Click here to switch to the map view.

The map label for this gene is ppx [H]

Identifier: 183219866

GI number: 183219866

Start: 440254

End: 441855

Strand: Direct

Name: ppx [H]

Synonym: LEPBI_I0447

Alternate gene names: 183219866

Gene position: 440254-441855 (Clockwise)

Preceding gene: 183219863

Following gene: 183219867

Centisome position: 12.23

GC content: 41.7

Gene sequence:

>1602_bases
ATGCTACCTTTCTCACAAATCTTACGCAAACCAAACCAGGCATTTCGCTCGGAAAAGATCCTCGCTGCCATTGATTTAGG
CACCAATTCCTTCCACATTGTCGTCGTAAAACTAAGACCGGACGGTACACTTGAATACTTAACAAAAGAAAAAGAATCTG
TCCGATTAGGGAGTGGTAGCAGTGATTATGCGGTGATCAAAGACGATGCGATCGAGCGTGGTATCGCTTGTTTGAAACGA
TTCAAAACCTTAGCTGACTCCTACAAAGCGGAAATCAGAGCAGTTGCCACAAGTGCCCTAAGGGAAGCCGAAAATCGTCA
GGTCTTTCTTGACCGAGCTGAGAAAGAAACGAGCATCCAAATCCAAGTCATTTCAGGAAACGAAGAAGCCCGCCTCATTT
ATTTGGGGATTTTACAAGGACTTCCCGTGTTTGACAAACGAATCCTCTTAATTGACATCGGGGGAGGCAGTACAGAACTC
CTCATTGGAGAAAAGGGTGAAATTCTTTTTTCCACCAGCATGAAGTTAGGTGCCATTCGATTAACGGAGAAATACCTAAA
AAAAGATCCCCTTTCGGCCACTGATTTACAAAAATGTAGGATCCACATTGAATCAGTGTTATCTGCTTTTTTACCGCAAA
TTGAGAGATTAAAACCCTTTTTGGTTGTGGGAAGTTCCGGAACCATTACCTCGGTGACTTCCATGGTACTCGAAAAAAAA
GGGGAAAAGAGAGAACGACTGAACGGAACAGAGATTACAATCGATTTGTTTAAAGAAATCCGCAAACAAGTATTAGATGC
AGAAAGTATCAAAAAAAGGTTAAAAATTCCAGGACTTGATGCCAAACGAGGGGATATCATTGTGGGTGGGGTTTTGGTTT
TGGACGAAGTGTTACAAAGGATCAAAGCGCCTTCGTTTACAGTGAGTGACTTTGCTCTAAGAGAAGGGATTGTCTACGAC
ACGATTGAATCTTGGTATCGGCATACAGACACATCTTTACCAAGACTCGATAACATTCGAGACAAGGCGATTAAAACCGT
AGCCAATCTTTACCCACAAGGGAAAAAACATGCAGAAGCCGTAACGAAACTCACCTTGCAATTGTTTGATGACCTTACAA
ACTTACATGGACTTGGTAATTTAGAACGAGATTATTTAGAAACGGCATGTTACCTCCACCAAGTGGGGCTTTGTATTTCC
CATCACAACTACCACAAACATAGTTATTATATCATTCGAAACTCTGAGGCGATGGTTGGTTTTTCCAATGCTGAAATTGA
AATCATAGCCCTTCTTGCCCGTTACCATAGAAAGGGGGGACCCAAAGGGAAACACGAAGAGTTCAAAAACCTTCGGCCCG
AAGACCAACTCCTAGTCAAAAAACTGGCCTCGTTTCTTCGGATTGGAGATGGACTTGACCGTTCTGAAAAATCCATTATT
GATCGATTGGATGCCGTCGTGGAAAAAGGAAAGGTGAGCTGTCGATTGTATTTTAAAAAGAACGAAGATCCCAATTTGGA
AATTTGGTCTGTATCGGAAAAAAAGGATTTGTTTGAAGATACATTCAGTACGACTTTAGAATTTCATTTGCATCCAATAT
GA

Upstream 100 bases:

>100_bases
GGGTTACACCAAAATAATACAATTCTACCCGTTCCCCATAATTTTCGGCTGGTTTTTGCTTTCAACCGTAAAAATTTTCG
ATAGGCTAGTTAGATACAAA

Downstream 100 bases:

>100_bases
CTAGAATCATCATTTCGTTTTGTTTTTTCATCTGTTTGACCGAATCCACCACTGCGCTTCCGATCGACTTATCCAAAAAT
TGGTATGTCACAAAAGGATT

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MLPFSQILRKPNQAFRSEKILAAIDLGTNSFHIVVVKLRPDGTLEYLTKEKESVRLGSGSSDYAVIKDDAIERGIACLKR
FKTLADSYKAEIRAVATSALREAENRQVFLDRAEKETSIQIQVISGNEEARLIYLGILQGLPVFDKRILLIDIGGGSTEL
LIGEKGEILFSTSMKLGAIRLTEKYLKKDPLSATDLQKCRIHIESVLSAFLPQIERLKPFLVVGSSGTITSVTSMVLEKK
GEKRERLNGTEITIDLFKEIRKQVLDAESIKKRLKIPGLDAKRGDIIVGGVLVLDEVLQRIKAPSFTVSDFALREGIVYD
TIESWYRHTDTSLPRLDNIRDKAIKTVANLYPQGKKHAEAVTKLTLQLFDDLTNLHGLGNLERDYLETACYLHQVGLCIS
HHNYHKHSYYIIRNSEAMVGFSNAEIEIIALLARYHRKGGPKGKHEEFKNLRPEDQLLVKKLASFLRIGDGLDRSEKSII
DRLDAVVEKGKVSCRLYFKKNEDPNLEIWSVSEKKDLFEDTFSTTLEFHLHPI

Sequences:

>Translated_533_residues
MLPFSQILRKPNQAFRSEKILAAIDLGTNSFHIVVVKLRPDGTLEYLTKEKESVRLGSGSSDYAVIKDDAIERGIACLKR
FKTLADSYKAEIRAVATSALREAENRQVFLDRAEKETSIQIQVISGNEEARLIYLGILQGLPVFDKRILLIDIGGGSTEL
LIGEKGEILFSTSMKLGAIRLTEKYLKKDPLSATDLQKCRIHIESVLSAFLPQIERLKPFLVVGSSGTITSVTSMVLEKK
GEKRERLNGTEITIDLFKEIRKQVLDAESIKKRLKIPGLDAKRGDIIVGGVLVLDEVLQRIKAPSFTVSDFALREGIVYD
TIESWYRHTDTSLPRLDNIRDKAIKTVANLYPQGKKHAEAVTKLTLQLFDDLTNLHGLGNLERDYLETACYLHQVGLCIS
HHNYHKHSYYIIRNSEAMVGFSNAEIEIIALLARYHRKGGPKGKHEEFKNLRPEDQLLVKKLASFLRIGDGLDRSEKSII
DRLDAVVEKGKVSCRLYFKKNEDPNLEIWSVSEKKDLFEDTFSTTLEFHLHPI
>Mature_533_residues
MLPFSQILRKPNQAFRSEKILAAIDLGTNSFHIVVVKLRPDGTLEYLTKEKESVRLGSGSSDYAVIKDDAIERGIACLKR
FKTLADSYKAEIRAVATSALREAENRQVFLDRAEKETSIQIQVISGNEEARLIYLGILQGLPVFDKRILLIDIGGGSTEL
LIGEKGEILFSTSMKLGAIRLTEKYLKKDPLSATDLQKCRIHIESVLSAFLPQIERLKPFLVVGSSGTITSVTSMVLEKK
GEKRERLNGTEITIDLFKEIRKQVLDAESIKKRLKIPGLDAKRGDIIVGGVLVLDEVLQRIKAPSFTVSDFALREGIVYD
TIESWYRHTDTSLPRLDNIRDKAIKTVANLYPQGKKHAEAVTKLTLQLFDDLTNLHGLGNLERDYLETACYLHQVGLCIS
HHNYHKHSYYIIRNSEAMVGFSNAEIEIIALLARYHRKGGPKGKHEEFKNLRPEDQLLVKKLASFLRIGDGLDRSEKSII
DRLDAVVEKGKVSCRLYFKKNEDPNLEIWSVSEKKDLFEDTFSTTLEFHLHPI

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=424, Percent_Identity=33.4905660377358, Blast_Score=212, Evalue=5e-56,
Organism=Escherichia coli, GI48994966, Length=417, Percent_Identity=29.4964028776978, Blast_Score=190, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 60201; Mature: 60201

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPFSQILRKPNQAFRSEKILAAIDLGTNSFHIVVVKLRPDGTLEYLTKEKESVRLGSGS
CCCHHHHHCCCHHHHCCCCEEEEEEECCCCEEEEEEEECCCCCHHHHHCCCHHEEECCCC
SDYAVIKDDAIERGIACLKRFKTLADSYKAEIRAVATSALREAENRQVFLDRAEKETSIQ
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEE
IQVISGNEEARLIYLGILQGLPVFDKRILLIDIGGGSTELLIGEKGEILFSTSMKLGAIR
EEEEECCCCCEEEEEEHHCCCCCCCCEEEEEEECCCCEEEEEECCCCEEEECCCCCCHHH
LTEKYLKKDPLSATDLQKCRIHIESVLSAFLPQIERLKPFLVVGSSGTITSVTSMVLEKK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHC
GEKRERLNGTEITIDLFKEIRKQVLDAESIKKRLKIPGLDAKRGDIIVGGVLVLDEVLQR
CCHHHHCCCCEEEHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHH
IKAPSFTVSDFALREGIVYDTIESWYRHTDTSLPRLDNIRDKAIKTVANLYPQGKKHAEA
HCCCCCEEHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
VTKLTLQLFDDLTNLHGLGNLERDYLETACYLHQVGLCISHHNYHKHSYYIIRNSEAMVG
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEECCCEEEE
FSNAEIEIIALLARYHRKGGPKGKHEEFKNLRPEDQLLVKKLASFLRIGDGLDRSEKSII
ECCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
DRLDAVVEKGKVSCRLYFKKNEDPNLEIWSVSEKKDLFEDTFSTTLEFHLHPI
HHHHHHHHCCCCEEEEEEECCCCCCEEEEECCHHHHHHHHHHHCEEEEEEECC
>Mature Secondary Structure
MLPFSQILRKPNQAFRSEKILAAIDLGTNSFHIVVVKLRPDGTLEYLTKEKESVRLGSGS
CCCHHHHHCCCHHHHCCCCEEEEEEECCCCEEEEEEEECCCCCHHHHHCCCHHEEECCCC
SDYAVIKDDAIERGIACLKRFKTLADSYKAEIRAVATSALREAENRQVFLDRAEKETSIQ
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEE
IQVISGNEEARLIYLGILQGLPVFDKRILLIDIGGGSTELLIGEKGEILFSTSMKLGAIR
EEEEECCCCCEEEEEEHHCCCCCCCCEEEEEEECCCCEEEEEECCCCEEEECCCCCCHHH
LTEKYLKKDPLSATDLQKCRIHIESVLSAFLPQIERLKPFLVVGSSGTITSVTSMVLEKK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHC
GEKRERLNGTEITIDLFKEIRKQVLDAESIKKRLKIPGLDAKRGDIIVGGVLVLDEVLQR
CCHHHHCCCCEEEHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHH
IKAPSFTVSDFALREGIVYDTIESWYRHTDTSLPRLDNIRDKAIKTVANLYPQGKKHAEA
HCCCCCEEHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
VTKLTLQLFDDLTNLHGLGNLERDYLETACYLHQVGLCISHHNYHKHSYYIIRNSEAMVG
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEECCCEEEE
FSNAEIEIIALLARYHRKGGPKGKHEEFKNLRPEDQLLVKKLASFLRIGDGLDRSEKSII
ECCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
DRLDAVVEKGKVSCRLYFKKNEDPNLEIWSVSEKKDLFEDTFSTTLEFHLHPI
HHHHHHHHCCCCEEEEEEECCCCCCEEEEECCHHHHHHHHHHHCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]