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The map label for this gene is ftsI [H]

Identifier: 183219682

GI number: 183219682

Start: 249557

End: 251368

Strand: Reverse

Name: ftsI [H]

Synonym: LEPBI_I0257

Alternate gene names: 183219682

Gene position: 251368-249557 (Counterclockwise)

Preceding gene: 183219683

Following gene: 183219681

Centisome position: 6.98

GC content: 39.02

Gene sequence:

>1812_bases
ATGACAGAATACAAACTTCGTTTTCAGTACATCTTCTATTTTATCTTATCCTTATTTGCCGTTTTGTTTTTCCGAGTGGT
GTATCTCACCTACTTTAATGAAAACATCATCAATCTAAAAGCCAATAAATTTGTCCAAAGAGGTACAATTTATGATCGAA
GAGGCATTGAACTTGCGATCTCAAGAGAATCTGCAACCGTTGGAATTGATCCTTCCAATATTTACGACCCAGAGCTCACC
GCACAAGAGTTAGGCCCTGTCCTCGGAATTCCCACAAACAAACTTGTTGATACCATTCGAGATAAACAAAATTATTTTTT
ATTAAAAAGAGAAATAGAATTATTCAAAGCGGAAAAAATCAAAACTCTTTCGCTTCCAGGTGTAAGAGTCGAAAAAGAAT
ACAAACGAATTTACCCTCAAGGCAGTTTGGCGGCAAGTTTACTTGGATTTACTGGTTATGATGATGACAAAGCATTATCT
GGACTTGAGATGTTGTACAATCTGGAATTATTATCAACTCCAGATGCAGAGTCCACAAAAGGAAATAATATCCACCTAAC
AATCGATAGTATCATACAATACCGATTGGAAAAATCCTTACAAAAAGCATTCATTCAAACAGCATCCAAACGTGGAATTG
GGATGATCATGGATACAGAAACAGGAAAAATCCTGGCAATGGCATCCTTTCCTAGTTTTGATCCCAACAATTTCCAAAAC
TTTCCTGTGGAGTCACATACAAACTGGTCCATCCGACATGTCTATGAACCAGGTTCCACAATGAAAATTTTCATCGCTCT
TATGCTTTTGAACGAGGGTAAAATTCTACCTGGAGAAAGGTTCCATTGTCCAGGTTACATTGAAATTGGAAAAACCATCA
TCCGATGTACAGATAACCACGGCCATTTGAATTTGGATGAAATTCTCCAATATTCATGTAATGTCGGAATCATCAAAGCC
GCACAAAAAATCGATGAAGCAACTTACTACCGTTATTTGGAAAATTTTAAATTCGGGAAACGAACCAATTTTTCCATCCA
TGAAGCAAAAGGATATTTAGCACCTCAAAATAAATGGAACAAAAGTACTCCGTACTTTCTTTCGATTGGCCAAGGAGTTT
CCGTTACTCCCATCCAACTCATCACAGCTGCTGCGGCTGTTGTCAATGGTGGCATTTTATTTGAACCATCAGTGGTTTCC
CAAATCACCAACTCCTATGGGGAATTGGTGCATGAATTTTCCACAAAATCAGAGTTACTCGGAATCAAGCCTGGTGCTGC
AGCTAAAACATTAAATGCAATGGGCAAGGCAGTTTCCCAAGGAACTGGGAAAAAGGCATATTTAGAAAACTACTTTATCG
CAGGAAAAACGGGAACCTCACAAAAAGCAAAAGCGGGCGAAGGATACCAGGAAGGATTATTTACTGCTAGTTTTCTTGGA
TTTTTTCCTGCCGACAAACCAAAGTATGTTGGTCTCATAGTTTTTGATGAACCAGGTGGTGAGTCTCATACAGGAGGTGG
GATTGCGGCTCCAGTATTTCGTGAGGTCGTAGAGAGTATCATTCCCATTGTGGAACGAAGTGAAAAGGCATTGGTTTACC
GATTACAAAATGAAAAAAACAAAGTGTTTAAGGTAGATCCCAAACAAATGCCAGATGTCACAGGCCTCACGGCATCGGAA
GTCCTACAAGTGTTAAAACAATTAAAAGTGAAATACACGTTAGAAGGTTCAGGGTTTGTGAAAACACAAGAGCCGAAACC
CAATGCCCCTCTTTCTCCCGATACAAACGTTAAAATTGGATTAGAACCGTAA

Upstream 100 bases:

>100_bases
TCTTGCTTGGTGACAATCGTCAGTATTCTACTGACTCTAGATCCTTTGGTCTAGTGCCCGTGGAAAAAATCAAAGGAAAG
GTAATCTTTTATTTTTAACA

Downstream 100 bases:

>100_bases
GTGAACGAAACTTTCCTTTCCCAAAACTTAGCCAGTTTGCCTTCCCAACTTTCATCATTTTTACAAAATGAACCCTCAAA
TGGAAATGGATTCCAAATCA

Product: peptidoglycan synthetase FtsI

Products: NA

Alternate protein names: Sporulation-specific penicillin-binding protein [H]

Number of amino acids: Translated: 603; Mature: 602

Protein sequence:

>603_residues
MTEYKLRFQYIFYFILSLFAVLFFRVVYLTYFNENIINLKANKFVQRGTIYDRRGIELAISRESATVGIDPSNIYDPELT
AQELGPVLGIPTNKLVDTIRDKQNYFLLKREIELFKAEKIKTLSLPGVRVEKEYKRIYPQGSLAASLLGFTGYDDDKALS
GLEMLYNLELLSTPDAESTKGNNIHLTIDSIIQYRLEKSLQKAFIQTASKRGIGMIMDTETGKILAMASFPSFDPNNFQN
FPVESHTNWSIRHVYEPGSTMKIFIALMLLNEGKILPGERFHCPGYIEIGKTIIRCTDNHGHLNLDEILQYSCNVGIIKA
AQKIDEATYYRYLENFKFGKRTNFSIHEAKGYLAPQNKWNKSTPYFLSIGQGVSVTPIQLITAAAAVVNGGILFEPSVVS
QITNSYGELVHEFSTKSELLGIKPGAAAKTLNAMGKAVSQGTGKKAYLENYFIAGKTGTSQKAKAGEGYQEGLFTASFLG
FFPADKPKYVGLIVFDEPGGESHTGGGIAAPVFREVVESIIPIVERSEKALVYRLQNEKNKVFKVDPKQMPDVTGLTASE
VLQVLKQLKVKYTLEGSGFVKTQEPKPNAPLSPDTNVKIGLEP

Sequences:

>Translated_603_residues
MTEYKLRFQYIFYFILSLFAVLFFRVVYLTYFNENIINLKANKFVQRGTIYDRRGIELAISRESATVGIDPSNIYDPELT
AQELGPVLGIPTNKLVDTIRDKQNYFLLKREIELFKAEKIKTLSLPGVRVEKEYKRIYPQGSLAASLLGFTGYDDDKALS
GLEMLYNLELLSTPDAESTKGNNIHLTIDSIIQYRLEKSLQKAFIQTASKRGIGMIMDTETGKILAMASFPSFDPNNFQN
FPVESHTNWSIRHVYEPGSTMKIFIALMLLNEGKILPGERFHCPGYIEIGKTIIRCTDNHGHLNLDEILQYSCNVGIIKA
AQKIDEATYYRYLENFKFGKRTNFSIHEAKGYLAPQNKWNKSTPYFLSIGQGVSVTPIQLITAAAAVVNGGILFEPSVVS
QITNSYGELVHEFSTKSELLGIKPGAAAKTLNAMGKAVSQGTGKKAYLENYFIAGKTGTSQKAKAGEGYQEGLFTASFLG
FFPADKPKYVGLIVFDEPGGESHTGGGIAAPVFREVVESIIPIVERSEKALVYRLQNEKNKVFKVDPKQMPDVTGLTASE
VLQVLKQLKVKYTLEGSGFVKTQEPKPNAPLSPDTNVKIGLEP
>Mature_602_residues
TEYKLRFQYIFYFILSLFAVLFFRVVYLTYFNENIINLKANKFVQRGTIYDRRGIELAISRESATVGIDPSNIYDPELTA
QELGPVLGIPTNKLVDTIRDKQNYFLLKREIELFKAEKIKTLSLPGVRVEKEYKRIYPQGSLAASLLGFTGYDDDKALSG
LEMLYNLELLSTPDAESTKGNNIHLTIDSIIQYRLEKSLQKAFIQTASKRGIGMIMDTETGKILAMASFPSFDPNNFQNF
PVESHTNWSIRHVYEPGSTMKIFIALMLLNEGKILPGERFHCPGYIEIGKTIIRCTDNHGHLNLDEILQYSCNVGIIKAA
QKIDEATYYRYLENFKFGKRTNFSIHEAKGYLAPQNKWNKSTPYFLSIGQGVSVTPIQLITAAAAVVNGGILFEPSVVSQ
ITNSYGELVHEFSTKSELLGIKPGAAAKTLNAMGKAVSQGTGKKAYLENYFIAGKTGTSQKAKAGEGYQEGLFTASFLGF
FPADKPKYVGLIVFDEPGGESHTGGGIAAPVFREVVESIIPIVERSEKALVYRLQNEKNKVFKVDPKQMPDVTGLTASEV
LQVLKQLKVKYTLEGSGFVKTQEPKPNAPLSPDTNVKIGLEP

Specific function: Penicillin-binding protein with an unknown catalytic activity. May have a specialized role in the morphogenesis of spore cortex, which is a modified form of peptidoglycan. Pore cortex formation is determined primarily by the mother cell [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PASTA domain [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=569, Percent_Identity=27.768014059754, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1786854, Length=595, Percent_Identity=24.5378151260504, Blast_Score=108, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005543
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR011927 [H]

Pfam domain/function: PF03793 PASTA; PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 67149; Mature: 67018

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEYKLRFQYIFYFILSLFAVLFFRVVYLTYFNENIINLKANKFVQRGTIYDRRGIELAI
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCCCCCEEEE
SRESATVGIDPSNIYDPELTAQELGPVLGIPTNKLVDTIRDKQNYFLLKREIELFKAEKI
ECCCCEEECCCCCCCCCCCCHHHCCCEECCCHHHHHHHHHCCCCEEEEHHHHHHHHHCCE
KTLSLPGVRVEKEYKRIYPQGSLAASLLGFTGYDDDKALSGLEMLYNLELLSTPDAESTK
EEECCCCCEECHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCCCCCCCC
GNNIHLTIDSIIQYRLEKSLQKAFIQTASKRGIGMIMDTETGKILAMASFPSFDPNNFQN
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCCCCCCC
FPVESHTNWSIRHVYEPGSTMKIFIALMLLNEGKILPGERFHCPGYIEIGKTIIRCTDNH
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCEEEEEECCC
GHLNLDEILQYSCNVGIIKAAQKIDEATYYRYLENFKFGKRTNFSIHEAKGYLAPQNKWN
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCC
KSTPYFLSIGQGVSVTPIQLITAAAAVVNGGILFEPSVVSQITNSYGELVHEFSTKSELL
CCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHCCHHHEE
GIKPGAAAKTLNAMGKAVSQGTGKKAYLENYFIAGKTGTSQKAKAGEGYQEGLFTASFLG
ECCCCHHHHHHHHHHHHHHCCCCCEEEHHCEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
FFPADKPKYVGLIVFDEPGGESHTGGGIAAPVFREVVESIIPIVERSEKALVYRLQNEKN
CCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
KVFKVDPKQMPDVTGLTASEVLQVLKQLKVKYTLEGSGFVKTQEPKPNAPLSPDTNVKIG
CEEEECHHHCCCCCCCCHHHHHHHHHHCCEEEEECCCCEEEECCCCCCCCCCCCCCEEEE
LEP
CCC
>Mature Secondary Structure 
TEYKLRFQYIFYFILSLFAVLFFRVVYLTYFNENIINLKANKFVQRGTIYDRRGIELAI
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCCCCCEEEE
SRESATVGIDPSNIYDPELTAQELGPVLGIPTNKLVDTIRDKQNYFLLKREIELFKAEKI
ECCCCEEECCCCCCCCCCCCHHHCCCEECCCHHHHHHHHHCCCCEEEEHHHHHHHHHCCE
KTLSLPGVRVEKEYKRIYPQGSLAASLLGFTGYDDDKALSGLEMLYNLELLSTPDAESTK
EEECCCCCEECHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCCCCCCCC
GNNIHLTIDSIIQYRLEKSLQKAFIQTASKRGIGMIMDTETGKILAMASFPSFDPNNFQN
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCCCCCCC
FPVESHTNWSIRHVYEPGSTMKIFIALMLLNEGKILPGERFHCPGYIEIGKTIIRCTDNH
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCEEEEEECCC
GHLNLDEILQYSCNVGIIKAAQKIDEATYYRYLENFKFGKRTNFSIHEAKGYLAPQNKWN
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCC
KSTPYFLSIGQGVSVTPIQLITAAAAVVNGGILFEPSVVSQITNSYGELVHEFSTKSELL
CCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHCCHHHEE
GIKPGAAAKTLNAMGKAVSQGTGKKAYLENYFIAGKTGTSQKAKAGEGYQEGLFTASFLG
ECCCCHHHHHHHHHHHHHHCCCCCEEEHHCEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
FFPADKPKYVGLIVFDEPGGESHTGGGIAAPVFREVVESIIPIVERSEKALVYRLQNEKN
CCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
KVFKVDPKQMPDVTGLTASEVLQVLKQLKVKYTLEGSGFVKTQEPKPNAPLSPDTNVKIG
CEEEECHHHCCCCCCCCHHHHHHHHHHCCEEEEECCCCEEEECCCCCCCCCCCCCCEEEE
LEP
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8289242; 9384377; 8244929; 8436954 [H]