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The map label for this gene is pdxH

Identifier: 183220796

GI number: 183220796

Start: 1466248

End: 1466886

Strand: Reverse

Name: pdxH

Synonym: LEPBI_I1407

Alternate gene names: 183220796

Gene position: 1466886-1466248 (Counterclockwise)

Preceding gene: 183220797

Following gene: 183220794

Centisome position: 40.75

GC content: 42.88

Gene sequence:

>639_bases
TTGAATGATTTAGCGCATATGCGCACAAATTACGTACGTTCTGTCCTTTCGGAAGAGACAGCTGGTTTTGATCCATTGGC
ACTTTTTTCGTTATGGTTTTCTGAGGCCAAAGAAGAAGGAGAGTTAGAACCCAATGCCATGAGCCTTTCCACAGTGAACA
CGGATGGCAAACCATCTGTCCGAATTGTACTCCTCAAAGGCCTTATCCGAAACGAGTTTCAATTTTTCACTAACTACAGT
TCCCACAAAGGAAAGGACATCGAACAAAATCGGAACGTGGCACTCACTTTTTTTTGGCCCAAAATGGAACGCCAAATTCG
TATCGAAGGAACAGTAACAAAAATACCAAAAGAAGAATCCGAAGCCTACTTTAAAATCCGACCAAGAGAATCACAACTAG
GAGCCCTCACATCAAACCAAAGTTCGGTGGTGGTTTCTAGAGAAGAATTGGAAACCAAGTTTCAAACTCTCGAGAAAGAA
TGGGAAGGGAAAGAGATACCCATGCCGGAATCTTGGGGAGGGTATTCGGTATCTCCTAACAAAATTGAATTTTGGCAAGG
TAGAGCGGGTAGACTCCATGACCGAATTGTATTCGAACGGAAAAACGAAAATTGGATTCGGTCGAGACTATCGCCTTAA

Upstream 100 bases:

>100_bases
CCGATGGGACTCTATTTTTCATTAGGAATCTTTTTTACTTTTTTTTTCAAACTAATCGTCCATTATTATGAATGGGAGGG
GTTCTTAAATTATGGAAACA

Downstream 100 bases:

>100_bases
ATGAATGTCTCTTTTGAAAACATTTACTCAAATTCGAACATTGGAATTTAACGCAGAAAAACGTTTAACCGTGTAAGTTC
AAAAGATGTCCCAGTTTTGT

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MNDLAHMRTNYVRSVLSEETAGFDPLALFSLWFSEAKEEGELEPNAMSLSTVNTDGKPSVRIVLLKGLIRNEFQFFTNYS
SHKGKDIEQNRNVALTFFWPKMERQIRIEGTVTKIPKEESEAYFKIRPRESQLGALTSNQSSVVVSREELETKFQTLEKE
WEGKEIPMPESWGGYSVSPNKIEFWQGRAGRLHDRIVFERKNENWIRSRLSP

Sequences:

>Translated_212_residues
MNDLAHMRTNYVRSVLSEETAGFDPLALFSLWFSEAKEEGELEPNAMSLSTVNTDGKPSVRIVLLKGLIRNEFQFFTNYS
SHKGKDIEQNRNVALTFFWPKMERQIRIEGTVTKIPKEESEAYFKIRPRESQLGALTSNQSSVVVSREELETKFQTLEKE
WEGKEIPMPESWGGYSVSPNKIEFWQGRAGRLHDRIVFERKNENWIRSRLSP
>Mature_212_residues
MNDLAHMRTNYVRSVLSEETAGFDPLALFSLWFSEAKEEGELEPNAMSLSTVNTDGKPSVRIVLLKGLIRNEFQFFTNYS
SHKGKDIEQNRNVALTFFWPKMERQIRIEGTVTKIPKEESEAYFKIRPRESQLGALTSNQSSVVVSREELETKFQTLEKE
WEGKEIPMPESWGGYSVSPNKIEFWQGRAGRLHDRIVFERKNENWIRSRLSP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=229, Percent_Identity=44.1048034934498, Blast_Score=200, Evalue=6e-52,
Organism=Escherichia coli, GI1787926, Length=212, Percent_Identity=41.5094339622642, Blast_Score=176, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17553712, Length=220, Percent_Identity=45, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6319509, Length=208, Percent_Identity=43.75, Blast_Score=165, Evalue=4e-42,
Organism=Drosophila melanogaster, GI45551845, Length=229, Percent_Identity=39.7379912663755, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24644901, Length=229, Percent_Identity=39.7379912663755, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24644903, Length=191, Percent_Identity=28.2722513089005, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_LEPBA (B0SGE9)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001962451.1
- ProteinModelPortal:   B0SGE9
- SMR:   B0SGE9
- GeneID:   6389499
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_1353
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- ProtClustDB:   CLSK2336578
- BioCyc:   LBIF355278:LBF_1353-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24621; Mature: 24621

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 61-61 BINDING 64-64 BINDING 66-66 BINDING 83-83 BINDING 123-123 BINDING 127-127 BINDING 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLAHMRTNYVRSVLSEETAGFDPLALFSLWFSEAKEEGELEPNAMSLSTVNTDGKPSV
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCE
RIVLLKGLIRNEFQFFTNYSSHKGKDIEQNRNVALTFFWPKMERQIRIEGTVTKIPKEES
EEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEECCCCCC
EAYFKIRPRESQLGALTSNQSSVVVSREELETKFQTLEKEWEGKEIPMPESWGGYSVSPN
CCEEEECCCCHHHCEEECCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
KIEFWQGRAGRLHDRIVFERKNENWIRSRLSP
EEEEECCCCCCCCCEEEEEECCCHHHHHCCCC
>Mature Secondary Structure
MNDLAHMRTNYVRSVLSEETAGFDPLALFSLWFSEAKEEGELEPNAMSLSTVNTDGKPSV
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCE
RIVLLKGLIRNEFQFFTNYSSHKGKDIEQNRNVALTFFWPKMERQIRIEGTVTKIPKEES
EEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEECCCCCC
EAYFKIRPRESQLGALTSNQSSVVVSREELETKFQTLEKEWEGKEIPMPESWGGYSVSPN
CCEEEECCCCHHHCEEECCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
KIEFWQGRAGRLHDRIVFERKNENWIRSRLSP
EEEEECCCCCCCCCEEEEEECCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA