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The map label for this gene is cvrA [H]

Identifier: 183219872

GI number: 183219872

Start: 448359

End: 449831

Strand: Direct

Name: cvrA [H]

Synonym: LEPBI_I0453

Alternate gene names: 183219872

Gene position: 448359-449831 (Clockwise)

Preceding gene: 183219871

Following gene: 183219875

Centisome position: 12.46

GC content: 40.33

Gene sequence:

>1473_bases
ATGATCGATAGTTTTACTTTACAAGCACTCGTAATTTCCACACTCATCATCTTTTCCATTCTTTCGAGTAAACTTTTTTT
CCGTTTTGGATTTCCGATTCTACTCATTTTTTTAACCTTTGGAATGTTAGCTGGTTCGGATGGACCTGGTGGCATTGACT
TTAGTGATTATGGTTTAGCACAATCCATTGGAATCTTTGCTTTGATTTATATTCTGTTTTTAGGTGGCCTTGAAAGTGAA
TGGGATAGTTTAAAAAACTTTTTAGCTGTTGGGATCCGGCTTTCCATCATCGGCACCATCCTTACGGCTCTTATCTTGGG
TGTCCTCATCCATTTATTATTCCCGGTCCTTGGGTTTTTGGAATCCTTTTTACTTGGTTCCATCGTCAGTGCCACTGATG
CCGCTTCTGTGTTTAATATTTTTAAAACAGATTCTTCAGACCTTCCTATGCACTTAAAAAAGATCATCGAATTTGAATCG
GGATCGAATGATGCAGTGGGAGTTTTACTCACAACCATTTTTATGAACTTAATCACGGCTGATGTGAGTTTTAGTGGTTT
CCAATTCTTACGTTTTTTTGTGATGCAGGTTCTTGTGGGGATGATGATGGGATACAGCATGGGAATTCTCATCTTGTATT
TAATGAACTCCGTCAAACTTGGATATGATGGTCTTTATTTGGTATTTATCATCGCATCCGTTCCTTTTATTTATGCGGTT
GCAACTGTTTTCCAAGGGAATGGATTTTTAGCAGTGTATGTGGCAGGGATCATTGTGGGTCGAAACAAATTCATTCATAA
AAAATCCATCTTTCGGTTTTTAAATGGATATGTTTGGATTTTACAAATTGGAATGTTCCTTTGTTTTGGACTTCTTGTCT
ATCCAACAAGGATGGCTGATATTTGGGTACCAGGACTCCTCATTGGTGTTTTACTGATTCTCTTGGCAAGGCCCCTTGCG
GTTTTCATTTCCCTCTTCCGTGTGAATTTACCTGTAAAAGAAAAATTATTTATCTCTTGGGTGGGCCTACGCGGGGCATC
CCCCATCATCCTTGCTACTTTTCCGATTGCCCAAGGTCTTGTTTGGGGAGATTTACTCTTTCATATCGTATTCTTTGTGG
TATTAGTTTCCCTTCTCGTCCAAGGTTCCCTCATCCCTCGAGTGGCCCAGTGGTTGGGAATCTTAAAAAATGACCCCGAT
CGGAAAATATACAGACCAACTGACTTTGATAACATTGAGTTTCCAGGAATGACCTTACAAGAGTTAATTGTTCCATACAA
CTCCAGTGTCGTCGACAAAGCTTTGTTCGAAATTAAACTTCCGGAACAATCGCATATCCTTCTCATTGCTCGAGGGGAAC
AATTCCTCATCCCATCGGGTAACACACAGGTGAAAGGTGGGGATGTGGTATGGGTGCTCGCAAAAGATGATGTGATGCCC
ATCATTGGCAGAACCTTTATGGCAATTGCTTAA

Upstream 100 bases:

>100_bases
AATCCTGATGATTTCAAAGTACACCCCATCCTAAAAGCAAAAGCTCTCGAAATCCTTTCCTGCAAACAGTAAGTGGTTTG
GATTCGTCTAAGGTGTAAAC

Downstream 100 bases:

>100_bases
AAATTAATCCACAAGTTTCATTGGTTTTTATGATTTCTTTTTTGTTGAAACCATCTTTTTGTCCAATCGGAATAGATAAT
ACACTGGTAAGGCGATGAGT

Product: putative ion transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MIDSFTLQALVISTLIIFSILSSKLFFRFGFPILLIFLTFGMLAGSDGPGGIDFSDYGLAQSIGIFALIYILFLGGLESE
WDSLKNFLAVGIRLSIIGTILTALILGVLIHLLFPVLGFLESFLLGSIVSATDAASVFNIFKTDSSDLPMHLKKIIEFES
GSNDAVGVLLTTIFMNLITADVSFSGFQFLRFFVMQVLVGMMMGYSMGILILYLMNSVKLGYDGLYLVFIIASVPFIYAV
ATVFQGNGFLAVYVAGIIVGRNKFIHKKSIFRFLNGYVWILQIGMFLCFGLLVYPTRMADIWVPGLLIGVLLILLARPLA
VFISLFRVNLPVKEKLFISWVGLRGASPIILATFPIAQGLVWGDLLFHIVFFVVLVSLLVQGSLIPRVAQWLGILKNDPD
RKIYRPTDFDNIEFPGMTLQELIVPYNSSVVDKALFEIKLPEQSHILLIARGEQFLIPSGNTQVKGGDVVWVLAKDDVMP
IIGRTFMAIA

Sequences:

>Translated_490_residues
MIDSFTLQALVISTLIIFSILSSKLFFRFGFPILLIFLTFGMLAGSDGPGGIDFSDYGLAQSIGIFALIYILFLGGLESE
WDSLKNFLAVGIRLSIIGTILTALILGVLIHLLFPVLGFLESFLLGSIVSATDAASVFNIFKTDSSDLPMHLKKIIEFES
GSNDAVGVLLTTIFMNLITADVSFSGFQFLRFFVMQVLVGMMMGYSMGILILYLMNSVKLGYDGLYLVFIIASVPFIYAV
ATVFQGNGFLAVYVAGIIVGRNKFIHKKSIFRFLNGYVWILQIGMFLCFGLLVYPTRMADIWVPGLLIGVLLILLARPLA
VFISLFRVNLPVKEKLFISWVGLRGASPIILATFPIAQGLVWGDLLFHIVFFVVLVSLLVQGSLIPRVAQWLGILKNDPD
RKIYRPTDFDNIEFPGMTLQELIVPYNSSVVDKALFEIKLPEQSHILLIARGEQFLIPSGNTQVKGGDVVWVLAKDDVMP
IIGRTFMAIA
>Mature_490_residues
MIDSFTLQALVISTLIIFSILSSKLFFRFGFPILLIFLTFGMLAGSDGPGGIDFSDYGLAQSIGIFALIYILFLGGLESE
WDSLKNFLAVGIRLSIIGTILTALILGVLIHLLFPVLGFLESFLLGSIVSATDAASVFNIFKTDSSDLPMHLKKIIEFES
GSNDAVGVLLTTIFMNLITADVSFSGFQFLRFFVMQVLVGMMMGYSMGILILYLMNSVKLGYDGLYLVFIIASVPFIYAV
ATVFQGNGFLAVYVAGIIVGRNKFIHKKSIFRFLNGYVWILQIGMFLCFGLLVYPTRMADIWVPGLLIGVLLILLARPLA
VFISLFRVNLPVKEKLFISWVGLRGASPIILATFPIAQGLVWGDLLFHIVFFVVLVSLLVQGSLIPRVAQWLGILKNDPD
RKIYRPTDFDNIEFPGMTLQELIVPYNSSVVDKALFEIKLPEQSHILLIARGEQFLIPSGNTQVKGGDVVWVLAKDDVMP
IIGRTFMAIA

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=461, Percent_Identity=35.3579175704989, Blast_Score=237, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 54124; Mature: 54124

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA