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The map label for this gene is rnd [H]

Identifier: 183219597

GI number: 183219597

Start: 166847

End: 168067

Strand: Reverse

Name: rnd [H]

Synonym: LEPBI_I0172

Alternate gene names: 183219597

Gene position: 168067-166847 (Counterclockwise)

Preceding gene: 183219608

Following gene: 183219596

Centisome position: 4.67

GC content: 38.66

Gene sequence:

>1221_bases
ATGCAAATCAATTCCAACTATATTCTCGTCGATACAGCAAAAGCTTTGGATTTGGCCCTGATCAATCTAAGGCAGTCCAA
AATCATGTCGATTGACACAGAGTCTTCGGGTTATTACACATATTATCCCAAAGTTTGTCTCATTCAGATCAATTCCAATG
GCAAAAACTACCTCATAGACCCGCTAAAAATCACAAATTTGTCAGCTTTGGGTCCTTTGTTTGAAGATCCCAATATTCTG
AAAATCTTCCATTCCGCACAAGATGACATCAAAGCCCTCAAACGTGACTTTGGGTTCAAATTTGTGAACACGGCGGATAC
GATGATCAGCTCTCGATTATTGTCTTTGGAACAAAGTTCGTTGTCATTTGTTGTGGAACACTACCACAAGGTAACCCTTT
CCAAAGTGGAACAAAAGTCCAATTGGGAAATTCGCCCTCTGCAAAAACAACAACTCAAGTATGCCGCCCTCGACACAGCC
TATTTAGAATCCATTTGGTTAAAAATGGAAGAAGATCTCAAACGCAGGTCTTTGTATGATGAAGCCAAGTCTGAATTTGA
TTTCATTGCTTCGGAAGATTACGTAGCCAAGGAAGGGGAAGGATTTTCCCTTGGAAAATTTCCTGACATTCTCAATTTCA
CCCCTCTCGAACGTCGAAAAATTTTAGAACTACTTCGTTACCGAGATGAAAAAGCAAAACGAATCAACAAAGCAAGTTTT
CGCGTCTTTAATAATGACAGATTATCTCAATCAGTCAAAGAACAACCAAACGAAGAAAAATGTATTGAATGGTTTGGAAA
AAAAGATGGTACTGAGATTTATAAATTACTCATTGCGGAATACAATGATCCTATTGATACTTCGGAACTCTCCAAACGAC
ATGGGGAAGATTTAAACGAAGATGAAAATCATAAATTCCAAAACGCTAAAAAATGGCGTCTTCGCATTATGCGTGCTAGA
CGAATGGAACATTCTCTTTTACCATCCAATAAACAACTCATCACTGTTTTAAGAGCAGCTCCTAAAAACTTAGAAGAATT
AAAAGCCCTGAATGTATTCTCTGATTGGAAAGTACAAAACTATGGTCCAAGTTTACTTGCTGCCATCCAAGGACTCCCTT
TTGATTCGATGATCAACCGATTGGTTGCCATCCGTTCCAAAGAAGCATTTGTAGCCAAACGTAGGAAAAAACAAAACCAA
AACTCGAAAGACGAGGGTTGA

Upstream 100 bases:

>100_bases
CTATTGTAGATGCCGTATATGGCACATTCTTCTTTTGGTTTGTCAGATTGGAGAATCATTGTTAGAATGACAATTGCAGT
ATTTCCATAATCCCAATTAG

Downstream 100 bases:

>100_bases
TGTTACCCTACCAGTCCTTTGTAAATCAACTTTCAAGGGACTTCGATGCAATCCCTGATACATCGGAAACAAAATCCGGT
GTCATCTTTCCTCTGTTTGG

Product: putative ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MQINSNYILVDTAKALDLALINLRQSKIMSIDTESSGYYTYYPKVCLIQINSNGKNYLIDPLKITNLSALGPLFEDPNIL
KIFHSAQDDIKALKRDFGFKFVNTADTMISSRLLSLEQSSLSFVVEHYHKVTLSKVEQKSNWEIRPLQKQQLKYAALDTA
YLESIWLKMEEDLKRRSLYDEAKSEFDFIASEDYVAKEGEGFSLGKFPDILNFTPLERRKILELLRYRDEKAKRINKASF
RVFNNDRLSQSVKEQPNEEKCIEWFGKKDGTEIYKLLIAEYNDPIDTSELSKRHGEDLNEDENHKFQNAKKWRLRIMRAR
RMEHSLLPSNKQLITVLRAAPKNLEELKALNVFSDWKVQNYGPSLLAAIQGLPFDSMINRLVAIRSKEAFVAKRRKKQNQ
NSKDEG

Sequences:

>Translated_406_residues
MQINSNYILVDTAKALDLALINLRQSKIMSIDTESSGYYTYYPKVCLIQINSNGKNYLIDPLKITNLSALGPLFEDPNIL
KIFHSAQDDIKALKRDFGFKFVNTADTMISSRLLSLEQSSLSFVVEHYHKVTLSKVEQKSNWEIRPLQKQQLKYAALDTA
YLESIWLKMEEDLKRRSLYDEAKSEFDFIASEDYVAKEGEGFSLGKFPDILNFTPLERRKILELLRYRDEKAKRINKASF
RVFNNDRLSQSVKEQPNEEKCIEWFGKKDGTEIYKLLIAEYNDPIDTSELSKRHGEDLNEDENHKFQNAKKWRLRIMRAR
RMEHSLLPSNKQLITVLRAAPKNLEELKALNVFSDWKVQNYGPSLLAAIQGLPFDSMINRLVAIRSKEAFVAKRRKKQNQ
NSKDEG
>Mature_406_residues
MQINSNYILVDTAKALDLALINLRQSKIMSIDTESSGYYTYYPKVCLIQINSNGKNYLIDPLKITNLSALGPLFEDPNIL
KIFHSAQDDIKALKRDFGFKFVNTADTMISSRLLSLEQSSLSFVVEHYHKVTLSKVEQKSNWEIRPLQKQQLKYAALDTA
YLESIWLKMEEDLKRRSLYDEAKSEFDFIASEDYVAKEGEGFSLGKFPDILNFTPLERRKILELLRYRDEKAKRINKASF
RVFNNDRLSQSVKEQPNEEKCIEWFGKKDGTEIYKLLIAEYNDPIDTSELSKRHGEDLNEDENHKFQNAKKWRLRIMRAR
RMEHSLLPSNKQLITVLRAAPKNLEELKALNVFSDWKVQNYGPSLLAAIQGLPFDSMINRLVAIRSKEAFVAKRRKKQNQ
NSKDEG

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=169, Percent_Identity=34.3195266272189, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI50301240, Length=163, Percent_Identity=34.9693251533742, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1788105, Length=258, Percent_Identity=30.2325581395349, Blast_Score=95, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17531757, Length=175, Percent_Identity=31.4285714285714, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32564304, Length=107, Percent_Identity=32.7102803738318, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324574, Length=270, Percent_Identity=31.8518518518519, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI161078302, Length=170, Percent_Identity=34.1176470588235, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 47178; Mature: 47178

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQINSNYILVDTAKALDLALINLRQSKIMSIDTESSGYYTYYPKVCLIQINSNGKNYLID
CEECCCEEEEECHHHHHHHHHHHHHHHEEEEECCCCCEEEEECEEEEEEECCCCCEEEEC
PLKITNLSALGPLFEDPNILKIFHSAQDDIKALKRDFGFKFVNTADTMISSRLLSLEQSS
CEEECCHHHHCCCCCCCCCEEHHHCCHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHH
LSFVVEHYHKVTLSKVEQKSNWEIRPLQKQQLKYAALDTAYLESIWLKMEEDLKRRSLYD
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAKSEFDFIASEDYVAKEGEGFSLGKFPDILNFTPLERRKILELLRYRDEKAKRINKASF
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHE
RVFNNDRLSQSVKEQPNEEKCIEWFGKKDGTEIYKLLIAEYNDPIDTSELSKRHGEDLNE
EEECCHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC
DENHKFQNAKKWRLRIMRARRMEHSLLPSNKQLITVLRAAPKNLEELKALNVFSDWKVQN
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC
YGPSLLAAIQGLPFDSMINRLVAIRSKEAFVAKRRKKQNQNSKDEG
CCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQINSNYILVDTAKALDLALINLRQSKIMSIDTESSGYYTYYPKVCLIQINSNGKNYLID
CEECCCEEEEECHHHHHHHHHHHHHHHEEEEECCCCCEEEEECEEEEEEECCCCCEEEEC
PLKITNLSALGPLFEDPNILKIFHSAQDDIKALKRDFGFKFVNTADTMISSRLLSLEQSS
CEEECCHHHHCCCCCCCCCEEHHHCCHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHH
LSFVVEHYHKVTLSKVEQKSNWEIRPLQKQQLKYAALDTAYLESIWLKMEEDLKRRSLYD
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAKSEFDFIASEDYVAKEGEGFSLGKFPDILNFTPLERRKILELLRYRDEKAKRINKASF
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHE
RVFNNDRLSQSVKEQPNEEKCIEWFGKKDGTEIYKLLIAEYNDPIDTSELSKRHGEDLNE
EEECCHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC
DENHKFQNAKKWRLRIMRARRMEHSLLPSNKQLITVLRAAPKNLEELKALNVFSDWKVQN
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC
YGPSLLAAIQGLPFDSMINRLVAIRSKEAFVAKRRKKQNQNSKDEG
CCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]