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The map label for this gene is prs [H]

Identifier: 183219661

GI number: 183219661

Start: 227116

End: 228057

Strand: Reverse

Name: prs [H]

Synonym: LEPBI_I0236

Alternate gene names: 183219661

Gene position: 228057-227116 (Counterclockwise)

Preceding gene: 183219662

Following gene: 183219660

Centisome position: 6.34

GC content: 43.95

Gene sequence:

>942_bases
ATGAATCCTAGCGAAGTTGTAGTATTTTCTGGAAATGCAAATAGACCTTTAGCAGAAGAAATCTGCAAAAACTTAAAGAT
TCCGAATGGCCAAATCTCTGTGAAGCGATTTTCAGATGGAGAAAGTTCTGTCAAAATCGAAGAGAATGTCCGTGGTCGCG
ATGTATTTGTTGTCCAATCCATAAGCTACCCTGCTAACGACAGTTTAATGGAACTTCTACTCATCATTGATGCAGCAAGA
AGGGCCTCTGCTCGTCGCATTACTGCCGTTATCCCATATTATGGGTATGGTCGCCAAGACAGAAAGGTGGAACCAAGAGT
TCCCATTTCGGCTCGTATGGTGGCCGATTTAATCGAAACGGTGGGTCCTGACCGTGTCCTGACAATGGACCTTCATGCTG
ACCAAATCCAAGGTTTTTTCCGAATTCCCGTGGACCATTTGTATTTTTCACCAGTTCTTGCTGAGTACATCAACTCACTT
GGAATGGATGATCTTGTGATTGTATCCCCTGATTCTGGGGGAGCGGAACGTGCTCGTAATTTTGGGAAAAAAGTAAACGG
GTCTCTTGCCATCATCGACAAACGGAGACCCAAAGCAAATGAGTCAGTCGTCATGCATGTGATAGGTGACATCAAAGACA
AAAACTGTTTGTTACTTGATGATATGATCGATACTGGTGGAACCATTGCGAAGGCAGCCACTGCCCTCTACGAAAATGGA
GCAAAATCGGTATTGTGTTGTGCTTCTCACGGAGTTCTTTCCGGCGAAGCTCCTTCGAAACTCAACGAGGCAAAATTCAA
TCCGATTGTCCTCTCCAATTCTATTGTCATTCCCGAGAGCAAAAAAATAAATCACTTGAAAACGCTCTCGATCGCCCCAC
TCTTTGCTAAAGCCATCGAGCGGATTCATAACGAAGAATCAATCTCTAGTCTGTTTTCATAA

Upstream 100 bases:

>100_bases
GAGCACAAACTTTGACCAATGCTTTAGAAAGCCATGGAATCAATTCTCCCGATGATTTGGCTCTTGCGAAACAATATATA
GATAATGGGTTGGTTGGAGT

Downstream 100 bases:

>100_bases
CTTTAAGGAACATAATCATGGAAAAAATCAGTATCAAAGCACAACCAAGAACTTCAACAGGAAAAGGTCCTGCCAGAAGA
ATGCGTGTGGAAGGTTTAGT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MNPSEVVVFSGNANRPLAEEICKNLKIPNGQISVKRFSDGESSVKIEENVRGRDVFVVQSISYPANDSLMELLLIIDAAR
RASARRITAVIPYYGYGRQDRKVEPRVPISARMVADLIETVGPDRVLTMDLHADQIQGFFRIPVDHLYFSPVLAEYINSL
GMDDLVIVSPDSGGAERARNFGKKVNGSLAIIDKRRPKANESVVMHVIGDIKDKNCLLLDDMIDTGGTIAKAATALYENG
AKSVLCCASHGVLSGEAPSKLNEAKFNPIVLSNSIVIPESKKINHLKTLSIAPLFAKAIERIHNEESISSLFS

Sequences:

>Translated_313_residues
MNPSEVVVFSGNANRPLAEEICKNLKIPNGQISVKRFSDGESSVKIEENVRGRDVFVVQSISYPANDSLMELLLIIDAAR
RASARRITAVIPYYGYGRQDRKVEPRVPISARMVADLIETVGPDRVLTMDLHADQIQGFFRIPVDHLYFSPVLAEYINSL
GMDDLVIVSPDSGGAERARNFGKKVNGSLAIIDKRRPKANESVVMHVIGDIKDKNCLLLDDMIDTGGTIAKAATALYENG
AKSVLCCASHGVLSGEAPSKLNEAKFNPIVLSNSIVIPESKKINHLKTLSIAPLFAKAIERIHNEESISSLFS
>Mature_313_residues
MNPSEVVVFSGNANRPLAEEICKNLKIPNGQISVKRFSDGESSVKIEENVRGRDVFVVQSISYPANDSLMELLLIIDAAR
RASARRITAVIPYYGYGRQDRKVEPRVPISARMVADLIETVGPDRVLTMDLHADQIQGFFRIPVDHLYFSPVLAEYINSL
GMDDLVIVSPDSGGAERARNFGKKVNGSLAIIDKRRPKANESVVMHVIGDIKDKNCLLLDDMIDTGGTIAKAATALYENG
AKSVLCCASHGVLSGEAPSKLNEAKFNPIVLSNSIVIPESKKINHLKTLSIAPLFAKAIERIHNEESISSLFS

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=313, Percent_Identity=44.7284345047923, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI84875539, Length=316, Percent_Identity=44.620253164557, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI4506127, Length=311, Percent_Identity=45.3376205787781, Blast_Score=275, Evalue=5e-74,
Organism=Homo sapiens, GI28557709, Length=311, Percent_Identity=44.6945337620579, Blast_Score=272, Evalue=4e-73,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=32.7536231884058, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI194018537, Length=342, Percent_Identity=33.3333333333333, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI310128524, Length=145, Percent_Identity=31.0344827586207, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI310115209, Length=145, Percent_Identity=31.0344827586207, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI310118259, Length=145, Percent_Identity=31.0344827586207, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI310119946, Length=145, Percent_Identity=31.0344827586207, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1787458, Length=308, Percent_Identity=53.2467532467532, Blast_Score=328, Evalue=4e-91,
Organism=Caenorhabditis elegans, GI17554704, Length=316, Percent_Identity=44.3037974683544, Blast_Score=269, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI25149168, Length=309, Percent_Identity=44.6601941747573, Blast_Score=268, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17554702, Length=309, Percent_Identity=44.6601941747573, Blast_Score=267, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI71989924, Length=311, Percent_Identity=44.3729903536978, Blast_Score=266, Evalue=9e-72,
Organism=Caenorhabditis elegans, GI17570245, Length=339, Percent_Identity=29.2035398230088, Blast_Score=163, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6319403, Length=317, Percent_Identity=44.794952681388, Blast_Score=277, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6320946, Length=316, Percent_Identity=43.6708860759494, Blast_Score=274, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6321776, Length=315, Percent_Identity=44.7619047619048, Blast_Score=269, Evalue=5e-73,
Organism=Saccharomyces cerevisiae, GI6322667, Length=195, Percent_Identity=43.0769230769231, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324511, Length=112, Percent_Identity=40.1785714285714, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21355239, Length=311, Percent_Identity=46.3022508038585, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI45551540, Length=334, Percent_Identity=43.1137724550898, Blast_Score=261, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24651458, Length=355, Percent_Identity=33.5211267605634, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24651456, Length=355, Percent_Identity=33.5211267605634, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI281362873, Length=355, Percent_Identity=33.5211267605634, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24651454, Length=355, Percent_Identity=33.5211267605634, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24651462, Length=202, Percent_Identity=37.1287128712871, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24651464, Length=202, Percent_Identity=37.1287128712871, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI45552010, Length=191, Percent_Identity=38.2198952879581, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34214; Mature: 34214

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE ; PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPSEVVVFSGNANRPLAEEICKNLKIPNGQISVKRFSDGESSVKIEENVRGRDVFVVQS
CCCCCEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCEEEECCCCCCEEEEEEE
ISYPANDSLMELLLIIDAARRASARRITAVIPYYGYGRQDRKVEPRVPISARMVADLIET
CCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
VGPDRVLTMDLHADQIQGFFRIPVDHLYFSPVLAEYINSLGMDDLVIVSPDSGGAERARN
CCCCEEEEEECCHHHHCCEEECCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHH
FGKKVNGSLAIIDKRRPKANESVVMHVIGDIKDKNCLLLDDMIDTGGTIAKAATALYENG
HHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCCEEEEECHHCCCCHHHHHHHHHHHCC
AKSVLCCASHGVLSGEAPSKLNEAKFNPIVLSNSIVIPESKKINHLKTLSIAPLFAKAIE
CCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCEECCCCCCCCCEEHHHHHHHHHHHHH
RIHNEESISSLFS
HHCCHHHHHHHCC
>Mature Secondary Structure
MNPSEVVVFSGNANRPLAEEICKNLKIPNGQISVKRFSDGESSVKIEENVRGRDVFVVQS
CCCCCEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCEEEECCCCCCEEEEEEE
ISYPANDSLMELLLIIDAARRASARRITAVIPYYGYGRQDRKVEPRVPISARMVADLIET
CCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
VGPDRVLTMDLHADQIQGFFRIPVDHLYFSPVLAEYINSLGMDDLVIVSPDSGGAERARN
CCCCEEEEEECCHHHHCCEEECCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHH
FGKKVNGSLAIIDKRRPKANESVVMHVIGDIKDKNCLLLDDMIDTGGTIAKAATALYENG
HHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCCEEEEECHHCCCCHHHHHHHHHHHCC
AKSVLCCASHGVLSGEAPSKLNEAKFNPIVLSNSIVIPESKKINHLKTLSIAPLFAKAIE
CCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCEECCCCCCCCCEEHHHHHHHHHHHHH
RIHNEESISSLFS
HHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA