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The map label for this gene is creB [H]

Identifier: 183219817

GI number: 183219817

Start: 392958

End: 393635

Strand: Direct

Name: creB [H]

Synonym: LEPBI_I0395

Alternate gene names: 183219817

Gene position: 392958-393635 (Clockwise)

Preceding gene: 183219815

Following gene: 183219818

Centisome position: 10.92

GC content: 38.35

Gene sequence:

>678_bases
ATGATCAAAATTTTACTCATTGAAGATGAACCCGGGATCCAAGAAACAATCCAAATTGCATTAGAAGCAGAAGGGTTTTC
TTTGTCCATTGCCCCAACAGGCATACAGGGTTTACAAATGTTAGCTGACGATATCTCTCTCATTCTCCTGGATATCGGAC
TTCCTGACCAAAGTGGATTTGAAGTATTAAAATCAATTCGCAAAGCTGCGTCGATCCCTGTGATTTTTTTGACAGCACGT
AGTTCTGAAATCGATAAAGTGTTGGGATTGGAAATTGGTGCAGACGATTACATCGTCAAGCCATTCAGCCCAAGGGAACT
TTTGGCAAGGATCAGAGCTATATTACGTCGTACACAAAATCCATTGGTTTTGGAACAAAAATCAAACCAAAAATTAAGAA
TTTCCCTGGATAAAAAACTCGTTTATTATAATGGAAAAAATTTGAATTTATCACCTTACGAATACAAAACGATGGAATTA
TTTTTTAAATGGCCTGGCCGTATCTTCACTCGTGAAGAAATTATGGACAGTGTTTGGACAGAACCTGAGGATAGTTTTGA
TCGTGCTGTTGACACTGTGATCAAAAACATTCGGGCAAGGTTCAAAGAGATGGATCCAAATTTTGATCCTATTGAAACGA
GAAGAGGACAGGGGTACGGCTTAAAGGAAACAATATGA

Upstream 100 bases:

>100_bases
AAAAAGAGTCAACTTGGAATTATCTGATTGCTTTTCTTTTTAACTTTTATTCACTGAATTTTGTTCAGATCCAATTTGAT
AGGATCTACCGCCTCCCCAA

Downstream 100 bases:

>100_bases
ATCTTTGGTTACGAATCATTATCAGTTTTTTTTTATCTTAAGTGTTGGTTTTTATTATTTAATCGATAAAACAGAAGAAT
CCATCCGGCCTCGGTATATG

Product: transcriptional regulatory protein CreB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MIKILLIEDEPGIQETIQIALEAEGFSLSIAPTGIQGLQMLADDISLILLDIGLPDQSGFEVLKSIRKAASIPVIFLTAR
SSEIDKVLGLEIGADDYIVKPFSPRELLARIRAILRRTQNPLVLEQKSNQKLRISLDKKLVYYNGKNLNLSPYEYKTMEL
FFKWPGRIFTREEIMDSVWTEPEDSFDRAVDTVIKNIRARFKEMDPNFDPIETRRGQGYGLKETI

Sequences:

>Translated_225_residues
MIKILLIEDEPGIQETIQIALEAEGFSLSIAPTGIQGLQMLADDISLILLDIGLPDQSGFEVLKSIRKAASIPVIFLTAR
SSEIDKVLGLEIGADDYIVKPFSPRELLARIRAILRRTQNPLVLEQKSNQKLRISLDKKLVYYNGKNLNLSPYEYKTMEL
FFKWPGRIFTREEIMDSVWTEPEDSFDRAVDTVIKNIRARFKEMDPNFDPIETRRGQGYGLKETI
>Mature_225_residues
MIKILLIEDEPGIQETIQIALEAEGFSLSIAPTGIQGLQMLADDISLILLDIGLPDQSGFEVLKSIRKAASIPVIFLTAR
SSEIDKVLGLEIGADDYIVKPFSPRELLARIRAILRRTQNPLVLEQKSNQKLRISLDKKLVYYNGKNLNLSPYEYKTMEL
FFKWPGRIFTREEIMDSVWTEPEDSFDRAVDTVIKNIRARFKEMDPNFDPIETRRGQGYGLKETI

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=40.2654867256637, Blast_Score=183, Evalue=8e-48,
Organism=Escherichia coli, GI1788394, Length=219, Percent_Identity=35.6164383561644, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=36.7256637168142, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=35.5555555555556, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=38.0530973451327, Blast_Score=138, Evalue=2e-34,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=37.6681614349776, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=38.0090497737557, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=34.070796460177, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=29.7413793103448, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=210, Percent_Identity=32.3809523809524, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=30.9734513274336, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1789402, Length=229, Percent_Identity=34.9344978165939, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=27.7272727272727, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=26.3829787234043, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=33.6448598130841, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25661; Mature: 25661

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKILLIEDEPGIQETIQIALEAEGFSLSIAPTGIQGLQMLADDISLILLDIGLPDQSGF
CEEEEEEECCCCHHHHEEEEEECCCCEEEECCCCHHHHHHHHHCCEEEEEEECCCCCHHH
EVLKSIRKAASIPVIFLTARSSEIDKVLGLEIGADDYIVKPFSPRELLARIRAILRRTQN
HHHHHHHHHHCCCEEEEEECCCCHHHHHCEEECCCCEEECCCCHHHHHHHHHHHHHHCCC
PLVLEQKSNQKLRISLDKKLVYYNGKNLNLSPYEYKTMELFFKWPGRIFTREEIMDSVWT
CEEEEECCCCEEEEEEEEEEEEECCCCCCCCCCCCEEEEEEEECCCCEEEHHHHHHHHCC
EPEDSFDRAVDTVIKNIRARFKEMDPNFDPIETRRGQGYGLKETI
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCC
>Mature Secondary Structure
MIKILLIEDEPGIQETIQIALEAEGFSLSIAPTGIQGLQMLADDISLILLDIGLPDQSGF
CEEEEEEECCCCHHHHEEEEEECCCCEEEECCCCHHHHHHHHHCCEEEEEEECCCCCHHH
EVLKSIRKAASIPVIFLTARSSEIDKVLGLEIGADDYIVKPFSPRELLARIRAILRRTQN
HHHHHHHHHHCCCEEEEEECCCCHHHHHCEEECCCCEEECCCCHHHHHHHHHHHHHHCCC
PLVLEQKSNQKLRISLDKKLVYYNGKNLNLSPYEYKTMELFFKWPGRIFTREEIMDSVWT
CEEEEECCCCEEEEEEEEEEEEECCCCCCCCCCCCEEEEEEEECCCCEEEHHHHHHHHCC
EPEDSFDRAVDTVIKNIRARFKEMDPNFDPIETRRGQGYGLKETI
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503 [H]