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The map label for this gene is creC [H]

Identifier: 183219818

GI number: 183219818

Start: 393640

End: 395079

Strand: Direct

Name: creC [H]

Synonym: LEPBI_I0396

Alternate gene names: 183219818

Gene position: 393640-395079 (Clockwise)

Preceding gene: 183219817

Following gene: 183219819

Centisome position: 10.94

GC content: 34.03

Gene sequence:

>1440_bases
TTGGTTACGAATCATTATCAGTTTTTTTTTATCTTAAGTGTTGGTTTTTATTATTTAATCGATAAAACAGAAGAATCCAT
CCGGCCTCGGTATATGGAGACCATCGAAGAATCATTAAACGATACCTCTCATGTGCTTTCTGCTCTCGTCGAAGAAAAAT
TAAAAGAAAACCCTAGAAAAAGATTCCAATTCAAATCACTAGTTAATGAGTTGTTTCGAAAACCGTTTCAGAATATTCGT
AAACGTAATTTTGAAGCCAAAATTTATTCGCTACTAAAAACAAATGCAGACATTCAGATGTACATTACTGATGAAAAAGG
GTTTGTCATTTTTGATTCGGAATTATTTCGAGAAGGTCTGGATTATTCAAAATACAACGATGTTTACCTTACATTAAAAG
GTAAGTATGGTGTCAGATCCAGCAAAATGTTTGATACAGAAAAGGAAGGAGCTTTGTTCATTGCTTCTCCCATTCGATAT
GAAAAAGAAATCATCGGTGTTTTAACTGTCATTAAACCTAAAATCGGTGTGATCCCATTTATTGAAGAAGCTAAAAATAA
ATTTTGGCGAATATCTTTGTTGGTTGCATCAGCGATTGCGATTGTTTTTAGTTTACTTGCTTATATTAGTTTTCGACCTA
TTCTTCGATTGTCTCAGTATATAACCTCCCTTAGAAACAAAGATAAAATTCCTTTTCCAAAATTAGGAATCAAAGAATTA
AATGATTTAGGAAAAGAGGTAGACCAACTTGTTTTGGAACTGGAAGGGAAAAAATATGTAGAGTCGTATGTACAAACTCT
GACTCACGAAATCAAAAGTCCTCTCTCTTCGATTCTTGCATCTGTCGAACTAATCCAAACACATCCCAAAGAGATGGAAA
GATTAACAAAAACCATTGATGCAGAAGCAAAACGGATCCAAAATTTAATCGATCAATTATTGGAATTATCTTCGTTGGAA
GGGAAAAATTCAATTCAATTAGATGATACGATTGAACTGATATCCTTACTTGAGGAAGTGTTGGCTCGATTTGAAATTGA
ATTCGAACGTAAATCGCTACATGTGATGAAACGATTTGATATGGGTCGTATACAAATGAAGGGAAATGTAAACTACATCC
GTATGGCAATTGAAAATATTCTACGGAATTCGATTGAGTTTGCCAATCCCAAAGATACCATTACTGTAGAACTTGTATCG
ACTCTGAATCATCAAATCAATTTAGTGATCTCTGACCAAGGTCAATCTATTCCAGATTATGCTTTGCCAAAGGTAACAGA
TAAGTTTTTTTCTTTGCCAAGACCTATTGGTCTTCGTAAAAGTTCCGGTCTTGGTCTAAGCATCGTGAAAGAAATATTAG
ACCTTCACCAAGCCGAGCTCACCATTCGAAATTTGGAACCTAAGGGAGTTGAAGTAAAAGTTTTATTTCAAAATTCTTAA

Upstream 100 bases:

>100_bases
AAAAACATTCGGGCAAGGTTCAAAGAGATGGATCCAAATTTTGATCCTATTGAAACGAGAAGAGGACAGGGGTACGGCTT
AAAGGAAACAATATGAATCT

Downstream 100 bases:

>100_bases
TCCTCACACAATCCTCACATTGCTAACATAATAAACTCACCAATACCAATTACATTGGATGTTAGGAGTTTTTTATGAGT
AAATTAATATCTTCTGTAAA

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MVTNHYQFFFILSVGFYYLIDKTEESIRPRYMETIEESLNDTSHVLSALVEEKLKENPRKRFQFKSLVNELFRKPFQNIR
KRNFEAKIYSLLKTNADIQMYITDEKGFVIFDSELFREGLDYSKYNDVYLTLKGKYGVRSSKMFDTEKEGALFIASPIRY
EKEIIGVLTVIKPKIGVIPFIEEAKNKFWRISLLVASAIAIVFSLLAYISFRPILRLSQYITSLRNKDKIPFPKLGIKEL
NDLGKEVDQLVLELEGKKYVESYVQTLTHEIKSPLSSILASVELIQTHPKEMERLTKTIDAEAKRIQNLIDQLLELSSLE
GKNSIQLDDTIELISLLEEVLARFEIEFERKSLHVMKRFDMGRIQMKGNVNYIRMAIENILRNSIEFANPKDTITVELVS
TLNHQINLVISDQGQSIPDYALPKVTDKFFSLPRPIGLRKSSGLGLSIVKEILDLHQAELTIRNLEPKGVEVKVLFQNS

Sequences:

>Translated_479_residues
MVTNHYQFFFILSVGFYYLIDKTEESIRPRYMETIEESLNDTSHVLSALVEEKLKENPRKRFQFKSLVNELFRKPFQNIR
KRNFEAKIYSLLKTNADIQMYITDEKGFVIFDSELFREGLDYSKYNDVYLTLKGKYGVRSSKMFDTEKEGALFIASPIRY
EKEIIGVLTVIKPKIGVIPFIEEAKNKFWRISLLVASAIAIVFSLLAYISFRPILRLSQYITSLRNKDKIPFPKLGIKEL
NDLGKEVDQLVLELEGKKYVESYVQTLTHEIKSPLSSILASVELIQTHPKEMERLTKTIDAEAKRIQNLIDQLLELSSLE
GKNSIQLDDTIELISLLEEVLARFEIEFERKSLHVMKRFDMGRIQMKGNVNYIRMAIENILRNSIEFANPKDTITVELVS
TLNHQINLVISDQGQSIPDYALPKVTDKFFSLPRPIGLRKSSGLGLSIVKEILDLHQAELTIRNLEPKGVEVKVLFQNS
>Mature_479_residues
MVTNHYQFFFILSVGFYYLIDKTEESIRPRYMETIEESLNDTSHVLSALVEEKLKENPRKRFQFKSLVNELFRKPFQNIR
KRNFEAKIYSLLKTNADIQMYITDEKGFVIFDSELFREGLDYSKYNDVYLTLKGKYGVRSSKMFDTEKEGALFIASPIRY
EKEIIGVLTVIKPKIGVIPFIEEAKNKFWRISLLVASAIAIVFSLLAYISFRPILRLSQYITSLRNKDKIPFPKLGIKEL
NDLGKEVDQLVLELEGKKYVESYVQTLTHEIKSPLSSILASVELIQTHPKEMERLTKTIDAEAKRIQNLIDQLLELSSLE
GKNSIQLDDTIELISLLEEVLARFEIEFERKSLHVMKRFDMGRIQMKGNVNYIRMAIENILRNSIEFANPKDTITVELVS
TLNHQINLVISDQGQSIPDYALPKVTDKFFSLPRPIGLRKSSGLGLSIVKEILDLHQAELTIRNLEPKGVEVKVLFQNS

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=469, Percent_Identity=31.5565031982942, Blast_Score=249, Evalue=4e-67,
Organism=Escherichia coli, GI1786600, Length=237, Percent_Identity=25.3164556962025, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786783, Length=297, Percent_Identity=22.8956228956229, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790346, Length=231, Percent_Identity=27.7056277056277, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=288, Percent_Identity=25, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788393, Length=244, Percent_Identity=25, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI87082128, Length=236, Percent_Identity=24.1525423728814, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55363; Mature: 55363

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTNHYQFFFILSVGFYYLIDKTEESIRPRYMETIEESLNDTSHVLSALVEEKLKENPRK
CCCCCCHHHHHHHHHHHHEEECCHHHHCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCHHH
RFQFKSLVNELFRKPFQNIRKRNFEAKIYSLLKTNADIQMYITDEKGFVIFDSELFREGL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCEEEECHHHHHCCC
DYSKYNDVYLTLKGKYGVRSSKMFDTEKEGALFIASPIRYEKEIIGVLTVIKPKIGVIPF
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCC
IEEAKNKFWRISLLVASAIAIVFSLLAYISFRPILRLSQYITSLRNKDKIPFPKLGIKEL
HHHHCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
NDLGKEVDQLVLELEGKKYVESYVQTLTHEIKSPLSSILASVELIQTHPKEMERLTKTID
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AEAKRIQNLIDQLLELSSLEGKNSIQLDDTIELISLLEEVLARFEIEFERKSLHVMKRFD
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MGRIQMKGNVNYIRMAIENILRNSIEFANPKDTITVELVSTLNHQINLVISDQGQSIPDY
CCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHCCEEEEEECCCCCCCCCC
ALPKVTDKFFSLPRPIGLRKSSGLGLSIVKEILDLHQAELTIRNLEPKGVEVKVLFQNS
CCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCCCEEEEEEECC
>Mature Secondary Structure
MVTNHYQFFFILSVGFYYLIDKTEESIRPRYMETIEESLNDTSHVLSALVEEKLKENPRK
CCCCCCHHHHHHHHHHHHEEECCHHHHCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCHHH
RFQFKSLVNELFRKPFQNIRKRNFEAKIYSLLKTNADIQMYITDEKGFVIFDSELFREGL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCEEEECHHHHHCCC
DYSKYNDVYLTLKGKYGVRSSKMFDTEKEGALFIASPIRYEKEIIGVLTVIKPKIGVIPF
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCC
IEEAKNKFWRISLLVASAIAIVFSLLAYISFRPILRLSQYITSLRNKDKIPFPKLGIKEL
HHHHCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
NDLGKEVDQLVLELEGKKYVESYVQTLTHEIKSPLSSILASVELIQTHPKEMERLTKTID
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AEAKRIQNLIDQLLELSSLEGKNSIQLDDTIELISLLEEVLARFEIEFERKSLHVMKRFD
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MGRIQMKGNVNYIRMAIENILRNSIEFANPKDTITVELVSTLNHQINLVISDQGQSIPDY
CCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHCCEEEEEECCCCCCCCCC
ALPKVTDKFFSLPRPIGLRKSSGLGLSIVKEILDLHQAELTIRNLEPKGVEVKVLFQNS
CCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]