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The map label for this gene is cssR [H]

Identifier: 183220810

GI number: 183220810

Start: 1484784

End: 1485467

Strand: Reverse

Name: cssR [H]

Synonym: LEPBI_I1422

Alternate gene names: 183220810

Gene position: 1485467-1484784 (Counterclockwise)

Preceding gene: 183220811

Following gene: 183220809

Centisome position: 41.27

GC content: 46.49

Gene sequence:

>684_bases
ATGAAACCAAGAATTTTACTCGTAGAAGATGATGAGGGCCTCGGGGAAACCTTAAAAGAACGTTTGGAACAAGACAAATA
CCGTGTAGAGTGGGCCAAAACAATTTCCGAGGCTGAAAACCTCTACCGACCAAATGCCTTTGATTTGGTCGTTCTCGACT
TACGGTTACCTGATGGGAATGGATTTGATTTAGCGGAAATGATTGTCAAAAAGGAAAAGGACCTTCCTTTTTTATTCCTC
ACAGCCCAAGCAGGGGCACAGGAACGACTCCGCGGCTTTGAGTTAGGTGCTGCTGAATTCATTCCCAAACCCTTTCACTT
AAAAGAATTCCTGATTCGTTTGGAACGTGTGATCTCCCTCACCCGCCCGCATTATGGCCAAAAATGGAAAATGGATACAA
AAGAAATCCATTTGGACTCCTTTCTGATTAAAAACGAGGATGGAACGAGCACCCTTCTCTCCAAACGAGATTGTTCCCTA
CTTGCCCTCCTCCTCACAGATCCCGCAAAAGTATTTAGCCGCTCGGAAATTTTGGATTTTATCGTAGGGGAAGACAGTTT
CCCAACGGAACGGACCATCGACAATGCCATTGTGCGCCTGCGAGATGCCCTGGGGGAAGGATCCATCCGAAATGTAAGGG
GTGTGGGTTACCAATGGATAGGCCCTCTTCAACCCTTGGTATGA

Upstream 100 bases:

>100_bases
TTTATATTGTGAAAAAATTGATGGAAAAGATGAAAGGGAAATTAGAATTTCCGAACAGTTCGTACGGATTTCAAGTCAAA
CTGAGTTTGAACGAGGTCAC

Downstream 100 bases:

>100_bases
CCAACTTCCGCCTTATGGAATTCGGAAAATCCACCGATACTCTAAGGGATGAAACAAGGAATTCTCTATAGTTTATTATT
TTTGGGATCCTTGTTTTCGG

Product: putative two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MKPRILLVEDDEGLGETLKERLEQDKYRVEWAKTISEAENLYRPNAFDLVVLDLRLPDGNGFDLAEMIVKKEKDLPFLFL
TAQAGAQERLRGFELGAAEFIPKPFHLKEFLIRLERVISLTRPHYGQKWKMDTKEIHLDSFLIKNEDGTSTLLSKRDCSL
LALLLTDPAKVFSRSEILDFIVGEDSFPTERTIDNAIVRLRDALGEGSIRNVRGVGYQWIGPLQPLV

Sequences:

>Translated_227_residues
MKPRILLVEDDEGLGETLKERLEQDKYRVEWAKTISEAENLYRPNAFDLVVLDLRLPDGNGFDLAEMIVKKEKDLPFLFL
TAQAGAQERLRGFELGAAEFIPKPFHLKEFLIRLERVISLTRPHYGQKWKMDTKEIHLDSFLIKNEDGTSTLLSKRDCSL
LALLLTDPAKVFSRSEILDFIVGEDSFPTERTIDNAIVRLRDALGEGSIRNVRGVGYQWIGPLQPLV
>Mature_227_residues
MKPRILLVEDDEGLGETLKERLEQDKYRVEWAKTISEAENLYRPNAFDLVVLDLRLPDGNGFDLAEMIVKKEKDLPFLFL
TAQAGAQERLRGFELGAAEFIPKPFHLKEFLIRLERVISLTRPHYGQKWKMDTKEIHLDSFLIKNEDGTSTLLSKRDCSL
LALLLTDPAKVFSRSEILDFIVGEDSFPTERTIDNAIVRLRDALGEGSIRNVRGVGYQWIGPLQPLV

Specific function: Member of the two-component regulatory system CssS/CssR required to control the cellular response to secretion stress [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=30.9734513274336, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=32.2869955156951, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=27.6595744680851, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=28.9473684210526, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1789402, Length=216, Percent_Identity=32.4074074074074, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1786784, Length=219, Percent_Identity=29.6803652968037, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790552, Length=228, Percent_Identity=28.9473684210526, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=27.3542600896861, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=27.0742358078603, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=24.8888888888889, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=29.8245614035088, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=26.2008733624454, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=24.4444444444444, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25954; Mature: 25954

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPRILLVEDDEGLGETLKERLEQDKYRVEWAKTISEAENLYRPNAFDLVVLDLRLPDGN
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCC
GFDLAEMIVKKEKDLPFLFLTAQAGAQERLRGFELGAAEFIPKPFHLKEFLIRLERVISL
CCHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHH
TRPHYGQKWKMDTKEIHLDSFLIKNEDGTSTLLSKRDCSLLALLLTDPAKVFSRSEILDF
HCCCCCCCCCCCHHHEEHHHEEEECCCCCHHHHHHCCHHEEEHHHCCHHHHHHHHHHHHH
IVGEDSFPTERTIDNAIVRLRDALGEGSIRNVRGVGYQWIGPLQPLV
HCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCC
>Mature Secondary Structure
MKPRILLVEDDEGLGETLKERLEQDKYRVEWAKTISEAENLYRPNAFDLVVLDLRLPDGN
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCC
GFDLAEMIVKKEKDLPFLFLTAQAGAQERLRGFELGAAEFIPKPFHLKEFLIRLERVISL
CCHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHH
TRPHYGQKWKMDTKEIHLDSFLIKNEDGTSTLLSKRDCSLLALLLTDPAKVFSRSEILDF
HCCCCCCCCCCCHHHEEHHHEEEECCCCCHHHHHHCCHHEEEHHHCCHHHHHHHHHHHHH
IVGEDSFPTERTIDNAIVRLRDALGEGSIRNVRGVGYQWIGPLQPLV
HCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9639930; 9384377; 11555295 [H]