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The map label for this gene is ahpC2 [C]

Identifier: 183220748

GI number: 183220748

Start: 1414651

End: 1415244

Strand: Direct

Name: ahpC2 [C]

Synonym: LEPBI_I1358

Alternate gene names: 183220748

Gene position: 1414651-1415244 (Clockwise)

Preceding gene: 183220747

Following gene: 183220749

Centisome position: 39.3

GC content: 40.4

Gene sequence:

>594_bases
ATGCCACAAGTGACATCACATGCCCCTGATTTTAAAGCAACCGCAGTGATCGGGGACAGTTTCAAAGAAATCAAATTATC
TGATTACAAGGGAAAATGGGTGGTACTCTTTTTCTATCCACTTGATTTTACATTTGTATGTCCAACAGAGATCATTGAAT
ACGATGCAAAACTAGAAGATTTTAAAAAGATCGGAGCTGAAGTTTTGGGTGTATCTGTTGATAGCGAATTTTCACACTTA
GCTTGGAAAAAAACGCCTAAAAAAGAAGGTGGTATTGGAGAGATCAAATACCCACTCATCGCAGACAAAACAAAAGAAAT
TGCAAAGTCTTTTGGTGTTCTCATTGAGTCAGGTCCTGATGCAGGAGTTGCTTTACGCGGAACTTTCATCATCGACCCAC
AAGGTATCATCCGCCAAGCAACTGTTAACGACCTTCCAGTAGGACGTAACATTGAAGAAGCACTCAGACTCATCAAGGCT
TTCCAATTCGTGGAAAAACATGGTGAAGTTTGTCCTGCAAACTGGGATGAAGGGAAAAAAACGATGAAAGCAGATCCTAC
AGGGTCCAAAGCTTACTTCGCTTCTGTAAATTAA

Upstream 100 bases:

>100_bases
TGGCAAGTGAGGAGTGGGATTTGGAAAACTTCCGGCTCAGACAAAAACATCTAGACAGAATCTAAGCATTGTACTTAGAA
TAATTCTAAGGAGTGACATT

Downstream 100 bases:

>100_bases
TTTCAATTTCTCTATCAGTAGAGAATGGGAGAAACAATGGAATCTACAACAAACACGGACAAGACGAATGTTCAATTTTA
CCAAGCGGACAATTTTCCAA

Product: alkyl hydroperoxide reductase subunit C

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MPQVTSHAPDFKATAVIGDSFKEIKLSDYKGKWVVLFFYPLDFTFVCPTEIIEYDAKLEDFKKIGAEVLGVSVDSEFSHL
AWKKTPKKEGGIGEIKYPLIADKTKEIAKSFGVLIESGPDAGVALRGTFIIDPQGIIRQATVNDLPVGRNIEEALRLIKA
FQFVEKHGEVCPANWDEGKKTMKADPTGSKAYFASVN

Sequences:

>Translated_197_residues
MPQVTSHAPDFKATAVIGDSFKEIKLSDYKGKWVVLFFYPLDFTFVCPTEIIEYDAKLEDFKKIGAEVLGVSVDSEFSHL
AWKKTPKKEGGIGEIKYPLIADKTKEIAKSFGVLIESGPDAGVALRGTFIIDPQGIIRQATVNDLPVGRNIEEALRLIKA
FQFVEKHGEVCPANWDEGKKTMKADPTGSKAYFASVN
>Mature_196_residues
PQVTSHAPDFKATAVIGDSFKEIKLSDYKGKWVVLFFYPLDFTFVCPTEIIEYDAKLEDFKKIGAEVLGVSVDSEFSHLA
WKKTPKKEGGIGEIKYPLIADKTKEIAKSFGVLIESGPDAGVALRGTFIIDPQGIIRQATVNDLPVGRNIEEALRLIKAF
QFVEKHGEVCPANWDEGKKTMKADPTGSKAYFASVN

Specific function: Reduces peroxides. May play an important role in eliminating peroxides generated during metabolism [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=190, Percent_Identity=62.1052631578947, Blast_Score=255, Evalue=1e-68,
Organism=Homo sapiens, GI5802974, Length=196, Percent_Identity=58.1632653061224, Blast_Score=254, Evalue=4e-68,
Organism=Homo sapiens, GI32483377, Length=193, Percent_Identity=57.5129533678757, Blast_Score=246, Evalue=7e-66,
Organism=Homo sapiens, GI5453549, Length=195, Percent_Identity=54.8717948717949, Blast_Score=239, Evalue=1e-63,
Organism=Homo sapiens, GI4505591, Length=188, Percent_Identity=60.1063829787234, Blast_Score=239, Evalue=1e-63,
Organism=Homo sapiens, GI32455266, Length=188, Percent_Identity=60.1063829787234, Blast_Score=239, Evalue=1e-63,
Organism=Homo sapiens, GI32455264, Length=188, Percent_Identity=60.1063829787234, Blast_Score=239, Evalue=1e-63,
Organism=Homo sapiens, GI33188454, Length=88, Percent_Identity=69.3181818181818, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI4758638, Length=182, Percent_Identity=29.1208791208791, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1786822, Length=183, Percent_Identity=42.0765027322404, Blast_Score=147, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17554494, Length=189, Percent_Identity=57.1428571428571, Blast_Score=234, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI193204376, Length=186, Percent_Identity=57.5268817204301, Blast_Score=228, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI32565831, Length=186, Percent_Identity=57.5268817204301, Blast_Score=228, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI25153706, Length=183, Percent_Identity=28.9617486338798, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323613, Length=195, Percent_Identity=54.3589743589744, Blast_Score=218, Evalue=7e-58,
Organism=Saccharomyces cerevisiae, GI6320661, Length=195, Percent_Identity=52.8205128205128, Blast_Score=211, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6319407, Length=179, Percent_Identity=33.5195530726257, Blast_Score=99, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17157991, Length=197, Percent_Identity=58.3756345177665, Blast_Score=251, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24641739, Length=197, Percent_Identity=58.3756345177665, Blast_Score=251, Evalue=2e-67,
Organism=Drosophila melanogaster, GI17738015, Length=194, Percent_Identity=58.2474226804124, Blast_Score=249, Evalue=8e-67,
Organism=Drosophila melanogaster, GI24656348, Length=194, Percent_Identity=54.1237113402062, Blast_Score=229, Evalue=8e-61,
Organism=Drosophila melanogaster, GI17864676, Length=194, Percent_Identity=54.1237113402062, Blast_Score=229, Evalue=8e-61,
Organism=Drosophila melanogaster, GI21357347, Length=193, Percent_Identity=50.7772020725389, Blast_Score=219, Evalue=7e-58,
Organism=Drosophila melanogaster, GI17975518, Length=181, Percent_Identity=36.4640883977901, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24652436, Length=181, Percent_Identity=35.9116022099448, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24652434, Length=182, Percent_Identity=35.7142857142857, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24581278, Length=179, Percent_Identity=31.8435754189944, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 21759; Mature: 21628

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQVTSHAPDFKATAVIGDSFKEIKLSDYKGKWVVLFFYPLDFTFVCPTEIIEYDAKLED
CCCCCCCCCCCEEEEEECCCCCEEEEECCCCCEEEEEEECCCEEEECCHHHHHHCCCHHH
FKKIGAEVLGVSVDSEFSHLAWKKTPKKEGGIGEIKYPLIADKTKEIAKSFGVLIESGPD
HHHHHHHHEEECCCCCHHHHHHCCCCCCCCCCCCEECCEECCHHHHHHHHHCEEEECCCC
AGVALRGTFIIDPQGIIRQATVNDLPVGRNIEEALRLIKAFQFVEKHGEVCPANWDEGKK
CCEEEEEEEEECCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
TMKADPTGSKAYFASVN
EEECCCCCCEEEEEECC
>Mature Secondary Structure 
PQVTSHAPDFKATAVIGDSFKEIKLSDYKGKWVVLFFYPLDFTFVCPTEIIEYDAKLED
CCCCCCCCCCEEEEEECCCCCEEEEECCCCCEEEEEEECCCEEEECCHHHHHHCCCHHH
FKKIGAEVLGVSVDSEFSHLAWKKTPKKEGGIGEIKYPLIADKTKEIAKSFGVLIESGPD
HHHHHHHHEEECCCCCHHHHHHCCCCCCCCCCCCEECCEECCHHHHHHHHHCEEEECCCC
AGVALRGTFIIDPQGIIRQATVNDLPVGRNIEEALRLIKAFQFVEKHGEVCPANWDEGKK
CCEEEEEEEEECCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
TMKADPTGSKAYFASVN
EEECCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]