAAAATCCAGTAA

Product: putative signal peptide

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKSSYFVSLVLIPLFLFSADIPEDPENRLELPANSLYQFQTESGETLQYPNSIKLWFGGDVMFNWGVRDAMRSDDIMFSF
RSFFRYLDQFDYRFINLETPILHKTPAADQRKSYVFYGERRDLTVLRSLGIDGVFLGNNHTMDFGENGLFETLDLLDEFK
ILHTGAGKNTDQALLPIQVKKGNTEFRLFSFSDTGETRLFSGTNSPGAAYFRVATAEKIIKKTKPGQVNVLSVHWGVEYN
PTPMETERNAAKYLINAGYKVIIGHHPHVPQGIEVFPKGIVVYSLGNFFFGSKNQYLKHNISVVTHFDGDKLLFVEVIPV
FGKHQSMPGDHYFFPLGPKEAENFLKEYAILCKQLGTDLVISGGRGYVFFEKELKAKLKP

Sequences:

>Translated_380_residues
MKSSYFVSLVLIPLFLFSADIPEDPENRLELPANSLYQFQTESGETLQYPNSIKLWFGGDVMFNWGVRDAMRSDDIMFSF
RSFFRYLDQFDYRFINLETPILHKTPAADQRKSYVFYGERRDLTVLRSLGIDGVFLGNNHTMDFGENGLFETLDLLDEFK
ILHTGAGKNTDQALLPIQVKKGNTEFRLFSFSDTGETRLFSGTNSPGAAYFRVATAEKIIKKTKPGQVNVLSVHWGVEYN
PTPMETERNAAKYLINAGYKVIIGHHPHVPQGIEVFPKGIVVYSLGNFFFGSKNQYLKHNISVVTHFDGDKLLFVEVIPV
FGKHQSMPGDHYFFPLGPKEAENFLKEYAILCKQLGTDLVISGGRGYVFFEKELKAKLKP
>Mature_380_residues
MKSSYFVSLVLIPLFLFSADIPEDPENRLELPANSLYQFQTESGETLQYPNSIKLWFGGDVMFNWGVRDAMRSDDIMFSF
RSFFRYLDQFDYRFINLETPILHKTPAADQRKSYVFYGERRDLTVLRSLGIDGVFLGNNHTMDFGENGLFETLDLLDEFK
ILHTGAGKNTDQALLPIQVKKGNTEFRLFSFSDTGETRLFSGTNSPGAAYFRVATAEKIIKKTKPGQVNVLSVHWGVEYN
PTPMETERNAAKYLINAGYKVIIGHHPHVPQGIEVFPKGIVVYSLGNFFFGSKNQYLKHNISVVTHFDGDKLLFVEVIPV
FGKHQSMPGDHYFFPLGPKEAENFLKEYAILCKQLGTDLVISGGRGYVFFEKELKAKLKP

Specific function: Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapB and CapC [H]

COG id: COG2843

COG function: function code M; Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CapA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019079 [H]

Pfam domain/function: PF09587 PGA_cap [H]

EC number: NA

Molecular weight: Translated: 43229; Mature: 43229

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSSYFVSLVLIPLFLFSADIPEDPENRLELPANSLYQFQTESGETLQYPNSIKLWFGGD
CCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEECCCCCEEECCCEEEEEECCE
VMFNWGVRDAMRSDDIMFSFRSFFRYLDQFDYRFINLETPILHKTPAADQRKSYVFYGER
EEEECCCHHHHCCCHHHHHHHHHHHHHHHCCEEEEEECCCCEECCCCCCCCCCEEEEECC
RDLTVLRSLGIDGVFLGNNHTMDFGENGLFETLDLLDEFKILHTGAGKNTDQALLPIQVK
CCCHHHHHCCCCEEEECCCCEECCCCCCHHHHHHHHHHHEEEECCCCCCCCCEEEEEEEE
KGNTEFRLFSFSDTGETRLFSGTNSPGAAYFRVATAEKIIKKTKPGQVNVLSVHWGVEYN
CCCCEEEEEEECCCCCEEEEECCCCCCCEEEEEHHHHHHHHHCCCCEEEEEEEEECCEEC
PTPMETERNAAKYLINAGYKVIIGHHPHVPQGIEVFPKGIVVYSLGNFFFGSKNQYLKHN
CCCCCCCCHHHHHEEECCEEEEECCCCCCCCCCEECCCCEEEEEECCEEECCCCCEEEEC
ISVVTHFDGDKLLFVEVIPVFGKHQSMPGDHYFFPLGPKEAENFLKEYAILCKQLGTDLV
EEEEEEECCCEEEEEEEEEHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCEE
ISGGRGYVFFEKELKAKLKP
EECCCEEEEEEHHHHCCCCC
>Mature Secondary Structure
MKSSYFVSLVLIPLFLFSADIPEDPENRLELPANSLYQFQTESGETLQYPNSIKLWFGGD
CCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEECCCCCEEECCCEEEEEECCE
VMFNWGVRDAMRSDDIMFSFRSFFRYLDQFDYRFINLETPILHKTPAADQRKSYVFYGER
EEEECCCHHHHCCCHHHHHHHHHHHHHHHCCEEEEEECCCCEECCCCCCCCCCEEEEECC
RDLTVLRSLGIDGVFLGNNHTMDFGENGLFETLDLLDEFKILHTGAGKNTDQALLPIQVK
CCCHHHHHCCCCEEEECCCCEECCCCCCHHHHHHHHHHHEEEECCCCCCCCCEEEEEEEE
KGNTEFRLFSFSDTGETRLFSGTNSPGAAYFRVATAEKIIKKTKPGQVNVLSVHWGVEYN
CCCCEEEEEEECCCCCEEEEECCCCCCCEEEEEHHHHHHHHHCCCCEEEEEEEEECCEEC
PTPMETERNAAKYLINAGYKVIIGHHPHVPQGIEVFPKGIVVYSLGNFFFGSKNQYLKHN
CCCCCCCCHHHHHEEECCEEEEECCCCCCCCCCEECCCCEEEEEECCEEECCCCCEEEEC
ISVVTHFDGDKLLFVEVIPVFGKHQSMPGDHYFFPLGPKEAENFLKEYAILCKQLGTDLV
EEEEEEECCCEEEEEEEEEHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCEE
ISGGRGYVFFEKELKAKLKP
EECCCEEEEEEHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2536679; 10475962; 12004073 [H]