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The map label for this gene is nuoA [H]

Identifier: 183220686

GI number: 183220686

Start: 1351303

End: 1351698

Strand: Direct

Name: nuoA [H]

Synonym: LEPBI_I1296

Alternate gene names: 183220686

Gene position: 1351303-1351698 (Clockwise)

Preceding gene: 183220685

Following gene: 183220687

Centisome position: 37.54

GC content: 39.9

Gene sequence:

>396_bases
ATGAGAGCATTTTCATACATGGGATCCGCACCGGATAGTTTTGCACCAATCCTCTTACAACTTTTGCTCGGAGTCGGTTT
CTCCGCTCTGATCTTATCTCTGGCCTTTCTTTTAAACCCAAAGAAAAAATCGAAACCCCAAGATACATTCGAATGTGGTG
TGACGTATTATGGAGATGCGAGGGGACTGTTTAATATCAAGTTTTATCTTGTGGCAGTTCTTTTCATCCTCTTTGATATT
GAGGCTGTGTTCTTATACCCGTGGGCCGTCAATTTGATTGGTTTCAAAGAAGCGGGTTTGGGTACGTTTTTTCTTTTCGA
AATGTTTTTCTTTTTACTCATCTTAGTTGTGGGTCTATATTATATCTGGAAAAAAGGAGCACTGGAATGGGATTAA

Upstream 100 bases:

>100_bases
TGAGAGTTTATCTCAAAAATTGGACTTCTCCCTACAAATCTCGAAAAATACACGAAAACAAAGGGGAAATTCTTTCTCAT
CTTGACAACTAACCCCTTTC

Downstream 100 bases:

>100_bases
CAGAAACACTATCCAAACCAGGCGAGATGTTTGGTGATATGTTCCAAGTTGCCACACTCGACAATGTCGTGCAGTGGGGG
CAAAGTTTTTCTTTATGGCC

Product: NADH-quinone oxidoreductase subunit A

Products: NA

Alternate protein names: NADH dehydrogenase I subunit A; NDH-1 subunit A; NUO1 [H]

Number of amino acids: Translated: 131; Mature: 131

Protein sequence:

>131_residues
MRAFSYMGSAPDSFAPILLQLLLGVGFSALILSLAFLLNPKKKSKPQDTFECGVTYYGDARGLFNIKFYLVAVLFILFDI
EAVFLYPWAVNLIGFKEAGLGTFFLFEMFFFLLILVVGLYYIWKKGALEWD

Sequences:

>Translated_131_residues
MRAFSYMGSAPDSFAPILLQLLLGVGFSALILSLAFLLNPKKKSKPQDTFECGVTYYGDARGLFNIKFYLVAVLFILFDI
EAVFLYPWAVNLIGFKEAGLGTFFLFEMFFFLLILVVGLYYIWKKGALEWD
>Mature_131_residues
MRAFSYMGSAPDSFAPILLQLLLGVGFSALILSLAFLLNPKKKSKPQDTFECGVTYYGDARGLFNIKFYLVAVLFILFDI
EAVFLYPWAVNLIGFKEAGLGTFFLFEMFFFLLILVVGLYYIWKKGALEWD

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0838

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 3 (chain A)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 3 family [H]

Homologues:

Organism=Escherichia coli, GI1788625, Length=111, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023043
- InterPro:   IPR000440 [H]

Pfam domain/function: PF00507 Oxidored_q4 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 14897; Mature: 14897

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00251 TNF_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAFSYMGSAPDSFAPILLQLLLGVGFSALILSLAFLLNPKKKSKPQDTFECGVTYYGDA
CCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEECCC
RGLFNIKFYLVAVLFILFDIEAVFLYPWAVNLIGFKEAGLGTFFLFEMFFFLLILVVGLY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
YIWKKGALEWD
HHHHCCCCCCC
>Mature Secondary Structure
MRAFSYMGSAPDSFAPILLQLLLGVGFSALILSLAFLLNPKKKSKPQDTFECGVTYYGDA
CCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEECCC
RGLFNIKFYLVAVLFILFDIEAVFLYPWAVNLIGFKEAGLGTFFLFEMFFFLLILVVGLY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
YIWKKGALEWD
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA