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The map label for this gene is mdlA [C]

Identifier: 183219628

GI number: 183219628

Start: 197523

End: 198833

Strand: Reverse

Name: mdlA [C]

Synonym: LEPBI_I0203

Alternate gene names: 183219628

Gene position: 198833-197523 (Counterclockwise)

Preceding gene: 183219629

Following gene: 183219627

Centisome position: 5.52

GC content: 39.44

Gene sequence:

>1311_bases
GTGAATCGGTTTTTTGATACCATGACCATCCAAAAGTCCATACACTCCTTGTTAGTTGATGGGCTAGCCGTAATTTTGAC
CACTGTGATCGGATTTGTGCTCATTTCCTTTTATCACCCCATTTTCATTGTTTTCTCTCTCTTCATCTTGTTTGTAGGAG
GGTATCTGGTGATCTACCAATTGGGTAGACCAGCTTCAGAAAATTATATTAAAATATCCAAAGAAAAATACAAAGTAGCA
GCATGGCTCGAAGAAATTTCTCGCCATTCAGCCTTATTCCACTCAACGTTTGGTTCTCATTTTGCCATCGAAAAAGCGGA
TTCCCTTATCCGTGATTACTTATTTGCTCGTAAAAAATACTTTTCCGTTTATATCAAACAAATCATTGGACTTGTCGGCA
TACAAGCGTTAGCCAGTGCGATTGTTCTTGGTATTGGTGGGTATCTTGTCATCCATAGACAATTGACCATCGGACAGTTG
GTGGCCGCAGAACTTGTCATCGCAAAGGTGCTTAGCGATATATCCAAGTTCGGAAAACAACTCGATAGTTTTTATAGTTT
GATTGCGGCTGTGGATAAAATCAATTCTGTCTTCCATTTGCCTACACTAAAGGCAAAAACAGTTCCTTTCGAAATTCCGA
AAGGTCCTATCCAAGTCCAACTTTCGGGAATCGATTATTCCCTTGCCAATGGACATAAAATTTTCACTCAGTTCAATTTA
AAAGTGCAAGCAGGAAAAGCCATCGGTGTCTCGTCTAACACACCTTATGATGCCCATATCTTACTTGATTTGCTGAGTGG
CCTTAGGGAACCAAATTCTGGAATTGTGGAATACAATCACCAAAACATCCACGAAGTGTCCAAGGAACAAATCCAAACCT
ACACTGTTCTTGTCAGAGGGAATGAAATTTTTGAAGGCACTATATTGGAAAACATCCGAGTTGGAAGAGAAGAAATTTCT
CTCATCACAATCCGTGATCTTTTAGACAATCTTGGACTTTGGAAAACCATCCAATCCTTACCTCATGGTATTCACACACA
GCTGTTAACGTTTGGCCATCCTTTTGATAATGTACAATCTGCAGTTCTTACCTTAACCCGGGCTCTTATCGGAAATCCAA
AACTGATTCTCATTGATGGAATCCTTGACCAATTGCCACCACCCTTGTTAAATTCTTGTTTGAAACATTTACTCCAAAAA
AATCGAGAATCAACAGTTTTCATTGTGTCCAAGTCACCAACCATCCTTGGGCAAATGGACCAAATCTTAAAGTTGGAAGA
TGATTCTCATTCATTAAAGGTGAATCCATAA

Upstream 100 bases:

>100_bases
TTTTACAACGCCGTGTTTTGTTCGGATCGCAACGGAATTTGCCGTTCGGTTTCCAAGGATCCGCCAAGATGCCTTAGACA
AACACCACAACCCAGAACTT

Downstream 100 bases:

>100_bases
ACAACTATGAACACTAATATGTCACCAAAATGGAAACTTCGTAAAAACCTACCTTCTTACCGGTTGGTGCAAACAGCACT
TCCTGCACAAAGTTTAGCCT

Product: ABC transporter membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MNRFFDTMTIQKSIHSLLVDGLAVILTTVIGFVLISFYHPIFIVFSLFILFVGGYLVIYQLGRPASENYIKISKEKYKVA
AWLEEISRHSALFHSTFGSHFAIEKADSLIRDYLFARKKYFSVYIKQIIGLVGIQALASAIVLGIGGYLVIHRQLTIGQL
VAAELVIAKVLSDISKFGKQLDSFYSLIAAVDKINSVFHLPTLKAKTVPFEIPKGPIQVQLSGIDYSLANGHKIFTQFNL
KVQAGKAIGVSSNTPYDAHILLDLLSGLREPNSGIVEYNHQNIHEVSKEQIQTYTVLVRGNEIFEGTILENIRVGREEIS
LITIRDLLDNLGLWKTIQSLPHGIHTQLLTFGHPFDNVQSAVLTLTRALIGNPKLILIDGILDQLPPPLLNSCLKHLLQK
NRESTVFIVSKSPTILGQMDQILKLEDDSHSLKVNP

Sequences:

>Translated_436_residues
MNRFFDTMTIQKSIHSLLVDGLAVILTTVIGFVLISFYHPIFIVFSLFILFVGGYLVIYQLGRPASENYIKISKEKYKVA
AWLEEISRHSALFHSTFGSHFAIEKADSLIRDYLFARKKYFSVYIKQIIGLVGIQALASAIVLGIGGYLVIHRQLTIGQL
VAAELVIAKVLSDISKFGKQLDSFYSLIAAVDKINSVFHLPTLKAKTVPFEIPKGPIQVQLSGIDYSLANGHKIFTQFNL
KVQAGKAIGVSSNTPYDAHILLDLLSGLREPNSGIVEYNHQNIHEVSKEQIQTYTVLVRGNEIFEGTILENIRVGREEIS
LITIRDLLDNLGLWKTIQSLPHGIHTQLLTFGHPFDNVQSAVLTLTRALIGNPKLILIDGILDQLPPPLLNSCLKHLLQK
NRESTVFIVSKSPTILGQMDQILKLEDDSHSLKVNP
>Mature_436_residues
MNRFFDTMTIQKSIHSLLVDGLAVILTTVIGFVLISFYHPIFIVFSLFILFVGGYLVIYQLGRPASENYIKISKEKYKVA
AWLEEISRHSALFHSTFGSHFAIEKADSLIRDYLFARKKYFSVYIKQIIGLVGIQALASAIVLGIGGYLVIHRQLTIGQL
VAAELVIAKVLSDISKFGKQLDSFYSLIAAVDKINSVFHLPTLKAKTVPFEIPKGPIQVQLSGIDYSLANGHKIFTQFNL
KVQAGKAIGVSSNTPYDAHILLDLLSGLREPNSGIVEYNHQNIHEVSKEQIQTYTVLVRGNEIFEGTILENIRVGREEIS
LITIRDLLDNLGLWKTIQSLPHGIHTQLLTFGHPFDNVQSAVLTLTRALIGNPKLILIDGILDQLPPPLLNSCLKHLLQK
NRESTVFIVSKSPTILGQMDQILKLEDDSHSLKVNP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI42741659, Length=297, Percent_Identity=23.2323232323232, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI9961250, Length=316, Percent_Identity=22.7848101265823, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI4505771, Length=316, Percent_Identity=22.7848101265823, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI9961252, Length=316, Percent_Identity=22.7848101265823, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193209708, Length=197, Percent_Identity=25.8883248730964, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI115533592, Length=311, Percent_Identity=20.9003215434084, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25146777, Length=297, Percent_Identity=22.8956228956229, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323217, Length=400, Percent_Identity=21.75, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324985, Length=404, Percent_Identity=21.7821782178218, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI23397593, Length=448, Percent_Identity=22.0982142857143, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 48604; Mature: 48604

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS50893 ABC_TRANSPORTER_2 ; PS50929 ABC_TM1F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRFFDTMTIQKSIHSLLVDGLAVILTTVIGFVLISFYHPIFIVFSLFILFVGGYLVIYQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LGRPASENYIKISKEKYKVAAWLEEISRHSALFHSTFGSHFAIEKADSLIRDYLFARKKY
CCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
FSVYIKQIIGLVGIQALASAIVLGIGGYLVIHRQLTIGQLVAAELVIAKVLSDISKFGKQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDSFYSLIAAVDKINSVFHLPTLKAKTVPFEIPKGPIQVQLSGIDYSLANGHKIFTQFNL
HHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCEEEEEECCCEEECCCCEEEEEEEE
KVQAGKAIGVSSNTPYDAHILLDLLSGLREPNSGIVEYNHQNIHEVSKEQIQTYTVLVRG
EEEECCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHEEEEEEEEC
NEIFEGTILENIRVGREEISLITIRDLLDNLGLWKTIQSLPHGIHTQLLTFGHPFDNVQS
CCEECCHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHCCCCHHHHHH
AVLTLTRALIGNPKLILIDGILDQLPPPLLNSCLKHLLQKNRESTVFIVSKSPTILGQMD
HHHHHHHHHHCCCCEEEEECHHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHH
QILKLEDDSHSLKVNP
HHHEECCCCCCEEECC
>Mature Secondary Structure
MNRFFDTMTIQKSIHSLLVDGLAVILTTVIGFVLISFYHPIFIVFSLFILFVGGYLVIYQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LGRPASENYIKISKEKYKVAAWLEEISRHSALFHSTFGSHFAIEKADSLIRDYLFARKKY
CCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
FSVYIKQIIGLVGIQALASAIVLGIGGYLVIHRQLTIGQLVAAELVIAKVLSDISKFGKQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDSFYSLIAAVDKINSVFHLPTLKAKTVPFEIPKGPIQVQLSGIDYSLANGHKIFTQFNL
HHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCEEEEEECCCEEECCCCEEEEEEEE
KVQAGKAIGVSSNTPYDAHILLDLLSGLREPNSGIVEYNHQNIHEVSKEQIQTYTVLVRG
EEEECCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHEEEEEEEEC
NEIFEGTILENIRVGREEISLITIRDLLDNLGLWKTIQSLPHGIHTQLLTFGHPFDNVQS
CCEECCHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHCCCCHHHHHH
AVLTLTRALIGNPKLILIDGILDQLPPPLLNSCLKHLLQKNRESTVFIVSKSPTILGQMD
HHHHHHHHHHCCCCEEEEECHHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHH
QILKLEDDSHSLKVNP
HHHEECCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]