Click here to switch to the map view.

The map label for this gene is fadH2 [H]

Identifier: 183221428

GI number: 183221428

Start: 2127024

End: 2129042

Strand: Reverse

Name: fadH2 [H]

Synonym: LEPBI_I2046

Alternate gene names: 183221428

Gene position: 2129042-2127024 (Counterclockwise)

Preceding gene: 183221430

Following gene: 183221427

Centisome position: 59.15

GC content: 44.33

Gene sequence:

>2019_bases
ATGACAGCATATCCCACATTACTTTCTCCCTTATCTCTTGGATTCACCACACTCAAAAACCGAACCATCATGGGTTCCAT
GCACACTGGTTTAGAGGAAGCTCCGAATGGTTACGATCGGATGGCCGCATTTTACGGGGAAAGAGCGAAGGGTGGTGTCG
CACTCATTGTCACAGGAGGCATTGCTCCGAATGAAGCAGGGCGTGTGGCAAAGGGTGGTAGTGTGATGGACACGGAAGAG
GAGGCTCTCCACCACCGAGTGGTCACGGAAGCTGTCCATAAAGAAGGTGGAAAAATTGCCATGCAAATCCTACATACAGG
AAGGTATGGGTATCATGATAAAATTGTTGGGGCATCCAATGTCCGAGCACCTATCAATATGTTCAAACCACACCCTCTCA
CAGAAGAGGAAATTTGGAAAACCATTGAAGATTTTGTACGCTGCTCCGAATTAGCAAAGTTAGCTGGATATGATGGGGTT
GAAATTATGGGGAGCGAAGGTTACCTCATCAACCAATTCATTGCCAAAAGGACAAACAACCGAATCGATGATTGGGGAGG
GAGTTTTGAAAATCGAATTAAGTTCCCAATTGAAATCATCAAGGCTGTTCGAAAAAAATTAGGTACAGACTTTATCATCA
TCTACCGTCTGTCAATGTTAGACTTAGTGGAGGAAGGTGGAAATATAGACGAAGTCCTTCACTTGGCAAAAGAAATTGAA
AAAGCGGGAGCAACCATCATCAACACAGGGATTGGTTGGCATGAAGCAAGGATTCCAACCATCGCCATGATGGTACCAAG
AGCTGCTTTTACTTGGGTCACAGCAAAAGTGAAGGGACATGTCAACATTCCCTTAGTTACTTCTAACCGGATCAATACTC
CTGAAGTTGCGGAAGAGGTTCTTTCACGTGGTGATGCCGATTTGGTTTCTATGGCACGTCCTTTCCTTGCGGATTCCTTT
TTTGTGGAAAAAGCGAAAGCTGGTAAACCAGAAGAGATCAACACTTGTATCGCTTGTAACCAAGCATGCCTTGATCATAT
TTTCCAAGGAAAAACCGCAAGTTGTTTGGTGAACCCTAGAGCTTGCCATGAAACGGAACTTGTCATCACCCAAACAAAAA
ATGTAAAAAAAGTTGCCGTAGTGGGAGCTGGGCCTGGTGGGATGTCTTGTGCCAAAACTCTTGCGGAACGTGGGCATTCC
GTCACATTGTTTGATGCGCAATCCGAATTAGGTGGTCAATTGAACATTGCCAGACGAATTCCTGGTAAAGAAGAGTTTAA
AGAAACCATTCGCTATTTTGATACGATGTTAAAAAAATTCAAAGTGAATGTGAAACTGAATACTTATGTATCGAGTGAAG
ATTTGATCGCAGAAGGTTTTGAAGAAGTCGTACTTGCAACAGGAGTCATTCCCAGGATTCCTGAAATTCCAGGGATCAAT
GGACCGAATGTTCTGAGTTATGTGGACGTTGTATTAAAAGGCAAACCAGTTGGAAAAAGGGCAGTCGTCATGGGAGCAGG
TGGAATCGGATTTGATGTGAGTATTTTGCTTACAGATCCAGGCCATGCATTTACCACAGAAAATTACTTAAAGGAATGGG
GGATCCAAACCTCCATCGAAAAGAACGGTGGCCTTGGTTCCAAAGAAACGCCAACGGGTGTAAGAGATGTTACCATGTTA
AAACGTTCGAATAGTAAATTTGGAGCCACACTTGGTAAAACCACAGGTTGGATCCATAAAACCTCTTTGGAAGACCGTAA
GGTGAACCAAATCTCCGGTGTGACGTATAAAGCAATTGAGTCAGATGGAGTTGTCATCGAGGTGAAAGGGGAAACAAAAA
AAATCCCTTGTGATACAGTGGTTGTCTGCGCAGGCCAAGACCCGAACCGGGCACTTTTGGAACCTTTACAGAAAGCCAAA
ATCCCTGTGCACTTAATTGGTGGTGCCGACCTTGCTTCCGAACTAGATGCCAAACGAGCTATTGACCAAGGGACAAGGCT
TGCTGTTTCGATTGGCTAA

Upstream 100 bases:

>100_bases
TTTCTCCGTGAGAATTTCCACAGGACAAAGTTATATCCGTTCTTTATTAGATTGCAAGTAAATCTTGCCAAATTCCCTGA
ATTTCTACACTTGGGTCTTT

Downstream 100 bases:

>100_bases
TTTGCACTTCGAAACTCACCCAGTTTCATGGGAAACAAATCTGATTCGGTTCCCATGAAAGCACTGAAAGTTTCTGTCCG
GAATGCTGAATTCCAAATCA

Product: 2,4-dienoyl coenzyme A reductase

Products: NA

Alternate protein names: 2,4-dienoyl coenzyme A reductase [H]

Number of amino acids: Translated: 672; Mature: 671

Protein sequence:

>672_residues
MTAYPTLLSPLSLGFTTLKNRTIMGSMHTGLEEAPNGYDRMAAFYGERAKGGVALIVTGGIAPNEAGRVAKGGSVMDTEE
EALHHRVVTEAVHKEGGKIAMQILHTGRYGYHDKIVGASNVRAPINMFKPHPLTEEEIWKTIEDFVRCSELAKLAGYDGV
EIMGSEGYLINQFIAKRTNNRIDDWGGSFENRIKFPIEIIKAVRKKLGTDFIIIYRLSMLDLVEEGGNIDEVLHLAKEIE
KAGATIINTGIGWHEARIPTIAMMVPRAAFTWVTAKVKGHVNIPLVTSNRINTPEVAEEVLSRGDADLVSMARPFLADSF
FVEKAKAGKPEEINTCIACNQACLDHIFQGKTASCLVNPRACHETELVITQTKNVKKVAVVGAGPGGMSCAKTLAERGHS
VTLFDAQSELGGQLNIARRIPGKEEFKETIRYFDTMLKKFKVNVKLNTYVSSEDLIAEGFEEVVLATGVIPRIPEIPGIN
GPNVLSYVDVVLKGKPVGKRAVVMGAGGIGFDVSILLTDPGHAFTTENYLKEWGIQTSIEKNGGLGSKETPTGVRDVTML
KRSNSKFGATLGKTTGWIHKTSLEDRKVNQISGVTYKAIESDGVVIEVKGETKKIPCDTVVVCAGQDPNRALLEPLQKAK
IPVHLIGGADLASELDAKRAIDQGTRLAVSIG

Sequences:

>Translated_672_residues
MTAYPTLLSPLSLGFTTLKNRTIMGSMHTGLEEAPNGYDRMAAFYGERAKGGVALIVTGGIAPNEAGRVAKGGSVMDTEE
EALHHRVVTEAVHKEGGKIAMQILHTGRYGYHDKIVGASNVRAPINMFKPHPLTEEEIWKTIEDFVRCSELAKLAGYDGV
EIMGSEGYLINQFIAKRTNNRIDDWGGSFENRIKFPIEIIKAVRKKLGTDFIIIYRLSMLDLVEEGGNIDEVLHLAKEIE
KAGATIINTGIGWHEARIPTIAMMVPRAAFTWVTAKVKGHVNIPLVTSNRINTPEVAEEVLSRGDADLVSMARPFLADSF
FVEKAKAGKPEEINTCIACNQACLDHIFQGKTASCLVNPRACHETELVITQTKNVKKVAVVGAGPGGMSCAKTLAERGHS
VTLFDAQSELGGQLNIARRIPGKEEFKETIRYFDTMLKKFKVNVKLNTYVSSEDLIAEGFEEVVLATGVIPRIPEIPGIN
GPNVLSYVDVVLKGKPVGKRAVVMGAGGIGFDVSILLTDPGHAFTTENYLKEWGIQTSIEKNGGLGSKETPTGVRDVTML
KRSNSKFGATLGKTTGWIHKTSLEDRKVNQISGVTYKAIESDGVVIEVKGETKKIPCDTVVVCAGQDPNRALLEPLQKAK
IPVHLIGGADLASELDAKRAIDQGTRLAVSIG
>Mature_671_residues
TAYPTLLSPLSLGFTTLKNRTIMGSMHTGLEEAPNGYDRMAAFYGERAKGGVALIVTGGIAPNEAGRVAKGGSVMDTEEE
ALHHRVVTEAVHKEGGKIAMQILHTGRYGYHDKIVGASNVRAPINMFKPHPLTEEEIWKTIEDFVRCSELAKLAGYDGVE
IMGSEGYLINQFIAKRTNNRIDDWGGSFENRIKFPIEIIKAVRKKLGTDFIIIYRLSMLDLVEEGGNIDEVLHLAKEIEK
AGATIINTGIGWHEARIPTIAMMVPRAAFTWVTAKVKGHVNIPLVTSNRINTPEVAEEVLSRGDADLVSMARPFLADSFF
VEKAKAGKPEEINTCIACNQACLDHIFQGKTASCLVNPRACHETELVITQTKNVKKVAVVGAGPGGMSCAKTLAERGHSV
TLFDAQSELGGQLNIARRIPGKEEFKETIRYFDTMLKKFKVNVKLNTYVSSEDLIAEGFEEVVLATGVIPRIPEIPGING
PNVLSYVDVVLKGKPVGKRAVVMGAGGIGFDVSILLTDPGHAFTTENYLKEWGIQTSIEKNGGLGSKETPTGVRDVTMLK
RSNSKFGATLGKTTGWIHKTSLEDRKVNQISGVTYKAIESDGVVIEVKGETKKIPCDTVVVCAGQDPNRALLEPLQKAKI
PVHLIGGADLASELDAKRAIDQGTRLAVSIG

Specific function: Catalyzes the NADP-dependent reduction of 2,4-dienoyl- CoA to yield trans-2- enoyl-CoA [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789463, Length=674, Percent_Identity=58.4569732937685, Blast_Score=840, Evalue=0.0,
Organism=Escherichia coli, GI1787939, Length=355, Percent_Identity=27.0422535211268, Blast_Score=99, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17565138, Length=226, Percent_Identity=30.0884955752212, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17540738, Length=218, Percent_Identity=28.4403669724771, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17564188, Length=232, Percent_Identity=26.7241379310345, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17559802, Length=227, Percent_Identity=26.431718061674, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17559804, Length=227, Percent_Identity=25.5506607929515, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI72001454, Length=232, Percent_Identity=25.8620689655172, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17566914, Length=222, Percent_Identity=27.9279279279279, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321973, Length=235, Percent_Identity=27.6595744680851, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6325086, Length=237, Percent_Identity=27.4261603375527, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR001155 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF07992 Pyr_redox_2 [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 72824; Mature: 72693

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAYPTLLSPLSLGFTTLKNRTIMGSMHTGLEEAPNGYDRMAAFYGERAKGGVALIVTGG
CCCCCCHHHHHHHCHHHHCCCEEEEHHHCCHHHCCCCHHHHHHHHCCCCCCCEEEEEECC
IAPNEAGRVAKGGSVMDTEEEALHHRVVTEAVHKEGGKIAMQILHTGRYGYHDKIVGASN
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCCCCCCCCCC
VRAPINMFKPHPLTEEEIWKTIEDFVRCSELAKLAGYDGVEIMGSEGYLINQFIAKRTNN
CCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCC
RIDDWGGSFENRIKFPIEIIKAVRKKLGTDFIIIYRLSMLDLVEEGGNIDEVLHLAKEIE
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHH
KAGATIINTGIGWHEARIPTIAMMVPRAAFTWVTAKVKGHVNIPLVTSNRINTPEVAEEV
HCCCEEEECCCCCCCCCCCEEEEHHCCHHEEEEEEEEECEEEEEEEECCCCCCHHHHHHH
LSRGDADLVSMARPFLADSFFVEKAKAGKPEEINTCIACNQACLDHIFQGKTASCLVNPR
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHCCCCCEEEECCC
ACHETELVITQTKNVKKVAVVGAGPGGMSCAKTLAERGHSVTLFDAQSELGGQLNIARRI
CCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECHHHCCCCEEEEECC
PGKEEFKETIRYFDTMLKKFKVNVKLNTYVSSEDLIAEGFEEVVLATGVIPRIPEIPGIN
CCHHHHHHHHHHHHHHHHHHEEEEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GPNVLSYVDVVLKGKPVGKRAVVMGAGGIGFDVSILLTDPGHAFTTENYLKEWGIQTSIE
CCCHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHCCCCEEEC
KNGGLGSKETPTGVRDVTMLKRSNSKFGATLGKTTGWIHKTSLEDRKVNQISGVTYKAIE
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCHHHHHCCCEEEEEC
SDGVVIEVKGETKKIPCDTVVVCAGQDPNRALLEPLQKAKIPVHLIGGADLASELDAKRA
CCCEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHH
IDQGTRLAVSIG
HCCCCEEEEEEC
>Mature Secondary Structure 
TAYPTLLSPLSLGFTTLKNRTIMGSMHTGLEEAPNGYDRMAAFYGERAKGGVALIVTGG
CCCCCHHHHHHHCHHHHCCCEEEEHHHCCHHHCCCCHHHHHHHHCCCCCCCEEEEEECC
IAPNEAGRVAKGGSVMDTEEEALHHRVVTEAVHKEGGKIAMQILHTGRYGYHDKIVGASN
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCCCCCCCCCC
VRAPINMFKPHPLTEEEIWKTIEDFVRCSELAKLAGYDGVEIMGSEGYLINQFIAKRTNN
CCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCC
RIDDWGGSFENRIKFPIEIIKAVRKKLGTDFIIIYRLSMLDLVEEGGNIDEVLHLAKEIE
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHH
KAGATIINTGIGWHEARIPTIAMMVPRAAFTWVTAKVKGHVNIPLVTSNRINTPEVAEEV
HCCCEEEECCCCCCCCCCCEEEEHHCCHHEEEEEEEEECEEEEEEEECCCCCCHHHHHHH
LSRGDADLVSMARPFLADSFFVEKAKAGKPEEINTCIACNQACLDHIFQGKTASCLVNPR
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHCCCCCEEEECCC
ACHETELVITQTKNVKKVAVVGAGPGGMSCAKTLAERGHSVTLFDAQSELGGQLNIARRI
CCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECHHHCCCCEEEEECC
PGKEEFKETIRYFDTMLKKFKVNVKLNTYVSSEDLIAEGFEEVVLATGVIPRIPEIPGIN
CCHHHHHHHHHHHHHHHHHHEEEEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GPNVLSYVDVVLKGKPVGKRAVVMGAGGIGFDVSILLTDPGHAFTTENYLKEWGIQTSIE
CCCHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHCCCCEEEC
KNGGLGSKETPTGVRDVTMLKRSNSKFGATLGKTTGWIHKTSLEDRKVNQISGVTYKAIE
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCHHHHHCCCEEEEEC
SDGVVIEVKGETKKIPCDTVVVCAGQDPNRALLEPLQKAKIPVHLIGGADLASELDAKRA
CCCEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHH
IDQGTRLAVSIG
HCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9346310; 9278503 [H]