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The map label for this gene is nuoD

Identifier: 183220689

GI number: 183220689

Start: 1352784

End: 1354004

Strand: Direct

Name: nuoD

Synonym: LEPBI_I1299

Alternate gene names: 183220689

Gene position: 1352784-1354004 (Clockwise)

Preceding gene: 183220688

Following gene: 183220690

Centisome position: 37.58

GC content: 43.24

Gene sequence:

>1221_bases
ATGGTAATGTACGAAAAAACAGCCGAACACTTCGGCCAAAAATTCAAAGACCTACCAGAAGGTCATTTACTTGTCAACTT
AGGGCCAAGCCATCCTGCCACACATGGAATATTACAAAACGTAATCCAAATTGATGGAGAACGAGTGGTGGATACAGAAT
CCGTCATTGGGTATGTGCACCGTTGTTTTGAAAAGTTAGGCGAACGTTATGACTACAACCAGTTTTTGGTTTGTACTGAT
CGCATGAACTACGTATCCACTCCACTCAATAATATTGGATGGATCCTCACTGTCGAAAAGATGATGCAAATCCAAGTGCC
CGATCGTGTGACCTATGTTCGGATGATCATCTCGGAACTTTCTCGGATCATGGACCATATCATCTGTAATGGAATTATGG
GTGTGGATCTTGGTGCCTTTTCTGGACTTTTACATCTTTTTCATCATAGAGAGAACATTTATCAAATTTTAGAAAAACTC
ACTGGGGCACGCCTCACCACAACCTTTTGCCGAGTGGGAGGAATGGAACGAGATATTTATCCGGAATTCCAAACAGAGAT
CAAACTCATTTTAAAGGGCTTAAAACCAGCGTTAGACGAATTTGAAGAACTCCTCATTCGTAACAAAATTTTTAACGAAA
GGACAAAGGGCATTGGCGGGATTTCCGCAGACAGGGCCATTGCTTATGGATTTTCGGGTCCTAATTTACGGGCAGCAGGT
GTTCCTTGGGACGTGAGAAAAGATGACCCTTATATGTTTTATGATAAGGTAAATTTTGACATCCCTGTGGGAGAAGATGG
TTCTGCTCTTGACCGAACCTTGGTTCGTATGGAAGAAATGCGTCAATCCATGAAGATCATCGAACAGCTGATTGACGGGA
TCCCTGAGGGACCTTATCATGCCGATGTCCCTCATAGTTTCCTTCCACCAAAAGACCGAGTGTACCATAATATGGAAGAA
CTCATTTATCATTTTAAAATCATCATGCATGGTGTAAAAGTCCCACCAGGAGAATACTATCATGCCACTGAAGCGGCCAA
TGGAGAGCTTGGATTTTATGTAGTGTCCGAAGGGGATAAATCACCTTGGCGAGTGCATGTAAGACGGCCTTGTTTTTGGT
ACTACCAGGCATTTCCGGAAATGGTGAAAGGTGGTTTACTGGCGGATACTATCGCCACCATGTCATCGCTCAATGTCATC
GCAGGGGAGCTTGATTGTTAA

Upstream 100 bases:

>100_bases
GATTATCCATTAGAAGGCCCTGGCCAAGACTATCTCATTGAAGACCTACTGACCATTCACGTAAAAGAGGATATTACCGG
TTAGGCGGTAAACAATCATT

Downstream 100 bases:

>100_bases
TGGCGTATCAATTTTCACAAGAATCCGAAACAAGGTTCCAAAGGCTCATCCCACAATTCCCAAGCAAACGTTCTCTCATT
TTGCCCTGTTTATTTTTGTT

Product: NADH-quinone oxidoreductase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MVMYEKTAEHFGQKFKDLPEGHLLVNLGPSHPATHGILQNVIQIDGERVVDTESVIGYVHRCFEKLGERYDYNQFLVCTD
RMNYVSTPLNNIGWILTVEKMMQIQVPDRVTYVRMIISELSRIMDHIICNGIMGVDLGAFSGLLHLFHHRENIYQILEKL
TGARLTTTFCRVGGMERDIYPEFQTEIKLILKGLKPALDEFEELLIRNKIFNERTKGIGGISADRAIAYGFSGPNLRAAG
VPWDVRKDDPYMFYDKVNFDIPVGEDGSALDRTLVRMEEMRQSMKIIEQLIDGIPEGPYHADVPHSFLPPKDRVYHNMEE
LIYHFKIIMHGVKVPPGEYYHATEAANGELGFYVVSEGDKSPWRVHVRRPCFWYYQAFPEMVKGGLLADTIATMSSLNVI
AGELDC

Sequences:

>Translated_406_residues
MVMYEKTAEHFGQKFKDLPEGHLLVNLGPSHPATHGILQNVIQIDGERVVDTESVIGYVHRCFEKLGERYDYNQFLVCTD
RMNYVSTPLNNIGWILTVEKMMQIQVPDRVTYVRMIISELSRIMDHIICNGIMGVDLGAFSGLLHLFHHRENIYQILEKL
TGARLTTTFCRVGGMERDIYPEFQTEIKLILKGLKPALDEFEELLIRNKIFNERTKGIGGISADRAIAYGFSGPNLRAAG
VPWDVRKDDPYMFYDKVNFDIPVGEDGSALDRTLVRMEEMRQSMKIIEQLIDGIPEGPYHADVPHSFLPPKDRVYHNMEE
LIYHFKIIMHGVKVPPGEYYHATEAANGELGFYVVSEGDKSPWRVHVRRPCFWYYQAFPEMVKGGLLADTIATMSSLNVI
AGELDC
>Mature_406_residues
MVMYEKTAEHFGQKFKDLPEGHLLVNLGPSHPATHGILQNVIQIDGERVVDTESVIGYVHRCFEKLGERYDYNQFLVCTD
RMNYVSTPLNNIGWILTVEKMMQIQVPDRVTYVRMIISELSRIMDHIICNGIMGVDLGAFSGLLHLFHHRENIYQILEKL
TGARLTTTFCRVGGMERDIYPEFQTEIKLILKGLKPALDEFEELLIRNKIFNERTKGIGGISADRAIAYGFSGPNLRAAG
VPWDVRKDDPYMFYDKVNFDIPVGEDGSALDRTLVRMEEMRQSMKIIEQLIDGIPEGPYHADVPHSFLPPKDRVYHNMEE
LIYHFKIIMHGVKVPPGEYYHATEAANGELGFYVVSEGDKSPWRVHVRRPCFWYYQAFPEMVKGGLLADTIATMSSLNVI
AGELDC

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=390, Percent_Identity=39.4871794871795, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI260898743, Length=385, Percent_Identity=39.2207792207792, Blast_Score=285, Evalue=4e-77,
Organism=Escherichia coli, GI145693162, Length=398, Percent_Identity=35.427135678392, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1789076, Length=289, Percent_Identity=28.3737024221453, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788832, Length=289, Percent_Identity=27.681660899654, Blast_Score=119, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17568379, Length=399, Percent_Identity=36.5914786967419, Blast_Score=290, Evalue=7e-79,
Organism=Caenorhabditis elegans, GI17555284, Length=385, Percent_Identity=37.4025974025974, Blast_Score=288, Evalue=4e-78,
Organism=Drosophila melanogaster, GI24638644, Length=384, Percent_Identity=39.84375, Blast_Score=312, Evalue=2e-85,
Organism=Drosophila melanogaster, GI221459469, Length=382, Percent_Identity=40.0523560209424, Blast_Score=308, Evalue=3e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_LEPBA (B0SFT7)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001962345.1
- ProteinModelPortal:   B0SFT7
- SMR:   B0SFT7
- GeneID:   6390021
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_1245
- HOGENOM:   HBG459705
- OMA:   THPATHG
- ProtClustDB:   CLSK814139
- BioCyc:   LBIF355278:LBF_1245-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR001135
- InterPro:   IPR022885

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 46380; Mature: 46380

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMYEKTAEHFGQKFKDLPEGHLLVNLGPSHPATHGILQNVIQIDGERVVDTESVIGYVH
CCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEECHHHHHHHHH
RCFEKLGERYDYNQFLVCTDRMNYVSTPLNNIGWILTVEKMMQIQVPDRVTYVRMIISEL
HHHHHHHHHCCCCCEEEEECCCHHHHCCHHHCCHHEEEHHHHHCCCCCHHHHHHHHHHHH
SRIMDHIICNGIMGVDLGAFSGLLHLFHHRENIYQILEKLTGARLTTTFCRVGGMERDIY
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
PEFQTEIKLILKGLKPALDEFEELLIRNKIFNERTKGIGGISADRAIAYGFSGPNLRAAG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCEECC
VPWDVRKDDPYMFYDKVNFDIPVGEDGSALDRTLVRMEEMRQSMKIIEQLIDGIPEGPYH
CCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ADVPHSFLPPKDRVYHNMEELIYHFKIIMHGVKVPPGEYYHATEAANGELGFYVVSEGDK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCEEEEEEECCCC
SPWRVHVRRPCFWYYQAFPEMVKGGLLADTIATMSSLNVIAGELDC
CCEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVMYEKTAEHFGQKFKDLPEGHLLVNLGPSHPATHGILQNVIQIDGERVVDTESVIGYVH
CCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEECHHHHHHHHH
RCFEKLGERYDYNQFLVCTDRMNYVSTPLNNIGWILTVEKMMQIQVPDRVTYVRMIISEL
HHHHHHHHHCCCCCEEEEECCCHHHHCCHHHCCHHEEEHHHHHCCCCCHHHHHHHHHHHH
SRIMDHIICNGIMGVDLGAFSGLLHLFHHRENIYQILEKLTGARLTTTFCRVGGMERDIY
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
PEFQTEIKLILKGLKPALDEFEELLIRNKIFNERTKGIGGISADRAIAYGFSGPNLRAAG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCEECC
VPWDVRKDDPYMFYDKVNFDIPVGEDGSALDRTLVRMEEMRQSMKIIEQLIDGIPEGPYH
CCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ADVPHSFLPPKDRVYHNMEELIYHFKIIMHGVKVPPGEYYHATEAANGELGFYVVSEGDK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCEEEEEEECCCC
SPWRVHVRRPCFWYYQAFPEMVKGGLLADTIATMSSLNVIAGELDC
CCEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA