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The map label for this gene is ruvA

Identifier: 183220888

GI number: 183220888

Start: 1561155

End: 1561754

Strand: Reverse

Name: ruvA

Synonym: LEPBI_I1501

Alternate gene names: 183220888

Gene position: 1561754-1561155 (Counterclockwise)

Preceding gene: 183220892

Following gene: 183220885

Centisome position: 43.39

GC content: 39.17

Gene sequence:

>600_bases
ATGATAGCAAGTTTACGCGGTAAATTACTCCAATTAGAAATTGATCGTTTGGTGGTGGAAGTGTCCGGTGTCGGGTATGA
AGTGATGATTCCCTTTCCCCTCCACTTGGAATGTAAGGACAAACTCAATACGGAAATTTATATCCATACGTTCCACTCCA
TCACTGATCGCGGGCAAAGACTATTTGGTTTTGGTTCTAAAAAAGATCGGGAATCCTTCGAACTCATCAAATCCCTCCAC
GGGATTGGAGAACTCACGGCACTCAAAATCCTTTCCTTTTTCCAAGCGGATGATTTGTATCAAATCGCCAAAGCAGATGA
TAAAAAAACCTTAGAAAAAATCCCCAAAGTAAAAGGAAAAACATCTGAAAAAATCCTTTTTGAAATCAAACAGAACCTAA
AAAAATTCGAAATGTTTTTAAACGAAGGGACAACCGAATCCAGTTTTGTGGATCGGGAAACAGACCTTGCAACTCTTGCT
TTAATCCAATTGGGTTTTGATGAAAAATCTGCCACCAAACAAGTTGCAGATGCCAAAAAATTAAATCCAGGTTTAAGTGC
CTCAGACATCGTAAAACAAGTGATTACTGGGACCAGATGA

Upstream 100 bases:

>100_bases
AAGCAACCTTTTTGTTCGATCGGATTGTGATTTGATCCAATGAAAAAAGAAGAGTAGTCATATTTGATCCATTCTTACAA
TGGGAAGGAAGAAGTGTTCC

Downstream 100 bases:

>100_bases
TTCAGAACATTCGGTGCAAATACCAACTGTTTTTTAATTTGATGAAACTCGGATTGATAAGGTAACGTTCTAGTTTAGGT
TGATCAGGGAATCGGAATTT

Product: Holliday junction DNA helicase RuvA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MIASLRGKLLQLEIDRLVVEVSGVGYEVMIPFPLHLECKDKLNTEIYIHTFHSITDRGQRLFGFGSKKDRESFELIKSLH
GIGELTALKILSFFQADDLYQIAKADDKKTLEKIPKVKGKTSEKILFEIKQNLKKFEMFLNEGTTESSFVDRETDLATLA
LIQLGFDEKSATKQVADAKKLNPGLSASDIVKQVITGTR

Sequences:

>Translated_199_residues
MIASLRGKLLQLEIDRLVVEVSGVGYEVMIPFPLHLECKDKLNTEIYIHTFHSITDRGQRLFGFGSKKDRESFELIKSLH
GIGELTALKILSFFQADDLYQIAKADDKKTLEKIPKVKGKTSEKILFEIKQNLKKFEMFLNEGTTESSFVDRETDLATLA
LIQLGFDEKSATKQVADAKKLNPGLSASDIVKQVITGTR
>Mature_199_residues
MIASLRGKLLQLEIDRLVVEVSGVGYEVMIPFPLHLECKDKLNTEIYIHTFHSITDRGQRLFGFGSKKDRESFELIKSLH
GIGELTALKILSFFQADDLYQIAKADDKKTLEKIPKVKGKTSEKILFEIKQNLKKFEMFLNEGTTESSFVDRETDLATLA
LIQLGFDEKSATKQVADAKKLNPGLSASDIVKQVITGTR

Specific function: The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday

COG id: COG0632

COG function: function code L; Holliday junction resolvasome, DNA-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvA family

Homologues:

Organism=Escherichia coli, GI1788168, Length=203, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVA_LEPBA (B0SGZ5)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001962540.1
- ProteinModelPortal:   B0SGZ5
- SMR:   B0SGZ5
- GeneID:   6388075
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_1447
- HOGENOM:   HBG529249
- OMA:   FRERILF
- ProtClustDB:   CLSK574640
- BioCyc:   LBIF355278:LBF_1447-MONOMER
- HAMAP:   MF_00031
- InterPro:   IPR011114
- InterPro:   IPR013849
- InterPro:   IPR003583
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR000085
- InterPro:   IPR010994
- Gene3D:   G3DSA:2.40.50.140
- SMART:   SM00278

Pfam domain/function: PF07499 RuvA_C; PF01330 RuvA_N; SSF50249 Nucleic_acid_OB; SSF47781 RuvA_2_like

EC number: =3.6.4.12

Molecular weight: Translated: 22393; Mature: 22393

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIASLRGKLLQLEIDRLVVEVSGVGYEVMIPFPLHLECKDKLNTEIYIHTFHSITDRGQR
CCCCCCHHHHEEEHHHHEEEECCCCEEEEECCCCCEEECCCCCCEEEEEEHHHHHHCCHH
LFGFGSKKDRESFELIKSLHGIGELTALKILSFFQADDLYQIAKADDKKTLEKIPKVKGK
EECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHCCCCCCC
TSEKILFEIKQNLKKFEMFLNEGTTESSFVDRETDLATLALIQLGFDEKSATKQVADAKK
CHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LNPGLSASDIVKQVITGTR
CCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MIASLRGKLLQLEIDRLVVEVSGVGYEVMIPFPLHLECKDKLNTEIYIHTFHSITDRGQR
CCCCCCHHHHEEEHHHHEEEECCCCEEEEECCCCCEEECCCCCCEEEEEEHHHHHHCCHH
LFGFGSKKDRESFELIKSLHGIGELTALKILSFFQADDLYQIAKADDKKTLEKIPKVKGK
EECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHCCCCCCC
TSEKILFEIKQNLKKFEMFLNEGTTESSFVDRETDLATLALIQLGFDEKSATKQVADAKK
CHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LNPGLSASDIVKQVITGTR
CCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA