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The map label for this gene is czcD [H]

Identifier: 183221221

GI number: 183221221

Start: 1923854

End: 1924834

Strand: Direct

Name: czcD [H]

Synonym: LEPBI_I1835

Alternate gene names: 183221221

Gene position: 1923854-1924834 (Clockwise)

Preceding gene: 183221220

Following gene: 183221224

Centisome position: 53.45

GC content: 40.57

Gene sequence:

>981_bases
ATGAGTAACAAACGACCCAAACGAAAAAAACTCATCTTCTACTTAAGTCTTTCAGGACTACTTTCGATTTTGATCTTTTG
TATCGAATGGGTTGGATCCAAAGAAAGCGGAAGCCTTGCACTCTTTGCTGATGCAGGGCATATTTTTGCCGATATCTTTG
CTCATCTCATCTCCCTTTTTGCCTTACTCATTGCTTCAAAAAAACCCAGCTCCAAATACCCGTTTGGTTTCCATCGTTTC
GAAGTGATTGCCGCTTTTTTAAATGGTCTTTTACTCATTGGTATCTCCCTATTCATTTTGTATGAAAGTTACGAACGATA
TTATGGAAATGCAACTGTTGAAGCAGATACCATGCTTGTGTATTCCCTCATAGGTTTTGGAATCAATCTGATTTCAGCAG
GTTTACTTGTTGGTGTGAGTAAAACAAGCCTCAACCTCAAGTCAGCCTACCTCCATGTTCTCAGTGATTTACTCGGAACT
TTAGCTGTGATTTTTGGAGCCCTACTCATTCGATTCACAGGTGTGAAACAAGTGGATAGTATCTTAAGCATCCTACTTGG
ATTGTTCATCTTAAAAACTTCGTATGGCATTGTGAAAGAGTCGGTCCAAATTCTCATTGAGGCCGATACCAGTGAATTCG
ACAAAGTCCATTTATTAGAACACATCAATGCACTATCAGGAATCCATTCAGTTCCCAAAATCACTGTACGCAAACTGACT
TCCGGTGTGTTTTCTGTGGAAATACAAGTGGCTACAAAGGATAACGCCAACCGTGACCAAATCACATTACAAATCCATCA
AGTCTTGAAGGAAGAATTTGGGGTACCGTTTGTATCTGTCGAAGTCCTGACTTATCCAATGCTGCAAAAATTGGAATCCC
TTACAGTTCGGGAATCAGAGCGAGAGTTTGGACACCATGGGCATGAACATGGTCATTCCCACGATCACAAACCAAACGAG
AAACACAAACATTCACACTAA

Upstream 100 bases:

>100_bases
CAACCTATTGTTCCCAATAGCACCAAAGAAAATAAGGCATTGAACCGAAGGGTGGACATTGTAGTCATTCCACGTGGTGC
AAGCTCACTCAACGGAAACC

Downstream 100 bases:

>100_bases
GCCATTCATTAAGTGGGTTTGTGTTTTTTCTTTTGGATTAAGTATTTGGTAAAGGAATCTTCCCAAACAAAAAGTTGGTA
GTCAGGGTCAATGGACTTTA

Product: putative cation efflux system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MSNKRPKRKKLIFYLSLSGLLSILIFCIEWVGSKESGSLALFADAGHIFADIFAHLISLFALLIASKKPSSKYPFGFHRF
EVIAAFLNGLLLIGISLFILYESYERYYGNATVEADTMLVYSLIGFGINLISAGLLVGVSKTSLNLKSAYLHVLSDLLGT
LAVIFGALLIRFTGVKQVDSILSILLGLFILKTSYGIVKESVQILIEADTSEFDKVHLLEHINALSGIHSVPKITVRKLT
SGVFSVEIQVATKDNANRDQITLQIHQVLKEEFGVPFVSVEVLTYPMLQKLESLTVRESEREFGHHGHEHGHSHDHKPNE
KHKHSH

Sequences:

>Translated_326_residues
MSNKRPKRKKLIFYLSLSGLLSILIFCIEWVGSKESGSLALFADAGHIFADIFAHLISLFALLIASKKPSSKYPFGFHRF
EVIAAFLNGLLLIGISLFILYESYERYYGNATVEADTMLVYSLIGFGINLISAGLLVGVSKTSLNLKSAYLHVLSDLLGT
LAVIFGALLIRFTGVKQVDSILSILLGLFILKTSYGIVKESVQILIEADTSEFDKVHLLEHINALSGIHSVPKITVRKLT
SGVFSVEIQVATKDNANRDQITLQIHQVLKEEFGVPFVSVEVLTYPMLQKLESLTVRESEREFGHHGHEHGHSHDHKPNE
KHKHSH
>Mature_325_residues
SNKRPKRKKLIFYLSLSGLLSILIFCIEWVGSKESGSLALFADAGHIFADIFAHLISLFALLIASKKPSSKYPFGFHRFE
VIAAFLNGLLLIGISLFILYESYERYYGNATVEADTMLVYSLIGFGINLISAGLLVGVSKTSLNLKSAYLHVLSDLLGTL
AVIFGALLIRFTGVKQVDSILSILLGLFILKTSYGIVKESVQILIEADTSEFDKVHLLEHINALSGIHSVPKITVRKLTS
GVFSVEIQVATKDNANRDQITLQIHQVLKEEFGVPFVSVEVLTYPMLQKLESLTVRESEREFGHHGHEHGHSHDHKPNEK
HKHSH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21359890, Length=308, Percent_Identity=26.9480519480519, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI52352805, Length=298, Percent_Identity=23.489932885906, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI289803013, Length=280, Percent_Identity=25.7142857142857, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI289803009, Length=280, Percent_Identity=25.7142857142857, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI289803007, Length=280, Percent_Identity=25.7142857142857, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI289803003, Length=280, Percent_Identity=25.7142857142857, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI64762489, Length=276, Percent_Identity=26.0869565217391, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI20070323, Length=328, Percent_Identity=22.5609756097561, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786966, Length=264, Percent_Identity=32.5757575757576, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI193210990, Length=302, Percent_Identity=26.8211920529801, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17555794, Length=319, Percent_Identity=24.7648902821317, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17555796, Length=302, Percent_Identity=25.8278145695364, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI32564488, Length=295, Percent_Identity=27.1186440677966, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320411, Length=223, Percent_Identity=31.390134529148, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24585900, Length=117, Percent_Identity=31.6239316239316, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24585898, Length=117, Percent_Identity=31.6239316239316, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24585896, Length=117, Percent_Identity=31.6239316239316, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI19921672, Length=117, Percent_Identity=31.6239316239316, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 36251; Mature: 36120

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKRPKRKKLIFYLSLSGLLSILIFCIEWVGSKESGSLALFADAGHIFADIFAHLISLF
CCCCCCCHHHEEEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHH
ALLIASKKPSSKYPFGFHRFEVIAAFLNGLLLIGISLFILYESYERYYGNATVEADTMLV
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHH
YSLIGFGINLISAGLLVGVSKTSLNLKSAYLHVLSDLLGTLAVIFGALLIRFTGVKQVDS
HHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ILSILLGLFILKTSYGIVKESVQILIEADTSEFDKVHLLEHINALSGIHSVPKITVRKLT
HHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
SGVFSVEIQVATKDNANRDQITLQIHQVLKEEFGVPFVSVEVLTYPMLQKLESLTVRESE
CCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHH
REFGHHGHEHGHSHDHKPNEKHKHSH
HHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SNKRPKRKKLIFYLSLSGLLSILIFCIEWVGSKESGSLALFADAGHIFADIFAHLISLF
CCCCCCHHHEEEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHH
ALLIASKKPSSKYPFGFHRFEVIAAFLNGLLLIGISLFILYESYERYYGNATVEADTMLV
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHH
YSLIGFGINLISAGLLVGVSKTSLNLKSAYLHVLSDLLGTLAVIFGALLIRFTGVKQVDS
HHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ILSILLGLFILKTSYGIVKESVQILIEADTSEFDKVHLLEHINALSGIHSVPKITVRKLT
HHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
SGVFSVEIQVATKDNANRDQITLQIHQVLKEEFGVPFVSVEVLTYPMLQKLESLTVRESE
CCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHH
REFGHHGHEHGHSHDHKPNEKHKHSH
HHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]