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The map label for this gene is glmU [H]

Identifier: 183219662

GI number: 183219662

Start: 228054

End: 228815

Strand: Reverse

Name: glmU [H]

Synonym: LEPBI_I0237

Alternate gene names: 183219662

Gene position: 228815-228054 (Counterclockwise)

Preceding gene: 183219663

Following gene: 183219661

Centisome position: 6.36

GC content: 42.13

Gene sequence:

>762_bases
ATGAACCCACATAATACTGTAACTGCTGTTATTTTGGCGGCGGGGAAAGGAACTCGAATGAAGAGTGAGCTTCCCAAGGT
TGCGGTTGTACTGAACGAATCTCCACTTTTACTCCACGTCCTCCGTAATATTGAAACTGCCGGAATAGACCGCAAGGTTG
TCGTTGTCGGTTATCGCAAAGACATTGTCACAGACATTGCAAAATCCTTTCCCGGTGTTGAATTTGCAGAACAAACAGAA
CAACTAGGCACTGGACATGCTGTGATTTCAGCTGAGAAACAACTTGCACCATATACTGGTTACACGATTGTTGCCTGCGG
TGATGCACCGCTCATATCATCATCTTCATTTTCCAATCTGATCGAACACCATAAATCCCATGGATATGTCGCCACTGTCC
TTTCCGCAAAAATGGAAAATCCAACTGGTTACGGACGGATCATTCGTTCTTCCGATGATGGAAGTCTCTTACGCATCGTA
GAAGAAAAAGATGCAAACCCCGAAGAAAAAGCCGTAAATGAAGTGAACACGGGGACCTATTGTTTTAATACAGAAGATCT
TTTTGGTGCCTTAAAACAAATTGGAAATAATAACGCACAAAAAGAATATTACCTCACAGACGTGATCAAAATTTTCCGAA
ACGAAGGGAAAAAGGTTGGAGCACAAACTTTGACCAATGCTTTAGAAAGCCATGGAATCAATTCTCCCGATGATTTGGCT
CTTGCGAAACAATATATAGATAATGGGTTGGTTGGAGTATGA

Upstream 100 bases:

>100_bases
CCTGTAGCCAAGCGGTAAGGCAGCGGTTTTTGGTATCGCCATTCCCTAGGTTCGAATCCTAGCAGGCCAGCCAGTTTTAA
AAGATCCGATAGAAAGAACG

Downstream 100 bases:

>100_bases
ATCCTAGCGAAGTTGTAGTATTTTCTGGAAATGCAAATAGACCTTTAGCAGAAGAAATCTGCAAAAACTTAAAGATTCCG
AATGGCCAAATCTCTGTGAA

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase / glucosamine-1-phosphate N-acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MNPHNTVTAVILAAGKGTRMKSELPKVAVVLNESPLLLHVLRNIETAGIDRKVVVVGYRKDIVTDIAKSFPGVEFAEQTE
QLGTGHAVISAEKQLAPYTGYTIVACGDAPLISSSSFSNLIEHHKSHGYVATVLSAKMENPTGYGRIIRSSDDGSLLRIV
EEKDANPEEKAVNEVNTGTYCFNTEDLFGALKQIGNNNAQKEYYLTDVIKIFRNEGKKVGAQTLTNALESHGINSPDDLA
LAKQYIDNGLVGV

Sequences:

>Translated_253_residues
MNPHNTVTAVILAAGKGTRMKSELPKVAVVLNESPLLLHVLRNIETAGIDRKVVVVGYRKDIVTDIAKSFPGVEFAEQTE
QLGTGHAVISAEKQLAPYTGYTIVACGDAPLISSSSFSNLIEHHKSHGYVATVLSAKMENPTGYGRIIRSSDDGSLLRIV
EEKDANPEEKAVNEVNTGTYCFNTEDLFGALKQIGNNNAQKEYYLTDVIKIFRNEGKKVGAQTLTNALESHGINSPDDLA
LAKQYIDNGLVGV
>Mature_253_residues
MNPHNTVTAVILAAGKGTRMKSELPKVAVVLNESPLLLHVLRNIETAGIDRKVVVVGYRKDIVTDIAKSFPGVEFAEQTE
QLGTGHAVISAEKQLAPYTGYTIVACGDAPLISSSSFSNLIEHHKSHGYVATVLSAKMENPTGYGRIIRSSDDGSLLRIV
EEKDANPEEKAVNEVNTGTYCFNTEDLFGALKQIGNNNAQKEYYLTDVIKIFRNEGKKVGAQTLTNALESHGINSPDDLA
LAKQYIDNGLVGV

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=182, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI11761619, Length=182, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1790168, Length=235, Percent_Identity=37.4468085106383, Blast_Score=137, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI133931050, Length=194, Percent_Identity=29.8969072164948, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=186, Percent_Identity=29.5698924731183, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21355443, Length=193, Percent_Identity=31.0880829015544, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24644084, Length=193, Percent_Identity=31.0880829015544, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 27341; Mature: 27341

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPHNTVTAVILAAGKGTRMKSELPKVAVVLNESPLLLHVLRNIETAGIDRKVVVVGYRK
CCCCCEEEEEEEECCCCCCCHHHCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECHH
DIVTDIAKSFPGVEFAEQTEQLGTGHAVISAEKQLAPYTGYTIVACGDAPLISSSSFSNL
HHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCHHCCCCCCEEEEEECCCCCCCCHHHHHH
IEHHKSHGYVATVLSAKMENPTGYGRIIRSSDDGSLLRIVEEKDANPEEKAVNEVNTGTY
HHHHHCCCCEEEHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHCCCCEE
CFNTEDLFGALKQIGNNNAQKEYYLTDVIKIFRNEGKKVGAQTLTNALESHGINSPDDLA
EECHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHH
LAKQYIDNGLVGV
HHHHHHHCCCCCC
>Mature Secondary Structure
MNPHNTVTAVILAAGKGTRMKSELPKVAVVLNESPLLLHVLRNIETAGIDRKVVVVGYRK
CCCCCEEEEEEEECCCCCCCHHHCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECHH
DIVTDIAKSFPGVEFAEQTEQLGTGHAVISAEKQLAPYTGYTIVACGDAPLISSSSFSNL
HHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCHHCCCCCCEEEEEECCCCCCCCHHHHHH
IEHHKSHGYVATVLSAKMENPTGYGRIIRSSDDGSLLRIVEEKDANPEEKAVNEVNTGTY
HHHHHCCCCEEEHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHCCCCEE
CFNTEDLFGALKQIGNNNAQKEYYLTDVIKIFRNEGKKVGAQTLTNALESHGINSPDDLA
EECHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHH
LAKQYIDNGLVGV
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA