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The map label for this gene is pthA [H]

Identifier: 183220682

GI number: 183220682

Start: 1348505

End: 1349071

Strand: Direct

Name: pthA [H]

Synonym: LEPBI_I1292

Alternate gene names: 183220682

Gene position: 1348505-1349071 (Clockwise)

Preceding gene: 183220681

Following gene: 183220683

Centisome position: 37.46

GC content: 43.03

Gene sequence:

>567_bases
ATGATTCACTTTTTAATCGTAGGGCTTGGAAACCCTGGAGACAAATACAAACATACCCGCCATAACATCGGATTTATGAT
CTTGGATCGTTTGGCTACTGAGTTTGGTGTGTCTTTTAAGGACGCTAAAAAATACGCTGAAACCACCTACTCTTGGGAAG
GGGATAAAATCCATTTACTCAAACCCTTGGAATTTATGAATCTTTCTGGCAAAGCAACCCAAACCCTTGCCAATTTGTAT
AAAATCCCACCCTCTCAAATCCTAGTGGTCCAAGACGAAGTGGACCTACCCTTTGGGAAAATCAAAAATAAAATAGGTGG
GGGAACCGCAGGTCATAATGGTCTAAAAGACATCGTGGCAAAACTTGGTTCACAAGACTTCCATCGGTTGCGTTTCGGGG
TTGGCAAACCGGAAAAGGGAGGAATGGAAGTGGCAGATTTTGTATTGCAAAATTTTAATGCAGAGGAACGGAATACCCTT
GATTCCCTCATCACGGAATCCGTTTCCAAACTACAAGATTGGATCCGAACAAACCGCACCCTCATCCAAAAGGAATCCCG
GTCATAA

Upstream 100 bases:

>100_bases
CGGACATCCATCCGATTCGCACCATAGGCATTGACTCCGACCAACAAGTGGCTGCTGTAAAGGCAACCGAACGAATGTTA
CATATTGTGCTTGGGAATTT

Downstream 100 bases:

>100_bases
ATGAAATTTGTTATTTTGGTGCGATCGAATGCTAACTTAGGATCATTCCAATGGGGACGAAACCGATGACGAAAGAAAAT
GATCCATCGATCAATTTAAA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MIHFLIVGLGNPGDKYKHTRHNIGFMILDRLATEFGVSFKDAKKYAETTYSWEGDKIHLLKPLEFMNLSGKATQTLANLY
KIPPSQILVVQDEVDLPFGKIKNKIGGGTAGHNGLKDIVAKLGSQDFHRLRFGVGKPEKGGMEVADFVLQNFNAEERNTL
DSLITESVSKLQDWIRTNRTLIQKESRS

Sequences:

>Translated_188_residues
MIHFLIVGLGNPGDKYKHTRHNIGFMILDRLATEFGVSFKDAKKYAETTYSWEGDKIHLLKPLEFMNLSGKATQTLANLY
KIPPSQILVVQDEVDLPFGKIKNKIGGGTAGHNGLKDIVAKLGSQDFHRLRFGVGKPEKGGMEVADFVLQNFNAEERNTL
DSLITESVSKLQDWIRTNRTLIQKESRS
>Mature_188_residues
MIHFLIVGLGNPGDKYKHTRHNIGFMILDRLATEFGVSFKDAKKYAETTYSWEGDKIHLLKPLEFMNLSGKATQTLANLY
KIPPSQILVVQDEVDLPFGKIKNKIGGGTAGHNGLKDIVAKLGSQDFHRLRFGVGKPEKGGMEVADFVLQNFNAEERNTL
DSLITESVSKLQDWIRTNRTLIQKESRS

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=177, Percent_Identity=32.7683615819209, Blast_Score=103, Evalue=8e-23,
Organism=Escherichia coli, GI1787455, Length=173, Percent_Identity=43.9306358381503, Blast_Score=119, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21102; Mature: 21102

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHFLIVGLGNPGDKYKHTRHNIGFMILDRLATEFGVSFKDAKKYAETTYSWEGDKIHLL
CEEEEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEE
KPLEFMNLSGKATQTLANLYKIPPSQILVVQDEVDLPFGKIKNKIGGGTAGHNGLKDIVA
CCHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCHHHHHH
KLGSQDFHRLRFGVGKPEKGGMEVADFVLQNFNAEERNTLDSLITESVSKLQDWIRTNRT
HHCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LIQKESRS
HHHCCCCC
>Mature Secondary Structure
MIHFLIVGLGNPGDKYKHTRHNIGFMILDRLATEFGVSFKDAKKYAETTYSWEGDKIHLL
CEEEEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEE
KPLEFMNLSGKATQTLANLYKIPPSQILVVQDEVDLPFGKIKNKIGGGTAGHNGLKDIVA
CCHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCHHHHHH
KLGSQDFHRLRFGVGKPEKGGMEVADFVLQNFNAEERNTLDSLITESVSKLQDWIRTNRT
HHCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LIQKESRS
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA