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The map label for this gene is ykcC [H]

Identifier: 183221373

GI number: 183221373

Start: 2070832

End: 2071821

Strand: Reverse

Name: ykcC [H]

Synonym: LEPBI_I1991

Alternate gene names: 183221373

Gene position: 2071821-2070832 (Counterclockwise)

Preceding gene: 183221374

Following gene: 183221372

Centisome position: 57.56

GC content: 38.79

Gene sequence:

>990_bases
ATGAAATATTATTTAGAAAAACGCAATTTCCCGAAACTACTTTCGATTATTATTCCTTGTTATAATGAGGAATCGGTTCT
TCCCATTTTGAGAGAACGATTAGATTCATTCTTACCTAAGTTACCTTCAAAAGTGGAACTAATCTTAGTCAATGATGGCA
GTAGCGACCATACGATTTTTGAATTGGTTGATTGGGCAAATAAAGATTCCAGGGTGAAAATTGTGAGTCTTTCTCGGAAT
TTTGGTCATCAAATCGCAGTGACGGCGGGTATGGATTATGCAAAAGGGGATGCCGTTGTGATCATGGATGCTGATTTACA
GGATCCACCAGAAGTAATTCTCGAAATGTTAAACCGTTTCCAAGATGGATATGATGTGGTTTATGGACAAAGACTAACTC
GCTCTGGTGAGTCTTGGTTTAAGAAAATAACAGCATGGATTTTTTATCGACTCATGAAGGTTTTGGTTCATAAGGATTTA
CCATTAGATTCAGGAGACTTCCGATTGATTTCGAGGAGATGTTTGGATGCTTTGAATGGCCTAAGAGAAAATCATCGATT
TCTACGGGGAATGAACGCTTGGATTGGATTTCCACAAATTCCAGTTTATTATAAGCGTGATCCTCGTGTAGCTGGAGAAA
CAAAATATCCGCTTCAAAAAATGTTAAAGTTGGCTATGAATGCTGCTGTATCGTTTTCACCACTTCCCTTGAGGTTTAGT
TTAGGTCTGGGTATTTTTGTGGCCTTCATTGGCTTTGCGGTCGGTATGTATGCTCTCTACCGTGCTTTTCAACATTTTAT
ACTTCATATGCCAATTGTTTACAATCCAGGTTGGGCCACAATTGTGACACTTATCTGCCTCATCGGCGGTTCAATTTTAA
TTTCCATAGGGATTCTAGGCGAGTACGTAGCTAGAATTTTCGAGGAATCCAAAGGTCGGCCTTTGTATGTTGTAGAATTT
GTAAAATCACAACAGAAACAGAAGCGTTAA

Upstream 100 bases:

>100_bases
AAATATGAATTCTTTAATTAGCGAAGCATACCTATGAAATGGATTTAAATATTAAAGTATAAGTTATAAATAAGGTTACT
CAAGTAGATTAAGAAAGAAA

Downstream 100 bases:

>100_bases
CATCATAAATTTTCATCAGATAAGAAAGTTAAATAAATAAAATATGAGTCTTTTCAAAAGAATAAATTCTGCAGTATGGT
TTAAGAAATTTTTATTTCCC

Product: putative glycosyltransferase

Products: GDP; dolichyl D-mannosyl phosphate

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MKYYLEKRNFPKLLSIIIPCYNEESVLPILRERLDSFLPKLPSKVELILVNDGSSDHTIFELVDWANKDSRVKIVSLSRN
FGHQIAVTAGMDYAKGDAVVIMDADLQDPPEVILEMLNRFQDGYDVVYGQRLTRSGESWFKKITAWIFYRLMKVLVHKDL
PLDSGDFRLISRRCLDALNGLRENHRFLRGMNAWIGFPQIPVYYKRDPRVAGETKYPLQKMLKLAMNAAVSFSPLPLRFS
LGLGIFVAFIGFAVGMYALYRAFQHFILHMPIVYNPGWATIVTLICLIGGSILISIGILGEYVARIFEESKGRPLYVVEF
VKSQQKQKR

Sequences:

>Translated_329_residues
MKYYLEKRNFPKLLSIIIPCYNEESVLPILRERLDSFLPKLPSKVELILVNDGSSDHTIFELVDWANKDSRVKIVSLSRN
FGHQIAVTAGMDYAKGDAVVIMDADLQDPPEVILEMLNRFQDGYDVVYGQRLTRSGESWFKKITAWIFYRLMKVLVHKDL
PLDSGDFRLISRRCLDALNGLRENHRFLRGMNAWIGFPQIPVYYKRDPRVAGETKYPLQKMLKLAMNAAVSFSPLPLRFS
LGLGIFVAFIGFAVGMYALYRAFQHFILHMPIVYNPGWATIVTLICLIGGSILISIGILGEYVARIFEESKGRPLYVVEF
VKSQQKQKR
>Mature_329_residues
MKYYLEKRNFPKLLSIIIPCYNEESVLPILRERLDSFLPKLPSKVELILVNDGSSDHTIFELVDWANKDSRVKIVSLSRN
FGHQIAVTAGMDYAKGDAVVIMDADLQDPPEVILEMLNRFQDGYDVVYGQRLTRSGESWFKKITAWIFYRLMKVLVHKDL
PLDSGDFRLISRRCLDALNGLRENHRFLRGMNAWIGFPQIPVYYKRDPRVAGETKYPLQKMLKLAMNAAVSFSPLPLRFS
LGLGIFVAFIGFAVGMYALYRAFQHFILHMPIVYNPGWATIVTLICLIGGSILISIGILGEYVARIFEESKGRPLYVVEF
VKSQQKQKR

Specific function: Involved In O Antigen Modification. Catalyzes The Transfer Of The Glucose Residue From Udp-Glucose To A Lipid Carrier (By Similarity). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 2 family. GtrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503363, Length=234, Percent_Identity=27.3504273504274, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1788692, Length=311, Percent_Identity=35.6913183279743, Blast_Score=197, Evalue=7e-52,
Organism=Escherichia coli, GI1788588, Length=317, Percent_Identity=29.6529968454259, Blast_Score=153, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6325441, Length=109, Percent_Identity=33.9449541284404, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24585265, Length=174, Percent_Identity=31.6091954022989, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001173 [H]

Pfam domain/function: PF00535 Glycos_transf_2 [H]

EC number: 2.4.1.83

Molecular weight: Translated: 37720; Mature: 37720

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYYLEKRNFPKLLSIIIPCYNEESVLPILRERLDSFLPKLPSKVELILVNDGSSDHTIF
CCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHH
ELVDWANKDSRVKIVSLSRNFGHQIAVTAGMDYAKGDAVVIMDADLQDPPEVILEMLNRF
HHHHHCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
QDGYDVVYGQRLTRSGESWFKKITAWIFYRLMKVLVHKDLPLDSGDFRLISRRCLDALNG
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
LRENHRFLRGMNAWIGFPQIPVYYKRDPRVAGETKYPLQKMLKLAMNAAVSFSPLPLRFS
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEHH
LGLGIFVAFIGFAVGMYALYRAFQHFILHMPIVYNPGWATIVTLICLIGGSILISIGILG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHCCHHHHHHHHHH
EYVARIFEESKGRPLYVVEFVKSQQKQKR
HHHHHHHHHCCCCCEEEHHHHHHHHHHCC
>Mature Secondary Structure
MKYYLEKRNFPKLLSIIIPCYNEESVLPILRERLDSFLPKLPSKVELILVNDGSSDHTIF
CCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHH
ELVDWANKDSRVKIVSLSRNFGHQIAVTAGMDYAKGDAVVIMDADLQDPPEVILEMLNRF
HHHHHCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
QDGYDVVYGQRLTRSGESWFKKITAWIFYRLMKVLVHKDLPLDSGDFRLISRRCLDALNG
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
LRENHRFLRGMNAWIGFPQIPVYYKRDPRVAGETKYPLQKMLKLAMNAAVSFSPLPLRFS
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEHH
LGLGIFVAFIGFAVGMYALYRAFQHFILHMPIVYNPGWATIVTLICLIGGSILISIGILG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHCCHHHHHHHHHH
EYVARIFEESKGRPLYVVEFVKSQQKQKR
HHHHHHHHHCCCCCEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDPmannose; dolichyl phosphate

Specific reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]