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The map label for this gene is pyrC [H]

Identifier: 183219732

GI number: 183219732

Start: 305566

End: 306810

Strand: Reverse

Name: pyrC [H]

Synonym: LEPBI_I0308

Alternate gene names: 183219732

Gene position: 306810-305566 (Counterclockwise)

Preceding gene: 183219733

Following gene: 183219731

Centisome position: 8.52

GC content: 41.77

Gene sequence:

>1245_bases
ATGGAAACAATTGCAGGAAAGATCGTCACCCACGAAAAAGAATTTTTGGGTAGCATCGAATTTGATCCAACGACAGGACT
CATCACAAAGGTGAAAGAAGGGATCGAACCTAAATCTCGCCAATTCTCAGAAGATTGTGTGATTTTTCCAGGTTTTGGAG
ACATCCATATCCATGCAAGAGAAGATGTCACAGGCAAACATACATACAAGGAAGATTTTTTATCTGCAAGTGCCGCAGCC
ATCAACGGTGGTGTGATCCATGTGGCTGATATGCCAAACAATCCAGTCCCTCCGATTGATGATGCAACTTACGCCGCCAA
ACAAGCGCTTACCGAAAAAGCTCCTATCCACATTACTTTGTATGCAGGAATCGGTCCCCATACAAAACCTCTTTCCAAAA
AAGTTCCTTATAAAGTGTTTATGGGTCCTTCCATTGGGGAATTGTTTTTCCATGACAATCCATCTCTCGAAGAAGTGATC
CAACATTACGAAGGCCAAGATGTGAGTTTCCATTGTGAAGACCCAGAAATTCTCATTGCAAACAAAGACCAACCCACGCA
TGAAACCAGGCGACCGAAAGAAGCCGAAACAGTGGCAACCGATTTTGCGCTGTATTTAATTGAGAAGTACAACCTCAAAG
GGAAACTTTGCCATTATTCGACAAAAGACGGTCTTTCTAAGATCATCGCGGCCAAAAAACGAGGTGTGAAGGTCACATGC
GAAGTGACTCCCACTCATTTGATGTTTGATACGGACATGTTAACAGAAACCAATCACAAATGGTTCCAAATGAACCCACC
CCTTCGTGGACGAGCGGATAGAGAAGCCATGGTGAAAGGGATTCTGGATGGGCATATTGATTATTTAGCGACCGACCATG
CCCCCCATTCCATCGAAGAAAAACAAAAAGGTACAAGTGGCATTTCCCAATTGGATACCTATGGACTTTTTGTCACATAT
ATGATACTGAATTTAAACATTCCCATGACTCTCATTGCCAAAATCTGTTCTAAAAATCCTGGTGAGTTTGTAGCACCGTA
TCTACCAAAACAGTTTGGAAAAGGTGTAGGTGTTATTAACGAAGGTTATGCGGCAAATTTTTCTATCCTCAATTTAAAAA
AACCAGTTGAATTTAAAAAATCCATGATTAAAAGTAAGTCCGGATGGTCGCCATTCGAAGGGTTCCAATTTCCAGGATCC
ATCGAAGCGGTCTATTATTTAGGCAAAGAAATACATGCGAAATGA

Upstream 100 bases:

>100_bases
CTTATTTTTAGCGTCCCATTCGGATATCAGATTAGAAATCAATGTAAATTCCCTTGAAACTTTCCTTCCCTCTCAGAATC
TGCTGATGGAAAGGGATAAA

Downstream 100 bases:

>100_bases
GCCTTTAGGCAAAAACATTCTCTCTGGACTCACAGTTAAATCACTCCTGAGTGAATATCCAAACAGCTTCCAAGTTTTGG
ATTGGGAAGGTAATTTTGTT

Product: dihydroorotase-like protein

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
METIAGKIVTHEKEFLGSIEFDPTTGLITKVKEGIEPKSRQFSEDCVIFPGFGDIHIHAREDVTGKHTYKEDFLSASAAA
INGGVIHVADMPNNPVPPIDDATYAAKQALTEKAPIHITLYAGIGPHTKPLSKKVPYKVFMGPSIGELFFHDNPSLEEVI
QHYEGQDVSFHCEDPEILIANKDQPTHETRRPKEAETVATDFALYLIEKYNLKGKLCHYSTKDGLSKIIAAKKRGVKVTC
EVTPTHLMFDTDMLTETNHKWFQMNPPLRGRADREAMVKGILDGHIDYLATDHAPHSIEEKQKGTSGISQLDTYGLFVTY
MILNLNIPMTLIAKICSKNPGEFVAPYLPKQFGKGVGVINEGYAANFSILNLKKPVEFKKSMIKSKSGWSPFEGFQFPGS
IEAVYYLGKEIHAK

Sequences:

>Translated_414_residues
METIAGKIVTHEKEFLGSIEFDPTTGLITKVKEGIEPKSRQFSEDCVIFPGFGDIHIHAREDVTGKHTYKEDFLSASAAA
INGGVIHVADMPNNPVPPIDDATYAAKQALTEKAPIHITLYAGIGPHTKPLSKKVPYKVFMGPSIGELFFHDNPSLEEVI
QHYEGQDVSFHCEDPEILIANKDQPTHETRRPKEAETVATDFALYLIEKYNLKGKLCHYSTKDGLSKIIAAKKRGVKVTC
EVTPTHLMFDTDMLTETNHKWFQMNPPLRGRADREAMVKGILDGHIDYLATDHAPHSIEEKQKGTSGISQLDTYGLFVTY
MILNLNIPMTLIAKICSKNPGEFVAPYLPKQFGKGVGVINEGYAANFSILNLKKPVEFKKSMIKSKSGWSPFEGFQFPGS
IEAVYYLGKEIHAK
>Mature_414_residues
METIAGKIVTHEKEFLGSIEFDPTTGLITKVKEGIEPKSRQFSEDCVIFPGFGDIHIHAREDVTGKHTYKEDFLSASAAA
INGGVIHVADMPNNPVPPIDDATYAAKQALTEKAPIHITLYAGIGPHTKPLSKKVPYKVFMGPSIGELFFHDNPSLEEVI
QHYEGQDVSFHCEDPEILIANKDQPTHETRRPKEAETVATDFALYLIEKYNLKGKLCHYSTKDGLSKIIAAKKRGVKVTC
EVTPTHLMFDTDMLTETNHKWFQMNPPLRGRADREAMVKGILDGHIDYLATDHAPHSIEEKQKGTSGISQLDTYGLFVTY
MILNLNIPMTLIAKICSKNPGEFVAPYLPKQFGKGVGVINEGYAANFSILNLKKPVEFKKSMIKSKSGWSPFEGFQFPGS
IEAVYYLGKEIHAK

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=375, Percent_Identity=28, Blast_Score=113, Evalue=4e-25,
Organism=Escherichia coli, GI1786722, Length=301, Percent_Identity=26.578073089701, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87082175, Length=414, Percent_Identity=24.1545893719807, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193204318, Length=377, Percent_Identity=26.790450928382, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6322218, Length=409, Percent_Identity=23.4718826405868, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24642586, Length=376, Percent_Identity=28.1914893617021, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 46036; Mature: 46036

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIAGKIVTHEKEFLGSIEFDPTTGLITKVKEGIEPKSRQFSEDCVIFPGFGDIHIHAR
CCCCCCHHEECCHHHCCCCCCCCCHHHHHHHHHCCCCCHHCCCCCEEEECCCCCEEEEEC
EDVTGKHTYKEDFLSASAAAINGGVIHVADMPNNPVPPIDDATYAAKQALTEKAPIHITL
CCCCCCCHHHHHHHHHHHHEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEE
YAGIGPHTKPLSKKVPYKVFMGPSIGELFFHDNPSLEEVIQHYEGQDVSFHCEDPEILIA
EECCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCHHHHHHHHCCCCCEEEECCCEEEEE
NKDQPTHETRRPKEAETVATDFALYLIEKYNLKGKLCHYSTKDGLSKIIAAKKRGVKVTC
CCCCCCHHHCCCCHHHHHHHHHHEEEHHHCCCCCEEEECCCHHHHHHHHHHHCCCEEEEE
EVTPTHLMFDTDMLTETNHKWFQMNPPLRGRADREAMVKGILDGHIDYLATDHAPHSIEE
EECCCEEEEECHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCHHEEECCCCCCCHHH
KQKGTSGISQLDTYGLFVTYMILNLNIPMTLIAKICSKNPGEFVAPYLPKQFGKGVGVIN
HHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEECCCCHHHHCCCCCEEC
EGYAANFSILNLKKPVEFKKSMIKSKSGWSPFEGFQFPGSIEAVYYLGKEIHAK
CCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECHHHCCC
>Mature Secondary Structure
METIAGKIVTHEKEFLGSIEFDPTTGLITKVKEGIEPKSRQFSEDCVIFPGFGDIHIHAR
CCCCCCHHEECCHHHCCCCCCCCCHHHHHHHHHCCCCCHHCCCCCEEEECCCCCEEEEEC
EDVTGKHTYKEDFLSASAAAINGGVIHVADMPNNPVPPIDDATYAAKQALTEKAPIHITL
CCCCCCCHHHHHHHHHHHHEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEE
YAGIGPHTKPLSKKVPYKVFMGPSIGELFFHDNPSLEEVIQHYEGQDVSFHCEDPEILIA
EECCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCHHHHHHHHCCCCCEEEECCCEEEEE
NKDQPTHETRRPKEAETVATDFALYLIEKYNLKGKLCHYSTKDGLSKIIAAKKRGVKVTC
CCCCCCHHHCCCCHHHHHHHHHHEEEHHHCCCCCEEEECCCHHHHHHHHHHHCCCEEEEE
EVTPTHLMFDTDMLTETNHKWFQMNPPLRGRADREAMVKGILDGHIDYLATDHAPHSIEE
EECCCEEEEECHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCHHEEECCCCCCCHHH
KQKGTSGISQLDTYGLFVTYMILNLNIPMTLIAKICSKNPGEFVAPYLPKQFGKGVGVIN
HHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEECCCCHHHHCCCCCEEC
EGYAANFSILNLKKPVEFKKSMIKSKSGWSPFEGFQFPGSIEAVYYLGKEIHAK
CCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]