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The map label for this gene is hemN [H]

Identifier: 183220562

GI number: 183220562

Start: 1214245

End: 1215585

Strand: Reverse

Name: hemN [H]

Synonym: LEPBI_I1166

Alternate gene names: 183220562

Gene position: 1215585-1214245 (Counterclockwise)

Preceding gene: 183220563

Following gene: 183220561

Centisome position: 33.77

GC content: 37.73

Gene sequence:

>1341_bases
ATGAAACAATTGCTAGAAAAATACGATACACCTGCCCCACGTTACACAAGTTACCCTACTGTTCCGTATTGGACAGATTC
TCCAACGACGGAAGAATGTATCCAATCCCTCGAAACATATCTTTTCCCGAAAGAATCTAAATTGGCAGTTTACCTTCATA
TCCCTTTTTGTGAGACACTTTGTACATTCTGCGGTTGTAACACTTCCATCACAAAAAACCATACCGTCGAAGAACCATAC
GTGAGCGCAATTCAAAAGGAATTACTGTTATACATAAAAAATGTCCCTTCTCTCAAAGGAAAAGAACTCAGCGAACTACA
TTTAGGTGGAGGTAGTCCCACTTATTTATCTGATTACAACCTCCAGTCTACAATCGAATCCATTTTGAATCAACTGGCTC
CTTCCCAAAATCCGCAGTATTCCATTGAAGTGGATCCAAGACGAACTAGAGTATCCCAATTAAAACTTTTAAGACAACTT
GGTTTCCATCGGATAAGTCTTGGTGTCCAAGATTTTGATCCAGAAGTTCAGAGGCTTGTAAACCGCATCCAACCATTTGA
ACTCACTGAAAATATTACATTAGAAGCAAGAGCACTTGGATTTGATTCCGTTAATTTTGATTTAATTTATGGGTTACCAA
AACAATCCTTAGATTCCATGAAATTCACGATTGAAAAAACATTGGAACTCAAACCAGATCGTATTGCCTTTTATTCTTAT
GCTCATGTACCTTGGATTAAGGCATCCCAACGTTTATTCACTGAAAATGACTTACCAGAACCAACACTCAAACGAGAGTT
ATATGAGATGGGAAGAACCCTTTTAGAAAAGGAAGGGTATCGGGAAATTGGAATGGACCATTTTGCGCTCCCACATGATA
AATTATGGAAGGCATTCCATTCTAAACAATTACATAGAAATTTTATGGGGTATAGTGATTCCAAAACTGATGTCATGCTT
GGACTCGGTTCATCTGCCATTTCCGAAACACCAAATCTTTTTTTCCAAAATATCAAACTCGAAATGAAGTATCGAAAGTC
TCTAGTGGATGGTATCCTACCCATTCTCAGAGGACACAAACTCACAAACTCAGACCAATTAAGAAAGGAATTGATATTAC
AACTTATGACATCTTGGGAAGTAAAAGTACCGAATGACTTACAAAGCCATGTGAGACAATTTTTGACCGAGATGGAAAAA
GACAATTTGGTCAATTGGCAGAAGGATACTCTTGTAGTGACAGAAACGGGAAAACCATTTTTAAGAATCGTGGCAATGGC
ATTTGATGAAAAACTGCAACTAAGCCAACCAACAAAACCTGTATTTTCAAAAGCAATATGA

Upstream 100 bases:

>100_bases
GAGTTGGTTGGGTTGCAGGCCTTGGGCATGGAGTTTTACAATTCACTCCTGAAGCTTCTATCCACTCCCTAATCGAAGAA
ACAAGAAAGGTGTTTACTAA

Downstream 100 bases:

>100_bases
AAGAAGACATTCATATCTTCGGTGGTGGCATCACAGGTTTGTTTCTCGCCTACCACCATGTCAAAAAAGGAAATCAGGTG
ACACTTTATGAAGAAAAAAA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MKQLLEKYDTPAPRYTSYPTVPYWTDSPTTEECIQSLETYLFPKESKLAVYLHIPFCETLCTFCGCNTSITKNHTVEEPY
VSAIQKELLLYIKNVPSLKGKELSELHLGGGSPTYLSDYNLQSTIESILNQLAPSQNPQYSIEVDPRRTRVSQLKLLRQL
GFHRISLGVQDFDPEVQRLVNRIQPFELTENITLEARALGFDSVNFDLIYGLPKQSLDSMKFTIEKTLELKPDRIAFYSY
AHVPWIKASQRLFTENDLPEPTLKRELYEMGRTLLEKEGYREIGMDHFALPHDKLWKAFHSKQLHRNFMGYSDSKTDVML
GLGSSAISETPNLFFQNIKLEMKYRKSLVDGILPILRGHKLTNSDQLRKELILQLMTSWEVKVPNDLQSHVRQFLTEMEK
DNLVNWQKDTLVVTETGKPFLRIVAMAFDEKLQLSQPTKPVFSKAI

Sequences:

>Translated_446_residues
MKQLLEKYDTPAPRYTSYPTVPYWTDSPTTEECIQSLETYLFPKESKLAVYLHIPFCETLCTFCGCNTSITKNHTVEEPY
VSAIQKELLLYIKNVPSLKGKELSELHLGGGSPTYLSDYNLQSTIESILNQLAPSQNPQYSIEVDPRRTRVSQLKLLRQL
GFHRISLGVQDFDPEVQRLVNRIQPFELTENITLEARALGFDSVNFDLIYGLPKQSLDSMKFTIEKTLELKPDRIAFYSY
AHVPWIKASQRLFTENDLPEPTLKRELYEMGRTLLEKEGYREIGMDHFALPHDKLWKAFHSKQLHRNFMGYSDSKTDVML
GLGSSAISETPNLFFQNIKLEMKYRKSLVDGILPILRGHKLTNSDQLRKELILQLMTSWEVKVPNDLQSHVRQFLTEMEK
DNLVNWQKDTLVVTETGKPFLRIVAMAFDEKLQLSQPTKPVFSKAI
>Mature_446_residues
MKQLLEKYDTPAPRYTSYPTVPYWTDSPTTEECIQSLETYLFPKESKLAVYLHIPFCETLCTFCGCNTSITKNHTVEEPY
VSAIQKELLLYIKNVPSLKGKELSELHLGGGSPTYLSDYNLQSTIESILNQLAPSQNPQYSIEVDPRRTRVSQLKLLRQL
GFHRISLGVQDFDPEVQRLVNRIQPFELTENITLEARALGFDSVNFDLIYGLPKQSLDSMKFTIEKTLELKPDRIAFYSY
AHVPWIKASQRLFTENDLPEPTLKRELYEMGRTLLEKEGYREIGMDHFALPHDKLWKAFHSKQLHRNFMGYSDSKTDVML
GLGSSAISETPNLFFQNIKLEMKYRKSLVDGILPILRGHKLTNSDQLRKELILQLMTSWEVKVPNDLQSHVRQFLTEMEK
DNLVNWQKDTLVVTETGKPFLRIVAMAFDEKLQLSQPTKPVFSKAI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=253, Percent_Identity=25.6916996047431, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI87082341, Length=441, Percent_Identity=36.9614512471655, Blast_Score=304, Evalue=8e-84,
Organism=Escherichia coli, GI1789325, Length=246, Percent_Identity=27.2357723577236, Blast_Score=112, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 51510; Mature: 51510

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLLEKYDTPAPRYTSYPTVPYWTDSPTTEECIQSLETYLFPKESKLAVYLHIPFCETL
CHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCHHHHH
CTFCGCNTSITKNHTVEEPYVSAIQKELLLYIKNVPSLKGKELSELHLGGGSPTYLSDYN
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHEECCCCCCCEECCCC
LQSTIESILNQLAPSQNPQYSIEVDPRRTRVSQLKLLRQLGFHRISLGVQDFDPEVQRLV
HHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHH
NRIQPFELTENITLEARALGFDSVNFDLIYGLPKQSLDSMKFTIEKTLELKPDRIAFYSY
HHCCCCCCCCCCEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEE
AHVPWIKASQRLFTENDLPEPTLKRELYEMGRTLLEKEGYREIGMDHFALPHDKLWKAFH
CCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHH
SKQLHRNFMGYSDSKTDVMLGLGSSAISETPNLFFQNIKLEMKYRKSLVDGILPILRGHK
HHHHHHHHCCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LTNSDQLRKELILQLMTSWEVKVPNDLQSHVRQFLTEMEKDNLVNWQKDTLVVTETGKPF
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHH
LRIVAMAFDEKLQLSQPTKPVFSKAI
HHHHHHHHCCHHCCCCCCCHHHHCCC
>Mature Secondary Structure
MKQLLEKYDTPAPRYTSYPTVPYWTDSPTTEECIQSLETYLFPKESKLAVYLHIPFCETL
CHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCHHHHH
CTFCGCNTSITKNHTVEEPYVSAIQKELLLYIKNVPSLKGKELSELHLGGGSPTYLSDYN
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHEECCCCCCCEECCCC
LQSTIESILNQLAPSQNPQYSIEVDPRRTRVSQLKLLRQLGFHRISLGVQDFDPEVQRLV
HHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHH
NRIQPFELTENITLEARALGFDSVNFDLIYGLPKQSLDSMKFTIEKTLELKPDRIAFYSY
HHCCCCCCCCCCEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEE
AHVPWIKASQRLFTENDLPEPTLKRELYEMGRTLLEKEGYREIGMDHFALPHDKLWKAFH
CCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHH
SKQLHRNFMGYSDSKTDVMLGLGSSAISETPNLFFQNIKLEMKYRKSLVDGILPILRGHK
HHHHHHHHCCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LTNSDQLRKELILQLMTSWEVKVPNDLQSHVRQFLTEMEKDNLVNWQKDTLVVTETGKPF
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHH
LRIVAMAFDEKLQLSQPTKPVFSKAI
HHHHHHHHCCHHCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]