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The map label for this gene is 183221149

Identifier: 183221149

GI number: 183221149

Start: 1841476

End: 1842042

Strand: Direct

Name: 183221149

Synonym: LEPBI_I1763

Alternate gene names: NA

Gene position: 1841476-1842042 (Clockwise)

Preceding gene: 183221141

Following gene: 183221151

Centisome position: 51.16

GC content: 39.68

Gene sequence:

>567_bases
TTGTCAAAATCCTTGCAATCCTTTAATCCTTCTCGGAGATTGAAAGTATCAATGAGTTCCTATGAAGAACATTCCATACG
TAAAAATCTCTTTAGCATAGGGAAATTAGGATATGCAAAAGGGGACAGACCCAATGTAGAATGTATCCTATGTGGTGTAC
GCGACAAAAATGAAATTGTCCCGAATCTCACCATTGCAGAAACGGATCTTTCCATCGTTTCGATCAATTTATTTCCCTAC
AATCCAGGACACATCATCATATTTCCCAAACGCCATATCATCCATTATTTAGAACTGACTGACGAAGAGGCTTTGGATAT
CCATAGACTGACCCAAAAAACCATGAGGATTTTGGAACAACAATGGAAGGTACAAGGTTTCAATACGGGATACAATTTGG
GGAAAAACAGTGGAGGGTCCATCCCCCACATCCACGAACACATTGTGCCTAGGTTTCCGAACGAAGCGGGATTTTTAGAT
GTACTTTCCAACACAAGGATTGTCATCTACGAACCTTACCAAATGTGGGAAGACCTAAAAAAACTTTGGGTAAAAGAAGA
AAACTAA

Upstream 100 bases:

>100_bases
GCGGATTCGGATTTTTGGTCTGTTGTAATAAGGAGATGACTTCACTTGGCAGGACGGGTATGTGAGGAGATTCTAACACT
GTTACTTTCTTACTGTATAC

Downstream 100 bases:

>100_bases
ATTTACGTTTTCTTCTGGTAAATCGTATGACCTAAAAACTTAAATTGGTCTGAGATTCCAAACATGGTTTCCGAGTGGCC
AAGGATCAAATACCCTTTGG

Product: putative hydrolase

Products: NA

Alternate protein names: ATP adenylyltransferase; Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase; AP,A phosphorylase [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MSKSLQSFNPSRRLKVSMSSYEEHSIRKNLFSIGKLGYAKGDRPNVECILCGVRDKNEIVPNLTIAETDLSIVSINLFPY
NPGHIIIFPKRHIIHYLELTDEEALDIHRLTQKTMRILEQQWKVQGFNTGYNLGKNSGGSIPHIHEHIVPRFPNEAGFLD
VLSNTRIVIYEPYQMWEDLKKLWVKEEN

Sequences:

>Translated_188_residues
MSKSLQSFNPSRRLKVSMSSYEEHSIRKNLFSIGKLGYAKGDRPNVECILCGVRDKNEIVPNLTIAETDLSIVSINLFPY
NPGHIIIFPKRHIIHYLELTDEEALDIHRLTQKTMRILEQQWKVQGFNTGYNLGKNSGGSIPHIHEHIVPRFPNEAGFLD
VLSNTRIVIYEPYQMWEDLKKLWVKEEN
>Mature_187_residues
SKSLQSFNPSRRLKVSMSSYEEHSIRKNLFSIGKLGYAKGDRPNVECILCGVRDKNEIVPNLTIAETDLSIVSINLFPYN
PGHIIIFPKRHIIHYLELTDEEALDIHRLTQKTMRILEQQWKVQGFNTGYNLGKNSGGSIPHIHEHIVPRFPNEAGFLDV
LSNTRIVIYEPYQMWEDLKKLWVKEEN

Specific function: Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues [H]

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI17556280, Length=87, Percent_Identity=34.4827586206897, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: =2.7.7.53 [H]

Molecular weight: Translated: 21788; Mature: 21657

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSLQSFNPSRRLKVSMSSYEEHSIRKNLFSIGKLGYAKGDRPNVECILCGVRDKNEIV
CCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCC
PNLTIAETDLSIVSINLFPYNPGHIIIFPKRHIIHYLELTDEEALDIHRLTQKTMRILEQ
CCCEEEECCEEEEEEEEEECCCCEEEEECCHHEEEEEECCCCHHHHHHHHHHHHHHHHHH
QWKVQGFNTGYNLGKNSGGSIPHIHEHIVPRFPNEAGFLDVLSNTRIVIYEPYQMWEDLK
HHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCEEECCCCEEEEECCHHHHHHHH
KLWVKEEN
HHHCCCCC
>Mature Secondary Structure 
SKSLQSFNPSRRLKVSMSSYEEHSIRKNLFSIGKLGYAKGDRPNVECILCGVRDKNEIV
CCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCC
PNLTIAETDLSIVSINLFPYNPGHIIIFPKRHIIHYLELTDEEALDIHRLTQKTMRILEQ
CCCEEEECCEEEEEEEEEECCCCEEEEECCHHEEEEEECCCCHHHHHHHHHHHHHHHHHH
QWKVQGFNTGYNLGKNSGGSIPHIHEHIVPRFPNEAGFLDVLSNTRIVIYEPYQMWEDLK
HHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCEEECCCCEEEEECCHHHHHHHH
KLWVKEEN
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036 [H]